[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gfap\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gfap":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100617005","analysis-of-nfl-and-gfap-in-different-dietary-patterns-100617005",false,"NCT07312994","Analysis of NfL and GFAP in Different Dietary Patterns","Vegan, Vegeratian, or Omnivore: Dietary Effects on the Brain Tissue Biomarkers","Inclusion Criteria:\n\n* Healthy individuals who have followed a vegan, vegetarian, or omnivorous diet for at least one consecutive year\n* Aged between 18 and 40 years\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Diagnose neurological disorders (e.g. neurodegenerative, inflammatory, autoimmune, infectious, vascular)\n* Eating disorders\n* Excessive alcohol consumption\n* Pregnancy\n* Recent moderate to severe infection (within the past 12 weeks) , including SARS-CoV-2\n* Recent trauma, injury, or surgery (within the past 12 weeks)\n* Significant BMI fluctuations (\\>5 points) within the last year\n* Patients who have been using Proton pump inhibitors (PPIs) for an extended period (e.g., 1 month).",true,"ALL","18 Years","40 Years",{"count":21,"type":22},300,"ESTIMATED","OBSERVATIONAL","This observational study aims to investigate the impact of different dietary patterns on brain tissue biomarkers in healthy young adults by measuring blood levels of NfL and GFAP.\n\nThe primary research question is: Do vegan, vegetarian, or omnivorous diets influence NfL and GFAP levels?",[26,27,28,29,30],"Neurofilament Light Chain","Glial Fibrillary Acidic Protein","GFAP","Vegan Diet","Vegetarian Diet","RECRUITING","2025-12-17",{"date":34,"type":35},"2025-12-31","ACTUAL",{"date":37,"type":35},"2025-12-18",{"date":39,"type":22},"2026-09",{"name":41,"class":42},"Salzburger Landeskliniken","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":54,"conditions":55,"keywords":61,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":43},"100603176","medium-term-effects-of-treatments-in-autoimmune-encephalitis-100603176","NCT07133113","Medium-term Effects of Treatments in Autoimmune Encephalitis","Medium-term Effects of Treatments in Autoimmune Encephalitis (META): a Real-life, Observational Prospective Study","META","Inclusion Criteria:\n\n* Adult or child patient with encephalitis defined as anti-GAD, NMDAR, LGI1, CASPR2, IgLON5 or GFAP\n* Untreated or with a decision to treat within the previous 30 days.\n\nExclusion Criteria:\n\n\\- Refusal by the referring doctor to participate or refusal by the patient mentioned in the objection to the use of his\u002Fher clinical data.",{"count":53,"type":22},200,"Autoimmune encephalitides are severe neurological disorders requiring urgent treatment, even though there is no standard guideline by lack of empirical evidence. Commonly used treatments are divided into so-called first-line (steroids, intravenous immunoglobulins, plasma exchanges) and second-line (rituximab, cyclophosphamide, tocilizumab, others), and may be used in association or sequentially. There is no standard practice, and initial treatment protocol may consist in first-line alone, first-line with rituximab, or first-line with dual immunosuppression (rituximab and cyclophosphamide). Absence of clear response to initial treatment in the first 4 to 6 weeks may indicate undertreatment and is generally followed by treatment escalation, mostly to dual immunosuppression. However, as the frequency of non-responders to initial treatment is unknown, it is still unclear whether dual immunosuppression should be offered to all patients from inception.",[56,57,58,59,60,28],"NMDAR Autoimmune Encephalitis","LGI1 Antibody Associated Encephalitis","CASPR2-Antibody","IgLON5","GAD65",[62,63],"Paraneoplastic neurological disorder","autoimmune encephalitis","2025-08-13",{"date":66,"type":35},"2025-08-20",{"date":68,"type":35},"2024-09-01",{"date":70,"type":22},"2027-03-01",{"name":72,"class":42},"Hospices Civils de Lyon",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":16,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":97,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":114,"locationsCount":43},"100572472","association-of-transcranial-alternating-current-stimulation-with-digital-cognitive-training-for-cognitive-remediation-in-older-adults-100572472","NCT06733714","Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults","Inclusion Criteria:\n\n* Healthy subjects over 50 years old, with cognitive complaints\n\nExclusion Criteria:\n\n* Estimated Intelligence Quotient \\\u003C80\n* Dependence on psychoactive substances (DSM-V)\n* Severe psychiatric or neurological disorders\n* Uncorrected visual\u002Fhearing problems\n* History of syncope for an unexplained reason or seizure less than a year ago\n* Previous stroke\n* Use of anticoagulants\n* Intracranial metallic prosthesis or cardiac pacemaker\n* Any contraindication to performing tACS","50 Years",{"count":81,"type":22},40,"INTERVENTIONAL",[84],"NA","BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy.\n\nDigital Cognitive Training (DCT) and Transcranial Alternating Current Stimulation (tACS) are two promising tools for cognitive remediation in this population. In this exploratory study, we investigate feasibility, tolerability and preliminary effects of the association of both interventions in older adults with cognitive complaints.\n\nMETHODS Older adults with cognitive complaints are being enrolled for this study, which comprises 5 daily sessions of 30 minutes of DCT using the BrainHQ platform while simultaneously receiving theta tACS (6Hz, 1.6mA) targeting the Left Dorsolateral Prefrontal Cortex.",[87,88,89,90,91,92,93,94,95,28,96],"Cognitive Dysfunction","Alzheimer Disease","Mild Cognitive Impairment","Cognitive Decline","Frontotemporal Degeneration","Dementia","Dementia, Vascular","Lewy Body Disease","Beta-Amyloid","Tau Protein",[98,99,100,101,102,103,104,105,106,107],"tacs","nibs","transcranial alternate current stimulation","mild cognitive impairment","MCI","ALzheimer","Cognition","Elderly","Older Adults","Cognitive enhancement","2024-12-09",{"date":110,"type":35},"2024-12-13",{"date":112,"type":35},"2024-12-02",{"date":70,"type":22},{"name":115,"class":42},"Universidade Federal do Rio de Janeiro"]