[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"glioma-of-brainstem\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:glioma-of-brainstem":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":20,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100637209","multicenter-prospective-study-on-mri-ai-model-for-midline-glioma-subtyping-and-prognosis-100637209",false,"NCT07608003","Multicenter Prospective Study on MRI AI Model for Midline Glioma Subtyping and Prognosis:","Application of MRI-Based Artificial Intelligence Models for Preoperative Molecular Subtyping and Prognostic Assessment of Midline Gliomas: A Multicenter Prospective Clinical Study","Inclusion Criteria:\n\n* Patients with diffuse gliomas were pathologically and molecularly diagnosed.\n* The clinical case data of all patients were complete.\n* Patients underwent preoperative MRI examination.\n\nExclusion Criteria:\n\n* The tumor is not located in the intracranial midline.\n* Cases in which MRI were incomplete or with significant noise and artifacts.","ALL",{"count":18,"type":19},500,"ESTIMATED","3 Years","OBSERVATIONAL","A vision-language model using preoperative MRI and clinical variables has been developed to simultaneously predict three key molecular markers in midline gliomas: H3K27M, IDH, and 1p\u002F19q. This prospective multicenter study will validate the model's accuracy in preoperative molecular subtyping and its value in prognostic assessment and clinical decision-making across multiple neurosurgical centers.",[24,25,26,27,28,29],"Gliomas Harboring IDH1 and\u002For IDH2 Mutations","Glioma Glioblastoma Multiforme","Glioma of Brainstem","Glioma, Diffuse Midline, H3K27M-mutant","Glioma : Oligodendroglioma or Astrocytoma","Gliomas",[31,32,33,34],"Midline gliomas","Molecular diagnosis","Foundation model","Prognosis prediction","RECRUITING","2026-05-25",{"date":38,"type":39},"2026-05-27","ACTUAL",{"date":41,"type":19},"2026-05-10",{"date":43,"type":19},"2030-12-31",{"name":45,"class":46},"Xiangya Hospital of Central South University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":47},"100377583","phase-1-gd2-car-t-cells-in-diffuse-intrinsic-pontine-gliomas-dipg--spinal-diffuse-midline-gliomadmg-100377583","NCT04196413","GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas (DIPG) & Spinal Diffuse Midline Glioma(DMG)","Phase 1 Clinical Trial of Autologous GD2 Chimeric Antigen Receptor (CAR) T Cells (GD2CART) for H3K27M-mutant Diffuse Midline Glioma (DMG)","INCLUSION CRITERIA\n\n1. Disease Status: Diagnosis of H3K27M mutant diffuse midline glioma (DMG)\n2. H3K27M or H3K27I mutation. Confirmed by CLIA test.\n3. Age: Greater than or equal to 2 year of age and less than or equal to 60 years of age.\n4. Prior Therapy:\n\n   * At least 4 weeks following completion of standard upfront radiation therapy.\n   * At least 3 weeks post chemotherapy or 5 half-lives, whichever is shorter, must have elapsed since any prior systemic therapy, except for systemic inhibitory\u002Fstimulatory immune checkpoint therapy that requires 3 months.\n   * Dordaviprone (Modeyso), previously known as ONC201, may be taken as prior therapy but - just as with other anti-cancer medications - administration must cease at least 5 half-lives prior to enrollment\n5. Performance Status:\n\n   Subjects \\> 16 years of age: Karnofsky ≥ 60% OR Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1; Subjects ≤ 16 years of age: Lansky scale ≥ 60%.\n\n   Subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score.\n6. Normal Organ and Marrow Function (supportive care is allowed per institutional standards, i.e. filgrastim, transfusion) i. ANC ≥ 1000\u002FuL ii. Platelet count ≥ 100,000\u002FuL iii. Absolute lymphocyte count ≥ 150\u002FuL iv. Hemoglobin ≥ 8 g\u002FdL v. Adequate renal, hepatic, pulmonary and cardiac function defined as:\n\n   \\- Creatinine within institutional norms for age (i.e.\n\n   ≤ 2 mg\u002FdL in adults or according to table below in children \\\u003C18 years) OR creatinine clearance (as estimated by Cockcroft Gault Equation) ≥ 60 mL\u002Fmin\n\n   Serum ALT\u002FAST ≤ 3.0 ULN (grade 1)\n   * Total bilirubin ≤ 1.5 mg\u002Fdl, except in subjects with Gilbert's syndrome.\n   * Cardiac ejection fraction ≥ 45%, no evidence of physiologically significant pericardial effusion as determined by an ECHO, and no clinically significant ECG findings\n   * Baseline oxygen saturation \\> 92% on room air\n7. Pregnancy Test Females of childbearing potential must have a negative serum or urine pregnancy test (females who have undergone surgical sterilization are not considered to be of childbearing potential) or NA\n8. Contraception Subjects of child-bearing or child-fathering potential must be willing to practice birth control from the time of enrollment on this study and for four (4) months after receiving the preparative regimen or for as long as GD2CART cells are detectable in peripheral blood or CSF.\n9. Ability to give informed consent. All subjects ≥ 18 years of age must be able to give informed consent. For subjects \\\u003C18 years old their legal authorized representative (LAR) (i.e. parent or guardian) must give informed consent. Pediatric subjects will be included in age appropriate discussion and written assent will be obtained for those \\> 7 years of age, when appropriate. If a minor becomes of age during participation of this study, he\u002Fshe will be asked to reconsent as an adult.\n\nEXCLUSION CRITERIA:\n\n1. For Dose Escalation: Bulky tumor involvement of cerebellar vermis or hemispheres (pontocerebellar peduncles involvement is acceptable), or thalamic lesions that in the investigator's assessment place the subject at unacceptable risk for herniation.\n\n   For Dose Expansion: Bulky disease that in the investigator's assessment place the subject at unacceptable risk for herniation. Thalamic DMG is permitted.\n2. Clinically significant swallowing dysfunction\u002Fdysphagia or prominent medullary dysfunction, as determined by the clinical investigator; or primary cervical cord tumors above C6\u002F7 that represent a high risk of respiratory compromise, as determined by the clinical investigator.\n3. Current systemic corticosteroid therapy above physiologic replacement levels.\n4. Ongoing use of dietary supplements, alternative therapies or extreme diet modifications or any medication not approved by the investigators\n5. Prior CAR therapy.\n6. Prior immunomodulatory therapy, except for checkpoint inhibitor therapy after at least 3 month wash-out.\n7. Uncontrolled fungal, bacterial, viral, or other infection. Previously diagnosed infection for which the patient continues to receive antimicrobial therapy is permitted if responding to treatment and clinically stable.\n8. Diagnosed ongoing infection with:\n\n   * HIV,\n   * Hepatitis B (HBsAg positive) or\n   * Hepatitis C virus (anti-HCV positive). A history of hepatitis B or hepatitis C is permitted if the viral load is undetectable per quantitative PCR and\u002For nucleic acid testing.\n9. Clinically significant systemic illness or medical condition (e.g. significant cardiac, pulmonary, hepatic or other organ dysfunction), that in the judgement of the principal investigator is likely to interfere with assessment of safety or efficacy of the investigational regimen and its requirements.\n10. Women who are pregnant or breastfeeding.\n11. In the investigator's judgment, the subject is unlikely to complete all protocol-required study visits or procedures, including follow-up visits, or comply with the study requirements for participation.\n12. Known sensitivity or allergy to any agents\u002Freagents used in this study.\n13. Primary immunodeficiency or history of autoimmune disease (e.g. Crohns, rheumatoid arthritis, systemic lupus) requiring systemic immunosuppression\u002Fsystemic disease modifying agents within the last 2 years\n\n    * All subject files must include supporting documentation to confirm subject eligibility.\n\nThe method of confirmation can include, but is not limited to, laboratory test results, radiology test results, subject self-report, and medical record review.\n\n\\*Anyone under 26, please contact Ashley Jacobs and anyone 26 and older, please contact Monica Reddy","2 Years","60 Years",{"count":58,"type":19},97,"INTERVENTIONAL",[61],"PHASE1","The primary purpose of this study is to test whether CAR T cells targeting GD2 (GD2CART) can be successfully made and safely given to children and adults with H3K27M-mutant diffuse midline glioma (DMG). Eligible subjects may have DMG arising in the pons (called difuse intrinisic pontine glioma, DIPG), the spinal cord, or other areas of the brain such as a thalamus",[64,26],"Glioma of Spinal Cord","2026-01-23",{"date":67,"type":39},"2026-01-26",{"date":69,"type":39},"2020-06-04",{"date":71,"type":19},"2043-07-31",{"name":73,"class":46},"Stanford University"]