[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gender-dysphoria-in-adolescents-and-adults\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gender-dysphoria-in-adolescents-and-adults":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100612369","the-effect-of-gender-affirmative-measures-on-breast-perception-in-trans-men-100612369",false,"NCT07252687","The Effect of Gender-affirmative Measures on Breast Perception in Trans Men","The Effect of Gender-affirmative Measures on Breast Perception in Trans Men (TRANSBREAST) - a Prospective Cohort Study","TRANSBREAST","Inclusion Criteria:\n\n* AFAB (Assigned Female At Birth)\n* before starting GAHT\n* before mastectomy\n\nExclusion Criteria:\n\n* Ongoing GAHT\n* Mastectomy already performed\n* Lack of capacity to give consent\n* Insufficient knowledge of German","FEMALE","16 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","Breast dysphoria in transmasculine or genderdiverse individuals is a distinct psychological burden associated with depression, anxiety and suicidality. The aim is to systematically investigate the effect of GAHT (gender-affirming hormone therapy) and mastectomy on this form of dysphoria.\n\nThe primary objective of this study is to analyse and investigate the psychological and physical effects of breast development on trans men or genderdiverse individuals.\n\nA secondary objective is to determine the extent to which the stress affects the well-being of trans men depending on the coping strategies used (binding vs. taping).",[25,26],"Transgender","Gender Dysphoria in Adolescents and Adults",[28,29,30,31,32],"transgender","breastdysphoria","trans male","non binary","genderdiverse","RECRUITING","2026-03-04",{"date":36,"type":37},"2026-03-06","ACTUAL",{"date":39,"type":37},"2025-11-30",{"date":41,"type":21},"2030-11",{"name":43,"class":44},"Medical University Innsbruck","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":57,"studyType":22,"phases":4,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":45},"100567581","puberty-testosterone-and-brain-development-100567581","NCT06670053","Puberty, Testosterone, and Brain Development","Effect of Testosterone on Brain Imaging and Headache in Transmasculine Adolescents","Inclusion Criteria:\n\n1. transmasculine and gender diverse\n2. assigned female at birth\n3. age 12-20 years at the time of enrollment\n4. plan to start testosterone clinically in \\\u003C 6 months\n5. if taking gonadotropin releasing hormone agonist (GnRHa, puberty blocker), was started on this type of drug 3+ months prior to enrollment\n\nExclusion Criteria:\n\n1. cognitive or psychiatric impairment resulting in inability to tolerate or perform the study procedures\n2. known history of stroke, multiple sclerosis, or other serious neurologic condition\n3. prior diagnosis of Turner Syndrome (monosomy X) or other difference of sexual development\n4. prior diagnosis of polycystic ovarian syndrome (PCOS)\n5. uncontrolled or untreated hypothyroidism\n6. MRI-specific exclusion criteria: (Weight \\> 500 lbs, severe claustrophobia, certain type of metal in body)","ALL","12 Years","20 Years",{"count":20,"type":21},"2 Years","Transmasculine youth (female sex assigned at birth, male gender identity) who begin clinical gender affirming hormone therapy (GAHT) with testosterone (T) may experience changes in headache. Researchers think this because studies published on effects of giving testosterone to cisgender females (female sex, female gender identity) and transmasculine adults seem to show an effect on pain.\n\nThis research will help us learn more about changes in headache and in brain structure and function in transmasculine youth during the first two years of T. Youth who will be starting T within 6 months, either on puberty blocker or not, as part of their regular medical care can participate and will be asked to attend 4 visits:\n\n* before starting T\n* after 6 months on T\n* after 1 year on T\n* after 2 years on T\n\nAt the visits, they will be asked to:\n\n* answer questions and surveys about their health\n* have a brain MRI done\n* give a small sample of blood\n\nand at their first visit, complete a physical exam. Some participants can also do a brief test of pain sensitivity. All participants will be asked to complete a headache diary for the first 6 months, for 1 month after the 1 year visit, and for 1 month after the 2 year visit.",[60,26,61,25],"Gender Identity","Headache",[63,64,65,66,67,68,69],"resting-state functional connectivity","pain task","fMRI","MRI","migraine","gender affirming hormone therapy","testosterone","2025-04-02",{"date":72,"type":37},"2025-04-03",{"date":74,"type":37},"2024-12-31",{"date":76,"type":21},"2026-12",{"name":78,"class":44},"University of Colorado, Denver"]