[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gingival-inflammation-and-bleeding\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gingival-inflammation-and-bleeding":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100620972","the-antiplaque-and-antigingivitis-effect-of-pure-green-tea-mouth-wash-compared-to-placebo-and-essential-oils-mouth-washes-100620972",false,"NCT07364565","The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes","The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes: A Double Blinded Randomized Controlled Clinical Trial.","Inclusion criteria:\n\n* Non-smokers\n* Systemically healthy\n* At least 24 teeth in the functional dentition, excluding third molars\n* Clinical diagnosis of periodontal health (no periodontal pockets \\> 3 mm, bleeding on probing percentage \\\u003C 10%, and no attachment loss).\n\nExclusion criteria:\n\n* Smokers.\n* Medically compromised patients.\n* Pregnant woman.\n* Allergies to green tea or EO.\n* Any condition that might affect the periodontal tissues.\n* Patients with any carious lesions (initial or active).\n* Patients who have overhang restorations, poorly designed crowns or bridges, and ortho retainers.\n* Use of systemic antibiotics or anti-inflammatory medications within 3 months prior to enrolment.",true,"ALL","18 Years",{"count":20,"type":21},44,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to to evaluate the antiplaque and antigingivitis effect of pure green tea mouthwash compared to placebo and essential oils mouthwashes in healthy patients.\n\nThe main questions it aims to answer are:\n\n* Does pure green tea mouthwash effectively reduce dental plaque?\n* Does pure green tea mouthwash reduce gingival inflammation?\n\nResearchers will compare pure green tea mouthwash to Listerine Total Care, Listerine Green Tea, and placebo to see if there is a difference in plaque accumulation and gum inflammation reduction.\n\nParticipants will be prohibited from using any sort of oral hygiene parctice for the whole study period (3 weeks). Instead, they will rinse with 10 ml of their assigned mouthwash twice daily for 30 seconds. Plaque index, gingival index, and staining index will be examined at multiple intervals and participants will rate their sense of oral freshness and good breath.",[27,28,29,30,31,32],"Dental Plaque","Patient Reported Outcome","Gingival Inflammation and Bleeding","Gingival Inflammation","Gingival Bleeding","Gingivitis",[34,35,36,37,38,39,40,41,42],"Green tea","Gingival inflammation","Plaque index","Essential oils","Mouthwash","Bleeding on probing","Camellia sinensis","Herbal medicine","Periodontal health","RECRUITING","2026-01-21",{"date":46,"type":47},"2026-01-23","ACTUAL",{"date":49,"type":47},"2025-12-01",{"date":51,"type":21},"2026-12",{"name":53,"class":54},"King Abdullah University Hospital","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":16,"sex":17,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":22,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":55},"100563441","phase-2-topical-10-povidone-iodine-in-preventing-white-spots-100563441","NCT06616207","Topical 10% Povidone-Iodine in Preventing White Spots","Efficacy and Safety of Topical 10% Povidone-Iodine in Preventing White Spots During Orthodontic Treatment","Inclusion Criteria:\n\n* Healthy children and teens (10-17 years old)\n* Transitional or permanent dentition of at least 4 permanent anterior teeth in each arch\n* Full fixed appliance orthodontic treatment is expected to last at least one year\n\nExclusion Criteria:\n\n* Allergies to iodine\n* Chronic prophylactic use of antibiotics\n* Diagnosis of thyroid disease\n* Conditions that could impair routine oral hygiene procedures.\n* Pregnant at enrollment","10 Years","17 Years",{"count":66,"type":21},80,[68],"PHASE2","The goal of this clinical trial is to learn if topical application on the all surface of 10% Povidone Iodine (Povi-One) in healthy participants in transitional or permanent dentition (10-17 y) prevents new white spot lesions in the maxillary anterior teeth at 1 year of follow-up.\n\nResearchers will compare Povi-One to a placebo to see if Povi-One works to prevent new white spot lesions.\n\nIt will also learn about the safety of topical 10% Povidone Iodine.\n\nThe main questions it aims to answer are:\n\n1. Does Povi-One prevent the development of any white spot lesion on the surface of maxillary anterior teeth?\n2. Does Povi-One lower the probability of any International Caries Detection and Assessment System (ICDAS) score greater than 0 and mean modified Löe-Silness Gingival Index (GI) in the intervention group?\n\nResearchers will\n\n1. Score GI without cleaning participants teeth, then score ICDAS of maxillary and mandibular incisors after participants brush and floss their teeth and take a photograph of maxillary 6 anterior teeth\n2. Apply Povi-one (or control) at the consultation appointment before placing fixed orthodontic appliances and 3, 6, and 9 months after appliance placement\n\nResearchers will\n\n1. Recall using Zoom 24-48 hours after the first application of Povi-One and examine the participant's mouth for oral lesions using a structured paper checklist\n2. Interview the caregiver to complete a paper questionnaire on adverse effects\n\nResearchers will\n\n1. Score GI, and then score ICDAS of maxillary and mandibular incisors in 6, 12 months after appliance placement\n2. Evaluate the development of white spot lesions on maxillary central and lateral incisors in 6, and 12 months after appliance placement",[71,29],"White Spot Lesions",[73,74,75,76],"Povidone-Iodine","White spot lesion","Topical application of 10% Povidone- Iodine in preventing white spots","Topical 10% Povidone-Iodine In Preventing White Spots During Orthodontic Treatment","2024-09-24",{"date":79,"type":47},"2024-09-27",{"date":81,"type":47},"2024-09-13",{"date":83,"type":21},"2027-03-31",{"name":85,"class":54},"University of Washington"]