[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gingival-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gingival-diseases":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,42,72,100,125,156,184,212,241],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100608716","gingival-phenotype-and-dental-crowding-in-pediatric-patients-100608716",false,"NCT07205172","Gingival Phenotype and Dental Crowding in Pediatric Patients","Gingival Phenotype and Dental Crowding in Pediatric Patients, a Pilot Study","BIOTIPO_PEDO","Inclusion Criteria:\n\n* Pediatric patients attending the Pediatric Dentistry and\u002For Orthodontics clinic (consultation and\u002For outpatient appointment).\n* Parents and\u002For legal guardians have signed the informed consent for participation in the study.\n* Age between 5 and 16 years.\n* Clinical dentition criteria by group:\n\nGroup 1 (Primary Dentition): Presence in the mandibular arch of deciduous teeth from canine to canine. Group 2 (Early Mixed Dentition): Presence in the mandibular arch of at least two permanent mandibular incisors, fully erupted (incisal edge at occlusal level) or partially erupted (≥50% of the crown), with no clinical attachment loss, and healthy gingiva or mild gingivitis (Gingival Index, GI ≤ 1). Group 3 (Late Mixed Dentition): Presence in the mandibular arch of all four permanent mandibular incisors fully erupted (incisal edge at occlusal level), with no clinical attachment loss, and healthy gingiva or mild gingivitis (GI ≤\n\n1). Group 4 (Permanent Dentition): Presence in the mandibular arch of all four permanent mandibular incisors fully erupted (incisal edge at occlusal level), with no clinical attachment loss, and healthy gingiva or mild gingivitis (GI ≤ 1).\n\nExclusion Criteria:\n\nPatient-related:\n\n* Parents and\u002For legal guardians have not signed the informed consent.\n* Patients who are not sufficiently cooperative to allow a routine dental examination.\n* Non-cooperative patients, including those with special needs.\n* Children with systemic diseases or undergoing medication that affects gingival tissues.\n* Patients who have already undergone orthodontic treatment or are currently undergoing orthodontic treatment.\n\nTooth-related:\n\n* Presence of dental agenesis or dental anomalies.\n* Dental sites with mucogingival problems.",true,"ALL","5 Years","16 Years",{"count":22,"type":23},180,"ESTIMATED","OBSERVATIONAL","The periodontal phenotype influences treatment outcomes across dental specialties, as tissues of different thickness respond differently to chemical, bacterial, and mechanical insults. In pediatric patients, understanding the gingival phenotype is particularly relevant: a thin phenotype may predispose to dehiscence, fenestration, and gingival recession-especially at the mandibular incisors-when tooth movement exceeds the biological limits of the bony housing.\n\nDuring the mixed dentition phase, significant changes in soft and hard tissues affect tooth position and periodontal stability, making early phenotype assessment essential. Interceptive orthodontics can reduce the long-term risk of mucogingival defects; early identification of a thin biotype allows for preventive strategies, including soft tissue grafting before critical orthodontic movements.\n\nNo studies have examined the association between dental crowding severity and periodontal phenotype in children. Adult data remain inconsistent: Kaya et al. found no correlation between phenotype and skeletal malocclusion, while Kong et al. reported a site-specific association between thin biotype and skeletal Class I\u002FIII at the mandibular central incisor. No predictive model exists for periodontal risk related to severe crowding in childhood.\n\nThis study aims to assess the periodontal phenotype in pediatric patients across different stages of dental transition and to investigate a possible association between a thin periodontal biotype and severe dental crowding.",[27,28],"Crowding, Tooth","Gingival Diseases","RECRUITING","2026-05-21",{"date":32,"type":33},"2026-05-26","ACTUAL",{"date":35,"type":33},"2025-12-16",{"date":37,"type":23},"2027-04",{"name":39,"class":40},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":17,"sex":18,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":52,"conditions":53,"keywords":58,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":41},"100634170","characterization-of-jak1-and-jak2-activation-in-gingival-tissues-during-homeostasis-and-periodontitis-100634170","NCT07536204","Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis","Unraveling the Role of JAK1 and JAK2 Pathway in Periodontitis: Drivers of Immunopathology and Possible Therapeutic Targets","Inclusion Criteria:\n\n* Adults\n* Sistemically healthy\n\nExclusion Criteria:\n\n* Active Maliganancy\n* History of radiation to the head-neck region\n* Chemotherapy or radiation within the last 5 years\n* History of hepatitis B\u002FC or HIV infection\n* Autoimmune diseases\n* Diagnosis of diabetes\n* Pregnancy or lactation\n* More than 3 hospitalizations over the last 3 years\n* Use of systemic antibiotics over the last 3 months\n* Use of systemic corticosteroids or immunosuppressants over the last 3 months\n* Use of cytokine therapy over the last 3 months\n* Use of large doses of pre\u002Fprobiotic supplements over the last 3 months\n* Smoke more than 10 cigarettes per day","18 Years",{"count":51,"type":23},30,"The goal of this observational study is to examine JAK1\u002F2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is:\n\nIs the JAK1\u002F2 pathway overactivated in periodontitis compared to health?\n\nParticipants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1\u002F2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.",[54,55,56,28,57],"Periodontitis","Periodontal Diseases","Periodontal Inflammation","Periodontal Attachment Loss",[59,60,54,61,62],"JAK1","JAK2","Gingiva","Inflammation","2026-04-10",{"date":65,"type":33},"2026-04-17",{"date":67,"type":33},"2023-06-01",{"date":69,"type":23},"2027-03-31",{"name":71,"class":40},"University of Chile",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":18,"minAge":49,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":41},"100501744","novosyn-quick-versus-monosyn-quick-suture-material-in-resective-periodontal-surgery-100501744","NCT05813236","NOVOSYN® Quick Versus MONOSYN® Quick Suture Material in Resective Periodontal Surgery","Randomized, Monocentric, Double Blinded, Prospective Study to Evaluate the Early Wound Healing After the Utilization of NOVOSYN® Quick Versus MONOSYN® Quick Suture Material in Resective Periodontal Surgery","NOQMOQS","Inclusion Criteria:\n\n* Adult patient undergoing resective periodontal surgery abd one of the incisions below has been performed:\n* Crestal incision\n* Vertical incision\n* Intrasulcular incision\n* Submarginal incision\n* Written informed consent regarding the data collection for the RCT\n\nExclusion Criteria:\n\n* Emergency surgery.\n* Pregnancy.\n* Breastfeeding\n* Patients taking medication that might affect wound healing.\n* Patients having a condition that might affect wound healing.\n* Patients with hypersensitivity or allergy to the suture material",{"count":81,"type":23},84,"INTERVENTIONAL",[84],"NA","The aim of this study is to prove that Novosyn Quick and Monosyn Quick are equivalent in early wound healing in adult patients undergoing resective periodontal surgery.\n\nIn order to show equivalence between Novosyn Quick and Monosyn Quick EHS, which is composed of 3 parameters: clinical signs of reepithelization, clinical signs of haemostasis and clinical signs of inflammation, will be calculated for each suture 10 ± 5 days postoperatively and cannot differ more than 2 points.\n\nFurthermore, complications, the handling of the suture material, pain, satisfaction of the patient and bacterial contamination of the thread (optional) will also be assessed as secondary objectives.",[87,28,55],"Gingivitis",[89],"Resective periodontal surgery","2026-03-05",{"date":92,"type":33},"2026-03-06",{"date":94,"type":33},"2023-06-28",{"date":96,"type":23},"2026-12",{"name":98,"class":99},"Aesculap AG","INDUSTRY",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":17,"sex":18,"minAge":49,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":82,"phases":110,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":41},"100468772","novel-dental-gel-as-an-adjunct-to-scaling-and-root-planing-100468772","NCT05384132","Novel Dental Gel as an Adjunct to Scaling and Root Planing","Randomized Control Trial of a Novel Dental Gel as an Adjunct to Scaling and Root Planing in Subjects With Stage II and III Periodontitis","Inclusion Criteria:\n\n* Male or female subjects at least 18 years of age.\n\n  * Subject must be willing and able to provide written informed consent.\n  * Available during the course of the study.\n  * Must have minimum of 20 natural teeth, excluding third molars.\n  * Must have at least 20 BOP sites, excluding third molars.\n  * Stage II or III, Grade B periodontitis with at least 4 teeth with a minimum PD of 5 mm and minimum CAL of 3mm.\n  * No antibiotic therapy for periodontal disease or chronic use of anti-inflammatory drugs (NSAIDs) within the past month of Baseline, or during the study.\n  * Must not have received definitive treatment (i.e., SRP or periodontal surgical therapy) for periodontitis in the last one year.\n  * Subject must be willing and able to comply with study visits as described in the protocol.\n  * Subjects must be available for follow up on the telephone.\n  * Able to read and understand the consent form in English\n\nExclusion Criteria:\n\n* • Pregnancy or breast feeding.\n\n  * Medical condition that requires pre-medication prior to dental procedures.\n  * Systemic conditions and use of medications that may affect periodontal tissues.\n  * Severe dental disease characterized multiple decayed, untreated dental sites.\n  * Presence of orthodontic appliances.\n  * Diseases of oral soft or hard tissues.\n  * Participating in another clinical trial currently or in the month preceding this study.\n  * Stage IV and\u002For Grade C periodontitis.\n  * Vertical bone defects 4mm or greater.\n  * Subjects who have active dental infections other than periodontitis that will require dental treatment during the study period.\n  * Excessive oral hygiene practices including use of water irrigation devices such as Waterpik or use of interdental cleansers more than twice daily.\n  * Non-English speaking\n  * Smokers, uncontrolled or brittle diabetics, HIV\u002FAIDS, and subjects with severe systemic disease, e.g., cancer, lupus, pemphigus vulgaris\u002Fpemphigoid, or other oral mucous membrane diseases that would interfere with performance of oral hygiene, e.g., erosive lichen planus, recurrent major aphthous lesions, etc.\n  * History of allergic reaction to any ingredient in the test\u002Fcontrol dentifrices.\n  * Presence of any condition, abnormality, or situation at Baseline that in the opinion of the Principal Investigator may preclude the subject's ability to comply with study requirements, including completion of the study or the quality of the data.\n  * Subjects unwilling to use manual toothbrush during the study.","85 Years",{"count":109,"type":23},76,[84],"This study will evaluate the use of Livionex Dental Gel (LDG) as a home care product in reducing probing pocket depth (PD) beyond the effect achieved by the current standard of care with SRP in periodontitis patients.",[55,28,113,114,115],"Gingival Pocket","Gum Bleed","Plaque, Dental","2025-12-09",{"date":118,"type":33},"2025-12-17",{"date":120,"type":33},"2022-10-14",{"date":122,"type":23},"2028-10-30",{"name":124,"class":40},"University of Alabama at Birmingham",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":17,"sex":18,"minAge":49,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":82,"phases":135,"briefSummary":136,"conditions":137,"keywords":140,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":41},"100497633","oct-vibrography-for-biomechanical-properties-of-tissues-100497633","NCT05759780","OCT Vibrography for Biomechanical Properties of Tissues","A Study to Test the Potential of OCT Vibrography for Measuring Biomechanical Properties of Tissues","Group 1:\n\nInclusion criteria:\n\n• Subjects with healthy eyes (age 18 - 75, N = 50)\n\nExclusion criteria:\n\n* Subjects with history of eye diseases, and previous eye surgeries.\n* Subjects with diabetes, glaucoma family history\n* Subjects allergic to anesthetic eyedrop, especially proparacaine\n* Subjects with severe allergy\n* Subjects who have difficulty biting\n* Subjects who have recurrent corneal erosion\n\nGroup 2:\n\nInclusion criteria:\n\n• Subjects with healthy skin (age 18 - 75, N = 10)\n\nExclusion criteria:\n\n• Subjects with open cuts\u002Fsores on the skin, skin infection, or any contagious skin condition\n\nGroup 3:\n\nInclusion criteria:\n\n• Subjects with healthy gingiva (age 18 - 75, N = 10)\n\nExclusion criteria:\n\n• Subjects with open cuts\u002Fsores on the gingiva, gingiva infection, or any contagious gingiva condition\n\nGroup 4:\n\nInclusion criteria:\n\n• Mild or moderate keratoconus subjects (age 18 - 40, N = 20)\n\nExclusion criteria:\n\n• Subjects with K-max above 60 diopters (Pentacam imaging) are excluded","75 Years",{"count":134,"type":23},90,[84],"The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.",[138,139,28],"Cornea","Skin Diseases",[141,142,143,144,145,146],"biomechanics","cornea","skin","gingiva","optical coherence tomography","vibrography","2025-10-21",{"date":149,"type":33},"2025-10-23",{"date":151,"type":33},"2023-08-19",{"date":153,"type":23},"2026-08-28",{"name":155,"class":40},"Massachusetts General Hospital",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":17,"sex":18,"minAge":49,"maxAge":163,"enrollmentInfo":164,"targetDuration":4,"studyType":82,"phases":166,"briefSummary":167,"conditions":168,"keywords":171,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":41},"100600940","biofiller-and-gingival-phenotype-thickening-100600940","NCT07104019","Biofiller and Gingival Phenotype Thickening","Evaluation of the Effectiveness of Blood Concentrate Biofiller in Thickening the Gingival Phenotype Around Natural Teeth","Inclusion Criteria:\n\n* Age between 18 and 60 years\n* Systemically healthy individuals\n* Presence of thin gingival phenotype in the mandibular anterior region (canine to canine)\n* No medications that affect wound healing\n* No history of bleeding disorders\n* No known allergy to anti-inflammatory drugs\n* Not pregnant or breastfeeding\n* Willingness to participate and provide informed consent\n* Non-smoker\n\nExclusion Criteria:\n\n* Systemic diseases (e.g., diabetes, hypertension, cancer, etc.)\n* Use of medications that may affect healing (e.g., corticosteroids, immunosuppressants)\n* History of radiotherapy or chemotherapy\n* Pregnancy or breastfeeding\n* Poor oral hygiene\n* Refusal to participate\n* Age under 18 years\n* Smoking\n* Presence of Class II or Class III orthodontic anomalies","65 Years",{"count":165,"type":23},34,[84],"The periodontal phenotype is defined as the combination of the gingival phenotype and the thickness of the buccal bone plate (bone morphotype). The gingival phenotype refers to the gingival thickness (GT) and the width of the keratinized tissue (KTW). A gingival thickness of ≤1 mm is classified as a thin phenotype, whereas a thickness \\>1 mm is considered a thick phenotype. Thin gingival biotypes tend to show more pronounced responses to inflammation, restorations, trauma, and parafunctional habits. Various methods are used to assess gingival thickness, including transgingival probing (TP), ultrasonic measurements, cone-beam computed tomography (CBCT) scans, visual assessment, and colored biotype probes (CBP). Periodontal plastic procedures performed using autogenous grafts such as connective tissue grafts (CTG) and free gingival grafts (FGG), or biomaterials such as acellular dermal matrices (ADM) and collagen matrices (CM), are known to significantly increase GT and the amount of keratinized tissue. However, creating a second surgical site in the oral cavity during these procedures may compromise patient comfort, prompting researchers to explore alternative methods. Additionally, the effectiveness of synthetic biomaterials has been found to be lower than that of autogenous grafts.\n\nPlatelet-rich concentrates have been used as a minimally invasive procedure for the past thirty years, showing a high capacity to release growth factors that support tissue regeneration. While platelet-rich plasma (PRP), as the first-generation platelet concentrate, is widely used, platelet-rich fibrin (PRF) has been increasingly applied across various fields of medicine and dentistry due to its ability to release more growth factors over a longer period, resulting in better clinical outcomes. PRF is a highly biocompatible material composed of autologous cells and growth factors entrapped in a fibrin matrix, and has been shown to degrade more slowly over time compared to conventional PRP. One of the main reported disadvantages of PRF (and especially PRP) is its relatively rapid resorption, typically within 2-3 weeks. Biofiller is an autologous material derived from the patient's own blood and includes platelet-poor plasma (PPP) and concentrated platelet-rich fibrin (PRF). The PPP component is heated to become enriched with albumin, thereby prolonging its resorption time. The PRF portion contains autologous cells and growth factors. However, conventional PRF is typically resorbed within 2-3 weeks, limiting its clinical application. Recent studies have shown that the resorption time of biofiller-a combination of PPP and PRF-can exceed 4 months.\n\nThe aim of this study is to compare the effectiveness of biofiller with connective tissue graft in increasing gingival thickness in patients with a thin gingival phenotype. A total of 34 patients (17 patients in each group) will be enrolled. Tunnel surgery will be performed to all participants and test group will receive biofiller only once. Control group will receive connective tissue surgery. Clinical parameters obtained from our patients at baseline and at follow-up visits at 1, 3, and 6 months - including gingival thickness (GT), keratinized tissue width (KTW), and soft tissue measurements assessed via intraoral scanners - will be compared.",[169,28,170],"Gingival Recession","Gingival Inflammation",[172,173,174],"biofiller","gingival phenotype modification","connective tissue graft","2025-08-06",{"date":177,"type":33},"2025-08-12",{"date":179,"type":33},"2025-07-30",{"date":181,"type":23},"2026-05-01",{"name":183,"class":40},"Inonu University",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":190,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":18,"minAge":49,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":82,"phases":194,"briefSummary":195,"conditions":196,"keywords":199,"overallStatus":203,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":208,"leadSponsor":210,"locationsCount":4},"100588069","how-can-prefabricated-membranes-load-ascorbic-acid-can-curtail-gingival-recession-100588069","NCT06936592","How Can Prefabricated Membranes Load Ascorbic Acid Can Curtail Gingival Recession?","How Can Prefabricated Membrane-loaded Ascorbic Acid Curtail the Gingival Recession?","recession","Inclusion Criteria:\n\n1. Patients of both genders with ages more than 18 years.\n2. At least two adjacent teeth in maxillary or mandibular anterior sextant with Cairo classification (RT1 or RT 2) labial GR defect.\n3. Good general health with no contraindications for periodontal surgery (American Society of Anesthesiologists I).\n4. Non-smoker patients.\n\nExclusion Criteria:\n\n1. Pregnant and lactating women.\n2. Teeth exhibiting pathologic mobility.\n3. Mal alignment teeth.\n4. Patients under active orthodontic therapy.\n5. Periodontal therapy during the last 6 months.\n6. Patients received antibiotics or non-steroidal anti-inflammatory drugs six months before the beginning of the study.","55 Years",{"count":51,"type":23},[84],"Periodontal diseases are a prevalent issue, often leading to gingival recession, where the gingival margin recedes, exposing the tooth root and causing various problems. Gingival recession can be managed through both non-surgical and surgical interventions The non-surgical approach often involves plaque control and addressing any underlying inflammatory conditions. However, in cases of advanced recession, surgical treatment may be necessary Several treatment techniques have been proposed, which can be divided into pedicle and free grafts. The latter can also be classified as free gingival grafts (FGG) or as connective tissue grafts (CTG). Other treatment options include soft tissue substitutes or regenerative therapies Harvesting graft from the palate has several problems, such as pain, inflammation, bleeding, flap necrosis, and infection at the donor site. For this reason, we need a substitute for soft tissue graft harvesting Carbopol polymers, also known as carbomers, are widely utilized in pharmaceutical formulations for their excellent mucoadhesive properties. This high molecular weight, cross-linked acrylic acid polymers are particularly effective in enhancing the adhesion of formulations to mucosal surfaces, thereby improving drug delivery and bioavailability",[197,28,198],"Gingival Recession, Localized","Recession, Gingival",[190,200,201,202],"membrane","ascorbic acide","graft","NOT_YET_RECRUITING","2025-04-17",{"date":206,"type":33},"2025-04-20",{"date":204,"type":23},{"date":209,"type":23},"2025-10-18",{"name":211,"class":40},"Minia University",{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":17,"sex":18,"minAge":219,"maxAge":220,"enrollmentInfo":221,"targetDuration":4,"studyType":82,"phases":223,"briefSummary":224,"conditions":225,"keywords":227,"overallStatus":203,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":41},"100545422","effectiveness-of-mysmile-app-for-improving-the-oral-health-of-secondary-school-children-100545422","NCT06381700","Effectiveness of MySmile App for Improving the Oral Health of Secondary School Children:","Effectiveness of MySmile App for Improving the Oral Health of Secondary School Children: A Cluster Randomised Controlled Trial","1. Inclusion criteria for school\n\n   * Government-funded secondary school\n   * Received SDS from the mobile dental squad\u002Fschool dental clinic at least once a year.\n   * High-risk schools with all indicators not meeting the district's benchmark.\n2. Inclusion criteria for the participants:\n\n   * Secondary school children aged 15-17 years old.\n   * Medium to high dental plaque level - Plaque score more than 50%\n   * Healthy with no chronic medical history and physical disabilities\n   * Understand the English language.\n   * Own a smartphone\u002F\u002F have access to an Android-based smartphone","15 Years","17 Years",{"count":222,"type":23},303,[84],"The goal of this cluster-randomised control trial is to assess the effectiveness of the MySmile app for improving oral health in secondary school children. The main questions it aims to answer are:\n\n1. Will the MySmile app be more effective in improving secondary school children's dental plaque and gingival health over and above the existing school dental service (SDS)?\n2. Will the MySmile app be more effective in improving secondary school children's oral health knowledge, attitudes, and behaviours over and above the existing SDS?\n3. Is the MySmile app easy to use by secondary school children?\n4. Is the MySmile app acceptable to use from the perspective of secondary school children?\n\nParticipants in the intervention group will receive the SDS and MySmile app. The control group will receive SDS only. Therefore the researcher will compare between the intervention and control group in terms of dental plaque, gingival health, oral health knowledge, oral health attitudes and oral health behaviours.",[226,28],"Oral Disease",[228,229,230,231],"Mobile apps","Prevention","Oral Health Promotion","Schoolchildren","2025-03-11",{"date":234,"type":33},"2025-03-12",{"date":236,"type":23},"2025-03",{"date":238,"type":23},"2025-08",{"name":240,"class":40},"University of Malaya",{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":248,"enrollmentInfo":249,"targetDuration":4,"studyType":82,"phases":251,"briefSummary":252,"conditions":253,"keywords":256,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":41},"100553791","evaluation-of-nonsurgical-treatment-of-deep-periodontal-pockets-7-10mm-using-airflow-prophylaxis-master-device-with-erythritol-powder-vs-conventional-instrumentation-100553791","NCT06490679","Evaluation Of Nonsurgical Treatment Of Deep Periodontal Pockets (7-10mm) Using AIRFLOW® Prophylaxis Master Device With Erythritol Powder vs Conventional Instrumentation","Evaluation Of Nonsurgical Treatment Of Deep Periodontal Pockets (7-10mm) Using AIRFLOW® Prophylaxis Master Device With Erythritol Powder vs Conventional Instrumentation: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Systemically healthy patients.\n* Patients with an age range between 16 to 80 years.\n* Patients have a minimum of 20 teeth.\n* Periodontitis patients with at least one residual pocket with a probing depth ranging from 7 to 10 mm.\n* Cooperative patients able and willing to come for follow up appointments.\n\nExclusion Criteria:\n\n* Pregnant and lactation females.\n* Patients reporting systemic conditions (eg: diabetes).\n* Patients with severe or unstable upper respiratory tract infections, chronic bronchitis\u002Fasthma.\n* Patients with severe inflammation and\u002For osteonecrosis.","80 Years",{"count":250,"type":23},46,[84],"Periodontitis is a chronic condition associated with the inflammatory destruction of the periodontal tissues ultimately leading to tooth loss. Clinically, it is identified by key features such as clinical attachment loss (CAL), bleeding upon probing (BOP), and an increase in probing pocket depth (PPD), and\u002For gingival recession. Periodontitis is mediated by polymicrobial dysbiosis with keystone pathogens affecting the virulence of the entire biofilm community. The removal of this biofilm and its retention factors is the ultimate goal of clinical treatment and oral measures applied. The elimination of the biofilm has traditionally been achieved with the use of either hand instruments or power driven devices. Promoting periodontal health or diminishing bacterial presence and calculus buildup on teeth can be accomplished with the same efficacy whether using manual scalers and curettes or ultrasonic scaling instruments. Both hand and ultrasonic instruments are characterized by being time- consuming and requiring technical skill, often causing patient discomfort and post-treatment pain, including hypersensitivity resulting from the loss of hard tissue when scaling the tooth surface. Ultrasonic instruments tend to leave a rougher surface behind compared to hand instruments. While effective the current techniques all have their disadvantages. The aim of this study is to evaluate changes in probing depth clinically, Bleeding on probing, Clinical attachment level, Plaque index, Calculus index, Patient pain\u002Fdiscomfort, Patient satisfaction, Cost effectiveness, Treatment time and Number of pockets closed after using AIRFLOW® Prophylaxis Master device with erythritol powder.",[254,54,28,255],"Periodontal Pocket","Gingival Bleeding",[257,258],"Air Abrasive","Erythritol","2024-08-07",{"date":261,"type":33},"2024-08-09",{"date":263,"type":33},"2024-03-01",{"date":265,"type":23},"2026-01-01",{"name":267,"class":40},"Cairo University"]