[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gingival-recession-plastic-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gingival-recession-plastic-surgery":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,51,75,97,127],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100588334","comparing-caf-and-tcaf-with-soft-tissue-grafting-for-treating-multiple-recessions-in-the-premandibula-100588334",false,"NCT06940050","Comparing CAF and TCAF With Soft Tissue Grafting for Treating Multiple Recessions in the Premandibula.","An RCT Between Coronally Advanced Flap (CAF) and Tunneled Coronally Advanced Flap (TCAF) in Combination With Soft Tissue Graft for Multiple Recession Coverage.","Inclusion Criteria:\n\n* at least 18 years old\n* good oral hygiene\n* presence of at least 2 recessions in the premandible\n* good general health\n\nExclusion Criteria:\n\n* smoker\n* pregnant women (assessed at each visit; if the patient appears pregnant during follow-up, x-rays will not be taken)","ALL","18 Years",{"count":19,"type":20},34,"ESTIMATED","INTERVENTIONAL",[23],"NA","Multiple techniques can be used for recession coverage. The most common techniques are : tunnel technique (T), coronally advanced flap (CAF) or a combination of both (TCAF). Tunnel and coronally advanced flap are frequently used in clinical practice, whereas the combined technique is a rather recent developed surgical approach.\n\nThis randomized controlled trial compares CAF and TCAF to determine which technique provides better root coverage for receding gums in the lower front teeth. The main question it aims to answer is:\n\n\\- What is the average root coverage achieved with each technique in the short and long term?\n\nThis may be clinically relevant because covering gum recession can reduce tooth sensitivity, improve aesthetics and make oral hygiene easier.\n\nResearchers will compare the coronally advanced flap (CAF = the gum is detached and repositioned higher) with the tunneled coronally advanced flap (TCAF = the gum is undermined, only partially detached and repositioned higher). In both techniques, a small piece of tissue is removed from the palate, which is used to cover the recession. The purpose of the connective tissue graft under the flap\u002Ftunnel is to increase thickness and provide support.\n\nParticipants will:\n\n* Undergo surgery (CAF or TCAF, randomly assigned) to cover recessions\n* Attend regular check-ups for up to 10 years after surgery\n* Keep a postoperative journal (recording medication use, pain levels, tooth sensitivity, etc.)",[26,27,28,29],"Gingival Recession, Localized","Gingival Recession, Plastic Surgery","Gingival Recessions","Gingival Recession, Mucogingival Surgery",[31,32,33,34,35,36,37],"TCAF","tunneled coronally advanced flap","CAF","coronally advanced flap","multiple adjacent gingival recessions","MAGR","premandible","RECRUITING","2025-09-25",{"date":41,"type":42},"2025-10-01","ACTUAL",{"date":44,"type":42},"2025-04-30",{"date":46,"type":20},"2037-12-31",{"name":48,"class":49},"University Hospital, Ghent","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":74,"locationsCount":50},"100605131","comparing-caf-and-tcaf-with-soft-tissue-grafting-for-treating-multiple-recessions-in-the-maxilla-100605131","NCT07158528","Comparing CAF and TCAF With Soft Tissue Grafting for Treating Multiple Recessions in the Maxilla.","An RCT Comparing Coronally Advanced Flap (CAF) and Tunneled Coronally Advanced Flap (TCAF) in Combination With a Soft Tissue Graft for Multiple Recessions Coverage in the Maxilla.","Inclusion Criteria:\n\n* At least 18 years of age\n* Good oral hygiene\n* Presence of multiple gingival recessions in the maxilla\n* Good general health\n\nExclusion Criteria:\n\n* Smoker\n* Pregnant women (assessed at each visit; if the patient becomes pregnant during follow-up, radiographs will not be taken)",{"count":19,"type":20},[23],"Multiple techniques can be used for recession coverage. The most common techniques are: tunnel technique (T), coronally advanced flap (CAF) or a combination of both (TCAF). Tunnel and coronally advanced flap are frequently used in clinical practice, whereas the combined technique is a relatively recently developed surgical approach.\n\nThis randomized controlled trial compares CAF and TCAF to determine which technique provides better root coverage for receding gums at multiple adjacent teeth in the upper jaw. The main question it aims to answer is:\n\n\\- What is the average root coverage achieved with each technique in the short and long term? This may be clinically relevant because covering gum recession can reduce tooth sensitivity, improve aesthetics and make oral hygiene easier.\n\nResearchers will compare the coronally advanced flap (CAF = the gum is detached and repositioned higher) with the tunneled coronally advanced flap (TCAF = the gum is undermined, only partially detached and repositioned higher). In both techniques, a small piece of tissue is removed from the palate, which is used to cover the recession. The purpose of the connective tissue graft under the flap\u002Ftunnel is to increase thickness and provide support.\n\nParticipants will:\n\n* Undergo surgery (CAF or TCAF, randomly assigned) to cover recessions\n* Attend regular check-ups for up to 10 years after surgery\n* Keep a postoperative journal (recording medication use, pain levels, tooth sensitivity, etc.)",[62,63,64,26,27,28,29],"Gingival Recession Generalized Moderate","Gingival Recession Localized Moderate","Gingival Recession, Generalized",[31,33,32,34,66,67,36,35],"maxilla","multiple recessions","2025-09-09",{"date":70,"type":42},"2025-09-16",{"date":72,"type":42},"2025-08-18",{"date":46,"type":20},{"name":48,"class":49},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":92,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":96,"locationsCount":50},"100605132","comparing-tcaf-and-mtun-with-soft-tissue-grafting-for-treating-single-recessions-in-the-premandible-100605132","NCT07158541","Comparing TCAF and MTUN With Soft Tissue Grafting for Treating Single Recessions in the Premandible","An RCT Comparing Tunneled Coronally Advanced Flap (TCAF) and Modified Tunnel Technique (MTUN) in Combination With a Soft Tissue Graft for Single Recession Coverage","Inclusion Criteria:\n\n* at least 18 years old\n* good oral hygiene\n* presence of one recession in the premandible\n* good general health\n\nExclusion Criteria:\n\n* smoker\n* pregnant women (assessed at each visit; if the patient appears pregnant during follow-up, x-rays will not be taken)",{"count":83,"type":20},24,[23],"Multiple techniques can be used for recession coverage. The most common techniques for single recessions are : tunnel technique (T) and coronally advanced flap (CAF) both combined with a palatal graft to provide sufficient gingival thickness. Recently two modifications have been described in literature, namely the tunneled coronally advanced flap and the modified tunnel. MTUN will function as the control group while people treated with the TCAF technique will function as the test group.\n\nThis randomized controlled trial compares MTUN and TCAF to determine which technique provides better root coverage for receding gums at single recession in the premandible. The main question it aims to answer is:\n\n\\- What is the average root coverage achieved with each technique in the short and long term? This may be clinically relevant because covering gum recession can reduce tooth sensitivity, improve aesthetics and make oral hygiene easier.\n\nResearchers will compare the modified tunnel technique (MTUN = the gum is undermined) with the tunneled coronally advanced flap (TCAF = the gum is undermined, only partially detached and repositioned higher). In both techniques, a small piece of tissue is removed from the palate, which is used to cover the recession. The purpose of the connective tissue graft under the flap\u002Ftunnel, is to increase thickness and provide support. Pain associated to the material used to cover the donorsite will be seen as the secondary research question. The site will either be covered by spongostan and multiple stitches or a palatal stent.\n\nParticipants will:\n\n* Undergo surgery (MTUN or TCAF, randomly assigned) to cover recessions\n* Attend regular check-ups for up to 10 years after surgery\n* Keep a postoperative journal (recording medication use, pain levels, tooth sensitivity, etc.)",[26,63,87,29,27],"Gingival Recession",[89,31,32,90,91,37],"MTUN","modified tunnel","single gingival recession",{"date":70,"type":42},{"date":94,"type":42},"2025-08-25",{"date":46,"type":20},{"name":48,"class":49},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":21,"phases":107,"briefSummary":108,"conditions":109,"keywords":110,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":126},"100599327","non-inferiority-of-fibroguide-collagen-membrane-compared-to-autologous-connective-tissue-graft-for-coverage-of-multiple-adjacent-recession-multicenter-trial-100599327","NCT07083050","Non-Inferiority of Fibroguide Collagen Membrane Compared to Autologous Connective Tissue Graft for Coverage of Multiple Adjacent Recession. Multicenter Trial.","Connective Tissue Graft vs Volume Stable Collagen Matrix (Geistlich Fibro-Gide®) for Coverage of Multiple Gingival Recession Defects in Combination With Coronally Advanced Flap (CAF) Randomized Multicenter Controlled Clinical Trial Assessing Non-Inferiority in Root Coverage","Inclusion Criteria:\n\n* Male and female, 18 to 70 years of age, with a minimum of two adjacent teeth with gingival recession (at least one with a depth ≥ 3 mm - RT1 or RT2 with 2 mm or less of interdental periodontal attachment loss) in anterior and premolar teeth in the maxilla and requiring surgical intervention, without medical contraindications to elective surgery. In case of recessions on five or more adjacent teeth, the teeth at the external sides will not be included in the study.\n* At least 2 mm marginal keratinized tissue width and irrespective of soft tissue thickness prior therapy. The study should involve treatment naïve patients in terms of root coverage procedures. Prior therapy should include treatment of gingival inflammation, if present, instructions in non-traumatic oral hygiene, and reconstruction of the cemento-enamel junction with adhesive dental materials in case of cervical abrasion or erosion involving this structure\n* Evidence of subject ability to achieve good oral hygiene and control gingivitis in the whole of the dentition (FMPS\\\u003C25% and FMBS\\\u003C25%)\n* Ability to understand study procedures and to comply with them for the entire length of the study. Ability and willingness to give written informed consent.\n\nExclusion Criteria:\n\n* Presence of untreated periodontitis\n* Persistence of uncorrected gingival trauma from tooth brushing\n* Interdental attachment loss greater than 2 mm or furcation involvement in the experimental teeth\n* Presence of less than 2 mm of keratinized tissue width\n* Presence of severe tooth malposition, rotation or clinically significant super-eruption\n* Self reported current smoking exceeding 10 cigarettes\u002Fday or pipe or cigar smoking\n* Rheumatoid arthritis or known sensitization to collagen based medical products.\n* Presence of medical contraindications to elective surgery\n* Participation in another interventional clinical trial\n* Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.\n* Inability or unwillingness of individual to give written informed consent.\n* Uncontrolled diabetes mellitus\n* Allergy to collagen\n* Pregnancy or lactation or sexually active female subjects who are of childbearing potential and who are not using hormonal or barrier methods of birth control (e.g., oral or parenteral contraceptives, diaphragm plus spermicide, condoms).\n* Radiotherapy\n* immunosuppressive therapy\n* chronic steroid therapy (inhaler or systemic).","70 Years",{"count":106,"type":20},160,[23],"This study deals with coverage of multiple denuded roots. The current standard treatment requires surgical correction and uses soft tissue taken from the roof of the mouth to enhance results. The hypothesis of this trial is that a synthetic collagen matrix (called Fibrogide) can be used to replace soft tissue taken from the subject. If the collagen matrix will prove to be equally as effective as the patient own tissue, it will be possible to avoid a more extensive surgery and decrease pain and discomfort.",[27],[111,112,113,114,115],"Gingival recession","Root coverage","Collagen Construct","Connective tissue graft","Morbidity","2025-08-04",{"date":118,"type":42},"2025-08-07",{"date":120,"type":42},"2015-07-12",{"date":122,"type":20},"2029-12-31",{"name":124,"class":125},"Maurizio Tonetti","NETWORK",2,{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":21,"phases":136,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":144,"leadSponsor":146,"locationsCount":4},"100597908","clinical-evaluation-of-tcaf-versus-caf-combined-with-connective-tissue-graft-in-the-treatment-of-multiple-rt2-gingival-recession-sites-100597908","NCT07064603","Clinical Evaluation of (TCAF) Versus (CAF) Combined With Connective Tissue Graft in the Treatment of Multiple RT2 Gingival Recession Sites","Clinical Evaluation of Tunneled Coronally Advanced Flap (TCAF) Versus Coronally Advanced Flap (CAF) Combined With Connective Tissue Graft in the Treatment of Multiple RT2 Gingival Recession Sites: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients age 18 years or older.\n* Multiple adjacent recession defect classified as RT2.\n* Patients with healthy systemic condition (Mazzotti et al., 2023).\n* An esthetic concern or hypersensitivity associated with GR\n* The gingival recessions must have at least 1.5 mm of KTW.\n* Presence of an identified CEJ (A step ≤ 1mm of the CEJ level)\n\nExclusion Criteria:\n\n* Full-mouth plaque and bleeding scores \\>20 (O'Leary et al., 1972)\n* Patients with active periodontal disease;\n* Intake of any medications known to affect gingival homeostasis or to interfere with wound healing\n* Pregnancy and nursing women\n* Smokers: a contraindication for any plastic periodontal surgery (Khuller, 2009).\n* Absence of cervical restorations, crowding or malalignment",{"count":135,"type":20},22,[23],"the aim of the study is to evaluate the changes in gingival recession depth reduction following, treatment of multiple RT2 recession with tunnel coronal advanced flap in comparison to coronal advanced flap, both combined with connective tissue graft",[27],"NOT_YET_RECRUITING","2025-07-13",{"date":142,"type":42},"2025-07-16",{"date":41,"type":20},{"date":145,"type":20},"2026-12-01",{"name":147,"class":49},"Cairo University"]