[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"general-anesthesia-with-propofol\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:general-anesthesia-with-propofol":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100642441","internal-jugular-vein-ultrasound-and-acute-kidney-injury-after-abdominal-surgery-100642441",false,"NCT07638306","Internal Jugular Vein Ultrasound and Acute Kidney Injury After Abdominal Surgery","Dynamic Internal Jugular Vein Assessment During Anesthesia Induction as a Predictor of Hemodynamic Instability and Postoperative Outcomes","PRO-JUGULAR","Inclusion Criteria:\n\n* Elective or Urgent (Non-emergent) major abdominal\u002F visceral surgery under general anesthesia\n* General anesthesia with propofol induction (TCI\u002F manual)\n* Expected surgical duration \\> 60 minutes\n* Continous BP monitoring (Invasive arterial line or non-invasive cuff at 2 minute recording intervals)\n* Serum creatinine and eGFR (CKD-EPI) available within 30 days prior to surgery\n* Written informed consent obtained before surgery\n* Patient accessible by phone 30 days postoperatively\n\nExclusion Criteria:\n\n* Emergency surgery (immediate life-saving, consent unobtainable)\n* End-stage renal disease (eGFR \\\u003C 15 mL\u002Fmin\u002F1.73 m²) or dialysis-dependent\n* Concomitant cardiac surgery or carotid endarterectomy\n* Liver transplantation\n* Known Internal Jugular Vein\u002F Inferior Vena Cava thrombosis or Superior Vena Cava syndrome\n* Any anatomical neck abnormalities precluding Internal jugular vein ultrasound\n* Induction with ketamine or etomidate as sole Induction agent\n* Neuraxial anesthesia (spinal or epidural) before propofol induction\n* Active decompensated heart failure (NYHA IV or acute pulmonary edema at time of Surgery)\n* Same-admission reoperation within 30-day study window\n* Withdrawal of consent at any point",true,"ALL","18 Years",{"count":21,"type":22},150,"ESTIMATED","1 Month","OBSERVATIONAL","This observational study aims to learn whether changes in the internal jugular vein during anesthesia induction can help predict low blood pressure and kidney injury after surgery. The main questions it aims to answer are:\n\n1. Can the internal jugular vein collapsibility index before anesthesia predict low blood pressure during induction?\n2. Can the change in internal jugular vein collapsibility from before to just after anesthesia predict low blood pressure during surgery and acute kidney injury after surgery?\n\nParticipants will have routine ultrasound scans of the neck before anesthesia and again shortly after they fall asleep for surgery. Researchers will also record blood pressure during surgery and measure kidney function after surgery using routine blood tests. and again shortly after they fall asleep for surgery. Researchers will also record blood pressure during surgery and measure kidney function after surgery using routine blood tests.",[27,28,29,30],"Intraoperative Hypotension","Jugular Veins","Hypotension on Induction","General Anesthesia With Propofol",[32,33,34,35,36],"Post-induction Hypotension","Internal Jugular Vein","Collapsibility Index","Propofol Induction","Acute Kidney Injury","NOT_YET_RECRUITING","2026-06-11",{"date":40,"type":41},"2026-06-15","ACTUAL",{"date":43,"type":22},"2026-06-01",{"date":45,"type":22},"2027-03-28",{"name":47,"class":48},"Tîrgu Mureș Emergency Clinical County Hospital, Romania","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100572178","phase-4-feasibility-of-closed-loop-tci-based-on-new-eeg-baseline-in-the-presence-of-low-dose-of-esketamine-100572178","NCT06729892","Feasibility of Closed-loop TCI Based on New EEG Baseline in the Presence of Low Dose of Esketamine","Feasibility of Closed-loop TCI Based on New BIS Baseline in the Presence of Low Dose of Esketamine: a Randomized Controlled Equivalence Trial.","Inclusion Criteria:\n\n* BMI 18\\~27kg· m-2;\n* American Society of Anesthesiologists (ASA)physical status I\\~II;\n* Undergoing elective laparoscopic surgery.\n\nExclusion Criteria:\n\n* Known or suspected neurological diseases, tumors, stroke, degenerative neurological diseases, epileptic seizures, serious head injuries, cognitive disorders, post-traumatic stress disorder, mental illnesses, severe depression, psychosis, etc.;\n* Contraindications to ketamine, propofol or remifentanil;\n* Use of psychotropic drugs within the past 7 days;\n* History of drug abuse or drug addiction within the past 30 days or during pregnancy;\n* Current participation in any other studies involving other drugs or devices.","55 Years",{"count":59,"type":22},120,"INTERVENTIONAL",[62],"PHASE4","The propofol-remifentanil closed-loop TCI system based on EEG guidance has been clinically verified, which enables more precise anesthetic dosing. As an adjunct to anesthesia, esketamine has been shown to stabilize hemodynamics, reduce opioid use, and reduce postoperative nausea and vomiting. However, due to its specific electroencephalographic excitatory effect, esketmine's clinical use in close-loop system has been limited. The aim of this experiment was to determine the specific impact of esketamine on EEG and thus obtain a new EEG baseline for close-loop system, which can broaden the application of close-loop TCI system in combination with other drugs.",[30,65],"Closed-Loop",[67,68,69,70],"eskemine","close-loop TCI","EEG","depth of anesthesia","2025-01-09",{"date":73,"type":41},"2025-01-13",{"date":75,"type":22},"2025-01-20",{"date":77,"type":22},"2025-05-30",{"name":79,"class":48},"bo xu"]