[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"generalised-anxiety-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:generalised-anxiety-disorder":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":34,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100481446","cbt-and-the-neural-circuits-of-anxiety-100481446",false,"NCT05549102","CBT and the Neural Circuits of Anxiety","The Impact of CBT on Shock-Potentiated Neural Circuity","Inclusion Criteria:\n\n* Enrolled in IAPT Step 3 (high intensity service)\n* Score of or above 8 on the GAD-7 (indicating moderate anxiety on a standard scale of anxiety; Spitzer et al., 2006)\n* Willing and able to provide written consent\n\nExclusion Criteria:\n\n* Score above 22 on the GAD-7\n* Past\u002Fpresent psychotic disorder, bipolar disorder\u002Fmania or alcohol\u002Fsubstance use disorder (outside a comorbid psychiatric episode)\n* History of medical illness that may impair cognitive function (e.g. serious head injury, endocrine disorder)\n* Current psychotropic pharmacological intervention (e.g. SSRIs) or use within 3 months\n* MRI contraindications such as pacemaker, aneurysm clip, cochlear implant, neurostimulator, IUD, shrapnel, metal fragments in eye, weight of above 250lbs or claustrophobia\n* Females who are pregnant, planning pregnancy, or breastfeeding","ALL","18 Years","64 Years",{"count":20,"type":21},174,"ESTIMATED","OBSERVATIONAL","This study will aim to test whether specific neural circuitry changes, proposed on the basis of a neurocognitive model of anxiety, are a mechanism of action for Cognitive Behavioural Therapy (CBT) interventions. This study aims to provide a theoretical model of the neurobiological mechanisms of CBT's therapeutic effect, where there currently is none, and potentially allow for more targeted\u002Fspecific approaches to anxiety disorders following the identification of key CBT mechanisms. The ultimate aim is to improve the efficacy of CBT, and more generally, psychological interventions for anxiety disorders.",[25,26,27,28,29,30,31,32,33],"Generalised Anxiety Disorder","Anxiety Disorders","CBT","Anxiety Depression","Anxiety Disorders and Symptoms","Anxiety Generalized","Anxiety","Anxiety Disorder Generalized","Anxiety Disorder; Mixed With Depression (Mild)",[35,36,37,38,27,39,40,41],"GAD","generalised anxiety disorder","anxiety disorders","cognitive behavioural therapy","psychological therapy","neural circuitry","emotional processing","RECRUITING","2025-06-25",{"date":45,"type":46},"2025-06-29","ACTUAL",{"date":48,"type":46},"2020-02-02",{"date":50,"type":21},"2025-12-01",{"name":52,"class":53},"UCLH\u002FUCL Joint Research Office","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":16,"minAge":62,"maxAge":17,"enrollmentInfo":63,"targetDuration":4,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":70,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":54},"100348170","a-neuro-technological-intervention-for-adolescents-with-gad-100348170","NCT03813290","A Neuro-Technological Intervention for Adolescents With GAD","A Neuro-Technological Intervention for Adolescents With Generalised Anxiety Disorder (GAD): A Feasibility Trial","Inclusion Criteria:\n\n* Between 13 to 18 years of age inclusive\n* Literate in English Language\n* Newly diagnosed with Generalised Anxiety Disorder: current episode, based on Computerised Diagnostic Interview Schedule for Children (C-DISC)\n* If on medication, dosage stable or unchanged for at least preceding 8 weeks\n* Has parental consent\n\nExclusion Criteria:\n\n* Diagnosis (as defined by DSM-5) of: anxiety disorder induced by medication, substance, or another medical condition; obsessive compulsive disorder; bipolar disorder; any psychotic disorder (lifetime); intellectual disability (i.e. IQ\\\u003C70); autism spectrum disorder; attention-deficit\u002Fhyperactivity disorder\n* History of substance or drug use disorder (as per DSM-5 criteria) within the last 3 months\n* Neurological disorders or insults (e.g. epilepsy, cerebrovascular accidents)\n* Metal in the cranium, skull defects, or skin lesions on scalp (e.g. cuts, abrasion, rash) at proposed electrode sites\n* Irregular heart rhythms or heart problems\n* Severe visual or hearing impairment\n* Prior experience with mindfulness-based therapy (e.g. mindfulness-based stress reduction \\[MBSR\\], mindfulness-based cognitive therapy \\[MBCT\\])","13 Years",{"count":64,"type":21},30,"INTERVENTIONAL",[67],"NA","This study aims to evaluate the safety and acceptability of a basic neuro-technological intervention in the treatment of adolescents with Generalised Anxiety Disorder (GAD). Our technology will deliver a mindfulness-based anxiety regulation intervention through a neuro- \u002F bio-feedback-based virtual reality (VR) game interface that is driven by a novel algorithm.",[25],[71,72,73],"Brain Computer Interface","Neuro technological intervention","Neurofeedback","2025-05-19",{"date":76,"type":46},"2025-05-22",{"date":78,"type":46},"2020-12-08",{"date":80,"type":21},"2026-01",{"name":82,"class":83},"National Healthcare Group, Singapore","OTHER_GOV"]