[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"genetic-epidemiology\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:genetic-epidemiology":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100552307","unraveling-the-genetic-basis-of-nicotine-addiction-for-novel-therapeutic-strategies-100552307",false,"NCT06471387","Unraveling the Genetic Basis of Nicotine Addiction for Novel Therapeutic Strategies","Exploring the Genetic and Molecular Underpinning of Nicotine Addiction for the Development of New Therapeutic Strategies","NicoGen","Inclusion Criteria:\n\n* Adults aged 18-60 years old\n* Current daily cigarette smoker\n* Able to understand study procedures and provide informed consent\n* For females, non-pregnant and non-lactating\n\nExclusion Criteria:\n\n* Presence of significant uncontrolled medical conditions (e.g. cardiovascular disease, respiratory disorders, cancer) that could affect smoking behaviors or study participation\n* Presence of major uncontrolled psychiatric disorders (e.g. schizophrenia, bipolar disorder, severe depression)\n* Current substance use disorder (except nicotine dependence)\n* Taking medications that could significantly interfere with study objectives (e.g. medications for smoking cessation)\n* Significant cognitive impairment that precludes ability to complete study procedures","ALL","18 Years","60 Years",{"count":21,"type":22},200,"ESTIMATED","OBSERVATIONAL","This case-control study aims to investigate the genetic and molecular bases of nicotine addiction to identify potential therapeutic targets. The project will involve drug repurposing using Mendelian Randomization, a smoking cessation intervention, and the analysis of methylation status in participants undergoing nicotine withdrawal.",[26,27,28,29,30,31],"Smoking Cessation","Smoking Cessation Intervention","Nicotine Addiction","Epigenetics","Molecular Biology","Genetic Epidemiology",[28,26,33,34,31,35,36],"Mendelian Randomization","Methylation","Drug Repurposing","Epigenetic Biomarkers","RECRUITING","2024-06-23",{"date":40,"type":41},"2024-06-25","ACTUAL",{"date":43,"type":41},"2023-11-01",{"date":45,"type":22},"2025-10-31",{"name":47,"class":48},"University of Cyprus","OTHER"]