[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gingival-pigmentation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gingival-pigmentation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,82,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100637285","phase-2-gingival-hyperpigmentation-treatment-100637285",false,"NCT07595705","Gingival Hyperpigmentation Treatment","Gingival Hyperpigmentation Treatment With Injectable Vitamin C in Conjunction With Glutathione Versus The Conventional Surgical Depigmentation: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\nThe selection criteria were done according to Gingival pigmentation index is as follows (Dummett and Bolden)10:\n\n1. Score0:absence of pigmentation\n2. Score1:spotsofbrowntoblackcolororpigments\n3. Score2:browntoblackpatchesbutnotdiffusepigmentation\n4. Score3:diffuse brown to black pigmentation,marginal,and attached.\n\nPatients who have Dummett and Bolden index score 1, 2, or 3 will be included in addition to the following criteria:\n\n1. above 18yrs\n2. systemically free\n3. physiologic gingival hyperpigmentation related to esthetic region\n4. well maintained oral hygiene and willing to undergo minor surgical procedures\n\nExclusion Criteria:\n\n1. systemic diseases associated with pathological hyperpigmentation or improper delayed wound healing (uncontrolled diabetes, autoimmune diseases, etc.)\n2. pregnant and lactating mothers\n3. usage of chlorhexidine or povidone iodine\n4. Local causes (smoking)\n5. periodontal diseases (plaque and non-plaque induced gingivitis or periodontitis)\n6. non compliant patients",true,"ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","It is a clinical study conducted to evaluate the effect of vitamin C and Glucathonine injection of pigmented gingival tissue versus surgical removal by scalpel",[27,28,29,30],"Gingival Pigmentation","Depigmentation","Vitamin C","Glutathione",[32,33,34,35],"depigmentation","vit c","glutathione","gingival depigmentation","RECRUITING","2026-05-15",{"date":39,"type":40},"2026-05-19","ACTUAL",{"date":42,"type":40},"2025-08-01",{"date":44,"type":21},"2027-10",{"name":46,"class":47},"Cairo University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":28,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":48},"100624478","clinical-evaluation-of-microneedling-technique-with-topical-application-of-silymarin-on-gingival-hyperpigmentation-in-comparison-with-diode-laser-and-scalpel-methods-100624478","NCT07410156","Clinical Evaluation of Microneedling Technique With Topical Application of Silymarin on Gingival Hyperpigmentation in Comparison With Diode Laser and Scalpel Methods.","Clinical Evaluation of Microneedling Technique With Topical Application of Silymarin on Gingival Hyperpigmentation in Comparison With Diode Laser and Scalpel Methods. A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Patients will be free from any systemic diseases according to criteria of Modified Cornell Medical Index\n2. Patient with physiologic pigmentation\n3. Non smoker\n4. Patient agree to sign the written consent\n5. Both genders\n\nExclusion Criteria:\n\n1. Pregnant and lactating women\n2. Systemic conditions affect melanin production\n3. Medications induce pigmentation or enlargement\n4. Those with known allergies to silymarin.",{"count":20,"type":21},[58],"NA","The present study will be carried to evaluate the efficacy of MN technique with topical Silymarin application in treating gingival hyperpigmentation in comparison with Laser and scalpel methods. This evaluation will be done clinically. The questions to be answered:\n\n* Is there a statistical difference between the microneedling (MN) technique with topical silymarin application, the scalpel technique, and the diode laser in providing clinical and aesthetic advantages in the treatment of gingival pigmentation?\n* What medical problems do participants have when using of Silymarin topically?\n\nParticipants will be:\n\nGroup 1 : The gingiva of the facial surfaces of the selected area will be de-epithelized by conventional method through blades no 15c.\n\nGroup 2 : The gingiva of the facial surfaces of the selected area will be de-epithelized by A Diode laser Device (serolaser).\n\nGroup 3 : The gingiva of the facial surfaces of the selected area will be treated by repetitive punctures with Dr.Pen ULTIMA - A6 needle tip. Silymarin is applied topically for ten minutes.",[27,61],"Gingival Hyperpigmentaion",[63,64,65,66,67,68,69,70,71,72],"Gingival depigmentation","Microneedling","Laser","Silymarin","Scalpel","Surgical depigmentation","Micro-needling","MN","Topical application","gingival hyperpigmentation","2026-02-07",{"date":75,"type":40},"2026-02-13",{"date":77,"type":21},"2026-07-01",{"date":79,"type":21},"2027-12",{"name":81,"class":47},"Fayoum University",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":94,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},"100620570","microneedling-with-platelet-rich-plasma-versus-microneedling-alone-for-gingival-depigmentation-100620570","NCT07359339","Microneedling With Platelet Rich Plasma Versus Microneedling Alone For Gingival Depigmentation","Microneedling With Platelet Rich Plasma Versus Microneedling Alone For Gingival Depigmentation: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* • Patients exhibiting melanin hyperpigmentation in the anterior region of the upper or lower gingiva.\n\n  * Age ≥ 18 year old.\n  * Patients should be free from any systemic diseases according to modified Cornell Medical index (Abramson 1966).\n  * Non- smokers\n\nExclusion Criteria:\n\n* • Fully edentulous patients.\n\n  * Patients with endocrine disorders causing hyperpigmentation or drug induced gingival pigmentation. (Sreeja, Ramakrishnan et al. 2015)\n  * Pregnant or lactating females.",{"count":90,"type":21},32,[58],"To evaluate the usage of microneedling with platelet rich plasma as a gingival depigmentation method in comparison to microneedling alone for pigment intensity reduction.\n\nPre-operative preparation phase includes ultrasonic scaling and oral hygiene instructions for all patients. Eligible patients will be randomly allocated into two groups.\n\nClinical photographs: Clinical photographs will be taken at baseline, 1 and 6 months postoperatively.\n\nIntervention Group (Group A): Microneedling will be done with application of Platelet Rich Plasma for depigmentation.\n\nControl Group (Group B): microneedling will be done alone for depigmentation.",[27],[95,96,97,64],"Pigmentation","Gingiva","PRP","2026-01-13",{"date":100,"type":40},"2026-01-22",{"date":102,"type":40},"2025-10-01",{"date":104,"type":21},"2026-11-10",{"name":46,"class":47},3,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":22,"phases":116,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":4},"100598325","phase-1-efficacy-of-microneedling-with-vitamin-c-in-performing-gingival-depigmentation-100598325","NCT07070024","Efficacy of Microneedling With Vitamin C in Performing Gingival Depigmentation","Efficacy of Microneedling With Vitamin C in Performing Gingival Depigmentation Compared With Conventional Scalpel and Diode Laser: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients with bilateral, diffuse and symmetric physiologic gingival pigmentation in the labial maxillary or mandible gingiva.\n2. Patients free from any systemic diseases according to criteria of Modified Cornell Medical Index. (Abramson J et al., 1966)\n3. Periodontally healthy patient.\n4. Patients with age between 18 and 50 years\n\nExclusion Criteria:\n\n1. Smokers.\n2. Drugs intake \"mainly those associated with gingival pigmentation\".\n3. Pregnant and lactating women.\n4. Patients with thin gingival phenotype \"with scalpel group\".\n5. Gingival pigmentation associated with occupational hazards.\n6. Individuals undergoing chemotherapy","50 Years",{"count":20,"type":21},[117,24],"PHASE1","The present study will be carried to clinically evaluate the efficacy of microneedling with vitamin C in performing gingival depigmentation in comparison with conventional scalpel and diode laser.",[27],"NOT_YET_RECRUITING","2025-07-15",{"date":123,"type":40},"2025-07-17",{"date":125,"type":21},"2025-07",{"date":127,"type":21},"2026-12",{"name":81,"class":47}]