[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gene-mutation-related-cancer\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gene-mutation-related-cancer":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100185446","cosegregation-of-variants-in-panel-of-genes-100185446",false,"NCT01689584","COsegregation of VARiants in Panel of Genes","Study of Family COsegregation of Nucleotide VARiants in the Panel of Genes to Validate Their Use in Genetic Counseling","COVAR","Inclusion Criteria:\n\nIndex cases:\n\n* A person carrying a variant of interest in a gene analyzed in a diagnostic setting by one of the laboratories within the Genetics and Cancer Group (GGC)-Unicancer network, classified as class 3, 4 or hypomorphic class 5, and selected by the national expert group for the gene concerned.\n* Age ≥ 18 years.\n* Signed written inform consent \"index case\"\n\nRelated parties:\n\n* Any relative of an index case with cancer\n* Any relative without cancer related to an index case, selected by the investigators, according to family structure and degree of related compared to the index case\n* For class 4 and hypomorphic class 5 variants; relatives currently undergoing analysis or having already obtained a test result for the variant of interest as part of clinical care.\n* Age ≥ 18 years\n* Information and signature of the informed consent \"selected relatives\"\n\nExclusion Criteria:\n\n* Minors\n* Persons deprived of liberty or under guardianship (including curators).\n* Absence of signed written inform consent","ALL","18 Years",{"count":20,"type":21},11000,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of the COVAR project is to achieve reliable classification of as many variants of interest as possible from the French OncoGenetics Database (FrOG, https:\u002F\u002Ffrog-db.fr\u002F) in order to use them for the genetic counseling. The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some cases to propose a prophylactic surgery.",[27,28],"Gene Mutation-Related Cancer","Genetic Predisposition",[30,31,32,33,34,35,36,37,38,39],"BRCA1","BRCA2","VUS","co-segregation","genetic counseling","PALB2","panel of genes","variant","hypomorphic","Hereditary cancer (breast, ovarian, prostate, pancreas, digestive track)","RECRUITING","2026-05-22",{"date":43,"type":44},"2026-05-27","ACTUAL",{"date":46,"type":44},"2012-07-02",{"date":48,"type":21},"2038-01-02",{"name":50,"class":51},"Institut Curie","OTHER",62,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100522961","genetic-information-assistant-in-telegenetics-100522961","NCT06089421","Genetic Information Assistant in Telegenetics","A Prospective, Randomized Trial to Compare Telegenetics to Counseling Via a Novel Genetic Information Assistant in High-risk Cancer Patients.","Inclusion Criteria:\n\n* At high risk for having a genetic pathogenic variant as assessed by a GC or physician according to the NCCN guidelines\n* Provision of signed and dated informed consent form.\n* Stated willingness to comply with all study procedures and availability for the duration of the study.\n* Male or female, aged 18 and over.\n* Subjects must have a smartphone with access to cellular and\u002For internet service or a computer with internet service.\n* Subjects must have technological competency\u002Fproficiency to use their Smartphone and\u002For computer in conjunction with the communication aid GIA.\n\nExclusion Criteria:\n\n* Cannot communicate in English or Spanish.\n* Subjects must not have completed panel-based cancer genetic testing in the past.",true,{"count":62,"type":21},96,[24],"The goal of this clinical trial is to learn about different ways cancer genetic screening can be provided to rural communities in participants at high risk for certain cancers. The main question it aims to answer is:\n\n• Does receiving pre-genetic test education with a chat bot or genetic counselor affect if the participant decides to get genetic testing?\n\nParticipants will:\n\n* have a pre-test genetic counselling session with a genetic counselor or the GIA chatbot\n* answer questions about their cancer genetic knowledge and how they are doing\n* provide a saliva sample for genetic testing to test for cancer gene mutations\n* have their genetic testing results provided to them.\n* have the option to share their genetic testing results with family members\n\nResearchers will compare how many participants who had pre-genetic counseling with the chatbot received genetic testing to how many participants who had pre-genetic counseling with a genetic counselor received genetic testing.",[27,28],"2025-09-17",{"date":68,"type":44},"2025-09-23",{"date":70,"type":44},"2025-04-01",{"date":72,"type":21},"2027-08-01",{"name":74,"class":51},"University of Virginia",1]