[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"genetic-anticipation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:genetic-anticipation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100290540","shanghai-high-myopia-study-100290540",false,"NCT03062085","Shanghai High Myopia Study","Visual Outcome Evaluation and Genetic Analysis: Shanghai High Myopia Study","Inclusion Criteria:\n\n* Clinical diagnosis of cataract\n* Must be able to cooperate with the ophthalmic examination\n\nExclusion Criteria:\n\n* Clinical diagnosis of mental illness\n* Mentally disabled","ALL","20 Years","100 Years",{"count":20,"type":21},60000,"ESTIMATED","5 Years","OBSERVATIONAL","The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of high myopic cataract and age-related cataract patients. The investigators will further investigate into the various genetic and environmental factors that may contribute to the pathogenesis of high myopic cataract.",[26,27,28,29],"High Myopia","Cataract","Visual Outcome","Genetic Anticipation","RECRUITING","2026-05-06",{"date":33,"type":34},"2026-05-11","ACTUAL",{"date":36,"type":34},"2015-01-01",{"date":38,"type":21},"2045-12-31",{"name":40,"class":41},"Shanghai High Myopia Study Group","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":50,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":42},"100502663","study-of-product-of-conception-derived-from-ultrasound-guided-manual-vacuum-aspiration-100502663","NCT05825183","Study of Product of Conception Derived From Ultrasound-guided Manual Vacuum Aspiration","Inclusion Criteria:\n\n1. Women 18 years old or above\n2. Women with miscarriage or TOP who are suitable candidates for MVA\n\n   * first trimester miscarriage or TOP\n   * No fetal heart beat or TOP in those with CRL 25mm\n   * incomplete miscarriage or TOP with POG \\\u003C5cm\n   * hemodynamically stable,\n   * tolerates well with speculum examination\n\nExclusion Criteria:\n\n1. Women who are not feasible for the MVA procedure\n\n   * cervical stenosis\n   * fibroid uterus \\>12 weeks in size\n   * known uterine malformation\n   * bleeding disorder\n   * clinically sepsis\n   * inability to tolerate pelvic examination\n2. History of psychological\u002F psychiatric problem\n3. Patient refusal",true,"FEMALE","18 Years",{"count":53,"type":21},100,"Early pregnancy loss is very common, approximately one in four women will experience a miscarriage in their lifetime. The etiology of pregnancy loss remains largely unknown, although genetic, anatomical, endocrinological and immunological abnormalities have been implicated.\n\nIt is known that embryonic\u002Ffetal chromosomal aberrations contributed to approximately 50% of early pregnancy loss, among which 60-70% were aneuploidies, largely can be detected by the current gold standard karyotyping approach recommended by various international societies. However, the drawbacks of conventional karyotyping include the risk of culture failure, maternal cell contamination (MCC), limited detection resolution (5-10 Mb), and differential growth of specific cell lineages which could hinder the diagnosis of genetic abnormalities, particularly mosaicisms. Additional genetic factors beyond the resolution of karyotyping are not well studied.",[29,56],"Immunological Abnormalities","2025-03-18",{"date":59,"type":34},"2025-03-20",{"date":61,"type":34},"2023-05-30",{"date":63,"type":21},"2028-10-31",{"name":65,"class":41},"Chinese University of Hong Kong",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":73,"maxAge":17,"enrollmentInfo":74,"targetDuration":76,"studyType":23,"phases":4,"briefSummary":77,"conditions":78,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":88,"locationsCount":42},"100290627","shanghai-pediatric-cataract-study-100290627","NCT03063216","Shanghai Pediatric Cataract Study","Visual Outcome Evaluation and Genetic Analysis: Shanghai Pediatric Cataract Study","Inclusion Criteria:\n\n* Clinical diagnosis of pediatric cataract\n* Must be able to cooperate with the ophthalmic examination\n\nExclusion Criteria:\n\n* Clinical diagnosis of mental illness\n* Mentally disabled","2 Months",{"count":75,"type":21},10000,"10 Years","The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of pediatric cataract participants, including congenital and traumatic cataract. The investigators will further investigate into the various genetic and environmental factors that may contribute to the pathogenesis of pediatric cataract.",[79,80,81,28,29],"Pediatric Cataract","Congenital Cataract","Traumatic Cataract","2024-09-25",{"date":84,"type":34},"2024-09-27",{"date":86,"type":34},"2009-01-01",{"date":38,"type":21},{"name":89,"class":41},"Evidence Based Cataract Study Group"]