[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"genetic-kidney-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:genetic-kidney-disease":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100577151","genomic-first-testing-in-chronic-kidney-disease-100577151",false,"NCT06794567","Genomic First Testing in Chronic Kidney Disease","Improving Diagnosis for Genetic Kidney Disease Through Early Genomic Assessment","Patients:\n\nInclusion Criteria:\n\n1. A diagnosis of CKD warranting a referral to a nephrologist for further assessment AND\n2. Screen positive for potential genetic kidney disease using the Ontario Health Provincial Genetics Program Eligibility Criteria for genetic assessment in CKD AND\n3. Index participant or substitute decision maker (SDM) can provide informed consent to participate.\n\nExclusion Criteria:\n\n1. Participant or SDM is unable to provide consent, for any reason, to be an unsuitable candidate for the study.\n2. Fail screening as set out by the Provincial Genetics Program Eligibility Criteria for genetic assessment in CKD.\n\nFamily Members:\n\nInclusion Criteria:\n\n1. Family\u002Fcaregiver or SDM can provide informed consent to participate AND\n2. Related patient participant must be enrolled in the study.\n\nExclusion Criteria:\n\n1. Family\u002Fcaregiver or SDM is unable to provide consent, for any reason, to be an unsuitable candidate for the study.\n2. Related patient participant is not enrolled in the study.\n\nHealthcare Provider:\n\nInclusion Criteria 1. Provided a referral for at least one study participant.\n\nExclusion Criteria:\n\n1\\. Is not a referring healthcare provider.\n\nQualitative Sub-Study:\n\nInclusion Criteria:\n\n1. Patient participant who is enrolled in the main study.\n2. 18 years or older.\n3. The guardian for a minor\n\nExclusion Criteria:\n\n1. \\\u003C18 years of age unless the guardian can conduct the interview\n2. Patient participant who is not enrolled in the main study.",true,"ALL",{"count":19,"type":20},2400,"ESTIMATED","OBSERVATIONAL","This multi-center study examines the role of genetic testing in patients with chronic kidney disease (CKD) who are identified as being at risk for genetic kidney disease, based on Ontario Health's Provincial Genetic Program (OH-PGP) guidelines. Participants will be assigned to either genome-wide sequencing or standard genetic testing, depending on when they were initially diagnosed with kidney disease.\n\nTo evaluate the impact of genetic testing, patients and caregivers will complete quality-of-life questionnaires before and after testing. Participants may also choose to take part in a one-on-one interview at the end of the study to provide additional insights. They will have the option to link their data to the Institute for Clinical Evaluative Sciences (ICES), allowing researchers to explore health outcomes such as the costs of genetic testing and healthcare resource use.\n\nFamily members of participants will be invited to provide DNA samples to help identify genetic changes in the affected individual. Referring physicians will complete a survey to assess the clinical value of genetic testing for each patient they refer. We will perform an economic analysis comparing the genome wide sequencing to the standard genetic testing group.\n\nThe study's findings will offer important guidance on how genetic testing influences patient care, clinical outcomes, and the timing of genomic assessments in managing CKD.",[24,25],"Chronic Kidney Disease(CKD)","Genetic Kidney Disease",[27,28,29],"Chronic Kidney Disease","Genetic Testing","Genome wide sequencing","NOT_YET_RECRUITING","2025-01-21",{"date":33,"type":34},"2025-01-27","ACTUAL",{"date":36,"type":20},"2025-03-01",{"date":38,"type":20},"2028-12-31",{"name":40,"class":41},"Dervla Connaughton","OTHER"]