[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"geriatric-health\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:geriatric-health":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100635727","longitudinal-assessment-of-lung-function-and-respiratory-muscle-strength-following-training-of-the-inspiratory-muscles-in-frail-older-adults-imt-3-100635727",false,"NCT07556445","Longitudinal Assessment of Lung Function and Respiratory Muscle Strength Following Training of the Inspiratory Muscles in Frail Older Adults (IMT-3)","Longitudinal Assessment of Lung Function and Respiratory Muscle Strength Following Training of the Inspiratory Muscles in Frail Older Adults: A Randomized, Double-Blind, Sham-Controlled Trial","Inclusion Criteria:\n\n* Adults aged 80 years or older.\n* Clinical diagnosis of frailty, defined by a Short Physical Performance\n* Battery (SPPB) score \\\u003C 9.\n* Ability to stand and walk with or without assistive devices.\n* Ability to understand and follow instructions for inspiratory muscle training.\n* Stable medical condition for at least 3 months prior to enrollment.\n* Capacity to provide informed consent or availability of a legal\n\nExclusion Criteria:\n\n* Severe cognitive impairment that prevents understanding the procedures.\n* Diagnosis of neuromuscular diseases affecting respiratory muscles (e.g., ALS, myopathies).\n* Severe or uncontrolled hypertension (≥180\u002F110 mmHg).\n* Recent thoracic or abdominal surgery (\\\u003C3 months).\n* Severe musculoskeletal disorders limiting participation in training.\n* History of recurrent syncope, severe dizziness, or intolerance to respiratory maneuvers.\n* Any condition judged by the research team to compromise safety or participation.",true,"ALL","80 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to evaluate the effects of an 8-week inspiratory muscle training program on lung function and respiratory muscle strength in frail older adults aged 80 years and above. Frailty is associated with reduced physical capacity, declines in functional performance, impaired respiratory performance, and a higher risk of disability. Inspiratory muscle training is a simple, low-cost intervention that may improve breathing function, inspiratory muscle strength, and overall health in very old adults, but evidence in this age group remains limited. Participants will be randomly assigned to one of two groups: a high-load inspiratory muscle training group or a low-load sham training group. Both groups will use a threshold device and perform 30 breaths once per day, five days per week, for eight weeks. The experimental group will train with progressively increasing resistance (50% to 80% of maximal inspiratory pressure), while the sham group will use a minimal and non-progressive load (15% of maximal inspiratory pressure). All sessions will be supervised and monitored for safety. The main goal of the study is to determine whether inspiratory muscle training improves maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP) and lung function. These outcomes will allow the evaluation of the clinical relevance of improvements in respiratory muscle strength in this population.\n\nAssessments will be performed before the intervention, immediately after the 8-week program, and again at one and three months after the end of the intervention to examine both immediate and short-term effects. This study may contribute valuable evidence regarding the safety, feasibility, and clinical benefits of inspiratory muscle training in frail very old adults, particularly its impact on respiratory muscle strength and lung function, supporting its potential implementation in rehabilitation and geriatric care.",[27,28,29,30],"Frailty Syndrome","Geriatric Health","Respiratory Muscle Weakness","Age-Related Frailty",[32,33,34,35],"Inspiratory Muscle Training","Older Adults","Lung Function","Respiratory Muscle Strength","NOT_YET_RECRUITING","2026-04-29",{"date":39,"type":40},"2026-04-30","ACTUAL",{"date":42,"type":21},"2026-05-20",{"date":44,"type":21},"2026-12-01",{"name":46,"class":47},"Universidad Francisco de Vitoria","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100618185","longitudinal-assessment-of-maximal-inspiratory-pressure-and-functional-capacity-following-inspiratory-muscle-training-in-frail-older-adults-imt-2-100618185","NCT07328334","Longitudinal Assessment of Maximal Inspiratory Pressure and Functional Capacity Following Inspiratory Muscle Training in Frail Older Adults (IMT-2)","Longitudinal Assessment of Maximal Inspiratory Pressure and Functional Capacity Following Inspiratory Muscle Training in Frail Older Adults: A Randomized, Double-Blind, Sham-Controlled Trial","Inclusion Criteria:\n\n* Adults aged 80 years or older.\n* Clinical diagnosis of frailty, defined by a Short Physical Performance Battery (SPPB) score \\\u003C 9.\n* Ability to stand and walk with or without assistive devices.\n* Ability to understand and follow instructions for inspiratory muscle training.\n* Stable medical condition for at least 3 months prior to enrollment.\n* Capacity to provide informed consent or availability of a legal\n\nExclusion Criteria:\n\n* Acute or unstable cardiovascular, respiratory, or metabolic conditions.\n* Severe cognitive impairment that prevents understanding the procedures.\n* Diagnosis of neuromuscular diseases affecting respiratory muscles (e.g., ALS, myopathies).\n* Severe or uncontrolled hypertension (≥180\u002F110 mmHg).\n* Recent thoracic or abdominal surgery (\\\u003C3 months).\n* Severe musculoskeletal disorders limiting participation in training.\n* History of recurrent syncope, severe dizziness, or intolerance to respiratory maneuvers.\n* Any condition judged by the research team to compromise safety or participation.",{"count":20,"type":21},[24],"This study aims to evaluate the effects of an 8-week inspiratory muscle training program on maximal inspiratory pressure and functional capacity in frail older adults aged 80 years and above. Frailty is associated with reduced physical capacity, declines in functional performance, impaired respiratory performance, and a higher risk of disability. Inspiratory muscle training is a simple, low-cost intervention that may improve breathing function, inspiratory muscle strength, and overall health in very old adults, but evidence in this age group remains limited.\n\nParticipants will be randomly assigned to one of two groups: a high-load inspiratory muscle training group or a low-load sham training group. Both groups will use a threshold device and perform 30 breaths once per day, five days per week, for eight weeks. The experimental group will train with progressively increasing resistance (50% to 80% of maximal inspiratory pressure), while the sham group will use a minimal and non-progressive load (15% of maximal inspiratory pressure). All sessions will be supervised and monitored for safety.\n\nThe main goal of the study is to determine whether inspiratory muscle training improves maximal inspiratory pressure (MIP), an established measure of global inspiratory muscle strength. Secondary outcomes include measures of functional capacity, reflecting the ability to perform physical tasks relevant to daily living in very old adults. These outcomes will allow the evaluation of the clinical relevance of improvements in inspiratory muscle strength in this population.\n\nAssessments will be performed before the intervention, immediately after the 8-week program, and again at one and three months after the end of the intervention to examine both immediate and short-term effects. This study may contribute valuable evidence regarding the safety, feasibility, and clinical benefits of inspiratory muscle training in frail very old adults, particularly its impact on inspiratory muscle strength and functional capacity, supporting its potential implementation in rehabilitation and geriatric care.",[27,28,29,30],[32,60,33],"Diaphragm Ultrasound","2026-01-03",{"date":63,"type":40},"2026-01-09",{"date":65,"type":21},"2026-02-01",{"date":67,"type":21},"2026-09-10",{"name":46,"class":47}]