[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gingival-recession\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gingival-recession":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,36,0,25,[9,48,76,102,125,146,167,187,206,233,255,278,297,321,348,372,393,424,447,467,493,517,543,567,587],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100592085","effect-of-microneedling-with-coronally-advanced-flap-for-management-of-rt1-gingival-recession-in-thin-gingival-phenotype-100592085",false,"NCT06988839","Effect Of Microneedling With Coronally Advanced Flap For Management of RT1 Gingival Recession In Thin Gingival Phenotype","Patient-Centered And Clinical Outcomes Of Microneedling With Coronally Advanced Flap For Management of RT1 Gingival Recession In Thin Gingival Phenotype : A Randomized Controlled Clinical Trial","RT1","Inclusion Criteria:\n\n* Presence of isolated RT1 buccal maxillary gingival recessions in esthetic zone with thin gingival phenotype (Gingival thickness≤1mm) associated with esthetic complaints and\u002For dental sensitivity and otherwise systemically healthy.\n* Gingival Recession ≥2mm , Keratinized tissue width≥2mm and clinically identifiable cementoenamel junction\n* Age 20years-50 years\n* Patient demonstrating compliance for maintaining good oral hygiene after Phase 1 therapy Plaque index (PI) \\\u003C1, Gingival Index (GI) \\\u003C1\n* Providing a written and verbal informed consent.\n\nExclusion Criteria:\n\n* Patient with systemic disease that can influence the outcome of therapy.\n* Pregnant females or on oral contraceptive pills or hormone replacement therapy.\n* Smokers and patients undergoing orthodontic therapy\n* Physically and mentally impaired patients.\n* Non vital, malpositioned tooth\n* Presence of cervical abrasions or restorations in the area\n* Previous history of periodontal surgery on the involved sites.","ALL","20 Years","50 Years",{"count":5,"type":22},"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to explore the effect of microneedling to increase the gingival tissue thickness which could improve the outcome of root coverage in coronally advanced flap procedure in thin gingival phenotype. The main question it aims to answer is that :\n\nDoes the use of microneedling procedure followed by coronally advanced flap has similar outcomes of root coverage in recession type 1 (RT1) gingival recession i.e. buccal gingival recessions without interdental clinical attachment loss in thin gingival phenotype as compared to coronally advanced flaps with connective tissue graft.\n\nSystemically healthy patients having isolated upper RT1 gingival recession will be assigned into two groups. Microneedling will be performed in one group (4 sessions each at a 10 days interval) followed by coronally advanced flap operation (at an interval of 2 months) and coronally advanced flap with connective tissue graft will be performed in the other group. Follow-up will be done at 1 month, 3 months and 6 months for evaluation of primary and secondary outcomes.",[28],"Gingival Recession",[30,31,32,33,34],"gingival recession","percutaneous collagen induction","root coverage","connective tissue graft","microneedle","RECRUITING","2026-06-11",{"date":38,"type":39},"2026-06-12","ACTUAL",{"date":41,"type":39},"2025-06-26",{"date":43,"type":22},"2026-12",{"name":45,"class":46},"Postgraduate Institute of Dental Sciences Rohtak","OTHER",1,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":47},"100639440","modified-coronally-advanced-tunnel-for-mandibular-lingual-root-coverage-100639440","NCT07590960","Modified Coronally Advanced Tunnel for Mandibular Lingual Root Coverage","Clinical Outcomes of Modified Coronally Advanced Tunnel Technique With Deepithelialized Connective Tissue Graft for Mandibular Lingual Root Coverage: A Case Series","Inclusion Criteria:\n\n* Age 18-65 years\n* Single or multiple Cairo RT1 lingual gingival recessions ≥3 mm on mandibular incisors, canines, or premolars\n* Identifiable CEJ on the lingual aspect\n* Vital uniradicular teeth\n* Full-mouth plaque score \\\u003C20%\n* Smokes less than 10 cigarettes per day\n* Adequate mouth opening for lingual access\n* Sufficient palatal donor tissue thickness (≥2 mm at 2-3 mm from gingival margin)\n\nExclusion Criteria:\n\n* Positive urine pregnancy test or self-reported lactation\n* Smoker more than 10 cigarettes per day\n* Uncontrolled systemic diseases, at the discretion of the PI (diabetes HbA1c \\>7%, cardiovascular disease, immunocompromised)\n* Use of medications affecting periodontal tissues (phenytoin, calcium channel blockers, immunosuppressants)\n* Use of blood thinners\n* Previous root coverage surgery at treated sites\n* Teeth with cervical restorations or caries on lingual surfaces\n* Inadequate attached gingiva (\\\u003C1 mm)\n* Prominent lingual frenum attachment requiring frenectomy","18 Years","65 Years",{"count":58,"type":22},20,[25],"This study will follow adults who have gum recession on the tongue side of the lower teeth. Participants will receive a gum surgery called the Modified Coronally Advanced Tunnel technique with a connective tissue graft taken from the roof of the mouth. The study will include 20 participants and will follow them for up to 24 months after surgery. The main outcome is how much of the exposed root is covered 6 months after surgery. The study will also measure gum thickness, gum width, tooth sensitivity, healing, patient comfort, satisfaction, and three-dimensional soft tissue changes using intraoral scans.",[28,62],"Mucogingival Deformity - Insufficient Keratinized Tissue",[28,64,65],"Tissue Grafts","Tooth Sensitivity","NOT_YET_RECRUITING","2026-06-02",{"date":69,"type":39},"2026-06-04",{"date":71,"type":22},"2026-06",{"date":73,"type":22},"2028-12",{"name":75,"class":46},"University of Pittsburgh",{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":47},"100640776","volume-stable-collagen-matrix-versus-subepithelial-connective-tissue-graft-for-multiple-gingival-recessions-100640776","NCT07613775","Volume-Stable Collagen Matrix Versus Subepithelial Connective Tissue Graft for Multiple Gingival Recessions","Volume-Stable Xenogeneic Collagen Matrix Versus Subepithelial Connective Tissue Graft for the Treatment of Multiple Gingival Recessions: A 12-Month Randomized Controlled Clinical Trial","VCMX-SCTG","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Presence of at least two Cairo RT1 gingival recessions in anterior teeth and\u002For premolars.\n* Gingival recession depth greater than or equal to 2 mm.\n* Presence of at least 2 mm of keratinized gingiva apical to the gingival recession.\n* Indication for root coverage treatment due to esthetic concern and\u002For dentin hypersensitivity.\n* Sites with non-carious cervical lesions may be included if they are previously restored and, after restoration, present residual gingival recession greater than or equal to 2 mm.\n* Good plaque control, defined as full-mouth plaque score and full-mouth marginal gingival bleeding score below 20%.\n\nExclusion Criteria:\n\n* Current smokers or individuals who stopped smoking less than 12 months before enrollment.\n* Decompensated systemic diseases.\n* Pregnancy or lactation.\n* Active periodontal disease.\n* Untreated root caries.\n* Previous mucogingival surgery in the study area.",{"count":85,"type":22},40,[25],"Gingival recession is a clinical condition in which the gingival margin is displaced apically, exposing the root surface. This condition may be associated with esthetic concerns, dentin hypersensitivity, and difficulties in oral hygiene. Subepithelial connective tissue grafting is considered a standard surgical approach for root coverage, but it requires harvesting tissue from the palate, which may increase postoperative discomfort. Volume-stable xenogeneic collagen matrices have been proposed as an alternative biomaterial to reduce the need for a palatal donor site.\n\nThis randomized controlled clinical trial will compare a volume-stable xenogeneic collagen matrix with an autogenous subepithelial connective tissue graft for the treatment of multiple gingival recessions. Participants will be allocated to one of two treatment groups. The test group will receive root coverage surgery using a volume-stable collagen matrix, while the control group will receive root coverage surgery using a subepithelial connective tissue graft. Clinical, patient-reported, esthetic, and digital outcomes will be assessed at baseline and during follow-up visits up to 12 months.\n\nThe primary outcome will be the change in gingival recession depth from baseline to 12 months. Secondary outcomes will include keratinized tissue width, gingival thickness, percentage of root coverage, complete root coverage, dentin hypersensitivity, patient-reported satisfaction, early wound healing, and digital volumetric changes assessed by intraoral scanning.",[28],[90,91,92,93],"Multiple Gingival Recessions","Volume-Stable Collagen Matrix","Subepithelial Connective Tissue Graft","Coronally Advanced Flap","2026-05-30",{"date":67,"type":39},{"date":97,"type":22},"2026-10-01",{"date":99,"type":22},"2027-12-01",{"name":101,"class":46},"University of Sao Paulo",{"id":103,"slug":104,"hasResults":12,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":23,"phases":111,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":4},"100639981","phase-2-topical-phenytoin-for-management-of-gingival-recession-100639981","NCT07590375","Topical Phenytoin for Management of Gingival Recession","Topical Phenytoin for Management of Gingival Recession: a Randomized Placebo-controlled Trial","Inclusion Criteria:\n\n* Patients having gingival recession types RT1 and RT2\n* Patients refusing surgical treatment options of their gingival recession.\n\nExclusion Criteria:\n\n* Patients who underwent periodontal surgery in the affected teeth.\n* Patients with sensitivity to the medication used in the study.\n* Patients with systemic problems or administering drugs which could affect their periodontium or healing.\n* Pregnant or lactating women.\n* Smoking patients.",{"count":110,"type":22},30,[112,113],"PHASE2","PHASE3","Gingival recession (GR) is a term that describes the displacement of the gingival margin apical to the cemento-enamel junction (CEJ) of a tooth. The gold standard of GR treatment is surgical coverage through coronally advanced flap with subepithelial connective tissue graft (CAF+SCTG) (3). But, the need for a non-invasive technique for managing GR has not been frequently addressed.\n\nPhenytoin (PHT), used as an anti-seizure medication, has an established side effect of causing drug-influenced gingival enlargement. Its stimulatory effects on soft tissue metabolism suggested PHT to be tested topically for its effectiveness in wound healing. However, none of the previous studies that investigated topical phenytoin has assessed gingival recession; except for a case series.",[28],"2026-05-14",{"date":118,"type":39},"2026-05-15",{"date":120,"type":22},"2026-06-01",{"date":122,"type":22},"2027-10",{"name":124,"class":46},"Cairo University",{"id":126,"slug":127,"hasResults":12,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":23,"phases":134,"briefSummary":135,"conditions":136,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":47},"100487930","changes-of-soft-tissue-grafting-a-randomized-study-100487930","NCT05633511","Changes of Soft Tissue Grafting: A Randomized Study","Volumetric Changes of Soft Tissue Grafting. Comparison of Autologous PRF (Platelet-rich Fibrin ) & Autogenous CTG (Connective Tissue Grafts) . A Split-mouth Randomized Design","Inclusion Criteria:\n\n1. Adults 18yrs or older\n2. Need of MG-tx for 2 or more sites for root coverage RT I and II (Cairo classification)\n3. Class A +\u002F-\n4. No class V restoration present\n\nExclusion Criteria:\n\n1. Patients who do not consent to recommended therapy\n2. Patients who smoke\n3. Patients who will not be able to comply with follow up protocols\n4. Those who self report that they are pregnant.",{"count":133,"type":22},50,[25],"To correct gum recession, patient's own tissue from the roof of the mouth is harvested and placed where there is root exposed. This is considered gold standard of treatment. Sometimes patient don't want to have second surgical site in their mouth and at the same time do not want to use alternative tissue from human or animal donor. Using patients' blood and preparing it as a membrane is the next best thing to correct gum recession.",[28],"2026-04-23",{"date":139,"type":39},"2026-04-29",{"date":141,"type":39},"2023-01-11",{"date":143,"type":22},"2036-12-30",{"name":145,"class":46},"Tufts University",{"id":147,"slug":148,"hasResults":12,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":153,"sex":18,"minAge":55,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":157,"phases":4,"briefSummary":158,"conditions":159,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":47},"100635791","gingival-recession-and-oral-health-related-quality-of-life-a-cross-sectional-study-100635791","NCT07557277","Gingival Recession and Oral Health-related Quality of Life: A Cross-sectional Study","Gingival Recession and Its Impact on Oral Health-related Quality of Life: A Cross-sectional Study","Inclusion Criteria:\n\n* Age 18-45 years old;\n* Patients who are willing to participate in the study and ready to give informed consent.\n* Cases defined for GR will be done according to Cairo at el.\n* The minimum threshold for reporting the presence of gingival recession will be greater than or equal to 1 mm.\n\nExclusion Criteria:\n\n* Systemic disease affecting the periodontal issues (e.g., bleeding disorders, diabetes mellitus etc.)\n* Patients under medication associated with gingival enlargement (e.g., calcium channel blockers, immunosuppressants or anticonvulsants).\n* Patients having masochistic habits (tongue thrusting, nail biting etc.)\n* Mobile teeth\n* Involved teeth with trauma from occlusion.\n* Involved teeth with prosthesis.\n* Endodontically involved\u002F RCT treated tooth\n* Patient undergoing\u002Funderwent orthodontic treatment",true,"45 Years",{"count":156,"type":22},346,"OBSERVATIONAL","Aim of this study is the assessment of gingival recession and its impact on oral health related quality of life in tertiary health care center in Haryana state.\n\nObjectives:\n\n1. Determine the prevalence of gingival recession (GR) through clinical screening.\n2. Classify patients with GR based on the system proposed by Cairo et al.\n3. Identify the risk factors associated with GR\n4. To assess the impact of GR on oral health related quality of life.",[28],"2026-04-22",{"date":139,"type":39},{"date":163,"type":39},"2026-03-15",{"date":165,"type":22},"2027-03-15",{"name":45,"class":46},{"id":168,"slug":169,"hasResults":12,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":20,"enrollmentInfo":174,"targetDuration":4,"studyType":157,"phases":4,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":47},"100622656","taking-measurements-of-a-gum-graft-site-as-it-heals-100622656","NCT07386457","Taking Measurements of a Gum Graft Site as it Heals","Dimensional Changes During Early Healing Following Subepithelial Connective Tissue Graft for Root Coverage","Inclusion Criteria:\n\n* Clinical (oral) Ohio State University College of Dentistry patient, treatment planned for SCTG procedure\n* Miller Recession Class I, II, or III\n* Teeth; Maxillary or mandibular incisors, canines, pre-molars\n* Gingival Index ≤ 1\n* Plaque Index ≤ 1\n* Able and willing to provide informed consent\n* Able and willing to complete questionnaire\n\nExclusion Criteria:\n\n* Carious lesions on the tooth selected for surgical root coverage\n* Taking any medications affecting the gingiva and\u002For oral mucosa: phenytoin, calcium channel blockers , cyclosporin A, immunostimulants\u002F immunomodulators\n* Quantitative and\u002For qualitative defects on host inflammatory cells\n* Organ transplant(s)\n* Type I or II diabetes\n* Currently pregnant or lactating\n* Usage of smokeless tobacco\n* Physical\u002Fmental handicap which can interfere with adequate oral hygiene performance",{"count":175,"type":22},15,"This is an observational study. The participants in this study will be patients at the Graduate Periodontics Clinic at The Ohio State University who are planning to get a gingival graft to treat their gum recession. Gingival grafts are a common way to treat this recession. The grafting surgery is not part of the study.\n\nThe main purpose of this study is to better understand the normal healing of a gum graft. In order to do that, the investigators will take different kinds of measurements.\n\n1. It is common for the tissue around the graft to have some swelling after the surgery. The investigators will measure the amount of swelling at different times as the graft heals. This will be done with a digital scanner which is passed over the area.\n2. A device which measures blood flow will be used to see how new blood vessels are forming. This is also a device which is only passed over the area, so it is not invasive.\n3. Saliva samples will be taken from around the teeth using sterile paper strips. This fluid will be analyzed for substances related to wound healing.\n4. Participants will fill out questionnaires about their experience with the graft healing.",[28],"2026-04-16",{"date":180,"type":39},"2026-04-20",{"date":182,"type":39},"2026-04-01",{"date":184,"type":22},"2027-05",{"name":186,"class":46},"Ohio State University",{"id":188,"slug":189,"hasResults":12,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":194,"targetDuration":4,"studyType":23,"phases":195,"briefSummary":196,"conditions":197,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":47},"100633405","comparative-evaluation-of-novel-3d-tunneling-technique-versus-modified-coronally-advanced-tunnel-mcat-with-connective-tissue-graft-in-the-management-of-multiple-rt2-gingival-recession-100633405","NCT07526259","Comparative Evaluation of Novel 3D Tunneling Technique Versus Modified Coronally Advanced Tunnel (MCAT) With Connective Tissue Graft in the Management of Multiple RT2 Gingival Recession","Comparative Evaluation of Novel 3D Tunneling Technique Versus Modified Coronally Advanced Tunnel (MCAT) With Connective Tissue Graft in the Management of Multiple RT2 Gingival Recession: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Buccal and lingual multiple adjacent recession defects classified as Cairo et al RT2.\n* Age ≥18 years\n* Full mouth plaque index score less than 20% O'Leary et al. 1972\n* Patients with healthy systemic condition\n* Clinical indication and\u002For patient request for root coverage\n\nExclusion Criteria:\n\n* Patients with systemically compromised health\n* Periodontal surgical treatment during the previous 24 months in the involved site\n* Pregnant or lactating mothers\n* Smokers\n* Non-compliant patients\n* Restored teeth\n* Non-carious cervical lesion",{"count":5,"type":22},[25],"Defects associated with severe interdental hard and soft tissue loss are challenging to the periodontist, mainly due to the increased avascular surface and the reduced interproximal periosteal bed. Reports on the surgical techniques used to address recession type 2 or 3 defects mostly showed statistics on the mid-facial root coverage that yielded outcomes that do not encompass coverage of the interdental exposed root surface which highlights areas of controversy in their use for papilla reconstruction. Several case reports and clinical studies have shown encouraging results, but the long-term data are not available in the literature yet. The novel 3D tunneling (3DT) method achieved significant clinical improvement with long term stability in a recent case series. However, additional research is needed to validate 3DT for its routine clinical use. Moreover, the 3DT method achieved a decrease in the lingual recession depth which should be pointed out that the technique also addresses lingual recession.",[28],"2026-04-10",{"date":200,"type":39},"2026-04-13",{"date":202,"type":39},"2025-05-10",{"date":204,"type":22},"2027-05-10",{"name":124,"class":46},{"id":207,"slug":208,"hasResults":12,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":213,"targetDuration":4,"studyType":23,"phases":215,"briefSummary":216,"conditions":217,"keywords":219,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":47},"100584680","patient-reported-outcomes-of-donor-site-healing-using-different-palatal-protection-techniques-100584680","NCT06892496","Patient-reported Outcomes of Donor Site Healing Using Different Palatal Protection Techniques","Patient-reported Outcomes of Donor Site Healing Using Different Palatal Protection Techniques: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* At least 18 years of age\n* Healthy or Mild controlled systemic diseases with no functional limitations (ASA I or ASA II)\n* Sites with 1 to 3 teeth or implants requiring soft-tissue grafting\n* Minimum palatal thickness of 2 mm\n* Willing to participate and sign an informed consent\n\nExclusion Criteria:\n\n* Patients with systemic conditions that could impair wound healing (i.e. diabetes, immunosuppressive, chemotherapy, etc.)\n* Pregnant patients\n* Patients with bleeding disorders or taking anticoagulants\n* Smokers\n* Patients with a history of palatal graft harvesting",{"count":214,"type":22},56,[25],"This study has been initiated to evaluate the question, \"What is the best way to protect the palate after a gum graft is removed?\" The overall objective is to determine if there is a difference in PROMs of donor site healing using different palatal post-operative protection techniques.",[218,28],"Mucosal Erosion",[220,221,222,223],"soft tissue graft","pain","wound healing","CPS: Chairside polymer stent","2026-03-31",{"date":226,"type":39},"2026-04-07",{"date":228,"type":39},"2025-03-07",{"date":230,"type":22},"2026-07",{"name":232,"class":46},"Virginia Commonwealth University",{"id":234,"slug":235,"hasResults":12,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":241,"targetDuration":4,"studyType":23,"phases":242,"briefSummary":243,"conditions":244,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":47},"100632446","the-impact-of-a-3d-imaging-tool-on-reducing-gum-recession-during-orthodontic-treatment-with-aligners-100632446","NCT07513792","The Impact of a 3D Imaging Tool on Reducing Gum Recession During Orthodontic Treatment With Aligners","The Impact of a 3D Imaging Visualization Tool for Orthodontic Treatment With Aligners in Reducing Periodontal Recession Occurrence","GOPRO","Inclusion Criteria:\n\n* more than 18years old\n* requesting an orthodontic treatment with aligners\n* dental class I or slight class II or III\n* presence of black corridors\n\nExclusion Criteria:\n\n* agenesis or extraction except for the 3rd molars\n* need of extraction for the orthodontic treatment-need for orthognathic surgery\n* generalized unilateral, bilateral, or anterior crossbite\n* active periodontal disease\n* presence of severe recession (≥2mm)\n* furcation involvement\n* absence of keratinized tissues\n* smoker \\> 10c\u002Fday-auto-immune disease or immunocompromised patients\n* uncontrolled diabetes\n* use of steroids or biphosphonates-local or systemic infection (medical treatment needed prior to entrance to the study)\n* pregnancy\n* alcoholism or chronically drug abuse",{"count":85,"type":22},[25],"This study investigates whether using 3D imaging technology (Cone Beam Computed Tomography or CBCT) for orthodontic treatment planning with aligners can reduce the risk of gingival recession in adult patients seeking dental arch expansion. Many aligner treatments involve expanding the dental arches to address issues like crowding and \"black corridors,\" but this can sometimes lead to gum recession.\n\nThe research compares two groups of patients: one group will have their treatment planned using CBCT, which allows for detailed 3D visualization of the teeth and bone structure, while the other group will follow a conventional 2D treatment plan. The goal is to see if the 3D tool helps prevent gum recession and other periodontal problems like bone thinning, as well as to assess the impact on other factors like upper airway dimensions.\n\nThe study is a randomized controlled trial with 40 participants. It will track changes in gum health, bone structure, and airway volume over the course of treatment. The researchers aim to find out if the advanced imaging tool provides significant benefits compared to traditional planning methods.",[245,28,246],"Orthodontic","Cone-Beam Computed Tomography","2026-03-30",{"date":226,"type":39},{"date":250,"type":39},"2025-09-04",{"date":252,"type":22},"2027-06-01",{"name":254,"class":46},"University of Liege",{"id":256,"slug":257,"hasResults":12,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":4,"eligibilityCriteria":261,"healthyVolunteers":153,"sex":18,"minAge":55,"maxAge":262,"enrollmentInfo":263,"targetDuration":4,"studyType":23,"phases":265,"briefSummary":266,"conditions":267,"keywords":268,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":47},"100565540","phase-2-evaluation-of-the-modified-vista-technique-using-alb-prf-vs-ctg-in-the-treatment-of-multiple-miller-class-iii-recessions-100565540","NCT06643507","Evaluation of the Modified VISTA Technique Using ALB-PRF vs CTG in the Treatment of Multiple Miller Class III Recessions","Clinical Evaluation of the Modified VISTA Technique (M-VISTA )Using Albumin-platelet Rich Fibrin (Alb-PRF) Versus Connective Tissue Graft (CTG)in the Treatment of Multiple Miler Class III RT2 Recessions A Randomized Clinical Trial","Inclusion Criteria:\n\n* 18 years old good oral hygiene\n\nExclusion Criteria:\n\n* smokers patients with poor oral hygiene","60 Years",{"count":264,"type":22},26,[112,113],"treatment of miller class III RT2 gingival recession using modified vista technique using connective tissue graft vs albumin PRF",[28],[269],"gingival recession, plastic surgery, soft tissue management","2026-03-19",{"date":272,"type":39},"2026-03-20",{"date":274,"type":39},"2025-04-20",{"date":276,"type":22},"2027-01-30",{"name":124,"class":46},{"id":279,"slug":280,"hasResults":12,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":153,"sex":18,"minAge":55,"maxAge":262,"enrollmentInfo":285,"targetDuration":4,"studyType":23,"phases":286,"briefSummary":287,"conditions":288,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":293,"leadSponsor":295,"locationsCount":47},"100623928","impact-of-root-surface-conditioning-with-erythritol-air-polishing-and-hand-instrumentation-on-recession-coverage-using-the-modified-tunnel-technique-and-subepithelial-connective-tissue-graft-100623928","NCT07403006","Impact of Root Surface Conditioning With Erythritol Air Polishing and Hand Instrumentation on Recession Coverage Using the Modified Tunnel Technique and Subepithelial Connective Tissue Graft.","Impact of Root Surface Conditioning With Erythritol Air Polishing Versus Hand Instrumentation on Recession Coverage Using the Modified Tunnel Technique and Subepithelial Connective Tissue Graft: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Multiple RT1 and\u002For RT2 gingival recessions, symmetrical and bilateral, with a minimum height of ≥ 1 mm\n* Full-mouth plaque score (FMPS) \\\u003C 15% (assessed on four surfaces per tooth)\n* Full-mouth bleeding on probing (FMBOP) \\\u003C 15% (assessed on four surfaces per tooth)\n* Detectable cemento-enamel junction (CEJ)\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* RT3 gingival recessions\n* Gingival recessions affecting second and third molars\n* Systemic or infectious diseases that may impair wound healing, including active malignancy, diabetes mellitus with HbA1c \\> 7.0%, history of head and neck radiotherapy, true xerostomia, and HIV\u002FAIDS\n* Cervical caries, non-carious cervical lesions, or Class V restorations interfering with the CEJ\n* Active periodontitis\n* Use of medications affecting periodontal tissues or wound healing, including systemic corticosteroids, immunosuppressants, isotretinoin, bisphosphonates, and monoclonal antibodies with immunosuppressive, antiresorptive, or antiangiogenic effects\n* Smoking\n* Pregnancy or breastfeeding",{"count":58,"type":22},[25],"This study aims to evaluate whether the method of root surface preparation influences surgical outcomes. It will assess whether manual root instrumentation can be replaced by a less invasive erythritol air-polishing technique.",[28],"2026-03-09",{"date":291,"type":39},"2026-03-10",{"date":289,"type":39},{"date":294,"type":22},"2027-07",{"name":296,"class":46},"Medical University of Warsaw",{"id":298,"slug":299,"hasResults":12,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":4,"eligibilityCriteria":303,"healthyVolunteers":153,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":304,"targetDuration":4,"studyType":157,"phases":4,"briefSummary":305,"conditions":306,"keywords":308,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":319,"locationsCount":47},"100627201","gingival-recessions-in-orthodontically-treated-and-untreated-adult-patients-100627201","NCT07445555","Gingival Recessions in Orthodontically Treated and Untreated Adult Patients","Gingival Recessions in Orthodontically Treated and Untreated Adult Patients: a Prospective Study","Inclusion Criteria:\n\n* Patients with or without previous history of orthodontic treatment with and without gingival recessions\n* ≥ 18 years old\n* American Society of Anesthesiologists Classification I or II\n\nExclusion criteria:\n\n* Patients with history of periodontal disease\n* taking the following medication: anticoagulants, phenytoin, cyclosporine, nifedipine or calcium channel blockers\n* Patients with prior history of radio or chemotherapy\n* Pregnant or breastfeeding patients\n* Patients with agenesis of one or more lower incisors\n\nExclusion Criteria:\n\nPatients with history of periodontal disease Patients taking the following medication: anticoagulants, phenytoin, cyclosporine, nifedipine or calcium channel blockers Patients with prior history of radio or chemotherapy Pregnant or breastfeeding patients Patients with agenesis of one or more lower incisors",{"count":133,"type":22},"To identify the predisposing parameters for gingival recessions in adult patients seeking orthodontic treatment. The ultimate aim is to provide a clinical guideline to estimate the risk of developing post-orthodontic gingival recessions.",[28,307],"Orthodontic Treatment",[30,309,310,311],"orthodontic treatment","gingival phenotype","occlusal factors","2026-03-02",{"date":314,"type":39},"2026-03-03",{"date":316,"type":39},"2023-11-15",{"date":318,"type":22},"2027-09-01",{"name":320,"class":46},"Universitaire Ziekenhuizen KU Leuven",{"id":322,"slug":323,"hasResults":12,"nctId":324,"briefTitle":325,"officialTitle":326,"acronym":327,"eligibilityCriteria":328,"healthyVolunteers":153,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":329,"targetDuration":4,"studyType":23,"phases":331,"briefSummary":332,"conditions":333,"keywords":335,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":340,"startDateStruct":342,"completionDateStruct":344,"leadSponsor":346,"locationsCount":47},"100626575","a-novel-volume-stable-matrix-for-gingival-recession-coverage-at-teeth-100626575","NCT07437417","A Novel Volume Stable Matrix for Gingival Recession Coverage at Teeth","Assessment of Connective Tissue Graft vs. a New Collagen Matrix for Periodontal Tissue Thickening and Coverage of Single or Multiple Adjacent Gingival Recessions of Orthodontically Treated Patients. A Randomized Clinical Trial","FibroGide","Inclusion Criteria:\n\n* Written informed consent\n* Healthy patients referred to the clinic for recession coverage\n* Miller Class I, II or III facial gingival recession (GR) defect, \\>3 mm, located on the buccal of the maxillary or mandibular canine and incisor area.\n\nExclusion Criteria:\n\n* History of diseases with hypocoagulability, instable diabetes mellitus, post-irradiation in the head and neck area, infectious diseases or heart diseases that need prophylactic antibiosis before dental treatments or a medication with effect on the gingiva: Ciclosporin A, compounds of Phenytoin, calcium channel blockers, pregnant or breastfeeding patients",{"count":330,"type":22},60,[25],"Periodontal health and preservation of the dentition without tooth loss are important quality of life components and should be safeguarded in order to provide optimal function and esthetics. Optimal treatment of gingiva recessions is likely to allow for more efficient use of healthcare resources and reduced costs long-term. It is evident that the prevalence in gingival recession is high and its consequences on the aging population constitute an important healthcare issue that requires further attention. The standard therapy of gingival recession encompasses a coronally advanced flap or coronally advanced tunnel flap and a connective tissue graft from the palate. Harvesting of the palatal graft involves a second surgical site and increased morbidity for the patients.This project aims to compare the connective tissue graft against a novel volume stable collagen matrix.\n\nPatients will be treated according to standard protocols of the Department of Periodontology. In the test group patient will undergo tissue thickening with a collagen matrix and the modified coronally advanced tunnel technique. The control group will undergo the standard protocol using a connective tissue graft from the palate along with the modified coronally advanced tunnel technique. No study specific risks do exist.",[28,334],"Connective Tissue Defect",[336,337,338],"Connective tissue graft","Collagen Matrix","single and multiple gingival recessions","2026-02-23",{"date":341,"type":39},"2026-02-27",{"date":343,"type":39},"2025-09-01",{"date":345,"type":22},"2030-08-01",{"name":347,"class":46},"University of Bern",{"id":349,"slug":350,"hasResults":12,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":355,"targetDuration":4,"studyType":23,"phases":357,"briefSummary":358,"conditions":359,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":47},"100504662","free-mucogingival-graft-for-isolated-root-coverage-100504662","NCT05851248","Free Mucogingival Graft for Isolated Root Coverage","Free Mucogingival Graft for Isolated Root Coverage and Correct Unfavorable Mucogingival Conditions in Lower Incisors: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Healthy patients with deep GR associated with lower incisor MCD.\n* Full mouth plaque and bleeding scores were \\\u003C20%.\n\nExclusion Criteria:\n\nPatient characteristics:\n\n* Smoking ≥10 cigarettes a day.\n* Medications or systemic contraindications for oral surgery.\n* Pregnancy.\n\nDefects:\n\n* Thin scalloped biotype (AND\u002FOR)\n* Underlying bone dehiscence (AND \u002FOR)\n* Generalized GR affecting most sextants.",{"count":356,"type":22},24,[25],"The goal of this clinical trial is to to describe and evaluate an approach, free mucogingival graft (FMG), in periodontal plastic surgery for root coverage (RC) in lower incisor gingival recessions (GR) with mucogingival conditions and deformities (MCD) that might negatively influence the outcomes of conventional RC procedures.",[360,28,361,362],"Free Mucogingival Grafts","Root Coverage","Periodontal Plastic Surgery","2026-02-16",{"date":365,"type":39},"2026-02-19",{"date":367,"type":39},"2023-01-02",{"date":369,"type":22},"2027-04-22",{"name":371,"class":46},"Universidad de Murcia",{"id":373,"slug":374,"hasResults":12,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":4,"eligibilityCriteria":378,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":379,"targetDuration":4,"studyType":23,"phases":381,"briefSummary":382,"conditions":383,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":391,"locationsCount":47},"100608338","changes-in-soft-tissue-thickness-following-multiple-coronally-advanced-tunnel-mcat-vs-vestibular-incision-subperiosteal-tunnel-access-vista-100608338","NCT07200258","Changes in Soft Tissue Thickness Following Multiple Coronally Advanced Tunnel (MCAT) vs Vestibular Incision Subperiosteal Tunnel Access (VISTA)","Changes in Soft Tissue Thickness Following Multiple Coronally Advanced Tunnel (MCAT) vs Vestibular Incision Subperiosteal Tunnel Access (VISTA): A Randomized Clinical Trial With 3D Volumetric Analysis","Inclusion Criteria:\n\n* Periodontally and systemically healthy adults (age ≥ 18 years).\n* At least two adjacent sites exhibiting gingival recessions classified as recession type 1 (RT1) o type 2 (RT2) (Cairo et al., 2011), associated with dental hypersensitivity or aesthetic concerns.\n* Presence ≥2 mm depth on at least one recession\n* Smokers ≤ 10 cigarettes.\n* Full-mouth plaque and bleeding scores ≤20%.\n* Patients being able to maintain good oral hygiene.\n\nExclusion Criteria:\n\n* Compromised general health.\n* Pregnancy or attempting to get pregnant (self-reported).\n* Untreated periodontal diseases\n* Presence of: (i) severe tooth malposition; (ii) root caries or inadequate prosthetic restorations; (iii) previous periodontal plastic surgery at the experimental sites.\n* Smokers \\>10 cigarettes",{"count":380,"type":22},44,[25],"This randomized clinical trial will compare two surgical methods for treating multiple adjacent gingival recessions (types RT1 and RT2): the Modified Coronally Advanced Tunnel (MCAT) and the Vestibular Incision Subperiosteal Tunnel Access (VISTA). Both methods will use connective tissue grafts (CTG), which are the best way to cover roots.\n\nThe main objective is to use three-dimensional (3D) digital volumetric analysis to look at how the thickness of soft tissue has changed after six and 12 months. Secondary outcomes include root coverage, esthetic outcomes, gingival health parameters, hypersensitivity, patient satisfaction, and wound healing quality.\n\nThere will be 44 volunteers, and they will be randomly assigned to one of the two surgical methods. Under the same settings, periodontal specialists in training will undertake the procedures at the Universidad Complutense de Madrid. There will be follow-up evaluations at different times up to 12 months after the procedure. The results of this study will help determine whether remote incisions via the VISTA technique offer improved outcomes compared to the MCAT technique.",[28],"2026-02-11",{"date":386,"type":39},"2026-02-13",{"date":388,"type":39},"2025-10-15",{"date":390,"type":22},"2028-07",{"name":392,"class":46},"Universidad Complutense de Madrid",{"id":394,"slug":395,"hasResults":12,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":4,"eligibilityCriteria":399,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":400,"targetDuration":4,"studyType":23,"phases":401,"briefSummary":402,"conditions":403,"keywords":408,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":415,"lastUpdatePostDateStruct":416,"startDateStruct":418,"completionDateStruct":420,"leadSponsor":422,"locationsCount":47},"100605132","comparing-tcaf-and-mtun-with-soft-tissue-grafting-for-treating-single-recessions-in-the-premandible-100605132","NCT07158541","Comparing TCAF and MTUN With Soft Tissue Grafting for Treating Single Recessions in the Premandible","An RCT Comparing Tunneled Coronally Advanced Flap (TCAF) and Modified Tunnel Technique (MTUN) in Combination With a Soft Tissue Graft for Single Recession Coverage","Inclusion Criteria:\n\n* at least 18 years old\n* good oral hygiene\n* presence of one recession in the premandible\n* good general health\n\nExclusion Criteria:\n\n* smoker\n* pregnant women (assessed at each visit; if the patient appears pregnant during follow-up, x-rays will not be taken)",{"count":356,"type":22},[25],"Multiple techniques can be used for recession coverage. The most common techniques for single recessions are : tunnel technique (T) and coronally advanced flap (CAF) both combined with a palatal graft to provide sufficient gingival thickness. Recently two modifications have been described in literature, namely the tunneled coronally advanced flap and the modified tunnel. MTUN will function as the control group while people treated with the TCAF technique will function as the test group.\n\nThis randomized controlled trial compares MTUN and TCAF to determine which technique provides better root coverage for receding gums at single recession in the premandible. The main question it aims to answer is:\n\n\\- What is the average root coverage achieved with each technique in the short and long term? This may be clinically relevant because covering gum recession can reduce tooth sensitivity, improve aesthetics and make oral hygiene easier.\n\nResearchers will compare the modified tunnel technique (MTUN = the gum is undermined) with the tunneled coronally advanced flap (TCAF = the gum is undermined, only partially detached and repositioned higher). In both techniques, a small piece of tissue is removed from the palate, which is used to cover the recession. The purpose of the connective tissue graft under the flap\u002Ftunnel, is to increase thickness and provide support. Pain associated to the material used to cover the donorsite will be seen as the secondary research question. The site will either be covered by spongostan and multiple stitches or a palatal stent.\n\nParticipants will:\n\n* Undergo surgery (MTUN or TCAF, randomly assigned) to cover recessions\n* Attend regular check-ups for up to 10 years after surgery\n* Keep a postoperative journal (recording medication use, pain levels, tooth sensitivity, etc.)",[404,405,28,406,407],"Gingival Recession, Localized","Gingival Recession Localized Moderate","Gingival Recession, Mucogingival Surgery","Gingival Recession, Plastic Surgery",[409,410,411,412,413,414],"MTUN","TCAF","tunneled coronally advanced flap","modified tunnel","single gingival recession","premandible","2025-09-09",{"date":417,"type":39},"2025-09-16",{"date":419,"type":39},"2025-08-25",{"date":421,"type":22},"2037-12-31",{"name":423,"class":46},"University Hospital, Ghent",{"id":425,"slug":426,"hasResults":12,"nctId":427,"briefTitle":428,"officialTitle":429,"acronym":4,"eligibilityCriteria":430,"healthyVolunteers":153,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":431,"targetDuration":4,"studyType":23,"phases":433,"briefSummary":434,"conditions":435,"keywords":436,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":445,"locationsCount":47},"100591907","clinical-evaluation-of-two-different-surgical-techniques-with-prf-in-the-treatment-of-multiple-gingival-recessions-100591907","NCT06986525","Clinical Evaluation of Two Different Surgical Techniques With PRF in the Treatment of Multiple Gingival Recessions","A Prospective Split-Mouth Clinical Study Comparing Coronally Advanced Flap and Tunnel Techniques Combined With Platelet-Rich Fibrin in the Treatment of Multiple Gingival Recessions","Inclusion Criteria:\n\n* Age 18 years or older\n* Systemically healthy individuals\n* Presence of bilateral Miller Class I-II multiple gingival recessions\n* Good oral hygiene and willingness to follow instructions\n* Signed informed consent\n\nExclusion Criteria:\n\n* Use of tobacco or smoking\n* Pregnancy or lactation\n* Presence of systemic diseases affecting periodontal health\n* Use of medications that may affect healing (e.g., corticosteroids)\n* Periodontal surgery in the same area within the last 6 months",{"count":432,"type":22},10,[25],"This prospective clinical study aims to evaluate and compare the effectiveness of coronally advanced flap (CAF) and tunnel techniques, both combined with platelet-rich fibrin (PRF), in the treatment of multiple Miller Class I-II gingival recessions. Eleven participants with bilateral defects will be treated using a split-mouth design. Periodontal parameters will be assessed at baseline, 3 months, and 6 months.",[28],[437,438,32],"gingival recessions","platelet rich fibrin","2025-08-13",{"date":441,"type":39},"2025-08-17",{"date":443,"type":22},"2025-08-15",{"date":163,"type":22},{"name":446,"class":46},"Pamukkale University",{"id":448,"slug":449,"hasResults":12,"nctId":450,"briefTitle":451,"officialTitle":452,"acronym":4,"eligibilityCriteria":453,"healthyVolunteers":153,"sex":18,"minAge":55,"maxAge":454,"enrollmentInfo":455,"targetDuration":4,"studyType":23,"phases":456,"briefSummary":457,"conditions":458,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":459,"startDateStruct":461,"completionDateStruct":463,"leadSponsor":465,"locationsCount":47},"100491817","dimensional-changes-randomized-clinical-trial-100491817","NCT05684068","Dimensional Changes: Randomized Clinical Trial","Dimensional Changes of Autogenous Free Epithelialized Gingival Grafts on Different Bed Preparations Among Dental Patients With Thin Tissue Phenotypes: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients 18-95 years of age\n* Inactive periodontal disease\n* Lack of, or an insufficient (less than 2 millimeters) band of keratinized tissue width on the buccal site (closest to the cheek)\n* Shallow vestibule depth (the space between the soft tissue (lips and cheeks), and the teeth and gums)\n* Thin gingival phenotype (less than 1.5mm of gum tissue depth).\n* Aberrant frenum attachment in need of free-epithelized gingival grafts.\n* At least one RT1, 2, or 3 (Cairo's classification) gingival recession defect on the mandibular anterior sextant (Teeth #22-27).\n* Non-smokers or past smokers (those who have stopped at minimum 6 months ago).\n* Patient willing and able to follow instruction related to the study procedures.\n\nExclusion Criteria:\n\n* Previous soft tissue augmentation procedures at the area of interest.\n* Current smokers (Light smokers meaning less than 10 cigarettes\u002Fday, heavy smokers meaning more than 10 cigarettes\u002Fday, or social smokers)\n* Uncontrolled systemic disease (uncontrolled diabetes defined by blood sugar HbA1c greater than 7%)\n* Any active local or systemic infections\n* Any diseases or medications that may compromise normal wound healing\n* Currently receiving chemotherapy or radiotherapy or a history of radiotherapy in head and neck area.\n* Severe hematologic (blood) disorders\n* Pregnancy or nursing mother\n* Patients undergoing orthodontic therapy\n* Patients taking antibiotics in the past 3 months","95 Years",{"count":133,"type":22},[25],"The goal of this clinical trial is to evaluate the dimensional changes in the short and long-term in patients with thin gum tissues who have gum grafts placed on either denuded bone or gum grafts placed on a bone with some tissues remaining.\n\nThe main question this study aims to answer is:\n\n\\- Does the placement of free-epithelized gingival grafts (gum grafts) on full thickness bed preparation (having all of the tissue removed from the bone) lead to similar clinical, digital, and patient-related outcomes and measurements over a period of 12 months versus split thickness bed preparation (where a small layer of tissue is left over the bone) in patients with thin gum tissue phenotypes (gum tissue is generally less than 1.5 millimeters) who are in need of soft tissue augmentation procedures?\n\nParticipants will be asked to attend 8 visits, which include: (i) screening visit, (ii) prophylaxis visit, (iii) random assignment to Group A or Group B along with surgery and digital data collection, (iv) 2-week post-operative visit, (v) 6-week post-operative visit, (vi) 3-month follow-up visit, (vii) 6-month follow-up visit, (viii) 12-month follow-up visit. Also, Group A will have a free epithelialized gingival\u002Fmucosal graft (gum graft) placed on full thickness periosteal bed preparation where all of the tissue was removed (test group). Group B will have a free epithelialized gingival\u002Fmucosal graft (gum graft) on split thickness periosteal bed preparation where only a portion of the tissue was removed (control group). Researchers will compare Group A and Group B to see if there is a difference in clinical, digital, and patient-related outcomes and measurements over a period of 12 months.",[28],{"date":460,"type":39},"2025-08-19",{"date":462,"type":22},"2028-08",{"date":464,"type":22},"2031-03",{"name":466,"class":46},"University of Iowa",{"id":468,"slug":469,"hasResults":12,"nctId":470,"briefTitle":471,"officialTitle":472,"acronym":4,"eligibilityCriteria":473,"healthyVolunteers":153,"sex":18,"minAge":55,"maxAge":56,"enrollmentInfo":474,"targetDuration":4,"studyType":23,"phases":476,"briefSummary":477,"conditions":478,"keywords":481,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":485,"startDateStruct":487,"completionDateStruct":489,"leadSponsor":491,"locationsCount":47},"100600940","biofiller-and-gingival-phenotype-thickening-100600940","NCT07104019","Biofiller and Gingival Phenotype Thickening","Evaluation of the Effectiveness of Blood Concentrate Biofiller in Thickening the Gingival Phenotype Around Natural Teeth","Inclusion Criteria:\n\n* Age between 18 and 60 years\n* Systemically healthy individuals\n* Presence of thin gingival phenotype in the mandibular anterior region (canine to canine)\n* No medications that affect wound healing\n* No history of bleeding disorders\n* No known allergy to anti-inflammatory drugs\n* Not pregnant or breastfeeding\n* Willingness to participate and provide informed consent\n* Non-smoker\n\nExclusion Criteria:\n\n* Systemic diseases (e.g., diabetes, hypertension, cancer, etc.)\n* Use of medications that may affect healing (e.g., corticosteroids, immunosuppressants)\n* History of radiotherapy or chemotherapy\n* Pregnancy or breastfeeding\n* Poor oral hygiene\n* Refusal to participate\n* Age under 18 years\n* Smoking\n* Presence of Class II or Class III orthodontic anomalies",{"count":475,"type":22},34,[25],"The periodontal phenotype is defined as the combination of the gingival phenotype and the thickness of the buccal bone plate (bone morphotype). The gingival phenotype refers to the gingival thickness (GT) and the width of the keratinized tissue (KTW). A gingival thickness of ≤1 mm is classified as a thin phenotype, whereas a thickness \\>1 mm is considered a thick phenotype. Thin gingival biotypes tend to show more pronounced responses to inflammation, restorations, trauma, and parafunctional habits. Various methods are used to assess gingival thickness, including transgingival probing (TP), ultrasonic measurements, cone-beam computed tomography (CBCT) scans, visual assessment, and colored biotype probes (CBP). Periodontal plastic procedures performed using autogenous grafts such as connective tissue grafts (CTG) and free gingival grafts (FGG), or biomaterials such as acellular dermal matrices (ADM) and collagen matrices (CM), are known to significantly increase GT and the amount of keratinized tissue. However, creating a second surgical site in the oral cavity during these procedures may compromise patient comfort, prompting researchers to explore alternative methods. Additionally, the effectiveness of synthetic biomaterials has been found to be lower than that of autogenous grafts.\n\nPlatelet-rich concentrates have been used as a minimally invasive procedure for the past thirty years, showing a high capacity to release growth factors that support tissue regeneration. While platelet-rich plasma (PRP), as the first-generation platelet concentrate, is widely used, platelet-rich fibrin (PRF) has been increasingly applied across various fields of medicine and dentistry due to its ability to release more growth factors over a longer period, resulting in better clinical outcomes. PRF is a highly biocompatible material composed of autologous cells and growth factors entrapped in a fibrin matrix, and has been shown to degrade more slowly over time compared to conventional PRP. One of the main reported disadvantages of PRF (and especially PRP) is its relatively rapid resorption, typically within 2-3 weeks. Biofiller is an autologous material derived from the patient's own blood and includes platelet-poor plasma (PPP) and concentrated platelet-rich fibrin (PRF). The PPP component is heated to become enriched with albumin, thereby prolonging its resorption time. The PRF portion contains autologous cells and growth factors. However, conventional PRF is typically resorbed within 2-3 weeks, limiting its clinical application. Recent studies have shown that the resorption time of biofiller-a combination of PPP and PRF-can exceed 4 months.\n\nThe aim of this study is to compare the effectiveness of biofiller with connective tissue graft in increasing gingival thickness in patients with a thin gingival phenotype. A total of 34 patients (17 patients in each group) will be enrolled. Tunnel surgery will be performed to all participants and test group will receive biofiller only once. Control group will receive connective tissue surgery. Clinical parameters obtained from our patients at baseline and at follow-up visits at 1, 3, and 6 months - including gingival thickness (GT), keratinized tissue width (KTW), and soft tissue measurements assessed via intraoral scanners - will be compared.",[28,479,480],"Gingival Diseases","Gingival Inflammation",[482,483,33],"biofiller","gingival phenotype modification","2025-08-06",{"date":486,"type":39},"2025-08-12",{"date":488,"type":39},"2025-07-30",{"date":490,"type":22},"2026-05-01",{"name":492,"class":46},"Inonu University",{"id":494,"slug":495,"hasResults":12,"nctId":496,"briefTitle":497,"officialTitle":497,"acronym":4,"eligibilityCriteria":498,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":20,"enrollmentInfo":499,"targetDuration":4,"studyType":23,"phases":501,"briefSummary":502,"conditions":503,"keywords":506,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":508,"lastUpdatePostDateStruct":509,"startDateStruct":511,"completionDateStruct":513,"leadSponsor":515,"locationsCount":47},"100600455","evaluating-the-clinical-efficacy-of-collagen-scaffold-ossix-volumax-with-piezo-surgical-decortication-in-enhancing-orthodontic-treatment-outcomes-a-randomized-controlled-trial-100600455","NCT07097714","Evaluating the Clinical Efficacy of Collagen Scaffold (Ossix VOLUMAX) With Piezo-Surgical Decortication in Enhancing Orthodontic Treatment Outcomes: A Randomized Controlled Trial","Gingival Phenotype: Participants must be diagnosed with a thin phenotype of gingiva. This could be measured using a periodontal probe to assess the thickness of the gingiva, typically less than 1 mm is considered thin. In this area may be gingival recession 1,2 Cairo type.\n\nDental Health: Participants must have a sufficient number of teeth and bone support to undergo orthodontic treatment. A minimum number of teeth or specific dental conditions may be outlined to ensure that the treatment can be applied effectively.\n\nMalocclusion: Participants must be diagnosed with malocclusion, specifically requiring correction in the mandibular incisors. The type and severity of malocclusion can be classified according to a recognized system such as the Angle classification or the Index of Orthodontic Treatment Need (IOTN).\n\nMedical History: Participants must not have any contraindications to dental surgery or orthodontic treatment, such as uncontrolled diabetes, bisphosphonate therapy, or a history of radiation to the jaws.\n\nConsent: Participants must be able to understand the nature of the study and provide informed consent to participate in the trial.\n\nAvailability: Participants must be available for the duration of the study and able to attend all scheduled appointments for treatment and follow-up assessments.\n\nPeriodontal Health: Participants should have good periodontal health or controlled periodontitis. This may involve a preliminary periodontal assessment, ensuring that there are no active diseases that could complicate the orthodontic treatment or surgical interventions.\n\nOrthodontic Treatment Status: Participants must not have undergone any orthodontic treatment in the past six months to ensure that any previous treatments do not affect the outcomes of the current study.\n\nNo Concurrent Dental Procedures: Participants should not be undergoing concurrent dental procedures that could affect the outcomes of the orthodontic treatment, such as implants or extensive restorative work, not coordinated with the current treatment plan Radiographic Evaluation: Suitable candidates must have clear radiographic evidence that supports the diagnosis of malocclusion and allows for the assessment of alveolar bone volume and gingival thickness. This may include recent CBCT scans or panoramic radiographs.\n\nNon-smoker Status:\n\nNon-smokers or individuals who have smoke less than 10 cigarettes per day may be included to avoid the confounding effects of smoking on periodontal health and healing.\n\nExclusion criteria:\n\nExisting Periodontal Disease: Individuals with active periodontal disease or significant periodontal bone loss that contraindicates orthodontic treatment.",{"count":500,"type":22},70,[25],"Recent advances in orthodontic treatment have explored various materials to enhance treatment efficacy, particularly focusing on collagen scaffolds. Collagen, being a primary component of the bone matrix, has garnered attention for its biocompatibility, cell adhesion, and osteoconductivity properties. Studies have shown that collagen scaffolds undergo natural degradation, mimicking biological processes, and play a significant role in tissue engineering (International Journal of Implant Dentistry, 2023). This aligns with the growing interest in minimally invasive methods that accelerate orthodontic treatment and improve tissue regeneration.\n\nIn this context, the application of collagen scaffolds, such as Ossix VOLUMAX, in conjunction with piezo-surgical decortication, presents a novel approach. This study aims to build upon the existing knowledge, exploring the efficacy of collagen scaffolds in enhancing orthodontic treatment outcomes, especially in patients with specific dental conditions like a thin gingival phenotype and malocclusion. The study\\'s hypothesis is grounded in the promising properties of collagen-based materials in dental and orthodontic applications, as evidenced by recent research in the field.",[504,28,505],"Dental Crowding","Thin Phenotype",[507],"Corticotomy, Soft Tissue Augmantation, Bone Augmentation, Ossix Volume, Collagene Scaffold, Orthodontics, Piezocision","2025-07-24",{"date":510,"type":39},"2025-07-31",{"date":512,"type":39},"2024-06-25",{"date":514,"type":22},"2026-09-25",{"name":516,"class":46},"NMSI DENTMASTER",{"id":518,"slug":519,"hasResults":12,"nctId":520,"briefTitle":521,"officialTitle":521,"acronym":4,"eligibilityCriteria":522,"healthyVolunteers":153,"sex":18,"minAge":55,"maxAge":523,"enrollmentInfo":524,"targetDuration":4,"studyType":23,"phases":525,"briefSummary":526,"conditions":527,"keywords":530,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":508,"lastUpdatePostDateStruct":535,"startDateStruct":537,"completionDateStruct":539,"leadSponsor":541,"locationsCount":47},"100433131","gain-of-keratinized-mucosa-around-teeth-and-dental-implants-using-a-combination-of-strip-gingival-graft-and-acellular-dermal-matrix-100433131","NCT04920136","Gain of Keratinized Mucosa Around Teeth and Dental Implants Using a Combination of Strip Gingival Graft and Acellular Dermal Matrix","Inclusion Criteria:\n\n* English speaking\n* At least 18 years old\n* Able to read and understand informed consent document\n* Patients with teeth\u002Fimplants lacking keratinized tissue.\n* Must be a patient of the UAB Dental School\n* Presence of periodontally healthy, non-carious neighboring teeth, healthy implants or edentulous ridges on either side of the involved site(s)\n\nExclusion Criteria:\n\n* Non-English speaking\n* Less than 18 years old\n* Smokers\u002Ftobacco users (\\>10 cigarettes\u002Fday)\n* Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing\n* Presence of active periodontal disease\n* Previous soft tissue grafting at the site(s) to be treated","99 Years",{"count":58,"type":22},[25],"This study is to compare the two techniques to achieve change in the tissue quality at areas of lack of Keratinized Tissue (KT) using soft tissue grafting with autogenous graft material (Free Gingival Graft)(FGG) vs Strip gingival graft with acellular dermal matrix (ADM) (SGG+ADM).",[28,528,529],"Lack of Keratinized Attached Peri-implant Mucosa","Thin Gingiva",[531,532,533,534],"Attached mucosa","Keratinized tissue","Dental implants","Connective tissue",{"date":536,"type":39},"2025-07-29",{"date":538,"type":39},"2021-09-17",{"date":540,"type":22},"2027-06-30",{"name":542,"class":46},"University of Alabama at Birmingham",{"id":544,"slug":545,"hasResults":12,"nctId":546,"briefTitle":547,"officialTitle":548,"acronym":4,"eligibilityCriteria":549,"healthyVolunteers":153,"sex":18,"minAge":55,"maxAge":523,"enrollmentInfo":550,"targetDuration":4,"studyType":23,"phases":551,"briefSummary":552,"conditions":553,"keywords":555,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":559,"lastUpdatePostDateStruct":560,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":565,"locationsCount":47},"100485693","the-effect-of-free-gingival-graft-on-root-closure-100485693","NCT05604391","The Effect of Free Gingival Graft on Root Closure","The Effect of Two Different Graft Positioning Techniques on Creeping Attachment in Free Gingival Graft Operations","Inclusion Criteria:\n\n1. 18-99 years old\n2. The patient does not have any systemic disease\n3. Presence of at least one tooth with gingival recession in the mandibular anterior region\n4. Excessive dentin sensitivity and impaired esthetics associated with recession\n5. Identification of the enamel-cementum boundary in the shrinkage region\n6. The tooth is alive and there are no irregularities, grooves, caries and restorations in the area to be treated.\n7. No periodontal surgical treatment in the relevant areas in the last 24 months\n8. Presence of adequate keratinized and attached gingiva in the donor area\n\nExclusion Criteria:\n\n1. Being outside the specified age range\n2. Any contraindication for systematic periodontal surgery\n3. Failure to define the enamel-cementum boundary in the withdrawal region\n4. Presence of caries, restoration, root concavity in the area to be treated\n5. Patients who smoke more than 10 cigarettes per day\n6. Patients who use drugs that suppress the immune system or impair recovery\n7. Patients using drugs that impair bleeding\n8. Insufficient keratinized and attached gingiva in the donor area",{"count":85,"type":22},[25],"Free gingival graft is a mucogingival surgical technique applied to increase keratinized gingival width and reduce gingival recession. Free gingival graft is one of the most widely used approaches in root closure treatments and in increasing the height of the keratinized gingiva. Evaluation of the effect of the amount of creeping attachment on the root surface caused by the free gingival grafts placed coronally and apical to the mucogingival line on the gingival recession in the mandibular anterior region with keratinized gingival deficiency with gingival recession. Forty patients with gingival recession and insufficient keratinized gingival height will be randomly divided into 2 main groups as free gingival grafts to be placed coronal and apical to the gingival recession.",[28,554],"Lack of Keratinized Gingiva",[556,557,558,30],"free gingival grafts","creeping attachment","root closure","2025-03-06",{"date":561,"type":39},"2025-03-10",{"date":563,"type":39},"2022-06-01",{"date":163,"type":22},{"name":566,"class":46},"Berceste Guler",{"id":568,"slug":569,"hasResults":12,"nctId":570,"briefTitle":571,"officialTitle":572,"acronym":4,"eligibilityCriteria":573,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":574,"targetDuration":4,"studyType":23,"phases":576,"briefSummary":577,"conditions":578,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":579,"lastUpdatePostDateStruct":580,"startDateStruct":582,"completionDateStruct":584,"leadSponsor":586,"locationsCount":4},"100580821","effect-of-botulinum-toxin-a-injection-in-treatment-of-recession-rt1-and-rt2-100580821","NCT06842290","Effect of Botulinum Toxin a Injection in Treatment of Recession RT1 and RT2","Effect of Botulinum Toxin -A Injection in Mentalis Muscle with Coronally Advanced Flap and De-epithelized Free Gingival Graft in Treatment of RT1 , RT2 Gingival Recession _Randomized Control Trial","Inclusion Criteria:\n\n* Single or multiple RT1, RT2 GR patient\n* patients ≥18 years\n* systemically healthy, full mouth plaque score, full mouth bleeding score ≤ 15% after phase I therapy\n* clinical indication and\u002For patient request for recession coverage\n* well motivated patients, maintaining oral hygiene throughout study\n\nExclusion Criteria:\n\n* Pregnant or lactating women\n* Smokers' patients\n* Teeth with cervical restorations\u002Fabrasion.\n* Patients had a systemic condition affect blood components and healing",{"count":575,"type":22},28,[25],"The goal of this study type: clinical trial\\] is to learn the effect of Botulinum Toxin \\_A injection in treatment of RT1andRT2 Gingival recession in lower anterior teeth .\n\nPrimary outcome is keratinzed tissue width. Researchers will compare Coronally Advanced flap with De-epithelized free gingival graft and Botulinum toxin-A injection in Mentalis muscle with coronally advanced flap with De-epithelized free gingival graft alone .\n\nThe outcome will be measured at baseline, after 3 months and after 6 mobths \\_medical history\n\n* 3 mm horizontal incisions, then two vertical incisions\n* deepitheliztion of anatomical papillae\n* superficial and deep incisions\n* harvesting DFGG\n* Suturing\n* BOTOX injection",[28],"2025-02-23",{"date":581,"type":39},"2025-02-25",{"date":583,"type":22},"2025-04-04",{"date":585,"type":22},"2026-10-16",{"name":124,"class":46},{"id":588,"slug":589,"hasResults":12,"nctId":590,"briefTitle":591,"officialTitle":592,"acronym":4,"eligibilityCriteria":593,"healthyVolunteers":153,"sex":18,"minAge":55,"maxAge":594,"enrollmentInfo":595,"targetDuration":4,"studyType":23,"phases":596,"briefSummary":597,"conditions":598,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":599,"lastUpdatePostDateStruct":600,"startDateStruct":602,"completionDateStruct":604,"leadSponsor":606,"locationsCount":47},"100492142","gingival-recession-rt1-treatment-with-different-gingival-augmentation-surgeries-100492142","NCT05688293","Gingival Recession (RT1) Treatment With Different Gingival Augmentation Surgeries","Gingival Recession (RT1) Treatment With Different Gingival Augmentation Surgeries Compared With Untreated Contralateral Sites: A Randomized Controlled Clinical Study","Inclusion Criteria:\n\n* Medically free patients (American Society of Anesthesiologists I; ASA I)\n* Patients diagnosed with recession (RT1)\n* Fair oral hygiene\n* Patient accepting to provides an informed consent and the follow-up\n\nExclusion Criteria:\n\n* Carious teeth and teeth with periapical infection.\n* Patients diagnosed with periodontitis\n* Smokers\n* Pregnant and lactating females","55 Years",{"count":110,"type":22},[25],"Thin gingival phenotype is one of the major causative factors of gingival recession type 1 which can result in hypersensitivity, discomfort, and compromised esthetics. This study assess the efficacy of increasing the gingival thickness from thin gingival phenotype to thick gingival phenotype in the treatment of patients suffering from gingival recession (RT1) and maintenance of results using either connective tissue graft or de-epithelized free gingival graft after non-surgical periodontal debridement compared to non-surgical periodontal debridement alone.",[28],"2025-02-08",{"date":601,"type":39},"2025-02-11",{"date":603,"type":39},"2025-02-05",{"date":605,"type":22},"2026-03-01",{"name":607,"class":46},"Misr International University"]