[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"general-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:general-surgery":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,59,84,122,152,174,200],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100377988","effect-of-giving-reduced-fluid-in-children-after-trauma-100377988",false,"NCT04201704","Effect of Giving Reduced Fluid in Children After Trauma","Effect of Restricted Fluid Management Strategy on Outcomes in Critically Ill Pediatric Trauma Patients: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n* Trauma patients older than 6 months and younger than 15 years admitted to the pediatric intensive care unit (PICU)\n* Patients admitted to the PICU directly from the Emergency Department (ED)\n* Patients admitted to the PICU from the operating room (OR)\n* Patients transferred to PICU from outside facility ED (need to have been in ED 12 hours or less)\n\nExclusion Criteria:\n\n* Patients transferred to PICU from outside PICU or inpatient floor\n* Patients transferred to PICU from outside facility ED if \\>12 hours\n* Patients expected to be discharged from the PICU within 24 hours\n* Patient with congenital heart disease as defined by a congenital cardiac defect requiring surgery or medication\n* Patient with diagnosis of chronic cardiac condition (e.g. hypertension, cardiac arrhythmia)\n* Patients with chronic kidney disease as defined by an abnormality of kidney structure or function, present for more than 3 months, with implications to health\n* Post-operative transplant, cardiac, and neurosurgical patients\n* Patients with traumatic brain injury\n* Patients with any disease that may affect baseline blood pressure and heart rate (endocrine disorders, certain genetic disorders, mitochondrial diseases)\n* Hypotension requiring vasopressor therapy\n* If massive transfusion protocol initiated","ALL","6 Months","15 Years",{"count":20,"type":21},250,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is designed to help decide how much intravenous (IV) fluid should be given to pediatric trauma patients. No standard currently exists for managing fluids in critically ill pediatric trauma patients, and many fluid strategies are now in practice. For decades, trauma patients got high volumes of IV fluid. Recent studies in adults show that patients actually do better by giving less fluid. The investigators do not know if this is true in children and this study is designed to answer that question and provide guidelines for IV fluid management in children after trauma.",[27,28,29,30,31],"Critical Illness","Pediatrics","General Surgery","Fluid Therapy","Wounds and Injuries",[30,33,34,31,35,36,37,38,39,40,41,42,43,44,45],"Intensive Care Units, Pediatric","Critical Care","Multiple Trauma","Treatment Outcome","Postoperative Complications","Resuscitation","Hemodynamics","Infusions, Intravenous","Isotonic Solutions","Crystalloid Solutions","Diuretics","Organism Hydration Status","Body Water","RECRUITING","2026-05-04",{"date":49,"type":50},"2026-05-07","ACTUAL",{"date":52,"type":50},"2018-08-27",{"date":54,"type":21},"2027-09",{"name":56,"class":57},"Columbia University","OTHER",4,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":16,"minAge":66,"maxAge":4,"enrollmentInfo":67,"targetDuration":4,"studyType":22,"phases":69,"briefSummary":71,"conditions":72,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100483183","phase-4-linezolid-or-vancomycin-surgical-site-infection-prophylaxis-100483183","NCT05571722","Linezolid or Vancomycin Surgical Site Infection Prophylaxis","LOVip","Inclusion Criteria:\n\n* Patients undergoing any elective surgery for which vancomycin is recommended in the guidelines as an alternative to beta-lactams including: neurosurgery, cardiac surgery, orthopedic surgery, vascular surgery, penile and testicular surgery, gastric banding procedure in digestive surgery.\n\nThis inclusion criteria can lead to the inclusion of patients who undergo a re-intervention provided that the re-intervention is not due to a suspected or proven infection and that the patient was not included in LOVip at the time of his\u002Fher first intervention;\n\n* Age ≥ 18 years-old;\n* Known allergy to beta-lactams AND\u002FOR suspected or proven MRSA colonization. Proven MRSA colonization is defined as a positive patient sample (any type of swab or biological fluid) for MRSA within 3 months prior to surgery. MRSA colonization is suspected when the patient undergoing surgery has received antibiotic treatment within 3 months prior to surgery or is undergoing re-intervention more than 5 days after the first surgery. MRSA is defined as a strain of Staphylococcus aureus resistant to oxacillin or cefoxitin, predicting non-susceptibility to all classes of beta-lactam antimicrobials (except anti-MRSA cephalosporins) (6). In contrast, MSSA is defined as an oxacillin sensitive strain of Staphylococcus aureus;\n* Informed consent of the patient;\n* Affiliated to a social security system or equivalent.\n\nExclusion Criteria:\n\n* Surgery for suspected or proven SSI (definition of SSI provided on chapter 3.6.1 Primary endpoint as defined by (5, 7)) according to international definitions;\n* Obesity defined by a body mass index (BMI) \\> 35 kg\u002Fm2 or a body weight \\> 100 kg;\n* Chronic kidney disease defined as glomerular filtration rate (GFR) \\\u003C 60 ml\u002Fmin per 1.73m2;\n* Known allergy to linezolid or vancomycin;\n* Hematologic malignancy;\n* Declared pregnancy or breastfeeding;\n* Patient under legal protection regime for adults;\n* Patient denying consent;\n* Patient already included in LOVip for a previous surgery.","18 Years",{"count":68,"type":21},1160,[70],"PHASE4","Anesthesia and surgical guidelines recommend the administration of a surgical antibiotic prophylaxis for patients undergoing \"clean\" surgery. The prescribed antibiotic should target the bacteria most commonly found in surgical site infections (SSIs) and the duration of administration should not exceed 24 hours to minimize the ecological risk of bacterial resistance emergence. Guidelines provide a framework for the administration of surgical antibiotic prophylaxis but their effectiveness is regularly re-evaluated by measuring the rates of SSIs and the microorganisms responsible for infectious complications after surgery.\n\nThe majority of interventions required the use of first or second generation cephalosporins as surgical antibiotic prophylaxis. For patients with allergy to beta-lactams, clindamycin and vancomycin are proposed as alternatives. In the patients with methicillin-resistant S. aureus (MRSA) colonization or if those at risk of developing MRSA-associated SSI (hospital ecology, previous antibiotic treatment), only vancomycin is recommended. Vancomycin pharmacokinetics and pharmacodynamics is complex and its tissue absorption varies according to the level of tissue inflammation. This is a difficult molecule to handle, exclusively administered via intravenous route.\n\nLinezolid is a synthetic antibiotic from the oxazolidinone class. By binding to the rRNA on the 30S and 50S ribosomal subunits, it inhibits the bacterial synthesis. It is therefore a bacteriostatic antibiotic approved for the treatment of both methicillin susceptible S. aureus (MSSA) and MRSA infections. It also covers a broad spectrum of Gram positive bacteria. Its pharmacokinetics allows rapid intravenous infusion, with rapid penetration into bone and soft tissue of the surgical site during hip surgery. A large Cochrane meta-analysis reported that linezolid was superior to vancomycin in skin infections, including MRSA infections, albeit with low quality evidence.\n\nWe therefore hypothesized that linezolid can be used instead of vancomycin for beta-lactam allergic patients and patients at risk of MRSA-associated SSI in general surgery.",[73,29],"Antibiotic Prophylaxis","2026-02-03",{"date":76,"type":50},"2026-02-05",{"date":78,"type":50},"2024-11-12",{"date":80,"type":21},"2029-12-03",{"name":82,"class":57},"Assistance Publique Hopitaux De Marseille",1,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":16,"minAge":91,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":95,"conditions":96,"keywords":103,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":117,"leadSponsor":119,"locationsCount":121},"100561028","enhanced-vitals-monitoring-after-major-surgery-trial-100561028","NCT06584825","Enhanced Vitals Monitoring After Major Surgery Trial","The Impact of Enhanced Postoperative Vitals Monitoring In-hospital and at Home vs. Standard Care After Inpatient Abdominal and Vascular Surgery: A Pilot Two-centre Randomized Controlled Study","Inclusion Criteria:\n\n1. Undergoing inpatient major abdominal (general surgery, urology, or gynecology) or vascular surgery at St. Paul's Hospital (SPH) and Mount Saint Joseph (MSJ) Hospital\n2. Length of stay of at least 48 hours (planned by the clinical team, or by the Canadian Institute of Health Information Discharge Abstract Database Expected Length of Stay (ELOS) for the surgical case mix group\n3. Self-reported fluency in reading and speaking in English for patient or home caregiver\n4. Living within British Columbia, Canada and in an area that is covered by Bell cellular network (the Cloud DX Inc. device has cellular Long Term Evolution (LTE) using the Bell network).\n\nExclusion Criteria:\n\n1. Patient refusal\n2. Transplant surgery, since these patients have a unique set of considerations and postoperative course.\n3. Inability to communicate with research personnel, perform self-monitoring of vital signs, or complete study surveys due to cognitive, language, visual, or hearing barriers\n4. Lack of capacity to consent to the study (including under the active influence of sedative medication or having received general anesthetic within the past 24 hours)\n5. Unable to use (or does not have a caregiver who can help put on\u002Ftake off) study monitoring device at home\n6. Preoperatively known planned discharge to a nursing home or rehabilitation facility\n7. Patient with known allergic reactions to any part material of the device\n8. Unable to monitor blood pressure accurately noninvasively using arm blood pressure cuffs, such as due to underlying vascular anatomy or non-pulsatile blood flow physiology\n9. Unlikely to be able to return the home monitoring kit (no fixed address, living too far away from site, etc.)","19 Years",{"count":93,"type":21},110,[24],"The aim of this clinical trial is to examine the feasibility of an enhanced vital sign monitoring solution in-hospital and at-home. This study includes adult patients undergoing inpatient major vascular or abdominal surgery. Researchers will compare the enhanced vitals monitoring group to the standard of care group to see if it may change post-operative management and outcomes. The primary question it aims to answer is if enhanced monitoring of surgical patient vitals can increase the number of days at home alive in the first 30 days after surgery. Participants in the intervention group will test two vitals monitoring devices, one in the hospital and one at home. They will also be asked to complete several questionnaires and a follow up phone call.",[97,98,99,29,100,101,102],"Surgery","Post Operative Complications","Quality of Recovery","Vascular Surgery","Urology","Gynecology",[104,105,106,107,108,109,110,111,112],"Days alive and at home","DAH30","Quality of Recovery 15","Pilot Randomized Controlled Trial","vitals","blood pressure","heart rate","oxygen saturation","device","2025-11-17",{"date":115,"type":50},"2025-11-21",{"date":113,"type":50},{"date":118,"type":21},"2027-12-31",{"name":120,"class":57},"University of British Columbia",2,{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":16,"minAge":66,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":131,"phases":4,"briefSummary":132,"conditions":133,"keywords":136,"overallStatus":142,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":83},"100607020","3d-modeling-for-detecting-locally-advanced-rectal-cancer-with-positive-circumferential-resection-margin-100607020","NCT07183124","3D Modeling for Detecting Locally Advanced Rectal Cancer With Positive Circumferential Resection Margin","Using 3D Modeling to Detect Locally Advanced Rectal Cancer With Positive Circumferential Resection Margin","Inclusion Criteria:\n\n* Diagnosed with rectal cancer, clinical stage II-III, with no distant metastasis (M0)\n* Age over 18 years, with adequate physical status classified as American Society of Anesthesiologists (ASA) I-III, capable of receiving treatment and surgery\n* No history of other malignancies or major diseases affecting study assessment within the past three years.\n* Complete medical records, including available CT and MRI imaging.\n\nExclusion Criteria:\n\n* Patients with clinical stage I or IV rectal cancer.\n* Age under 18 years, or physical status not meeting American Society of Anesthesiologists (ASA) I-III criteria, unable to undergo surgery or related treatment.\n* Presence of other major diseases or malignancies affecting tumor assessment (e.g., diagnosis of another malignancy within the past three years, uncontrolled cardiovascular disease).\n* Incomplete medical records or imaging data, including missing required CT or MRI images.",{"count":130,"type":21},1500,"OBSERVATIONAL","This retrospective study aims to develop an AI-assisted 3D modeling system to improve staging accuracy for stage II-III locally advanced rectal cancer (LARC). High-quality CT images from Taichung Veterans General Hospital will be used to reconstruct tumor boundaries and spatial relationships. The AI model will be trained and validated against MRI and pathology results to predict circumferential resection margin (CRM) status. Outcomes include sensitivity, specificity, accuracy, and agreement with standard imaging. This system seeks to support precise tumor staging and inform future clinical decision-making.",[29,134,135],"Oncology","Medical Informatics",[137,138,139,140,141],"rectal cancer","3D Modeling","deep learning","Pelvic CT Imaging","Clinical Prediction Model","NOT_YET_RECRUITING","2025-09-18",{"date":145,"type":50},"2025-09-19",{"date":147,"type":21},"2025-10-01",{"date":149,"type":21},"2026-07-31",{"name":151,"class":57},"Taichung Veterans General Hospital",{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":16,"minAge":66,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":131,"phases":4,"briefSummary":162,"conditions":163,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":83},"100517863","preoperative-walking-evaluation-and-postoperative-outcome-100517863","NCT06023069","Preoperative Walking Evaluation and Postoperative Outcome","Preoperative Walking Evaluation and Postoperative Outcome in Non-cardiac Surgery","PREVENT","Inclusion Criteria:\n\nAdult patients (equal to or over 18 years) undergoing elective non-cardiac surgery providing informed consent\n\nExclusion Criteria:\n\nPatients that can not provide informed consent.",{"count":161,"type":21},264,"The hypothesis is that physical activity is associated with a reduced risk of complications and death after surgery.\n\nSelf-reporting of physical activity is prone to be unreliable. In order to obtain a better picture of patients' physical activity, we intend to investigate the association between the average number of steps and postoperative outcomes. Many other objective measures of physical activity are costly and time-consuming to perform; for example, exercise tests, extensive sampling, and longer questionnaires.\n\nThe primary research question is: Do patients with a higher degree of physical activity, measured as the average number of steps recorded on the patient's mobile phone, have a reduced risk of peri\u002Fpostoperative complications and death, measured as Days At Home alive at 30 days (DAH30)?\n\nSecondary research questions include:\n\nIs physical activity, measured as the average number of steps recorded on the patient's mobile phone, linearly linked to DAH30? Is physical activity, measured as the average number of steps recorded on the patient's mobile phone, associated with specific peri\u002Fpostoperative organ impact, such as lung, heart, cerebral, infection, or kidney complications? Is physical activity, measured as the average number of steps recorded on the patient's mobile phone, also linked to long-term outcomes one year after surgery? Is physical activity, measured as the average number of steps recorded on the patient's mobile phone, solely associated with DAH30 and organ complications for specific patient groups in terms of age, comorbidities, and\u002For type of surgery?",[29,164],"Perioperative Medicine","2025-08-26",{"date":167,"type":50},"2025-09-03",{"date":169,"type":50},"2023-09-01",{"date":171,"type":21},"2026-12-31",{"name":173,"class":57},"Karolinska Institutet",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":180,"eligibilityCriteria":181,"healthyVolunteers":11,"sex":16,"minAge":66,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":131,"phases":4,"briefSummary":184,"conditions":185,"keywords":188,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":83},"100568218","perioperative-impact-of-physical-activity-on-short--and-long-term-morbidity-and-mortality-100568218","NCT06678360","Perioperative Impact of Physical Activity on Short- and Long-term Morbidity and Mortality","Perioperative Impact After Non-cardiac Surgery of Physical Activity on Short- and Long-term Morbidity and Mortality","PeriopIPA","Inclusion Criteria:\n\nAdult patients (equal to or over 18 years) undergoing elective non-cardiac surgery at the two study sites, Karolinska University Hospital Solna and Karolinska University Hospital Huddinge\n\nExclusion Criteria:\n\nPatients under the age of 18, transplant, day surgery, acute surgery, anesthesia monitoring, brachy therapy and gamma knife interventions. In case of multiple surgeries, only the first will be included.",{"count":183,"type":21},180000,"Over 300 million surgeries are performed globally every year. Complications after surgery - infections, cardiovascular conditions, postoperative pulmonary complications and renal impairment - affect survival and quality of life.\n\nAge and co-morbidity are unmodifiable factors, contributing to increased risk of these perioperative complications. However, a modifiable risk factor is physical activity. This study aims to test if self reported physical activity is associated to lower risk of perioperative morbidity and mortality.",[29,186,164,187],"Perioperative Complication","Physical Inactivity",[189,190,191],"MET-scores","Physical activity","Perioperative mortality","2025-06-02",{"date":194,"type":50},"2025-06-06",{"date":196,"type":50},"2024-11-01",{"date":198,"type":21},"2025-12-01",{"name":173,"class":57},{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":16,"minAge":207,"maxAge":4,"enrollmentInfo":208,"targetDuration":4,"studyType":22,"phases":210,"briefSummary":211,"conditions":212,"keywords":217,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":227},"100226241","improving-radical-treatment-through-mri-evaluation-of-pelvic-sigmoid-cancers-100226241","NCT02222844","Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers","IMPRESS","Inclusion Criteria:\n\n1. Have a suspected or proven sigmoid colon adenocarcinoma\n2. Is eligible for curative treatment\n3. Has no irresectable metastatic disease\n4. MRI can be reviewed by an MDT prior to surgery\n5. Has no decision regarding radical treatment\n6. Have provided written informed consent to participate in the study\n7. Be aged 16 years or over\n\nExclusion Criteria:\n\n1. Have metastatic disease (including resectable liver metastases)\n2. Have a synchronous second malignancy\n3. Are contraindicated for MRI\n4. Are contraindicated for or have allergy to Buscopan (e.g. glaucoma, small or large bowel obstruction, GFR\\\u003C30)\n5. Have severe co-morbidities or previous medical history that prevent the application of eventual chemo\u002Fradiotherapy","16 Years",{"count":209,"type":21},244,[24],"Patients with suspected or proven sigmoid colon adenocarcinoma, eligible for curative treatment whose MRI can be reviewed prior to surgery and has no decision regarding radical treatment are eligible. Patient are randomised to the control arm which the standard care of preoperative CT imaging and subsequent discussion by the Multidisciplinary Team or the interventional arm which has the additional use of MRI imaging and subsequent discussion by the Multidisciplinary Team. Patients are followed up at 1 and 3 years together with QoL questionnaires.",[213,214,215,216,29],"Cancer","Colorectal Neoplasms","Colon, Sigmoid","Magnetic Resonance Imaging",[213,214,215,216,29,37],"2024-10-16",{"date":220,"type":50},"2024-10-17",{"date":222,"type":50},"2014-08",{"date":224,"type":21},"2031-12",{"name":226,"class":57},"Imperial College London",16]