[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"general-anesthetic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:general-anesthetic":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,40,77,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100632227","phase-3-hsk3486-cipepofol-injectable-emulsion-for-induction-of-general-anesthesia-in-pediatric-subjects-undergoing-elective-surgery-100632227",false,"NCT07510945","HSK3486 (Cipepofol) Injectable Emulsion for Induction of General Anesthesia in Pediatric Subjects Undergoing Elective Surgery","A Multicenter, Randomized, Double-blinded, Propofol-controlled, Phase 3b Clinical Study to Evaluate the Efficacy and Safety of HSK3486 (Cipepofol) Injectable Emulsion for Induction of General Anesthesia in Pediatric Subjects Undergoing Elective Surgery","Inclusion Criteria:\n\n\\- 1. Subjects undergoing elective surgery requiring endotracheal intubation. 2. Males or females, aged ≥3 and \\\u003C18 years old, with ASA-PS I to IV. 3. For all females of childbearing potential, negative pregnancy test at screening and baseline. Additionally, females of childbearing potential must agree to use birth control (such as condom, intrauterine device \\[IUD\\], abstinence) from the time of consent until 30 days post study drug administration.\n\n4\\. Subjects must be able to adhere to the study visit schedule and complete all study assessments.\n\nExclusion Criteria:\n\n* 1\\. Subjects whose surgery is emergent, or who need emergency treatment during the surgery, or who need transfusion based on the investigator's judgment.\n\n  2\\. Contraindications to deep sedation\u002FGA or a history of adverse reaction to sedation\u002FGA.\n\n  3\\. Subjects known to be allergic to excipients in propofol injection, excipients in cipepofol injectable emulsion (soybean oil, glycerol, triglyceride, egg lecithin, sodium oleate and sodium hydroxide), benzodiazepines, opioids, rocuronium, atropine, and their active ingredients; and to have contraindications to propofol.\n\n  4\\. Subjects with history or evidence of any of sever system diseases increasing the risk of sedation\u002Fanesthesia prior to screening\u002Fbaseline and deemed unsuitable for participation by the investigator: 5. Subjects with respiratory tract management risks prior to\u002Fat screening. 6. Subjects who have participated in clinical studies of any drug within 1 month prior to screening.\n\n  7\\. Females of childbearing potential (i.e., post-menarche) who are unwilling to use contraception during the entire study period.\n\n  8\\. Subjects unsuitable for this study for any reason as judged by the investigator.","ALL","3 Years","17 Years",{"count":20,"type":21},400,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","This multicenter, randomized, double-blinded, propofol-controlled Phase 3b study enrolls pediatric subjects aged 3-17 years undergoing elective surgery with endotracheal intubation. Its primary purpose is to evaluate whether cipepofol is non-inferior to propofol in success of induction of general anesthesia in pediatrics undergoing elective surgery.",[27],"General Anesthetic","NOT_YET_RECRUITING","2026-03-29",{"date":31,"type":32},"2026-04-06","ACTUAL",{"date":34,"type":21},"2026-05",{"date":36,"type":21},"2028-05",{"name":38,"class":39},"Haisco Pharmaceutical Group Co., Ltd.","INDUSTRY",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":54,"conditions":55,"keywords":59,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":76},"100631498","ventilation-safety-in-beach-chair-shoulder-surgery-safelm-versus-i-gel-100631498","NCT07501468","Ventilation Safety in Beach Chair Shoulder Surgery: SafeLM Versus I-gel","Comparison of SafeLM™ Video Laryngeal Mask and I-gel® for Ventilation Safety After Transition to Beach Chair Position in Patients Undergoing Shoulder Surgery: A Prospective Randomized Controlled Study","SAFE-BCP","Inclusion Criteria:\n\n* Patients aged 18-80 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective shoulder surgery\n* Body mass index (BMI) between 18-40 kg\u002Fm\\^2\n* Adequate preoperative fasting (approximately 8 hours)\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>80 years\n* Refusal to participate\n* ASA physical status \\>= IV\n* BMI \\>40 kg\u002Fm\\^2\n* Failure of supraglottic airway device placement after three attempts\n* Revision surgery\n* Multiple trauma\n* Maxillofacial fracture\n* Active malignancy receiving radiotherapy or chemotherapy\n* Active infection or ongoing antibiotic therapy (except prophylaxis)\n* Chronic steroid or immunosuppressive therapy\n* Full stomach\n* Gastroesophageal reflux disease\n* History of gastric surgery\n* Gastroparesis\n* Known egg allergy","18 Years","80 Years",{"count":51,"type":21},70,[53],"NA","This study aims to compare the performance of SafeLM™ video laryngeal mask airway and i-gel® supraglottic airway device in patients undergoing shoulder surgery in the beach chair position under general anesthesia. The primary objective is to evaluate oropharyngeal leak pressure (OLP) within the first 10 minutes after transition to the beach chair position. Secondary objectives include assessment of ventilation safety, need for airway interventions, and postoperative airway-related complications. This prospective randomized study will provide data on the effectiveness and safety of a video-guided supraglottic airway device compared to a conventional device in a clinically challenging position.",[56,57,27,58],"Airway Management","Shoulder Surgery","Supraglottic Airway",[60,61,62,63,64,65],"Oropharyngeal Leak Pressure","SafeLM","i-gel","Ventilation Safety","Beach Chair Position","Video Laryngeal Mask Airway","2026-03-26",{"date":68,"type":32},"2026-03-30",{"date":70,"type":21},"2026-04-15",{"date":72,"type":21},"2026-09-15",{"name":74,"class":75},"Ankara City Hospital Bilkent","OTHER",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":76},"100619053","non-pharmacological-auditory-and-somatosensory-stimulation-in-anesthetic-emergence-100619053","NCT07339618","Non-pharmacological Auditory and Somatosensory Stimulation in Anesthetic Emergence","Effects of Non-pharmacological Auditory and Somatosensory Stimulation on the Efficiency and Quality of Emergence From General Anesthesia","Inclusion Criteria:\n\n1. Adult patients aged 18 to 65 years, with American Society of Anesthesiologists (ASA) physical status I-III;\n2. Scheduled for laparoscopic abdominal surgery, including gastric, colorectal, or biliary procedures;\n\nExclusion Criteria:\n\n1. ASA physical status IV;\n2. Body mass index (BMI) greater than 30 kg\u002Fm²;\n3. Presence of underlying neurological dysfunction, cognitive impairment, or auditory disorders;\n4. Neurological, cardiovascular, hepatic, or renal dysfunction;\n5. Current use of antipsychotic medications or a history of psychiatric illness;\n6. History of alcohol abuse or substance dependence;\n7. Exposure to general anesthesia or sedation within 1 month prior to surgery;\n8. Presence of intracranial implants or a history of epilepsy;\n9. Known allergy to any drugs used in this study;\n10. Preoperative use of electronic hearing aids or implanted auditory devices;\n11. Refusal to participate in the study.","65 Years",{"count":86,"type":21},205,[53],"This study intends to employ verbal stimulation, tactile stimulation, and kinetic stimulation as interventions during the emergence phase from general anesthesia to facilitate recovery.",[27,90],"Electroencephalographic",[92,93,94,95,96,97],"General anesthesia","Emergence","Verbal stimulation","Somatosensory stimulation","EEG","Recovery of consciousness","RECRUITING","2026-01-04",{"date":101,"type":32},"2026-01-14",{"date":103,"type":32},"2025-10-11",{"date":105,"type":21},"2027-06-30",{"name":107,"class":75},"West China Hospital",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":48,"enrollmentInfo":115,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":76},"100455454","general-anesthetics-related-changes-in-prefrontal-eeg-during-pediatric-surgical-anesthesia-100455454","NCT05210764","General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia","Inclusion Criteria:\n\n* patients aged 0-18 years, American Society of Anesthesiologists Physical Status I-II, scheduled for elective surgery in Peking University First Hospital.\n\nExclusion Criteria:\n\n* Preterm patients;\n* Height and weight not within the standard ranges for respective ages;\n* Surgery for head or heart;\n* Patients with muscular, neurologic or psychiatric diseases;\n* Patients with Congenital anomaly or hereditary diseases;\n* Patients with medication abuse;\n* Allergy to medication including propofol, sevoflurane, and ketamine;\n* Allergy to beans;\n* Refusal to participate the study by guardians.","1 Minute",{"count":116,"type":21},366,"OBSERVATIONAL","The change profiles of indices derived from pEEG such as phase-amplitude coupling and bicoherence based on individual general anesthetics in children have not been examined in previous literature. Whether those indices have the abilities to predict individual drug-related anesthesia depth in children need to be explored.",[27,120],"Electroencephalogram",[122,123],"general anesthetic","electroencephalogram","2025-07-28",{"date":126,"type":32},"2025-07-31",{"date":128,"type":32},"2022-06-01",{"date":130,"type":21},"2026-08",{"name":132,"class":75},"Peking University First Hospital"]