[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gingival-recession-localized\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gingival-recession-localized":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,47,75,94,125,151,182,205,227,254,281,302,320,346,372],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":43,"locationsCount":46},"100624433","palatal-wound-healing-after-free-gingival-graft-surgery-100624433",false,"NCT07409571","Palatal Wound Healing After Free Gingival Graft Surgery","Impact of Topical Triamcinolone Acetonide on Palatal Wound Healing, Patient Morbidity, and Quality of Life After Free Gingival Graft Surgery: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Patients presenting with insufficient attached gingiva and\u002For gingival recession requiring free gingival graft surgery\n* Systemically healthy individuals (ASA I)\n* Full-mouth plaque score (FMPS) \\\u003C 15% and full-mouth bleeding score (FMBS) \\\u003C 15% at the time of surgery\n* Ability and willingness to provide written informed consent and comply with study procedures\n\nExclusion Criteria:\n\n* Presence of systemic diseases that may affect wound healing (e.g., diabetes mellitus, immunological disorders)\n* Use of systemic corticosteroids, immunosuppressive drugs, or anti-inflammatory medications within the last 3 months\n* Current smokers or tobacco users\n* Pregnancy or lactation\n* History of periodontal surgery at the palatal donor site\n* Presence of active infection, ulceration, or pathological lesions at the palatal donor area\n* Known allergy or hypersensitivity to corticosteroids, collagen materials, or study-related medications",true,"ALL","18 Years",{"count":20,"type":21},55,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled clinical trial aims to evaluate the effects of topical triamcinolone acetonide application on wound healing and patient-reported outcomes at the palatal donor site following free gingival graft (FGG) surgery. A total of 55 patients with mucogingival deficiencies requiring FGG will be randomly assigned to either a control group receiving a collagen membrane or a test group receiving topical triamcinolone acetonide at the donor site. All palatal donor areas will be protected with a periodontal dressing. Clinical assessments will be performed on postoperative days 3, 7, 14, and 30. Wound epithelialization will be evaluated using the hydrogen peroxide bubbling test, while wound healing and scar formation will be assessed using the Landry, Turnbull, and Howley index and the modified Manchester Scar Scale, respectively. Patient-centered outcomes, including postoperative pain, discomfort, analgesic consumption, and oral health-related quality of life, will be assessed using visual analog scales and the Oral Health Impact Profile-14 questionnaire. The findings of this study are expected to provide evidence regarding the potential benefits of topical corticosteroid use in reducing palatal donor site morbidity following FGG surgery.",[27,28,29],"Gingival Recession, Localized","Postoperative Morbidity","Palatal Donor Site Wound Healing",[31,32,33,34],"Free Gingival Graft","Palatal Donor Site","Wound Healing","Triamcinolone Acetonide","RECRUITING","2026-05-20",{"date":38,"type":39},"2026-05-22","ACTUAL",{"date":41,"type":39},"2025-10-16",{"date":36,"type":21},{"name":44,"class":45},"Kahramanmaras Sutcu Imam University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":46},"100629102","oral-mucosa-wound-healing-after-gingival-recession-treatment-in-diabetic-patients-a-clinical-study-100629102","NCT07470281","Oral Mucosa Wound Healing After Gingival Recession Treatment in Diabetic Patients. A Clinical Study.","Oral Mucosa Wound Healing in Diabetic Patients. A Clinical Study on Closed Wounds","Inclusion Criteria:\n\n* aged ≥ 18 years;\n* non-diabetic and diabetic patients (HbA1c\\>7% (American Diabetes Association 2025) managed with oral hypoglycemic agents or insulin;\n* in the need of gingival recession treatment (RT1) in upper or lower arches with identifiable or restored cement-enamel junction (CEJ);\n* periodontal stable (BoP ≤25%)(Lang et al. 2003);\n* no morphological or pathological conditions in the palatal mucosa.\n\nExclusion Criteria:\n\n* patients with cardiovascular, blood dyscrasias, and immunodeficiency that contraindicate surgical procedures;\n* taking medications known to interfere with the wound healing process or that contraindicate the surgical procedure;\n* Pregnancy\u002Flactation (assessed via self-report);\n* current opportunistic oral lesions that mainly colonize the palate region;\n* subjects that have taken antibiotics within the last 3 months or need for antibiotic prophylaxis;\n* prisoners;\n* signs or symptoms of active extra-oral head and neck infection (swelling) as determined by a dentist at the time of evaluation;\n* subjects who cannot read or speak English or Spanish, and do not agree to having the assistance of an interpreter",{"count":55,"type":21},40,[24],"The goal of this clinical trial is to evaluate local and systemic factors involved in oral mucosal healing after gingival recession treatment in diabetic patients and to compare them with those in non-diabetic patients.\n\nDiabetic and non-diabetic volunteers of both sexes aged ≥ 18 years with gingival recession may participate. The main questions it aims to answer are:\n\n1. If the gingival recession reduction and percentage of root coverage are different in diabetics compared to non-diabetics.\n2. If different factors, such as the oral microbiome, inflammatory markers, and others, are associated with the clinical outcome.\n\nParticipants will be asked:\n\n* Receive the procedure to treat their gingival recession defects\n* To attend follow-up visits at 7, 14, 30, 90, and 180 days after treatment.\n* To provide different biological samples\n* To answer different questionnaires.",[59,60,27],"Diabetes Mellitus","Gingival Recession, Generalized",[62,63,64],"gingival recession","Diabetes","wound healing","NOT_YET_RECRUITING","2026-05-05",{"date":68,"type":39},"2026-05-11",{"date":70,"type":21},"2026-07",{"date":72,"type":21},"2030-04",{"name":74,"class":45},"Mauro Santamaria",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":83,"conditions":84,"keywords":85,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":93,"locationsCount":46},"100631458","palatal-wound-healing-after-free-gingival-graft-harvest-in-diabetic-patients-a-clinical-trial-100631458","NCT07500935","Palatal Wound Healing After Free Gingival Graft Harvest in Diabetic Patients: A Clinical Trial","Oral Mucosa Wound Healing in Diabetic Patients. A Clinical Study on Open and Closed Wounds",{"count":55,"type":21},[24],"The goal of this clinical trial is to evaluate local and systemic factors involved in palatal mucosal healing after Free Gingival Graft harvest in diabetic patients and to compare them with those in non-diabetic patients.\n\nDiabetic and non-diabetic volunteers of both sexes aged ≥ 18 years with gingival recession may participate. The main questions it aims to answer are:\n\n1. If the palatal wound healing (area of the wound) and percentage of wound epithelialization are different in diabetics compared to non-diabetics.\n2. If different factors, such as the oral microbiome, inflammatory markers, and others, are associated with the clinical outcome.\n\nParticipants will be asked:\n\n* Receive the procedure to treat their gingival recession defects\n* To attend follow-up visits at 7, 14, 30, and 90 days after treatment.\n* To provide different biological samples\n* To answer different questionnaires.",[59,60,27],[62,86,64],"diabetes","2026-04-29",{"date":89,"type":39},"2026-05-06",{"date":91,"type":21},"2026-06",{"date":72,"type":21},{"name":74,"class":45},{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":22,"phases":103,"briefSummary":104,"conditions":105,"keywords":106,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":121,"leadSponsor":123,"locationsCount":46},"100626056","theravex-oral-and-theravex-tissue-care-plus-in-the-healing-process-of-mucogingival-surgery-100626056","NCT07430670","Theravex Oral and Theravex Tissue Care Plus in the Healing Process of Mucogingival Surgery","Clinical Study on the Efficacy of Theravex Oral and Theravex Tissue Care Plus in Periodontal Surgery\" Modified Free Gingival Graft for the Treatment of RT1-RT2: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Healthy patients aged ≥ 18 years.\n* Patients with at least one mandibular incisor presenting a gingival recession RT1-RT2 and requiring a free gingival graft.\n* Periodontal health in either an intact or reduced periodontium (Chapple et al., 2018) with a plaque index ≤ 20% (O'Leary et al., 1972).\n* Initial probing depth ≤ 3 mm in the treated teeth.\n* No dental mobility (grade ≤ 1) in the treated teeth.\n* Well-defined CEJ\n* Agreement to take part in this study (signed informed consent).\n\nExclusion Criteria:\n\n* Smokers ≥10 cigarettes\u002Fday.\n* Patients treated with Theravex \\[IS1.1\\]\\[ma1.2\\]previously.\n* Untreated parafunctional habits.\n* Restorations that cannot be removed for proper treatment.\n* Pregnant patients or cases with uncertain pregnancy status (self-reported).\n* Patients with uncontrolled systemic diseases, neurological, psychiatric disorders, or other known conditions capable of influencing the results of the study.\n* Patients not attending follow-ups or not signing informed consent.",{"count":102,"type":21},30,[24],"This clinical study assesses the efficacy of two novel bioactive solutions, Theravex Oral and Theravex Tissue Care Plus, in enhancing soft tissue healing after periodontal surgery. The study focuses on patients undergoing a Modified Free Gingival Graft (M-FGG) technique to treat gingival recessions around mandibular incisors. Participants are randomly assigned to a test group receiving the Theravex treatment or a control group receiving a saline placebo. The primary goal is to measure the impact of these solutions on root coverage and other key outcomes, such as tissue gain, color integration, and postoperative pain, over a one-year period.",[27],[107,108,109,110,111,112,113,114,115,116],"Gingiva Recession","Modified Free Gingival Graft (M-FGG)","Theravex (Oral and Tissue Care Plus)","Bone Bioactive Liquid","Root Coverage","Soft Tissue Healing","Neovascularization","Spectrophotometry","Ultrasonography","Randomized Clinical Trial (RCT)","2026-02-17",{"date":119,"type":39},"2026-02-24",{"date":117,"type":39},{"date":122,"type":21},"2027-07-06",{"name":124,"class":45},"Universidad Complutense de Madrid",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":22,"phases":134,"briefSummary":135,"conditions":136,"keywords":139,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":46},"100624432","3d-digital-assessment-of-soft-tissue-changes-after-modified-fgg-100624432","NCT07409558","3D Digital Assessment of Soft Tissue Changes After Modified FGG","Three-Dimensional Direct Digital Evaluation of Soft Tissue Volumetric Changes After Modified Free Gingival Graft Surgery: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Age 18 years or older\n* Systemically healthy individuals\n* Non-smokers\n* Presence of localized Cairo Class II gingival recession with a vertical recession depth of ≥3 mm on the buccal surfaces of mandibular incisors\n* Probing pocket depth of ≤3 mm at the tooth\u002Fteeth to be treated\n* No tooth mobility (mobility grade ≤1)\n* Absence of cervical composite restorations or non-carious cervical lesions\n* Presence of a shallow vestibule (\\\u003C5 mm)\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Untreated periodontal disease\n* Presence of parafunctional habits\n* Poor oral hygiene, defined as a full-mouth plaque score \\>20%\n* Malpositioned, rotated, or crowded teeth in the buccal position\n* Known systemic diseases (e.g., acquired immunodeficiency syndrome, diabetes mellitus)\n* Any condition or medication that may affect gingival wound healing\n* ASA physical status classification III or higher",{"count":133,"type":21},34,[24],"The aim of this randomized controlled clinical trial is to evaluate the effects of conventional free gingival graft (FGG) and modified free gingival graft (ModFGG) techniques on soft tissue thickness, volumetric change, and creeping attachment in mandibular incisors using three-dimensional direct digital analysis. The study will include a total of 34 systemically healthy, non-smoking individuals with localized Cairo Class II gingival recession. Participants will be randomly assigned to the FGG (control) and ModFGG (test) groups. Clinical measurements will be performed before surgery and at 1, 3, and 6 months post-surgery. Soft tissue thickness and volumetric changes will be analyzed three-dimensionally by overlaying digital models obtained with an intraoral scanner. Gingival recession depth, keratinized tissue height, and creeping attachment will also be assessed. The aim is to provide clinical evidence regarding the effects of the modified free gingival graft technique on soft tissue stability and volumetric gains.",[27,137,138],"Soft Tissue Volume Changes","Keratinized Tissue Deficiency",[140,31,141,142],"Modified Free Gingival Graft","Soft Tissue Volume","Three-Dimensional Digital Analysis","2026-02-12",{"date":145,"type":39},"2026-02-13",{"date":147,"type":39},"2025-01-04",{"date":149,"type":21},"2026-07-31",{"name":44,"class":45},{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":22,"phases":159,"briefSummary":160,"conditions":161,"keywords":165,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":46},"100588334","comparing-caf-and-tcaf-with-soft-tissue-grafting-for-treating-multiple-recessions-in-the-premandibula-100588334","NCT06940050","Comparing CAF and TCAF With Soft Tissue Grafting for Treating Multiple Recessions in the Premandibula.","An RCT Between Coronally Advanced Flap (CAF) and Tunneled Coronally Advanced Flap (TCAF) in Combination With Soft Tissue Graft for Multiple Recession Coverage.","Inclusion Criteria:\n\n* at least 18 years old\n* good oral hygiene\n* presence of at least 2 recessions in the premandible\n* good general health\n\nExclusion Criteria:\n\n* smoker\n* pregnant women (assessed at each visit; if the patient appears pregnant during follow-up, x-rays will not be taken)",{"count":133,"type":21},[24],"Multiple techniques can be used for recession coverage. The most common techniques are : tunnel technique (T), coronally advanced flap (CAF) or a combination of both (TCAF). Tunnel and coronally advanced flap are frequently used in clinical practice, whereas the combined technique is a rather recent developed surgical approach.\n\nThis randomized controlled trial compares CAF and TCAF to determine which technique provides better root coverage for receding gums in the lower front teeth. The main question it aims to answer is:\n\n\\- What is the average root coverage achieved with each technique in the short and long term?\n\nThis may be clinically relevant because covering gum recession can reduce tooth sensitivity, improve aesthetics and make oral hygiene easier.\n\nResearchers will compare the coronally advanced flap (CAF = the gum is detached and repositioned higher) with the tunneled coronally advanced flap (TCAF = the gum is undermined, only partially detached and repositioned higher). In both techniques, a small piece of tissue is removed from the palate, which is used to cover the recession. The purpose of the connective tissue graft under the flap\u002Ftunnel is to increase thickness and provide support.\n\nParticipants will:\n\n* Undergo surgery (CAF or TCAF, randomly assigned) to cover recessions\n* Attend regular check-ups for up to 10 years after surgery\n* Keep a postoperative journal (recording medication use, pain levels, tooth sensitivity, etc.)",[27,162,163,164],"Gingival Recession, Plastic Surgery","Gingival Recessions","Gingival Recession, Mucogingival Surgery",[166,167,168,169,170,171,172],"TCAF","tunneled coronally advanced flap","CAF","coronally advanced flap","multiple adjacent gingival recessions","MAGR","premandible","2025-09-25",{"date":175,"type":39},"2025-10-01",{"date":177,"type":39},"2025-04-30",{"date":179,"type":21},"2037-12-31",{"name":181,"class":45},"University Hospital, Ghent",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":22,"phases":190,"briefSummary":191,"conditions":192,"keywords":195,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":204,"locationsCount":46},"100605131","comparing-caf-and-tcaf-with-soft-tissue-grafting-for-treating-multiple-recessions-in-the-maxilla-100605131","NCT07158528","Comparing CAF and TCAF With Soft Tissue Grafting for Treating Multiple Recessions in the Maxilla.","An RCT Comparing Coronally Advanced Flap (CAF) and Tunneled Coronally Advanced Flap (TCAF) in Combination With a Soft Tissue Graft for Multiple Recessions Coverage in the Maxilla.","Inclusion Criteria:\n\n* At least 18 years of age\n* Good oral hygiene\n* Presence of multiple gingival recessions in the maxilla\n* Good general health\n\nExclusion Criteria:\n\n* Smoker\n* Pregnant women (assessed at each visit; if the patient becomes pregnant during follow-up, radiographs will not be taken)",{"count":133,"type":21},[24],"Multiple techniques can be used for recession coverage. The most common techniques are: tunnel technique (T), coronally advanced flap (CAF) or a combination of both (TCAF). Tunnel and coronally advanced flap are frequently used in clinical practice, whereas the combined technique is a relatively recently developed surgical approach.\n\nThis randomized controlled trial compares CAF and TCAF to determine which technique provides better root coverage for receding gums at multiple adjacent teeth in the upper jaw. The main question it aims to answer is:\n\n\\- What is the average root coverage achieved with each technique in the short and long term? This may be clinically relevant because covering gum recession can reduce tooth sensitivity, improve aesthetics and make oral hygiene easier.\n\nResearchers will compare the coronally advanced flap (CAF = the gum is detached and repositioned higher) with the tunneled coronally advanced flap (TCAF = the gum is undermined, only partially detached and repositioned higher). In both techniques, a small piece of tissue is removed from the palate, which is used to cover the recession. The purpose of the connective tissue graft under the flap\u002Ftunnel is to increase thickness and provide support.\n\nParticipants will:\n\n* Undergo surgery (CAF or TCAF, randomly assigned) to cover recessions\n* Attend regular check-ups for up to 10 years after surgery\n* Keep a postoperative journal (recording medication use, pain levels, tooth sensitivity, etc.)",[193,194,60,27,162,163,164],"Gingival Recession Generalized Moderate","Gingival Recession Localized Moderate",[166,168,167,169,196,197,171,170],"maxilla","multiple recessions","2025-09-09",{"date":200,"type":39},"2025-09-16",{"date":202,"type":39},"2025-08-18",{"date":179,"type":21},{"name":181,"class":45},{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":4,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":22,"phases":214,"briefSummary":215,"conditions":216,"keywords":218,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":222,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":226,"locationsCount":46},"100605132","comparing-tcaf-and-mtun-with-soft-tissue-grafting-for-treating-single-recessions-in-the-premandible-100605132","NCT07158541","Comparing TCAF and MTUN With Soft Tissue Grafting for Treating Single Recessions in the Premandible","An RCT Comparing Tunneled Coronally Advanced Flap (TCAF) and Modified Tunnel Technique (MTUN) in Combination With a Soft Tissue Graft for Single Recession Coverage","Inclusion Criteria:\n\n* at least 18 years old\n* good oral hygiene\n* presence of one recession in the premandible\n* good general health\n\nExclusion Criteria:\n\n* smoker\n* pregnant women (assessed at each visit; if the patient appears pregnant during follow-up, x-rays will not be taken)",{"count":213,"type":21},24,[24],"Multiple techniques can be used for recession coverage. The most common techniques for single recessions are : tunnel technique (T) and coronally advanced flap (CAF) both combined with a palatal graft to provide sufficient gingival thickness. Recently two modifications have been described in literature, namely the tunneled coronally advanced flap and the modified tunnel. MTUN will function as the control group while people treated with the TCAF technique will function as the test group.\n\nThis randomized controlled trial compares MTUN and TCAF to determine which technique provides better root coverage for receding gums at single recession in the premandible. The main question it aims to answer is:\n\n\\- What is the average root coverage achieved with each technique in the short and long term? This may be clinically relevant because covering gum recession can reduce tooth sensitivity, improve aesthetics and make oral hygiene easier.\n\nResearchers will compare the modified tunnel technique (MTUN = the gum is undermined) with the tunneled coronally advanced flap (TCAF = the gum is undermined, only partially detached and repositioned higher). In both techniques, a small piece of tissue is removed from the palate, which is used to cover the recession. The purpose of the connective tissue graft under the flap\u002Ftunnel, is to increase thickness and provide support. Pain associated to the material used to cover the donorsite will be seen as the secondary research question. The site will either be covered by spongostan and multiple stitches or a palatal stent.\n\nParticipants will:\n\n* Undergo surgery (MTUN or TCAF, randomly assigned) to cover recessions\n* Attend regular check-ups for up to 10 years after surgery\n* Keep a postoperative journal (recording medication use, pain levels, tooth sensitivity, etc.)",[27,194,217,164,162],"Gingival Recession",[219,166,167,220,221,172],"MTUN","modified tunnel","single gingival recession",{"date":200,"type":39},{"date":224,"type":39},"2025-08-25",{"date":179,"type":21},{"name":181,"class":45},{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":233,"eligibilityCriteria":234,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":235,"enrollmentInfo":236,"targetDuration":4,"studyType":22,"phases":237,"briefSummary":238,"conditions":239,"keywords":242,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":250,"leadSponsor":252,"locationsCount":4},"100588069","how-can-prefabricated-membranes-load-ascorbic-acid-can-curtail-gingival-recession-100588069","NCT06936592","How Can Prefabricated Membranes Load Ascorbic Acid Can Curtail Gingival Recession?","How Can Prefabricated Membrane-loaded Ascorbic Acid Curtail the Gingival Recession?","recession","Inclusion Criteria:\n\n1. Patients of both genders with ages more than 18 years.\n2. At least two adjacent teeth in maxillary or mandibular anterior sextant with Cairo classification (RT1 or RT 2) labial GR defect.\n3. Good general health with no contraindications for periodontal surgery (American Society of Anesthesiologists I).\n4. Non-smoker patients.\n\nExclusion Criteria:\n\n1. Pregnant and lactating women.\n2. Teeth exhibiting pathologic mobility.\n3. Mal alignment teeth.\n4. Patients under active orthodontic therapy.\n5. Periodontal therapy during the last 6 months.\n6. Patients received antibiotics or non-steroidal anti-inflammatory drugs six months before the beginning of the study.","55 Years",{"count":102,"type":21},[24],"Periodontal diseases are a prevalent issue, often leading to gingival recession, where the gingival margin recedes, exposing the tooth root and causing various problems. Gingival recession can be managed through both non-surgical and surgical interventions The non-surgical approach often involves plaque control and addressing any underlying inflammatory conditions. However, in cases of advanced recession, surgical treatment may be necessary Several treatment techniques have been proposed, which can be divided into pedicle and free grafts. The latter can also be classified as free gingival grafts (FGG) or as connective tissue grafts (CTG). Other treatment options include soft tissue substitutes or regenerative therapies Harvesting graft from the palate has several problems, such as pain, inflammation, bleeding, flap necrosis, and infection at the donor site. For this reason, we need a substitute for soft tissue graft harvesting Carbopol polymers, also known as carbomers, are widely utilized in pharmaceutical formulations for their excellent mucoadhesive properties. This high molecular weight, cross-linked acrylic acid polymers are particularly effective in enhancing the adhesion of formulations to mucosal surfaces, thereby improving drug delivery and bioavailability",[27,240,241],"Gingival Diseases","Recession, Gingival",[233,243,244,245],"membrane","ascorbic acide","graft","2025-04-17",{"date":248,"type":39},"2025-04-20",{"date":246,"type":21},{"date":251,"type":21},"2025-10-18",{"name":253,"class":45},"Minia University",{"id":255,"slug":256,"hasResults":11,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":260,"eligibilityCriteria":261,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":262,"targetDuration":4,"studyType":22,"phases":264,"briefSummary":265,"conditions":266,"keywords":270,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":277,"leadSponsor":279,"locationsCount":4},"100585032","efficacy-of-a-gel-containing-polynucleotides-and-hyaluronic-acid-in-supraosseous-periodontal-defects-treated-with-the-single-flap-approach-100585032","NCT06897085","Efficacy of a Gel Containing Polynucleotides and Hyaluronic Acid in Supraosseous Periodontal Defects Treated with the Single Flap Approach","Efficacy of a Gel Containing Polynucleotides and Hyaluronic Acid in the Treatment of Periodontal Supraosseous Defects with the Single Flap Approach: a Randomized Controlled Trial","SFA-SD","INCLUSION CRITERIA Patient-specific\n\n* age≥ 18 years;\n* diagnosis of Stage III or IV periodontitis22;\n* good physical status (ASA1 and ASA2 according to Physical Status Classification System);\n* systemic and local conditions compatible with periodontal surgical procedures;\n* patient willing and fully capable to comply with the study protocol.\n\nSite-specific\n\n* defect located in an incisor, canine or premolar region which becomes exposed during spontaneous smiling;\n* defect with an intrabony component (as assessed on periapical radiograph and confirmed intra-surgically) ≤ 2 mm;\n* defect with a radiographic CEJ-BC≥ 4 mm; d) residual (following step I-II of treatment) PD≥6 mm at both interproximal aspects facing the SD.\n\nEXCLUSION CRITERIA Patient-specific\n\n* poorly controlled diabetes (HbA1C ≥ 7%);\n* history of radiation therapy in the head and neck area;\n* history of chemotherapy;\n* systemic disease or conditions with a documented effect on bone metabolism and\u002For periodontal status\u002Fhealing;\n* past (within 6 months prior to enrollment in the study) or current treatment with any medication with a documented effect on bone metabolism and\u002For periodontal status\u002Fhealing;\n* physical or mental handicap that can interfere with adherence to the study procedures and adequate hygienic compliance;\n* documented allergy to dental materials involved in the experimental protocol;\n* pregnancy or lactation;\n* history of drug or alcohol abuse.\n\nMoreover, participants will be immediately excluded from the study:\n\n* upon request to withdraw from further participation;\n* development of acute dental\u002Fperiodontal or oral conditions requiring treatment;\n* development of conditions conflicting with the exclusion criteria listed above\n* failure to comply with study instructions\u002Frequirements.\n\nSite-specific\n\n* presence of untreated endodontic lesions or inadequate endodontic treatment of teeth facing the SD;\n* presence of orthodontic appliances;\n* local conditions preventing proper plaque control at experimental sites;\n* grade III mobility.",{"count":263,"type":21},70,[24],"Treatment of supraosseous defects (SD) may be challenging due to their limited regenerative potential. When located in aesthetic areas, treatment may result in a gingival recession increase with consequent patients' concerns in terms of aesthetic or tooth sensibility. In the present study, a minimally-invasive surgical procedure (namely, the Single Flap Approach, SFA) will be combined with the application of a viscoelastic gel containing polynucleotides and hyaluronic acid that was reported to positively modulate periodontal wound healing. The outcomes, evaluated 6 months after treatment, will be compared to those obtained with SFA alone. The evaluated outcomes will be either clinical (evaluation of clinical parameters such as gingival recession, residual probing depth, clinical attachment gain) or related to patient's perception (such as evaluation of the aesthetic or tooth sensibility).",[267,27,268,269],"Periodontitis","Aesthetic Perception","Aesthetic Outcomes",[271,272],"minimally invasive","single flap approach","2025-03-26",{"date":275,"type":39},"2025-04-01",{"date":275,"type":21},{"date":278,"type":21},"2026-12-30",{"name":280,"class":45},"Azienda Unità Sanitaria Locale (A.U.S.L.) Ferrara, Italy",{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":288,"enrollmentInfo":289,"targetDuration":4,"studyType":22,"phases":290,"briefSummary":291,"conditions":292,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":4},"100566045","effectiveness-of-tuberosity-micro-connective-tissue-graft-for-treatment-of-multiple-adjacent-gingival-recession-defects-100566045","NCT06650072","Effectiveness of Tuberosity Micro Connective Tissue Graft for Treatment of Multiple Adjacent Gingival Recession Defects","Palatal vs Tuberosity Micro-connective Tissue Grafts for the Treatment of Multiple Adjacent Gingival Recession Defects: a Multi-center Controlled Randomized Clinical Trial","Inclusion Criteria:\n\n* age ≥18 years,\n* systemically healthy,\n* presenting adjacent RT1\u002FRT2 recessions, on both sides of the anterior maxilla, with an apico-coronal extension (i.e. recession depth) \\> 2mm combined with thick phenotype and deep root concavity.\n\nExclusion Criteria:\n\n* pregnancy or lactation,\n* heavy tobacco smoking (\\>15 cigarettes\u002Fday),\n* uncontrolled medical conditions and intake of medication that can affect gingival conditions.\n* uncorrected trauma from toothbrushing,\n* severe tooth malposition,\n* history of root coverage procedures.","60 Years",{"count":102,"type":21},[24],"The objective of this project is to compare post-operative pain associated with palatal and tuberosity donor sites for micro-CTG, and to evaluate the outcomes in both the donor and recipient sites.",[27],"2025-03-11",{"date":295,"type":39},"2025-03-12",{"date":297,"type":21},"2025-09-01",{"date":299,"type":21},"2026-09-01",{"name":301,"class":45},"Göteborg University",{"id":303,"slug":304,"hasResults":11,"nctId":305,"briefTitle":306,"officialTitle":307,"acronym":4,"eligibilityCriteria":308,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":288,"enrollmentInfo":309,"targetDuration":4,"studyType":22,"phases":310,"briefSummary":311,"conditions":312,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":319,"locationsCount":46},"100518469","effectiveness-of-micro-connective-tissue-graft-for-treatment-of-multiple-adjacent-gingival-recession-defects-100518469","NCT06030947","Effectiveness of Micro Connective Tissue Graft for Treatment of Multiple Adjacent Gingival Recession Defects","Tunnel Surgery Combined With a Micro Connective Tissue Graft for the Treatment of Multiple Adjacent Gingival Recession Defects: a Multi-center Randomized Controlled Clinical Trial.","Inclusion Criteria:\n\n* age ≥18 years,\n* systemically healthy,\n* presenting with a minimum of 4 and a maximum of 6 adjacent RT1\u002FRT2 recessions, located in the maxilla or mandible with an apico-coronal extension (i.e. recession depth) of ≥2 mm,\n* Full-Mouth Plaque Score (FMPS) \\\u003C20%,\n* Full-Mouth Bleeding Score (FMBS) \\\u003C20%.\n\nExclusion Criteria:\n\n* pregnancy or lactation,\n* tobacco smoking,\n* uncontrolled medical condition,\n* medication that can affect gingival conditions.\n* thick phenotype,\n* severe tooth malpositioning,\n* uncorrected trauma from toothbrushing,\n* a previous history of root coverage procedures\n* the presence of furcation defects.",{"count":102,"type":21},[24],"The objective of this project is to evaluate 1-year outcomes of treatment of MAGRD using a modified coronally advanced tunnel technique (MCAT) with either conventional CTG (control group) or micro-CTG (test group).",[27],{"date":314,"type":39},"2025-03-13",{"date":316,"type":39},"2025-03-01",{"date":318,"type":21},"2026-08-01",{"name":301,"class":45},{"id":321,"slug":322,"hasResults":11,"nctId":323,"briefTitle":324,"officialTitle":325,"acronym":326,"eligibilityCriteria":327,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":328,"targetDuration":4,"studyType":22,"phases":330,"briefSummary":332,"conditions":333,"keywords":335,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":342,"leadSponsor":344,"locationsCount":4},"100564812","phase-4-coronally-advanced-tunnel-combined-with-xenogenic-dermal-matrix-and-l-prf-100564812","NCT06634043","Coronally Advanced Tunnel Combined With Xenogenic Dermal Matrix and L-PRF","Coronally Advanced Tunnel Combined With Xenogenic Dermal Matrix and L-PRF for the Treatment of Cairo&Amp;#39;s Type 1 and Type 2 Multiple Recessions: A Randomized Comparative Study","CAF+XADM","Inclusion Criteria:\n\n* adult patients with ≥18 years of age. ability to understand all the study procedures and to comply with them throughout the entire study period. Ability and willingness to give written informed consent.\n\nan adequate level of oral hygiene (plaque index ≤ 25%) (O\\'Leary et al., 1972).\n\nan adequate general bleeding on probing (≤ 20%) treated periodontal disease. presence of two or more adjacent Cairo type I or II gingival recessions, with ≥1mm of keratinized gingiva in all the deffects.\n\nExclusion Criteria:\n\n* untreated periodontitis.\n* smokers \\> 5 cigarettes per day.\n* local or systemic diseases that would interfere with routine periodontal therapy (i.e., uncontrolled diabetes mellitus, cancer, HIV, chronic high-dose steroid therapy, metabolic bone disease, radiation, immunosuppressive disease, hepatic dysfunction, immunosuppressive disease, autoimmune disease).\n* treatment with anticoagulants or bisphosphonates.\n* pregnant or lactating women.\n* radiographic interproximal bone loss.\n* tooth Mobility. If present, splinting should be performed prior to treatment.\n* Active orthodontic treatment\n* allergy or intolerance to study medication\n* use of systemic antibiotics during the last 3 months\n* use of systemic antibiotics for endocarditis prophylaxis\n* patients with intentions to change residence that prevent follow-up",{"count":329,"type":21},44,[331],"PHASE4","Gingival recession is the exposure of the root surface due to the gum margin moving away from the crown of the tooth. It's common in adults and becomes more prevalent and severe with age. About 50% of people aged 18-64 and up to 88% of those over 65 have at least one site with gingival recession. The causes are multifactorial, including factors like aggressive brushing, thin gum tissue, orthodontic treatments, and more.\n\nA systematic review found that untreated gingival recessions tend to worsen over time, with a significant increase in both the number of sites and the depth of the recession. A new classification system for gingival recessions has been proposed, categorizing them based on the detection of the cementoenamel junction (CEJ) and interproximal attachment loss.\n\nSurgical techniques aim to restore the gum margin to its original position with minimal probing depths and good aesthetic results. The standard treatment involves a connective tissue graft from a donor site, but newer methods using substitutes like collagen matrices and platelet concentrates have shown comparable results.\n\nAcellular Dermal Matrix (ADM) is a processed dermal tissue used as a substitute for connective tissue in root coverage and implant soft tissue corrections. It has shown favorable results, especially in reducing patient morbidity and thickening the gingival phenotype. ADM can be combined with a coronally positioned flap or tunnel technique for effective root coverage.\n\nThe use of platelet concentrates, such as Leukocyte and Platelet-Rich Fibrin (L-PRF), has also become an important alternative. These concentrates improve healing by providing growth factors and cytokines, aiding in the development of microvascularization.\n\nThe objective is to assess whether combining Acellular Dermal Matrix (ADM) with Leukocyte and Platelet-Rich Fibrin (L-PRF) yields better or comparable results to ADM alone in terms of complete root coverage, percentage of root coverage (PRC), recession reduction (RecRED), gain of keratinized gingiva (KGG), height of the interdental papilla (IDH), and increased gingival thickness (GT) after 6 months.",[217,27,334],"Mucogingival Defects",[336,337],"acellular dermal matrix","coronally advenced tunnel","2025-01-27",{"date":340,"type":39},"2025-01-28",{"date":275,"type":21},{"date":343,"type":21},"2026-10-30",{"name":345,"class":45},"Andres Matteo Pascual La Rocca",{"id":347,"slug":348,"hasResults":11,"nctId":349,"briefTitle":350,"officialTitle":351,"acronym":4,"eligibilityCriteria":352,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":353,"enrollmentInfo":354,"targetDuration":4,"studyType":22,"phases":356,"briefSummary":357,"conditions":358,"keywords":360,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":46},"100572734","effect-of-modified-free-gingival-graft-and-conventional-free-gingival-graft-on-gingival-recession-100572734","NCT06737120","Effect of Modified Free Gingival Graft and Conventional Free Gingival Graft on Gingival Recession","Comparison of Conventional and Modified Free Gingival Graft Techniques in Treating Mandibular Incisor Gingival Recession: a Randomized Clinical Study","Inclusion Criteria:-volunteers aged between 18-65 years.\n\n* To be systemically healthy.\n* Not smoking.\n* Individuals aged 18 years and over.\n* Shallow vestibule (≤5 mm).\n* The periodontal pocket depth of the tooth\u002Fteeth to be treated should be ≤3 mm and the degree of tooth mobility should be ≤1.\n* There should be no cervical composite restoration and no caries-free lesions on the teeth to be treated.\n* Presence of Cairo Type 1 class gingival recession on the buccal surface of at most 2 of the mandibular incisors.\n\nExclusion Criteria:\n\n* pregnancy\n* untreated periodontal disease\n* parafunctional habits\n* poor oral hygiene (persistent whole mouth plaque index \\> 20%)\n* iodine allergy\n* excessive dental crowding or misalignment of teeth.","65 Years",{"count":355,"type":21},60,[24],"The aim of this clinical study is to understand whether the modified free gingival graft technique is superior to the conventional free gingival graft:\n\nWill gingival recession completely close in modified free gingival grafting areas? Will there be a significant increase in the amount of keratinized gingiva in modified free gingival grafting participants compared to traditional free gingival grafting participants? Participants will visit our clinic in the 1st, 3rd and 6th months. Necessary clinical parameter measurements will be made by the clinician.",[27,359,31],"Keratinized Tissue",[361,362,62],"modified free gingival graft","free gingival graft","2024-12-11",{"date":365,"type":39},"2024-12-17",{"date":367,"type":21},"2024-12-30",{"date":369,"type":21},"2025-07-30",{"name":371,"class":45},"AYSE HUMEYRA ORUC",{"id":373,"slug":374,"hasResults":11,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":4,"eligibilityCriteria":378,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":379,"targetDuration":4,"studyType":22,"phases":381,"briefSummary":382,"conditions":383,"keywords":384,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":394,"locationsCount":46},"100558634","clinical-evaluation-of-tunneled-coronally-advanced-flap-vs-coronally-advanced-flap-with-graft-for-gingival-recession-100558634","NCT06553677","Clinical Evaluation of Tunneled Coronally Advanced Flap v.s Coronally Advanced Flap With Graft for Gingival Recession","Clinical Evaluation of Tunneled Coronally Advanced Flap (TCAF) Versus Coronally Advanced Flap (CAF) Combined With Connective Tissue Graft in the Treatment of Isolated RT2 Gingival Recession Sites: A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Patients age 18 years or older.\n2. Isolated recession defect classified as RT2.\n3. Patients with healthy systemic condition.\n4. Clinical indication and\u002For patient request for root coverage.\n5. O'Leary index less than 20%.\n\nExclusion Criteria:\n\n1. Pregnant females\n2. Smokers: a contraindication for any plastic periodontal surgery.\n3. Unmotivated and uncooperative patients with poor oral hygiene\n4. Patients with habits that may compromise the longevity and affect the result of the study as alcoholism or parafunctional habits.",{"count":380,"type":21},22,[24],"The goal of this clinical trial is to evaluate gingival recession depth reduction using tunneled coronally advanced flap compared to coronally advanced flap, both combined with connective tissue graft in patients with isolated RT2 gingival recession sites.",[27],[166,168,385,386],"RT2","Gingival recession depth reduction","2024-08-11",{"date":389,"type":39},"2024-08-14",{"date":391,"type":21},"2024-08",{"date":393,"type":21},"2025-09",{"name":395,"class":45},"Cairo University"]