[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"genetic-association-studies\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:genetic-association-studies":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100607281","genetic-variants-in-stroke-100607281",false,"NCT07186517","Genetic Variants in Stroke","Assessment of Key Genetic vaRianTs and thEir iMpacts In Stroke","ÁRTEMIS-Brasil","Inclusion Criteria:\n\nCases\n\n* Age ≥18 years;\n* Confirmed diagnosis by neuroimaging (CT or MRI) of a first episode of ischemic stroke in the last 12 months;\n* TOAST classification of stroke available: cardioembolic, lacunar, atherosclerotic, or undetermined due to the presence of multiple sources (cardioembolic\u002Fatherosclerotic);\n* Modified Rankin Scale (mRS) ≤4 at the time of inclusion;\n* Ability and willingness to provide consent and participate in follow-up assessments.\n\nControls\n\n* Age ≥18 years;\n* Reside in the same household or, if not, in the same neighborhood as the case group participant;\n* Not be a blood relative of the case group participant;\n* Ability and willingness to provide consent and participate in follow-up assessments.\n\nExclusion Criteria:\n\nCases\n\n* Ischemic stroke with a distinct etiology based on TOAST criteria (e.g., infectious, autoimmune, endocarditis, reversible cerebral vasoconstriction syndrome, drug-related causes);\n* Diagnosis of monogenic or mitochondrial disorders, such as CADASIL, Fabry disease, homocystinuria, MELAS, sickle cell disease, among others;\n* Clinical conditions that reduce life expectancy to less than one year (e.g., neoplasia);\n* Inability to undergo magnetic resonance imaging (due to metal artifacts, MRI-incompatible implants, claustrophobia);\n* Other conditions that, at the investigator's discretion, prevent participation or compromise follow-up.\n\nControls\n\n* Personal history of stroke, transient ischemic attack (TIA), coronary, or peripheral artery disease;\n* Serious comorbidities that may impact participation or confound the results;\n* Clinical conditions that reduce life expectancy to less than one year;\n* Inability to provide consent due to cognitive impairment or other factors;\n* Inability to undergo magnetic resonance imaging (due to metal artifacts, incompatible implants, claustrophobia);\n* Diagnosis of monogenic or mitochondrial disorders, such as CADASIL, Fabry disease, homocystinuria, MELAS, or sickle cell disease;\n* Other conditions that, at the investigator's discretion, prevent participation or compromise follow-up.",true,"ALL","18 Years",{"count":21,"type":22},1000,"ESTIMATED","OBSERVATIONAL","Stroke is the leading cause of death and disability in Brazil and worldwide, with a significant socioeconomic impact. Despite advances in prevention and treatment, the role of genetic variants in ischemic stroke remains underexplored, especially in genetically diverse populations like Brazil's. International studies such as MEGASTROKE and GIGASTROKE have identified risk loci for stroke, but with low representation of the Latin American population. This study aims to fill that gap by evaluating the prevalence and clinical impact of genetic polymorphisms previously described in Brazilians, thereby laying the groundwork for precision medicine within Brazil's Unified Health System (SUS).",[26,27],"Stroke","Genetic Association Studies","NOT_YET_RECRUITING","2025-09-15",{"date":31,"type":32},"2025-09-22","ACTUAL",{"date":34,"type":22},"2025-10-01",{"date":36,"type":22},"2030-12-31",{"name":38,"class":39},"Hospital Moinhos de Vento","OTHER",11]