[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gingival-inflammation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gingival-inflammation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,44,69,103,133,166,193,216],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100590367","phase-4-investigation-of-the-interplay-between-local-oral-inflammation-microbiota-and-systemic-immune-responses-100590367",false,"NCT06966492","Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses.","ILIMSIR","Inclusion Criteria:\n\n1. Males and females, between 18-65 years of age;\n2. Availability for the duration of the study;\n3. ASA 1 Good general health (absence of any self-reported systemic disease or condition that, in the opinion of the Principal Investigator, might constitute a risk to the subject while participating in the study. Examples include heart problems, valve\u002Fhip replacements, etc);\n4. Willingness to provide information related to their medical history;\n5. Minimum of 20 uncrowned permanent natural teeth (excluding third molars and crowns);\n6. Informed Consent Form signed.\n\nExclusion Criteria:\n\n1. Subjects with more that 2 sites with pocket depth of \\> 4 mm and those presenting purulent exudate, tooth mobility, and\u002For extensive loss of periodontal attachment or alveolar bone;\n2. Oral pathology or a history of allergy to testing products;\n3. Subject using anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory medication or daily analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study; to be defined by the dental examiner;\n4. Subject participating in any other clinical study;\n5. Subject pregnant or breastfeeding;\n6. Subject allergic to oral care products and personal care consumer products\n7. Extended use of antibiotics or therapeutic mouthwash (eg: Chlorhexidine) any time during the three months prior to entry into the study;\n8. Ongoing use of medications known to affect the gingival tissues (i.e. calcium channel blockers, phenytoin, cyclosporine)\n9. Current smokers (or users of tobacco and vaping products) and subjects with a history of alcohol or drug abuse;\n10. An existing medical condition which prohibits eating or drinking for periods up to 4 hours.\n11. Individuals with orthodontic bands or removable partial dentures.\n12. Dental prophylaxis in the previous 3 months prior to the baseline examination",true,"ALL","18 Years","65 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","This is a clinical research study designed to measure changes in inflammation and the oral microbiome during a phase of good oral hygiene and the absence of oral hygiene. The goal of the study is to investigate the interplay between local oral inflammation, microbiota and systemic immune responses.",[28],"Gingival Inflammation",[30],"induced gingivitis","NOT_YET_RECRUITING","2026-05-22",{"date":34,"type":35},"2026-05-26","ACTUAL",{"date":37,"type":22},"2026-06",{"date":39,"type":22},"2027-06",{"name":41,"class":42},"Colgate Palmolive","INDUSTRY",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":43},"100624907","evaluation-of-a-toothpaste-containing-a-gum-health-active-in-participants-with-gingival-problem-100624907","NCT07415733","Evaluation of a Toothpaste Containing a Gum Health Active in Participants With Gingival Problem","A Randomized Clinical Study on the Effect of a Toothpaste Containing a Gum Health Active in Participants With Gingival Problem","Inclusion Criteria:\n\n* Participants need to be competent i.e., able to understand what is to take place and able to provide a free decision on agreeing to the activity\u002Ftaking part in the study on this.\n* Participants must be able to read and understand study instructions and any other relevant study documents.\n* Have at least 20 natural teeth without subgingival calculus, including 5 assessable teeth (excluding 3rd molars) in each quadrant.\n* Have a mean whole mouth BOP ≥ 10% at screening.\n* Willing to follow the lifestyle and dietary restrictions as detailed in the Information Sheet for study.\n\nExclusion Criteria:\n\n* Be pregnant or breastfeeding.\n* Participants who participated in gum health study within 3 months prior to screening.\n* Current participation in any other cosmetic studies, any dental clinical studies or clinical trials.\n* Participants who have used any gum health products in the 4 weeks prior to screening.\n* Obvious signs of untreated caries or significant periodontal disease, which in the opinion of the study dentist, will affect either the scientific validity of the study or if the participant to take part in the study would affect their wellbeing.\n* Have more than three sites with a probing pocket depth (PPD) of ≥ 5 mm.\n* Full or partial dentures wearers.\n* Current orthodontic treatment.\n* Smokers or those who have a recent smoking history, including e-cigarettes.\n* Diabetics.\n* Have had a dental prophylaxis in the month prior to enrolment or have one scheduled prior to the end of the study.\n* Medical condition and\u002For regular use of any medication which might affect the outcome of the study, as determined by the study dentist, principally a course of anti-inflammatory, antimicrobial or statin drugs within 4 weeks of screening.\n* Taking dietary supplements (e.g. multivitamins, antioxidants, fish oils, etc.).\n* Known allergy to any ingredient in study products.\n* The participant is a Unilever employee or a member of the study team.\n* Any participant who, in the judgement of the investigator, should not participate in the study.",{"count":52,"type":22},150,[54],"NA","The primary objective of this clinical study is to evaluate the impact on gingival health when participants switch to a fluoride toothpaste without gum-health actives for 4 weeks after using a proven gum-health toothpaste for 13 weeks.",[28,57,58],"Gingival Bleeding","Dental Plaque","RECRUITING","2026-04-29",{"date":62,"type":35},"2026-04-30",{"date":64,"type":35},"2026-02-27",{"date":66,"type":22},"2026-08",{"name":68,"class":42},"Unilever R&D",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":16,"sex":17,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":23,"phases":81,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":43},"100625328","determination-of-the-effects-of-stainless-steel-crowns-cemented-with-resin-cements-on-interleukin-10-12-18-levels-in-gingival-crevicular-fluid-100625328","NCT07421206","DETERMINATION OF THE EFFECTS OF STAINLESS STEEL CROWNS CEMENTED WITH RESIN CEMENTS ON INTERLEUKIN-10, 12, 18 LEVELS IN GINGIVAL CREVICULAR FLUID","Determination of the Effects of Stainless Steel Crowns Cemented With Resin Cements on Interleukin-10, Interleukin-12, and Interleukin-18 Levels in Gingival Crevicular Fluid","SSC-CYTO","Inclusion Criteria:\n\nChildren aged 6-10 years\n\nSystemically healthy pediatric patients\n\nPresence of bilateral mandibular second primary molars (teeth 75 and 85) requiring stainless steel crown restoration\n\nAbsence of clinical signs of active periodontal disease\n\nCooperative behavior sufficient to allow dental treatment and gingival crevicular fluid sampling\n\nWritten informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\nPresence of systemic diseases or medical conditions affecting periodontal health or immune response\n\nUse of antibiotics, anti-inflammatory drugs, or immunosuppressive medications within the last month\n\nPoor oral hygiene or untreated periodontal disease\n\nTeeth with pulpal pathology, mobility, or advanced root resorption\n\nHistory of allergy to dental materials used in the study\n\nLack of parental consent or inability to complete follow-up examination","6 Years","10 Years",{"count":80,"type":22},45,[54],"This split-mouth clinical study aimed to evaluate the early effects of stainless steel crowns cemented with self-adhesive resin cement and high-viscosity glass ionomer cement on clinical periodontal parameters and interleukin-10 (IL-10), interleukin-12 (IL-12), and interleukin-18 (IL-18) levels in gingival crevicular fluid in pediatric patients. The study included 45 systemically healthy children aged 6-10 years. Stainless steel crowns were placed on the mandibular second primary molars (teeth 75 and 85) in each patient; tooth 75 was cemented with a self-adhesive resin cement (G-Cem ONE™, GC, Japan), while tooth 85 was cemented using a high-viscosity glass ionomer restorative material (EQUIA Forte™ HT, GC, Tokyo, Japan). Plaque index, gingival index, and bleeding on probing were recorded before treatment and one week after cementation. Gingival crevicular fluid samples were collected at the same time points, and IL-10, IL-12, and IL-18 levels were analyzed using the ELISA method. A statistically significant reduction in plaque index values was observed in both cement groups at the one-week follow-up (p\\\u003C0.001), whereas no significant differences were found in gingival index or bleeding on probing values (p\\>0.05). IL-10 and IL-12 levels did not change significantly in either group, whereas IL-18 levels decreased significantly in the resin cement group and were significantly higher in the glass ionomer cement group postoperatively. These findings suggest that although different cementation materials used for stainless steel crowns yield similar short-term clinical periodontal outcomes, material-related differences may exist in gingival biological responses, particularly with respect to IL-18 levels.",[84,28,85],"Dental Caries","Periodontal Response to Dental Restorative Materials",[87,88,89,90,91,92],"Stabnless steel crown","gingival crevicular fluid","interleukin-10","interleukin-12","interleukin-18","resin cement","2026-02-12",{"date":95,"type":35},"2026-02-19",{"date":97,"type":22},"2026-02-16",{"date":99,"type":22},"2026-05-30",{"name":101,"class":102},"Afyonkarahisar Health Sciences University","OTHER",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":23,"phases":112,"briefSummary":114,"conditions":115,"keywords":116,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":132},"100602516","phase-3-effectiveness-of-toothpaste-tablets-on-plaque-gingival-health-and-caries-experiences-100602516","NCT07124533","Effectiveness of Toothpaste Tablets on Plaque, Gingival Health and Caries Experiences","Effectiveness of Toothpaste Tablets on Plaque, Gingival Health and Caries Experiences: A 6-week Randomized Controlled Trial","Inclusion Criteria:\n\n1. Subjects are 18 years or older;\n2. Subjects who will comply with study protocol;\n3. Subjects who can read and understand the consent form;\n4. Subjects available during the study period;\n5. Subjects have more than 20 teeth.\n\nExclusion Criteria:\n\n1\\. Subjects under the age of 18.",{"count":111,"type":22},50,[113],"PHASE3","Objectives: To evaluate the effectiveness of toothpaste tablets when compared to conventional dentifrices in removing plaque.\n\nMethods: 50 participants are randomized into two groups: Denttabs toothpaste tablets (T) and Colgate's Cavity Protection toothpaste (P). Both groups utilize their assigned dentifrice for 6 weeks. A pre and post-assessment measures the Gingival Index (GI) and Plaque Index (PI) and Decayed, Missing and Filled Teeth (DMFT). A questionnaire on the use of the product is distributed at the end of the study.",[28,84],[117,118,119,120,121,122],"Gingival Index","Plaque Index","Dentifrice","Toothpaste Tablets","Caries Experiences","Consumer Satisfaction","2026-01-28",{"date":125,"type":35},"2026-01-30",{"date":127,"type":22},"2026-05",{"date":129,"type":22},"2026-12",{"name":131,"class":102},"Loma Linda University",2,{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":23,"phases":142,"briefSummary":143,"conditions":144,"keywords":148,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":164,"locationsCount":43},"100620972","the-antiplaque-and-antigingivitis-effect-of-pure-green-tea-mouth-wash-compared-to-placebo-and-essential-oils-mouth-washes-100620972","NCT07364565","The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes","The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes: A Double Blinded Randomized Controlled Clinical Trial.","Inclusion criteria:\n\n* Non-smokers\n* Systemically healthy\n* At least 24 teeth in the functional dentition, excluding third molars\n* Clinical diagnosis of periodontal health (no periodontal pockets \\> 3 mm, bleeding on probing percentage \\\u003C 10%, and no attachment loss).\n\nExclusion criteria:\n\n* Smokers.\n* Medically compromised patients.\n* Pregnant woman.\n* Allergies to green tea or EO.\n* Any condition that might affect the periodontal tissues.\n* Patients with any carious lesions (initial or active).\n* Patients who have overhang restorations, poorly designed crowns or bridges, and ortho retainers.\n* Use of systemic antibiotics or anti-inflammatory medications within 3 months prior to enrolment.",{"count":141,"type":22},44,[54],"The goal of this clinical trial is to to evaluate the antiplaque and antigingivitis effect of pure green tea mouthwash compared to placebo and essential oils mouthwashes in healthy patients.\n\nThe main questions it aims to answer are:\n\n* Does pure green tea mouthwash effectively reduce dental plaque?\n* Does pure green tea mouthwash reduce gingival inflammation?\n\nResearchers will compare pure green tea mouthwash to Listerine Total Care, Listerine Green Tea, and placebo to see if there is a difference in plaque accumulation and gum inflammation reduction.\n\nParticipants will be prohibited from using any sort of oral hygiene parctice for the whole study period (3 weeks). Instead, they will rinse with 10 ml of their assigned mouthwash twice daily for 30 seconds. Plaque index, gingival index, and staining index will be examined at multiple intervals and participants will rate their sense of oral freshness and good breath.",[58,145,146,28,57,147],"Patient Reported Outcome","Gingival Inflammation and Bleeding","Gingivitis",[149,150,151,152,153,154,155,156,157],"Green tea","Gingival inflammation","Plaque index","Essential oils","Mouthwash","Bleeding on probing","Camellia sinensis","Herbal medicine","Periodontal health","2026-01-21",{"date":160,"type":35},"2026-01-23",{"date":162,"type":35},"2025-12-01",{"date":129,"type":22},{"name":165,"class":102},"King Abdullah University Hospital",{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":4,"eligibilityCriteria":172,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":173,"targetDuration":4,"studyType":23,"phases":175,"briefSummary":176,"conditions":177,"keywords":180,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":43},"100600940","biofiller-and-gingival-phenotype-thickening-100600940","NCT07104019","Biofiller and Gingival Phenotype Thickening","Evaluation of the Effectiveness of Blood Concentrate Biofiller in Thickening the Gingival Phenotype Around Natural Teeth","Inclusion Criteria:\n\n* Age between 18 and 60 years\n* Systemically healthy individuals\n* Presence of thin gingival phenotype in the mandibular anterior region (canine to canine)\n* No medications that affect wound healing\n* No history of bleeding disorders\n* No known allergy to anti-inflammatory drugs\n* Not pregnant or breastfeeding\n* Willingness to participate and provide informed consent\n* Non-smoker\n\nExclusion Criteria:\n\n* Systemic diseases (e.g., diabetes, hypertension, cancer, etc.)\n* Use of medications that may affect healing (e.g., corticosteroids, immunosuppressants)\n* History of radiotherapy or chemotherapy\n* Pregnancy or breastfeeding\n* Poor oral hygiene\n* Refusal to participate\n* Age under 18 years\n* Smoking\n* Presence of Class II or Class III orthodontic anomalies",{"count":174,"type":22},34,[54],"The periodontal phenotype is defined as the combination of the gingival phenotype and the thickness of the buccal bone plate (bone morphotype). The gingival phenotype refers to the gingival thickness (GT) and the width of the keratinized tissue (KTW). A gingival thickness of ≤1 mm is classified as a thin phenotype, whereas a thickness \\>1 mm is considered a thick phenotype. Thin gingival biotypes tend to show more pronounced responses to inflammation, restorations, trauma, and parafunctional habits. Various methods are used to assess gingival thickness, including transgingival probing (TP), ultrasonic measurements, cone-beam computed tomography (CBCT) scans, visual assessment, and colored biotype probes (CBP). Periodontal plastic procedures performed using autogenous grafts such as connective tissue grafts (CTG) and free gingival grafts (FGG), or biomaterials such as acellular dermal matrices (ADM) and collagen matrices (CM), are known to significantly increase GT and the amount of keratinized tissue. However, creating a second surgical site in the oral cavity during these procedures may compromise patient comfort, prompting researchers to explore alternative methods. Additionally, the effectiveness of synthetic biomaterials has been found to be lower than that of autogenous grafts.\n\nPlatelet-rich concentrates have been used as a minimally invasive procedure for the past thirty years, showing a high capacity to release growth factors that support tissue regeneration. While platelet-rich plasma (PRP), as the first-generation platelet concentrate, is widely used, platelet-rich fibrin (PRF) has been increasingly applied across various fields of medicine and dentistry due to its ability to release more growth factors over a longer period, resulting in better clinical outcomes. PRF is a highly biocompatible material composed of autologous cells and growth factors entrapped in a fibrin matrix, and has been shown to degrade more slowly over time compared to conventional PRP. One of the main reported disadvantages of PRF (and especially PRP) is its relatively rapid resorption, typically within 2-3 weeks. Biofiller is an autologous material derived from the patient's own blood and includes platelet-poor plasma (PPP) and concentrated platelet-rich fibrin (PRF). The PPP component is heated to become enriched with albumin, thereby prolonging its resorption time. The PRF portion contains autologous cells and growth factors. However, conventional PRF is typically resorbed within 2-3 weeks, limiting its clinical application. Recent studies have shown that the resorption time of biofiller-a combination of PPP and PRF-can exceed 4 months.\n\nThe aim of this study is to compare the effectiveness of biofiller with connective tissue graft in increasing gingival thickness in patients with a thin gingival phenotype. A total of 34 patients (17 patients in each group) will be enrolled. Tunnel surgery will be performed to all participants and test group will receive biofiller only once. Control group will receive connective tissue surgery. Clinical parameters obtained from our patients at baseline and at follow-up visits at 1, 3, and 6 months - including gingival thickness (GT), keratinized tissue width (KTW), and soft tissue measurements assessed via intraoral scanners - will be compared.",[178,179,28],"Gingival Recession","Gingival Diseases",[181,182,183],"biofiller","gingival phenotype modification","connective tissue graft","2025-08-06",{"date":186,"type":35},"2025-08-12",{"date":188,"type":35},"2025-07-30",{"date":190,"type":22},"2026-05-01",{"name":192,"class":102},"Inonu University",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":199,"enrollmentInfo":200,"targetDuration":4,"studyType":202,"phases":4,"briefSummary":203,"conditions":204,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":43},"100600675","bacteria-in-dental-plaque-and-atheroma-plaque-100600675","NCT07100574","Bacteria in Dental Plaque and Atheroma Plaque","Inclusion Criteria:\n\n* Diagnosed with endarterectomy\n* Not receiving chemotherapy\n* Not having received this treatment before\n\nExclusion Criteria:\n\n* Having systemic infection\n* Patients with severe heart disease","85 Years",{"count":201,"type":22},60,"OBSERVATIONAL","Periodontitis is considered a focus of infection where oral bacteria, bacterial by-products or inflammatory mediators can interact with other parts of the organism via the blood. Periodontal pathogen components such as DNA, RNA or specific antigens of P. gingivalis, Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Treponema denticola (T. denticola), Fusobacterium nucleatum (F. nucleatum) or Campylobacter rectus have been isolated from different tissues such as atheroma plaques, placenta, amniotic sac and respiratory tract. It has been reported that periodontitis may contribute to endothelial dysfunction leading to the formation of atherosclerosis.",[28,58,205,206],"Atheroma Plaque","Oral Bacteria","2025-08-01",{"date":209,"type":35},"2025-08-03",{"date":211,"type":35},"2024-12-10",{"date":213,"type":22},"2026-03-30",{"name":215,"class":102},"Istanbul Saglik Bilimleri University",{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":4,"eligibilityCriteria":222,"healthyVolunteers":16,"sex":17,"minAge":223,"maxAge":224,"enrollmentInfo":225,"targetDuration":4,"studyType":23,"phases":227,"briefSummary":228,"conditions":229,"keywords":231,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":43},"100594224","phase-3-triphila-mouthwash-effect-as-anti-plaque-and-anti-gingivitis-in-children-100594224","NCT07016659","Triphila Mouthwash Effect as Anti-plaque and Anti-gingivitis in Children","Assessing Antiplaque And Antigingivitis Efficacy Of Triphala Mouthwash Versus Chlorhexidine Mouthwash Among A Group Of Children: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients aged 9 to 13 years.\n* Apparently in good general health.\n* Both sexes.\n* Informed consent from their parents.\n* Patients with fair oral hygiene and gingival inflammation.\n* Participants should not have used mouthwashes for the follow-up period.\n\nExclusion Criteria:\n\n* Patients with known allergies to any ingredient used in the study.\n* History of immunosuppressive diseases.\n* History of antibiotic or anti-inflammatory therapy in the previous month till the start of the study.\n* Patients with orthodontic appliances.\n* Parents refused to participate or were unable to attend follow-up visits.","9 Years","13 Years",{"count":226,"type":22},36,[113],"The study aim to to assess the antiplaque and antigingivitis efficacy of Triphala mouthwash versus chlorhexidine mouthwash among children.\n\nOral health, acknowledged as equally significant to general health, has become an essential component of an individual's entire well-being. Dental caries and periodontal problems are the two predominant oral conditions that repeatedly affect nearly all individuals throughout their entire lives (Sharma et al., 2014).\n\nNumerous bacterial communities can be found in the oral cavity. These bacteria are harmless if proper health is maintained and are a healthy part of the human microbiome; However, disturbances to the local or systemic environment can lead to opportunistic infections such as periodontitis, gingivitis, or cavities .\n\nIt has been known that dental plaque plays a critical role in the development and progression of periodontal disease, gingivitis, and dental caries. Plaque control is the first line of defense against periodontal disease and gingival inflammation, and chemical plaque control methods should always be used in conjunction with mechanical methods .\n\nPlaque removal is constantly maintained by mechanical techniques like toothbrushing and flossing, which are essential for controlling and preventing gingivitis, periodontitis, and dental caries. For mechanical plaque control, children need chemotherapeutic agents like therapeutic mouthwash since they lack the motivation or hand-eye coordination to reach the interproximal locations on their own.\n\nHerbal medicine takes a preventative and promotional strategy. It is an integrated approach that treats diseases and promotes health by using a variety of treatments made from plants and their extracts. The use of natural herbs such as Triphala, Tulsi Patra, Jyestiamadh, Neem, Clove Oil, Pudina, Ajwain, and many more, either alone or in combination, has been shown by research to be a safe and effective treatment for a variety of oral health issues, including mouth ulcers, bleeding gums, halitosis, and tooth decay prevention .\n\nTriphala, which exhibits antibacterial, antiseptic, and anti-inflammatory effects, is one of the most popular formulas in traditional Ayurvedic medicine. It is extensively used in dentistry and includes equal amounts of Terminalia Chebula, Terminalia Belerica, and Emblica Officinalis .\n\nTriphala comprises tannins that facilitate the physical removal of microorganisms by aggregating them. This reduces the quantity of bacteria adhering to teeth during the initial phases of plaque development. Triphala mouth rinse exhibits extensive antibacterial activity against both Gram-positive and Gram-negative pathogens. It also demonstrates antioxidant properties that aid in minimizing dental plaque and gingivitis. The tannic acid in Triphala may facilitate plaque reduction by binding to bacterial cell surfaces that denature proteins and eradicate bacterial cells.",[230,28],"Plaque Accumulation",[232,233,234,235],"triphila mouthwash","anti-plaque","anti-gingivitis","children","2025-06-05",{"date":238,"type":35},"2025-06-12",{"date":240,"type":22},"2025-09-01",{"date":242,"type":22},"2026-10-01",{"name":244,"class":102},"Cairo University"]