[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"geriatric-syndromes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:geriatric-syndromes":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,41,52,85,114,143],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100053824","aging-geriatric-syndromes-and-clonal-hematopoiesis-100053824",false,"NCT02604563","Aging, Geriatric Syndromes and Clonal Hematopoiesis","Inclusion Criteria:\n\n* At least 50 years of age.\n* Able to understand written and spoken English.\n* Able to understand and willing to sign an IRB-approved written informed consent document (or that of a legally authorized representative, if applicable for the trauma cohort)\n\nExclusion Criteria:\n\n* Inability or unwillingness to complete health questionnaire (with the exception of hip and knee replacement participants).\n* History of a recent (\\\u003C30 days) acute viral illness.\n* Current cancer diagnosis and currently receiving chemotherapy or undergoing radiation therapy. A prior history of cancer is allowed if the participant completed therapy \\> 1 year prior to enrollment; participants with a prior diagnosis of cancer will be asked to sign a release of information for the research team to obtain records regarding their prior cancer treatment.\n* Current use of drugs that cause DNA damage (e.g. Cytoxan, azathioprine, etc.) for the treatment of a non-malignant disease.\n* Vulnerable populations (e.g. prisoners).\n* Known infection with Hepatitis B or C, HTLV, or HIV.\n* Additional exclusion for optional bone marrow aspirate\u002Fbiopsy substudy:\n\n  * Use of medications for anticoagulation or \"blood thinning\" including warfarin, low molecular weight heparins (enoxaparin, daltaparin) or direct-acting oral anticoagulants (dabigatran, rivaroxaban, apixaban, edoxaban or betrixaban)\n  * allergy to lidocaine or other local anesthetics.",true,"ALL","50 Years",{"count":19,"type":20},2000,"ESTIMATED","OBSERVATIONAL","In this study the investigators will incorporate a wide range of clinical variables associated with aging and cardiovascular disease to determine whether they are associated with mutation status independent of chronologic age. Clinically, aging can be operationalized using geriatric assessment, which entails a comprehensive multi-dimensional assessment of the health of an older adult, including measures of comorbidity, polypharmacy, functional status, cognition, depression, falls, social activities and social support. Given that aging is heterogeneous, geriatric assessment allows greater specificity for aging than chronological age alone.",[24,25,26,27],"Geriatrics","Aged","Geriatric Syndromes","Cardiovascular Diseases","RECRUITING","2026-07-09",{"date":31,"type":32},"2026-07-13","ACTUAL",{"date":34,"type":32},"2016-03-10",{"date":36,"type":20},"2030-04-30",{"name":38,"class":39},"Washington University School of Medicine","OTHER",1,{"id":42,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":43,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":44,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":45,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":49,"completionDateStruct":50,"leadSponsor":51,"locationsCount":40},"100255479","Inclusion Criteria:\n\n* At least 50 years of age.\n* Able to understand written and spoken English.\n* Able to understand and willing to sign an IRB-approved written informed consent document (or that of a legally authorized representative, if applicable for the trauma cohort)\n\nExclusion Criteria:\n\n* Inability or unwillingness to complete health questionnaire (with the exception of hip replacement participants).\n* History of a recent (\\\u003C30 days) acute viral illness.\n* Current cancer diagnosis and currently receiving chemotherapy or undergoing radiation therapy. A prior history of cancer is allowed if the participant completed therapy \\> 1 year prior to enrollment; participants with a prior diagnosis of cancer will be asked to sign a release of information for the research team to obtain records regarding their prior cancer treatment.\n* Current use of drugs that cause DNA damage (e.g. Cytoxan, azathioprine, etc.) for the treatment of a non-malignant disease.\n* Vulnerable populations (e.g. prisoners).\n* Known infection with Hepatitis B or C, HTLV, or HIV.\n* Additional exclusion for optional bone marrow aspirate\u002Fbiopsy substudy:\n\n  * Use of medications for anticoagulation or \"blood thinning\" including warfarin, low molecular weight heparins (enoxaparin, daltaparin) or direct-acting oral anticoagulants (dabigatran, rivaroxaban, apixaban, edoxaban or betrixaban)\n  * allergy to lidocaine or other local anesthetics.",{"count":19,"type":20},[24,25,26,27],"2026-05-07",{"date":48,"type":32},"2026-05-12",{"date":34,"type":32},{"date":36,"type":20},{"name":38,"class":39},{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":40},"100640551","improving-care-for-frail-older-adults-using-a-digital-needs-assessment-tool-100640551","NCT07580690","Improving Care for Frail Older Adults Using a Digital Needs Assessment Tool","Integrating Health and Social Service Needs for Frail Elders at Point of Care: Development and Evaluation of an IT-based Digital Needs-assessment Tool","Frailty","Inclusion Criteria:\n\n* Patient participant: (i) Aged \\>= 60 years at the time of recruitment; (ii) identified as frail, with a CFS score \\>= 5 and\u002For modified HFRS intermediate and high frailty risk (mHFRS) score \\>=5; (iii) Singapore citizens or permanent residents; (iv) able to speak and understand English, Chinese or Malay.\n* Proxy (when responding on behalf of eligible patients): (i) Relative or friend of the patient participant; (ii) Aged 21 years or older; (iii) Familiar with the older adult's health and social situation.\n\nExclusion Criteria:\n\n* Patient participant: (i) Currently involved in another study or (ii) residents of nursing homes, or (iii) patients known to home hospice or home palliative care services with a life expectancy of less than 6 months.\n* Proxy: primary caregivers who are foreign domestic workers will be excluded from the study.","60 Years",{"count":62,"type":20},200,"INTERVENTIONAL",[65],"NA","The goal of this trial is to evaluate whether a digital needs-assessment tool can improve care planning and outcomes for frail older adults (aged 60 years and above) hospitalized in Singapore. The tool is designed to identify patients' health and social service needs and support better care coordination after hospital discharge.\n\nThe main questions it aims to answer are:\n\n* Does the use of a digital needs-assessment tool improve the identification and management of health and social service needs in frail older adults?\n* Does this approach improve patient outcomes, such as quality of life, care satisfaction, and healthcare utilization after discharge?\n\nParticipants will:\n\n* Respond to a baseline questionnaire\n* Receive a personalized care plan based on identified needs by the tool\n* Be followed up at 1 month and 3 months after discharge through surveys\n* Some participants will receive additional follow-up phone calls to review care needs and service use\n* A subset of participants will take part in interviews to share their care experiences",[68,26,69],"Frail Elderly Patients","Frail Older Adults",[69,71,72,73,74,75],"Simple Segmentation Tool","Integrated Care","Care Coordination","Needs Assessment Tool","Health and Health-related Social Service","NOT_YET_RECRUITING","2026-05-05",{"date":48,"type":32},{"date":80,"type":20},"2026-05-01",{"date":82,"type":20},"2027-12-30",{"name":84,"class":39},"Duke-NUS Graduate Medical School",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":16,"minAge":92,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":63,"phases":95,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":4},"100635028","effect-of-animation-based-digital-education-on-risk-knowledge-and-frailty-in-older-adults-100635028","NCT07547358","EFFECT OF ANIMATION-BASED DIGITAL EDUCATION ON RISK KNOWLEDGE AND FRAILTY IN OLDER ADULTS","THE IMPACT OF A DIGITAL TRAINING MODEL DEVELOPED USING ANIMATION TECHNIQUE ON RISK KNOWLEDGE LEVEL AND FRAILTY AMONG OLDER ADULTS","Inclusion Criteria:\n\n* Aged 65 years or older\n* Ability to speak and understand Turkish\n* Minimum literacy level (able to read and write)\n* Mini-Mental State Examination (MMSE) score ≥ 24\n* No visual or auditory impairment, or ability to compensate for such impairments with assistive devices\n* Ability to interact with digital devices such as smartphones or tablets at a basic level\n\nExclusion Criteria:\n\n* Diagnosis of cognitive impairment or dementia\n\nWITHDRAWAL CRITERIA:\n\n* Participants will be withdrawn from the study if:\n* Serious health problems occur during any phase of the study or death occurs\n* Perception or compliance problems are identified during sessions\n* The participant fails to attend at least one educational session","65 Years",{"count":94,"type":20},66,[65],"With the global aging trend, the management of geriatric risks faced by older adults and the effectiveness of health education for this population are gaining increasing importance. Literature indicates that health education for older adults, when delivered through methods that support individual engagement and the use of digital tools, yields more effective results in terms of learning and behavior change. This doctoral study aims to evaluate the effect of a digital education model, structured based on the Health Belief Model and developed using branching scenario animation technique, on geriatric risk knowledge level and frailty status among older adults residing in nursing homes.\n\nThe study will be conducted as a randomized controlled trial in three nursing homes in Istanbul, with measurements at baseline (T0), immediately post-intervention (T1), 1-month follow-up (T2), and 3-month follow-up (T3). Based on power analysis, 66 participants will be randomly assigned to intervention and control groups (33 per group) using block randomization. The intervention group will receive scenario-based digital animation education developed on the Vyond platform and structured according to the theoretical components of the Health Belief Model. The control group will receive standard care during the study period and will be offered the same digital animation education after completion of all assessments (post 3-month follow-up).\n\nThe primary outcome is geriatric risk knowledge level, assessed using an interactive digital game called \"Knowledge Wheel.\" Secondary outcomes include frailty status, measured by the Edmonton Frail Scale, and technology acceptance. Changes in knowledge and frailty levels measured through assessment tools will reveal the short- and medium-term effects of the education. Thus, the model's impact on health-related behavior change in older adults will be comprehensively evaluated.\n\nThe unique aspect of this study is that it will be one of the first experimental studies to implement an interactive scenario-based digital education model in older adults. The findings are expected to contribute to the development of age-friendly health education models.",[98,99,26],"Aging","Frail Elderly",[101,102,103,104],"frailty","Older Adults","Digital Health Education","Branching Scenario Animation","2026-04-17",{"date":107,"type":32},"2026-04-23",{"date":109,"type":20},"2026-09-01",{"date":111,"type":20},"2027-02-01",{"name":113,"class":39},"Saglik Bilimleri Universitesi",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":15,"sex":16,"minAge":121,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":63,"phases":124,"briefSummary":125,"conditions":126,"keywords":132,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":40},"100634680","using-virtual-reality-to-improve-medical-training-100634680","NCT07542834","Using Virtual Reality to Improve Medical Training","Enhancing Osteopathic Medical Education Through Cinematic Virtual Reality","Inclusion Criteria: able to read and speak English, are age 18 years and older, and are a medical student enrolled at the Ohio University Heritage College of Osteopathic Medicine enrolled in the 2025-2026 academic year.\n\n\\-\n\nExclusion Criteria: unable to read and speak English, 17 years or younger, and are not a medical student enrolled at the Ohio University Heritage College of Osteopathic Medicine enrolled in the 2025-2026 academic year.\n\n\\-","18 Years",{"count":123,"type":20},100,[65],"As the U.S. population ages, future physicians must be prepared to care for older adults with multiple health conditions and complex needs. This study will test whether cinematic virtual reality (VR)-an immersive, interactive learning tool-is more effective than traditional lectures in helping medical students learn about geriatric care. Students who complete the VR training will experience realistic patient scenarios that show what can go wrong in medical care and learn how to apply osteopathic principles to improve outcomes. Researchers will compare students' performance on a clinical skills assessment and explore their experiences with the VR training. The goal is to determine whether cinematic virtual reality can better prepare students for residency and improve their ability to provide compassionate, high-quality care for older adults.",[127,26,128,129,130,131],"Type 2 Diabetes (T2DM)","Disability Hearing","Disability Physical","Urinary Tract Infection(UTI)","Delirium Confusional State",[133],"virtual reality, type 2 diabetes, geriatric syndromes, disability, elder abuse and neglect","2026-04-14",{"date":136,"type":32},"2026-04-21",{"date":138,"type":20},"2026-04-15",{"date":140,"type":20},"2027-06-30",{"name":142,"class":39},"Ohio University",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":16,"minAge":92,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":63,"phases":153,"briefSummary":154,"conditions":155,"keywords":159,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":4},"100619164","comprehensive-geriatric-assessment-in-primary-care-100619164","NCT07341061","Comprehensive Geriatric Assessment in Primary Care","Comprehensive Geriatric Assessment in Primary Care for Older Adults Across Levels of Frailty","PC-CGA","Inclusion Criteria:\n\n* Older adult patients receiving care at the Dalhousie Family Medicine Clinic and scheduled to undergo an eCGA as part of routine primary care.\n* Fluent in English and able to respond to interview and questionnaire items.\n* Able to provide informed consent; or, if judged unable to consent, able to provide assent AND has a substitute decision maker (SDM) who is willing to provide informed consent on their behalf.\n* (PAHA sub-study) Enrolled in the main eCGA study, willing to participate in a personalized physical activity- program, and available for follow-up contact.\n\nExclusion Criteria:\n\n* Not scheduled for, or not receiving, an eCGA at the investigator's family medicine clinic.\n* Unable to communicate in English, such that questionnaires and interviews cannot be completed.\n* Unable to provide informed consent and no SDM available or willing to consent on the patient's behalf.\n* (PAHA sub-study) Deemed unsuitable for the physical activity intervention by the treating family physician (e.g., medical or functional condition that, in the physician's judgment, makes participation in light-moderate exercise unsafe).",{"count":152,"type":20},120,[65],"This study evaluates the feasibility and acceptability of implementing the electronic Comprehensive Geriatric Assessment (eCGA) in primary care for adults aged 65 years and older. The study examines how frailty changes over 12 months, how patient self-assessments compare with physician assessments, and how patients perceive the value of the eCGA when used as part of routine care.\n\nThe study also includes an interventional randomized sub-study (PAHA), in which eligible participants receive a personalized physical activity program developed by a Clinical Exercise Physiologist. Participants are randomized to either an immediate-start or delayed-start exercise group, allowing assessment of the effects of a tailored activity intervention on frailty, physical activity participation, and goal attainment.\n\nFindings will inform how eCGA tools and personalized activity interventions can be integrated into primary care to support healthy aging and frailty management.",[58,98,26,156,157,158],"Mobility Limitation","Functional Decline","Sedentary Lifestyle",[58,160,161,162,163,164,102,165,166,167,168],"eCGA","electronic Comprehensive Geriatric Assessment","Primary Care","Frailty Index","Clinical Frailty Scale","Healthy Aging","Physical Activity Intervention","Exercise Intervention","Geriatric Assessment","2026-01-05",{"date":171,"type":32},"2026-01-14",{"date":173,"type":20},"2026-01-12",{"date":175,"type":20},"2029-01-12",{"name":177,"class":39},"Nova Scotia Health Authority"]