[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gingival-hyperpigmentation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gingival-hyperpigmentation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100632441","vitamin-c-for-gingival-depigmentation-100632441",false,"NCT07513727","Vitamin C for Gingival Depigmentation","Clinical and Histological Evaluation of Topical Vitamin C Application Using Three Modalities in Gingival Depigmentation","VitC-DePg","Inclusion Criteria:\n\n\\- 1- Both genders aged from 20-35 years. 2- Patients clinically diagnosed with physiologic gingival melanin pigmentation in the maxillary and mandibular keratinized gingiva.\n\n3- Patients complaining of compromised esthetics. 4- Patients should be systemically free any disease as verified by a medical history diagnostic sheet or via health questionnaire\n\nExclusion Criteria:\n\n\\- 1- Patient clinically diagnosed with periodontitis and \u002F or manifest poor oral hygiene with high plaque and gingival indices 2- Pregnant or lactating females. 3- Patients with clinical diagnosed lesion in the area of interest primarily the gingivae encompassing the maxillary \u002Fmandibular anterior teeth e.g. pigmented lesion of intestinal polyposis syndrome, McCune-Albright syndrome and fibro-osseous lesions as florid osseous dysplasia.\n\n4- Patient with previous treatment of gingival hyperpigmentation. 5- Patients with history of being allergic to the vitamin C. 6- Patients with any systemic disease ( e.g. Addison disease ) or drugs consumed that may cause clinical gingival hyperpigmentation 7- Patients who are active or previous smokers.","ALL","20 Years","40 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to evaluate the clinical and histopathological efficacy of topical vitamin C applications using three modalities (topical gel, microneedling , and mesotherapy) in gingival depigmentation. Assessment includes clinical evaluation, CIELAB analysis via DOPI, and histopathological examination (Fontana-Masson staining).",[28,29],"Gingival Hyperpigmentation","Gingival Melanin Pigmentation","RECRUITING","2026-03-31",{"date":33,"type":34},"2026-04-07","ACTUAL",{"date":36,"type":34},"2025-07-29",{"date":38,"type":22},"2026-05-01",{"name":40,"class":41},"Al-Azhar University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":19,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":54,"conditions":55,"keywords":56,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":42},"100623906","clinical-effectiveness-of-polishing-brush-compared-to-ceramic-soft-tissue-trimming-bur-in-gingival-depigmentation-100623906","NCT07402720","Clinical Effectiveness Of Polishing Brush Compared To Ceramic Soft Tissue Trimming Bur In Gingival Depigmentation","Clinical Effectiveness Of Polishing Brush Compared to Ceramic Soft Tissue Trimming Bur In Gingival Depigmentation: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Presence of melanin hyperpigmentation (Dummett Oral Pigmentation Index ≥ 2)\n* Presence of bilateral gingival pigmentation extending at least 3 teeth in each arch\n* Age range: e.g., 18-40 years (adjust based on your sample)\n* Non-smokers (or smokers \\\u003C10 cigarettes\u002Fday, specify if allowed)\n* Systemically healthy\n* Willingness to participate and sign informed consent 8\n* Available for follow-up appointments\n* No previous periodontal surgery in the area other than prophylaxis\n\nExclusion Criteria:\n\n* • Systemic conditions affecting healing (e.g., diabetes mellitus,immunosuppressive disorders)\n\n  * Pregnant or lactating women\n  * Heavy Smokers\n  * Ongoing orthodontic treatment in the affected area\n  * Use of medications affecting gingiva (e.g., phenytoin, cyclosporine, calcium channel blockers)\n  * Poor oral hygiene at baseline\n  * Active periodontal pockets \\>3 mm or clinical attachment loss\n  * Allergy to local anesthetics or materials used in the procedure\n  * History of alcohol or drug abuse\n  * Psychological conditions that may interfere with compliance","18 Years",{"count":52,"type":22},20,[25],"Gingival hyperpigmentation, particularly of melanin origin, can pose significant aesthetic concerns, especially among patients with a high smile line. Several depigmentation techniques have been proposed to manage this condition, including scalpel surgery, electrosurgery, cryotherapy, lasers, and various rotary instruments. Recently, minimally invasive rotary tools such as ceramic burs and polishing brushes have gained interest due to their potential to deliver controlled ablation with reduced postoperative discomfort and healing complications.\n\nCeramic soft tissue trimming burs are specially designed to remove superficial pigmented gingival layers with minimal trauma. However, these instruments may still generate heat and cause a degree of tissue damage. On the other hand, polishing brushes, traditionally used for surface finishing and stain removal, have recently been explored for soft tissue applications due to their gentle action and adaptability.\n\nDespite their increasing use, there is insufficient comparative clinical evidence on the efficacy, healing outcomes, and patient-centered experiences between these two modalities in gingival depigmentation. A split-mouth randomized controlled trial design offers the advantage of eliminating inter-individual variability. Thus, this study aims to assess and compare the clinical effectiveness of the polishing brush and ceramic trimming bur for gingival depigmentation in terms of pigment reduction, healing outcomes, postoperative pain, and recurrence.",[28],[57,58,59],"ceramic bur","polishing brush","gingival hyperpigmentation","2026-02-10",{"date":62,"type":34},"2026-02-12",{"date":64,"type":34},"2025-11-01",{"date":66,"type":22},"2027-03",{"name":68,"class":41},"Cairo University"]