[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gingival-recession-generalized\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gingival-recession-generalized":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,66,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100629102","oral-mucosa-wound-healing-after-gingival-recession-treatment-in-diabetic-patients-a-clinical-study-100629102",false,"NCT07470281","Oral Mucosa Wound Healing After Gingival Recession Treatment in Diabetic Patients. A Clinical Study.","Oral Mucosa Wound Healing in Diabetic Patients. A Clinical Study on Closed Wounds","Inclusion Criteria:\n\n* aged ≥ 18 years;\n* non-diabetic and diabetic patients (HbA1c\\>7% (American Diabetes Association 2025) managed with oral hypoglycemic agents or insulin;\n* in the need of gingival recession treatment (RT1) in upper or lower arches with identifiable or restored cement-enamel junction (CEJ);\n* periodontal stable (BoP ≤25%)(Lang et al. 2003);\n* no morphological or pathological conditions in the palatal mucosa.\n\nExclusion Criteria:\n\n* patients with cardiovascular, blood dyscrasias, and immunodeficiency that contraindicate surgical procedures;\n* taking medications known to interfere with the wound healing process or that contraindicate the surgical procedure;\n* Pregnancy\u002Flactation (assessed via self-report);\n* current opportunistic oral lesions that mainly colonize the palate region;\n* subjects that have taken antibiotics within the last 3 months or need for antibiotic prophylaxis;\n* prisoners;\n* signs or symptoms of active extra-oral head and neck infection (swelling) as determined by a dentist at the time of evaluation;\n* subjects who cannot read or speak English or Spanish, and do not agree to having the assistance of an interpreter",true,"ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to evaluate local and systemic factors involved in oral mucosal healing after gingival recession treatment in diabetic patients and to compare them with those in non-diabetic patients.\n\nDiabetic and non-diabetic volunteers of both sexes aged ≥ 18 years with gingival recession may participate. The main questions it aims to answer are:\n\n1. If the gingival recession reduction and percentage of root coverage are different in diabetics compared to non-diabetics.\n2. If different factors, such as the oral microbiome, inflammatory markers, and others, are associated with the clinical outcome.\n\nParticipants will be asked:\n\n* Receive the procedure to treat their gingival recession defects\n* To attend follow-up visits at 7, 14, 30, 90, and 180 days after treatment.\n* To provide different biological samples\n* To answer different questionnaires.",[27,28,29],"Diabetes Mellitus","Gingival Recession, Generalized","Gingival Recession, Localized",[31,32,33],"gingival recession","Diabetes","wound healing","NOT_YET_RECRUITING","2026-05-05",{"date":37,"type":38},"2026-05-11","ACTUAL",{"date":40,"type":21},"2026-07",{"date":42,"type":21},"2030-04",{"name":44,"class":45},"Mauro Santamaria","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":65,"locationsCount":46},"100631458","palatal-wound-healing-after-free-gingival-graft-harvest-in-diabetic-patients-a-clinical-trial-100631458","NCT07500935","Palatal Wound Healing After Free Gingival Graft Harvest in Diabetic Patients: A Clinical Trial","Oral Mucosa Wound Healing in Diabetic Patients. A Clinical Study on Open and Closed Wounds",{"count":20,"type":21},[24],"The goal of this clinical trial is to evaluate local and systemic factors involved in palatal mucosal healing after Free Gingival Graft harvest in diabetic patients and to compare them with those in non-diabetic patients.\n\nDiabetic and non-diabetic volunteers of both sexes aged ≥ 18 years with gingival recession may participate. The main questions it aims to answer are:\n\n1. If the palatal wound healing (area of the wound) and percentage of wound epithelialization are different in diabetics compared to non-diabetics.\n2. If different factors, such as the oral microbiome, inflammatory markers, and others, are associated with the clinical outcome.\n\nParticipants will be asked:\n\n* Receive the procedure to treat their gingival recession defects\n* To attend follow-up visits at 7, 14, 30, and 90 days after treatment.\n* To provide different biological samples\n* To answer different questionnaires.",[27,28,29],[31,58,33],"diabetes","2026-04-29",{"date":61,"type":38},"2026-05-06",{"date":63,"type":21},"2026-06",{"date":42,"type":21},{"name":44,"class":45},{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":76,"conditions":77,"keywords":83,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":46},"100605131","comparing-caf-and-tcaf-with-soft-tissue-grafting-for-treating-multiple-recessions-in-the-maxilla-100605131","NCT07158528","Comparing CAF and TCAF With Soft Tissue Grafting for Treating Multiple Recessions in the Maxilla.","An RCT Comparing Coronally Advanced Flap (CAF) and Tunneled Coronally Advanced Flap (TCAF) in Combination With a Soft Tissue Graft for Multiple Recessions Coverage in the Maxilla.","Inclusion Criteria:\n\n* At least 18 years of age\n* Good oral hygiene\n* Presence of multiple gingival recessions in the maxilla\n* Good general health\n\nExclusion Criteria:\n\n* Smoker\n* Pregnant women (assessed at each visit; if the patient becomes pregnant during follow-up, radiographs will not be taken)",{"count":74,"type":21},34,[24],"Multiple techniques can be used for recession coverage. The most common techniques are: tunnel technique (T), coronally advanced flap (CAF) or a combination of both (TCAF). Tunnel and coronally advanced flap are frequently used in clinical practice, whereas the combined technique is a relatively recently developed surgical approach.\n\nThis randomized controlled trial compares CAF and TCAF to determine which technique provides better root coverage for receding gums at multiple adjacent teeth in the upper jaw. The main question it aims to answer is:\n\n\\- What is the average root coverage achieved with each technique in the short and long term? This may be clinically relevant because covering gum recession can reduce tooth sensitivity, improve aesthetics and make oral hygiene easier.\n\nResearchers will compare the coronally advanced flap (CAF = the gum is detached and repositioned higher) with the tunneled coronally advanced flap (TCAF = the gum is undermined, only partially detached and repositioned higher). In both techniques, a small piece of tissue is removed from the palate, which is used to cover the recession. The purpose of the connective tissue graft under the flap\u002Ftunnel is to increase thickness and provide support.\n\nParticipants will:\n\n* Undergo surgery (CAF or TCAF, randomly assigned) to cover recessions\n* Attend regular check-ups for up to 10 years after surgery\n* Keep a postoperative journal (recording medication use, pain levels, tooth sensitivity, etc.)",[78,79,28,29,80,81,82],"Gingival Recession Generalized Moderate","Gingival Recession Localized Moderate","Gingival Recession, Plastic Surgery","Gingival Recessions","Gingival Recession, Mucogingival Surgery",[84,85,86,87,88,89,90,91],"TCAF","CAF","tunneled coronally advanced flap","coronally advanced flap","maxilla","multiple recessions","MAGR","multiple adjacent gingival recessions","RECRUITING","2025-09-09",{"date":95,"type":38},"2025-09-16",{"date":97,"type":38},"2025-08-18",{"date":99,"type":21},"2037-12-31",{"name":101,"class":45},"University Hospital, Ghent",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":16,"sex":17,"minAge":109,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":46},"100547553","novomatrix-in-gingival-recession-coverage-case-series-100547553","NCT06409468","NovoMatrix in Gingival Recession Coverage: Case Series","Safety and Efficacy of NovoMatrix in Gingival Recession Coverage \u002FA Pilot Clinical and Histological Case Series\u002F","Inclusion Criteria:\n\n* Male or female, between 20-70 years of age, who request gingival augmentation or recession coverage.\n* Subjects who are willing to sign an informed consent, participate and return for follow-up visits.\n* Subjects without significant medical history and currently not on medications that might complicate treatment outcomes.\n* Subjects demonstrating good oral hygiene (FMPS, FMBS less than 20%).\n\nExclusion Criteria:\n\n* Subjects who do not meet all the inclusion criteria or who will not cooperate with the protocol schedule.\n* Subjects who received and failed a previously placed autogenous graft.\n* Subjects who have significant untreated periodontal disease, caries, infection or chronic inflammation in the oral cavity within two adjacent tooth positions of the clinical trial area.\n* Subjects who have used nicotine-containing products within 3 weeks prior to surgery.\n* Subjects who are insulin-dependent diabetic or if their Hgb1c levels \\> 6.5%.\n* Subjects who have had a history of malignancy within the past 5 years (except for basal or squamous cell carcinoma of the skin or in situ cervical carcinoma).\n* Subjects who are nursing or pregnant.\n* Subjects who are presently taking medications (except estrogen\u002Fprogesterone therapy) or those who are undergoing treatment that in known to have an effect on bone turnover.\n* Subjects who have diseases that affect bone metabolism (excluding idiopathic osteoporosis).\n* Subjects with a history of an autoimmune disease, documented allergy or multiple allergies to any component of the agents used in this study.\n* Acutely infected mucogingival defect site.","20 Years","70 Years",{"count":112,"type":21},20,[24],"Twenty patients seeking treatment for gingival recession coverage, ranging from 20-70 years of age with multiple Miller Class I or II buccal gingival recessions (depth≥3 mm, at least 3 adjacent teeth) will be recruited for this study. Five patients within the study patient pool looking for further orthodontic or restorative treatment that requires removal of one single rooted tooth within the study site of interest will be selected for histological sample removal. All procedures performed in this study will be executed according to established routine protocols, with the exception of block biopsies of one hopeless tooth per patient (total of 5 patients) at 6 months.",[28],"2025-04-01",{"date":118,"type":38},"2025-04-04",{"date":120,"type":38},"2024-05-05",{"date":122,"type":21},"2025-12-15",{"name":124,"class":45},"Semmelweis University"]