[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"geneticsbirth-defects\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:geneticsbirth-defects":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100455039","vigor-virtual-genome-center-for-infant-health-100455039",false,"NCT05205356","VIGOR: Virtual Genome Center for Infant Health","Inclusion Criteria:\n\n* Newborns presenting with probable genetic conditions inpatient on the NICU. These may include (but is not limited to) those with unexplained hypotonia, seizures, metabolic disorders, disorders of sex development, interstitial lung disease, immunodeficiency or multiple congenital anomalies.\n* Babies must have at least one biologic parent available for consent and participation.\n* The criteria for inclusion are 100% phenotype based and do not include any demographic parameters.\n\nExclusion Criteria:\n\n* Presence of a likely nongenetic explanation for the phenotype (e.g., perinatal asphyxia explained by uterine rupture or placental pathology;\n* Clinical features pathognomonic for a recognizable chromosomal abnormality, such as trisomy 21;\n* Associations already known to have low genetic diagnostic yield, including VATER\u002FVACTERL association and OEIS complex;\n* Infants who die before enrollment;\n* Known family history of genetic disease that is plausibly the cause of the infant's illness; - Those with a prenatal genetic diagnosis.","ALL","0 Days","99 Years",{"count":19,"type":20},750,"ESTIMATED","OBSERVATIONAL","This study will provide rigorous evaluation of implementing a virtual genome center into community clinical settings without highly specialized resources, thereby offering generalizable insights as to how best to implement genomic medicine at scale and for other age groups. This intervention has great potential to address disparities in genomic medicine among low-income and underrepresented minority (URM) populations and will enhance capacity for providers and health systems to utilize highly specialized genomic techniques in their communities.\n\nThe goal of this study is to achieve equitable access to state-of-the-art genomic medical care to sick newborns in community centers that predominately care for low-income and racial\u002Fethnic minority populations through the creation of a virtual genome center (VIGOR). VIGOR will provide a venue for physician and family education, genomic expert consultation, reanalysis of unsolved sequencing data, and access to cutting edge therapeutic innovation, thereby facilitating institutionalization of genomic best practices in community settings, and not just highly specialized referral centers.",[24,25,26],"Genetics Disease","Genetics\u002FBirth Defects","Genetic Predisposition to Disease",[28],"Genetics","RECRUITING","2026-01-30",{"date":32,"type":33},"2026-02-03","ACTUAL",{"date":35,"type":33},"2022-03-22",{"date":37,"type":20},"2027-03-01",{"name":39,"class":40},"Boston Children's Hospital","OTHER",10]