[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"generalized-anxiety\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:generalized-anxiety":35},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,63,92,124,156,191,212],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":43,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":62},"100587910","implementing-team-based-treatment-for-pediatric-anxiety-in-community-mental-health-settings-100587910",false,"NCT06934525","Implementing Team-Based Treatment for Pediatric Anxiety in Community Mental Health Settings","Testing Delivery of Modalities in Community Health Settings: Developing Pathways to Health Equity","IMPACT-RI","Inclusion Criteria:\n\n* Age 5-18 inclusive\n* Primary or co-primary DSM-V diagnosis of anxiety or OCD\n* Symptom duration of at least 3 months\n* Outpatient care needed\n* Presence of a stable parent, or guardian, who can participate in treatment\n\nExclusion Criteria:\n\n* Other primary or co-primary psychiatric disorder which requires initiation of other active current treatment\n* Acute suicidality\n* Concurrent psychotherapy\n* Chronic medical illness that would preclude their active participation in treatment\n* Treatment with psychotropic medication that is not stable","ALL","5 Years","18 Years",{"count":21,"type":22},501,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to test how the delivery of Cognitive Behavioral Therapy (CBT) for pediatric anxiety and OCD via different methods might increase its availability and effectiveness. CBT involves teaching the patient skills to enable them to gradually come into contact with feared situations. This process of gradually approaching feared situations is called exposure. Although CBT with exposure has the best evidence for treating anxiety disorders, not all children have equal access or respond the same way to CBT. As part of this study, patients will receive weekly CBT treatment sessions involving a combination of weekly visits with an exposure coach and one visit a month with a licensed provider (e.g., psychologist, social worker). This treatment will be delivered using one of three methods: 1) in-person (face-to-face sessions, occurring in the office and the home\u002Fcommunity), or 2) telehealth (entirely remote sessions via web-based video conference), or 3) flexible (individualized mix of in-person and\u002For telehealth sessions). Eligible participants will be randomly assigned to one of these three methods. Results of this study will help determine which treatment method works best for whom.\n\nTreatment as described above will occur as part of care at partnering community care sites in Rhode Island. Providers from the following partnering community care sites will make up patient treatment teams: Blackstone Valley Community Health Care, Family Services of Rhode Island, Gateway Healthcare, Newport Mental Health, and Thrive Behavioral Health.\n\nThe research study is being conducted by the Pediatric Anxiety Research Center at Brown University Health. The research team will conduct the study assessments that patients will be asked to participate in as study participants. Patients will be asked to complete assessments prior to starting treatment, at two time points during treatment, at the end of treatment, and at two timepoints 3 and 6 months following the end of treatment. Participants will be compensated for their time completing research assessments.",[28,29,30,31,32,33,34,35,36,37,38,39,40,41,42],"Obsessive Compulsive Disorder (OCD)","Pediatric Anxiety Disorders","Anxiety Disorder","Anxiety","OCD","Phobia","Agoraphobia","Generalized Anxiety","Generalized Anxiety Disorder","Selective Mutism","Separation Anxiety","Social Anxiety","Social Anxiety Disorder","Panic Disorder","Pediatric Disorders",[44,45,46,47,48,49],"exposure therapy","cognitive behavioral therapy","anxiety treatment","exposure and response prevention therapy","ERP","pediatric anxiety treatment","RECRUITING","2026-05-13",{"date":53,"type":54},"2026-05-14","ACTUAL",{"date":56,"type":54},"2025-11-01",{"date":58,"type":22},"2029-08-01",{"name":60,"class":61},"Bradley Hospital","OTHER",1,{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":23,"phases":73,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":91},"100636440","optimization-of-late-imagery-rescripting-research-using-generative-artificial-intelligence-100636440","NCT07565714","Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence","ImRs_LLM_DeanG","Inclusion Criteria:\n\n* Age 18-35\n* Score ≥ 8 on GAD-7 (Plummer et al., 2016)\n* Ability to recall at least two childhood memories involving parental criticism\n\nExclusion Criteria:\n\n* History of prolonged physical or sexual abuse\n* Current psychotherapy or psychopharmacology\n* PTSD diagnosis (DSM-5 screening)\n* Substance abuse (TAPS tool)","35 Years",{"count":72,"type":22},40,[25],"The aim of the study is to examine the effect of imagery rescripting (ImRs) in the context of utilizing large language models (LLMs). Intervention will involve the prior presentation of the most aversive fragment of the memory, the so-called 'hotspot.' This intervention will allow for the replication of the effect described by Dibbets and Arntz (2016), according to which the prior activation of the most emotional element of a memory enhances the effectiveness of ImRs.\n\nThe study is also significant due to another ongoing study in which a substantial number of participants have already been examined; however, due to the exhaustion of funds, it was not possible to utilize the remainder of the recruited sample. Investigating an additional condition will allow for a more complete utilization of the available participant pool and significantly increase the project's scientific value by comparing the traditional ImRs mechanism with its AI-generated version.",[35,76,77],"Fear of Failure","Rumination",[76,79,35,80,81],"Intrusive Autobiographical Memories","Imagery Rescripting","AI","2026-05-03",{"date":84,"type":54},"2026-05-07",{"date":86,"type":22},"2026-04",{"date":88,"type":22},"2026-07",{"name":90,"class":61},"University of Social Sciences and Humanities, Warsaw",2,{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":98,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":23,"phases":101,"briefSummary":102,"conditions":103,"keywords":107,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":91},"100634341","enhancing-health-in-rural-populations-music-as-therapy-100634341","NCT07538427","Enhancing Health in Rural Populations: Music as Therapy","Inclusion Criteria:\n\n* residency at one of the two elder care facilities\n* ability to communicate in English.\n\nExclusion Criteria:\n\n* not a resident at one of the two elder care facilities\n* inability to communicate in English.",true,{"count":100,"type":22},60,[25],"The goal of this clinical trial is to learn whether a music-based intervention can improve mental and physical health and strengthen coping skills among adults living in residential care settings in northern Arizona. The main questions it aims to answer are: Does participation in the music-based intervention reduce stress, anxiety, depression, and pain?, and Does participation increase the use of music as a coping strategy and improve overall well-being?\n\nResearchers will compare participants' pre-intervention and post-intervention responses to determine whether the music classes are associated with improvements in health and coping outcomes. Participants will: Attend a 6-week music class held once per week for one hour; participate in active music activities such as drumming and rhythm exercises; complete a brief survey before and after the intervention. Some participants are also invited to complete a short interview about their experiences.",[104,35,105,106],"Stress","Chronic Pain","Depression Disorder",[108,109,110,111,112,113,114],"Music-based intervention","Active music therapy","Drumming","Non-pharmacological intervention","behavioral therapy","Aging populations","Community-based intervention","2026-04-15",{"date":117,"type":54},"2026-04-20",{"date":119,"type":54},"2026-03-12",{"date":121,"type":22},"2027-05-30",{"name":123,"class":61},"Northern Arizona University",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":17,"minAge":132,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":136,"phases":4,"briefSummary":137,"conditions":138,"keywords":142,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":5},"100601942","validation-of-a-rapid-screening-tool-for-anxiety-depressive-disorders-in-children-adolescents-and-young-adults-treated-in-oncology-multicenter-study-100601942","NCT07117058","Validation of a Rapid Screening Tool for Anxiety-depressive Disorders in Children, Adolescents and Young Adults Treated in Oncology. Multicenter Study.","Validation of a Rapid Screening Tool for Anxiety-depressive Disorders in Children, Adolescents and Young Adults Treated in Oncology. Multicenter Study. Short Title: HARMONY-Tool","HARMONY-Tool","Inclusion Criteria\n\n* Patients diagnosed with pediatric cancer before the age of 18,\n* Patient whose intensive treatment had ended at least 3 months prior to inclusion,\n* Patients considered to be in complete remission by the doctor responsible for their treatment,\n* Patient affiliated to or entitled under a social security scheme,\n* Patient having received informed information about the study OR the holder(s) of parental authority having received informed information about the study in the case of minors.\n\nExclusion Criteria\n\n* Refusal to participate expressed by the patient or minor,\n* Patients whose cancer has relapsed or progressed,\n* Pregnant women, women in labor, breast-feeding mothers,\n* Persons deprived of their liberty, hospitalized without consent, hospitalized for purposes other than those of the research,\n* Adults under legal protection (guardianship) or unable to express their consent.","7 Years","25 Years",{"count":135,"type":22},545,"OBSERVATIONAL","In France today, it is estimated that one in every 850 people aged between 20 and 45 is a childhood cancer survivor (CCS), equivalent to around 40,000 to 50,000 people. Some descriptive studies have established that the diagnosis and treatment of cancer can affect psychological health. A French study published by our team in 2015 and 2020 showed that in adulthood, 40% of CCS had anxiety symptoms, a rate significantly higher than that of the general French population (25%). However, although there are validated scales for screening children for psychological disorders (anxiety, depression, etc.), there is no rapid screening tool that can be used routinely by an oncologist during consultations. So, the study aims to develop and validate a short test, which could easily be carried out systematically during follow-up consultations after childhood cancer. It would make it possible to identify people with no psychological complications and, conversely, those in whom further investigation, based on the classic reference scales for assessing psychological disorders, would be relevant.",[35,139,140,141],"Introspective & Anxiety-Prone Patient","Depression, Anxiety","Survivors of Childhood Cancer",[143,144,145,146],"anxiety symptoms","childhood cancer","screening","psychological complication","2026-03-25",{"date":149,"type":54},"2026-03-30",{"date":151,"type":54},"2025-03-18",{"date":153,"type":22},"2027-09",{"name":155,"class":61},"Centre Hospitalier Universitaire de Saint Etienne",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":164,"enrollmentInfo":165,"targetDuration":4,"studyType":23,"phases":167,"briefSummary":168,"conditions":169,"keywords":175,"overallStatus":181,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":91},"100585999","ultra-brief-psychological-treatments-for-emotional-symptoms-and-disorders-100585999","NCT06909669","Ultra-brief Psychological Treatments for Emotional Symptoms and Disorders","Ultra-brief Psychological Treatments for Emocional Symptoms and Disorders: An Efficacy and Efficiency Analysis","UltraPsyBrief","Inclusion Criteria:\n\n\\- Patients presenting negative emotional symptomatology (anxiety, depression or somatizations), mild or moderate. Specifically, they will be included in the study if they present a score ≥ 5 on the PHQ-9, the GAD-7 or the PHQ-15.\n\nExclusion Criteria:\n\n* Bipolar disorder, personality disorder, psychosis or substance abuse, indicated by SCID-5-CV\n* Recent suicide attempt.\n* Severe emotional symptoms (PHQ-15 or GAD-7 ≥ 15; or PHQ-9 ≥ 20).","65 Years",{"count":166,"type":22},184,[25],"The main objective of this randomized clinical trial is to study if various modalities of brief (eight sessions) and ultra-brief (four sessions) transdiagnostic cognitive-behavioral treatment work for decrease emotional symptoms and disorders, as well as to find out which variables of cognition and of the intervention process itself are involved in the therapeutic improvement.\n\nThe investigators will compare the interventions of four groups: brief group treatment (1), ultra-brief group treatment (2), ultra-brief individual treatment (3) with the ultra-brief relaxation (control) group.\n\nThe main questions the study aims to answer are:\n\n* Will the brief and ultra-brief treatment formats works better than the relaxation-based control group?\n* Will results obtained between the brief group therapy group and the ultra-brief group therapy group be similar?\n* Will the individual ultra brief therapy be more effective than the two group therapies because of common factors, such as the therapeutic alliance?\n* Will group therapies be more beneficial for cost and in terms of capability to reduce emocional symptoms than individual therapy? Participants will be randomly assigned to each of the groups and will receive the corresponding treatment, with different number of sessions. They will answer a series of questionnaires at the beginning and at the end of the intervention, as well as 3 months and 6 months after the end of the treatment.",[170,36,35,31,171,172,173,174],"Depression - Major Depressive Disorder","Somatoform Disorders","Somatic Symptom Disorder (DSM-5)","Somatization","Emotional Disorders",[176,177,178,179,180],"ultra-brief therapy","brief therapy","transdiagnostic therapy","cognitive-behavioral therapy","randomized controled trial","NOT_YET_RECRUITING","2025-12-15",{"date":184,"type":54},"2025-12-22",{"date":186,"type":22},"2026-02",{"date":188,"type":22},"2028-09",{"name":190,"class":61},"Universidad de Córdoba",{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":197,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":70,"enrollmentInfo":198,"targetDuration":4,"studyType":23,"phases":200,"briefSummary":201,"conditions":202,"keywords":203,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":62},"100607527","optimization-of-imagery-rescripting-research-using-generative-artificial-intelligence-100607527","NCT07189715","Optimization of Imagery Rescripting Research Using Generative Artificial Intelligence","A Randomized Controlled Pilot Study on AI-Based Imagery Rescripting for Childhood Criticism Memories","FRBN",{"count":199,"type":22},80,[25],"This pilot randomized controlled trial will investigate the feasibility and effectiveness of using generative artificial intelligence to create personalized therapeutic scripts for imagery rescripting (ImRs). Eighty participants will listen to autobiographical scenarios based on their own memories of childhood criticism and neutral events. The scenarios will be generated by the Gemini large language model and reviewed by trained experimenters. On Day 1, all participants will be exposed to both critical and neutral scenarios and randomly assigned to either an experimental group receiving an ImRs intervention or a control group receiving no therapeutic modification. Skin conductance and subjective emotional ratings will be collected during the session, with follow-up questionnaires administered one week later. In addition, cognitive-behavioral therapists will evaluate the quality of the generated scripts. The study aims to assess emotional and physiological responses to AI-generated content, compare outcomes between groups, and explore the potential of large language models in scalable psychological interventions.",[35,76,77],[76,79,35,80,81],"2025-09-15",{"date":206,"type":54},"2025-09-24",{"date":208,"type":54},"2025-06-01",{"date":210,"type":22},"2025-12-31",{"name":90,"class":61},{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":219,"targetDuration":4,"studyType":136,"phases":4,"briefSummary":220,"conditions":221,"keywords":224,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":62},"100416441","experiences-of-anger-in-patients-in-primary-health-care-with-symptoms-of-generalized-anxiety-100416441","NCT04702711","Experiences of Anger in Patients in Primary Health Care With Symptoms of Generalized Anxiety","Experiences of Anger in Patients in Primary Health Care With Symptoms of Generalized Anxiety - a Qualitative Study From the Perspective of Patients and Health Care Professionals","Patients with symptoms of generalized anxiety\n\nInclusion Criteria:\n\n* Clinically significant level of symptoms of generalized anxiety which is confirmed by a self-rated diagnose of GAD on the questionnaire GAD-Q-IV (Newman et al., 2002; Moore et al., 2014). The questions of the GAD-Q-IV correspond to the A, B, C and D criteria of GAD in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5).\n* Sufficient knowledge in Swedish to be able to answer questionnaires and take part in an interview.\n* If the patient receives any medical or psychological treatment for generalized anxiety this should be recently started and\u002For not yet have led to any notable decrease of symptoms. In the case of pharmacological treatment this should not be associated with more extensive psychological side-effects.\n\nExclusion Criteria:\n\n* Severe psychiatric difficulties where the patient needs specialized psychiatric care\n* Known brain-injury or symptoms of dementia\n* The patient is in an acute crisis\n* Obvious alcohol or substance abuse\n\nHealth care professionals\n\nInclusion Criteria:\n\n* Have a health care profession and work at a primary health care center.\n* Current working experience of at least one year at a primary health care center which included contact with patients with symptoms of generalized anxiety\n\nExclusion Criteria:\n\n\\- Being at the primary health care center in the role of an external student",{"count":72,"type":22},"Symptoms of generalized anxiety is common in the general population and is often treated in primary health care. Anger is an emotion that can lead to interpersonal problems but can also be an agent for justice and change. Previous research has shown a link between generalized anxiety and anger but there is a lack of qualitative research investigating how individuals with symptoms of generalized anxiety experience anger.\n\nThe aim of this research study is to increase knowledge about how anger is experienced in adult patients in primary health care with symptoms of generalized anxiety and about the experiences of health care professionals working with patients with symptoms of generalized anxiety.",[35,222,223],"Anger","Primary Health Care",[35,225,222,223],"Worry","2025-04-11",{"date":228,"type":54},"2025-04-16",{"date":230,"type":54},"2020-10-19",{"date":232,"type":22},"2026-12",{"name":234,"class":235},"Kronoberg County Council","OTHER_GOV"]