[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gliomas-benign\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gliomas-benign":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,59],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":4},"100419702","a-study-using-brain-stimulation-and-behavioral-therapy-to-increase-extent-of-resection-in-low-grade-gliomas-100419702",false,"NCT04745156","A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas","Inducing Functional Plasticity in Glioma-Involved Functional Cortex With Deficit-Inducing Cortical Stimulation and Targeted Behavioral Therapy to Increase Extent of Resection","Inclusion Criteria:\n\n1. Age 18-65 years old\n2. Ability to understand a written informed consent document, and the willingness to sign it\n3. Radiographic evidence of likely low-grade glioma on MRI (i.e. non-enhancing) invading primary motor cortex in the non-dominant hemisphere.\n4. Karnofsky performance status (KPS) ≥ 75\n5. Normal or near normal motor strength (i.e., at least 3\u002F5 in relevant areas)\n6. Normal or near normal speech (Can consistently name at least 4\u002F5 cards)\n7. No medical contraindication to surgery\n8. Free of other illness that may shorten life expectancy\n\nExclusion Criteria:\n\n1. Presence of other malignancy not in remission\n2. Evidence of bi-hemispheric or widespread tumor involvement\n3. Likely candidate to receive GTR on initial resection\n4. Medically high-risk surgical candidate\n5. History of recent scalp or systemic infection\n6. Presence of other implants or foreign bodies in the head\n7. Inability to receive an MRI for any reason\n8. Inability to receive cortical stimulation for any reason\n9. Coagulation disorders and\u002For use of anti-thrombotic therapies\n10. Platelet count \\\u003C 50\n11. Diathermy procedures\n12. Electroconvulsive Therapy (ECT)\n13. Transcranial Magnetic Stimulation (TMS)\n14. Presence of implanted cardiac device (such as a pacemaker or defibrillator)\n15. Pregnant women","ALL","18 Years","65 Years",{"count":20,"type":21},3,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study uses a cranial implant to deliver cortical stimulation that, when paired with physiotherapy, will remap the brain so that critical brain functions can be protected during brain tumor surgery. This pilot study will provide initial evidence for the safety and feasibility of such a protocol which will lead to future pivotal trials that could radically change eloquent area brain surgery. For patients with otherwise incompletely resectable brain tumors, this could mean a longer life expectancy and a better quality of life.",[27,28,29,30,31,32],"Glioma","Glioma Intracranial","Gliomas Benign","Brain Tumor","Brain Cancer","Motor Cortex; Lesion",[34,35,36,37,38,39,40,41,42,43,44,45,46],"Brain Stimulation","NeuroPace","Cortex Stimulation","Neuroplasticity","Plasticity","Hand Motor Cortex","Primary Motor Cortex","M1","Motor Mapping","Resection","Surgery","Motor Rehabilitation","Prehabilitation","NOT_YET_RECRUITING","2026-01-09",{"date":50,"type":51},"2026-01-12","ACTUAL",{"date":53,"type":21},"2026-08-01",{"date":55,"type":21},"2027-09",{"name":57,"class":58},"Medical College of Wisconsin","OTHER",{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":67,"targetDuration":69,"studyType":70,"phases":4,"briefSummary":71,"conditions":72,"keywords":77,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":92},"100458790","seoul-cohort-of-brain-tumor-monitoring-study-solomon-100458790","NCT05254197","SeOuL cOhort of Brain Tumor MONitoring Study (SOLOMON)","The Risk of Growth in Patients With Non-malignant Brain Tumor: SeOuL cOhort of Brain Tumor MONitoring (SOLOMON) Study","SOLOMON","Inclusion Criteria for retrospective cohort\n\n* Patients with radiologically diagnosed brain neoplasm of CNS WHO grade 2 or less since 1998\n* Asymptomatic at first visit to the hospital\n* Patients who, based on the up-to-date knowledge, did not necessarily require immediate treatment at the first hospital visit\n* Patients who have had two or more MRs at least 3 months apart\n* No previous radiotherapy or radiosurgery for the brain lesion\n* 18 years old or more\n\nInclusion Criteria for prospective cohort\n\n* Patients with newly diagnosed brain neoplasm of CNS WHO grade 2 or less\n* Asymptomatic at first visit to the hospital\n* Patients who, based on the up-to-date knowledge, did not necessarily require immediate treatment at the first hospital visit and who are going to take follow-up MR exams\n* No previous radiotherapy or radiosurgery for the brain lesion\n* 18 years old or more\n* Patients who agree to participate by written consent\n\nExclusion Criteria\n\n* Patients who lost follow-up before the second MR exam\n* Patients requiring immediate treatment due to worsening of symptoms within 3 months of the first MR exam\n* Patients suspected to have other than a neoplasm at follow-up MR exams",{"count":68,"type":21},3000,"15 Years","OBSERVATIONAL","The registry of this study was subjected to patients who were radiologically diagnosed with a non-malignant brain tumor at Seoul National University Hospital since 2001, and who have had magnetic resonance (MR) re-examination after first MR exam or will be re-examined because it was determined that immediate treatment would not be needed at the first visit to the hospital. In all MRs taken by patients, the date of imaging and the volume of the tumor are measured, and we aim to establish a natural growth history for non-malignant brain tumors.",[73,74,75,76,29],"Brain Tumor, Primary","Meningioma","Schwannoma","Pituitary Adenoma",[78,79,74,75,80,81],"Non-malignant brain tumor","Benign brain tumor","Pituitary adenoma","Benign glioma","RECRUITING","2024-11-30",{"date":85,"type":51},"2024-12-03",{"date":87,"type":51},"2001-01-01",{"date":89,"type":21},"2035-12-31",{"name":91,"class":58},"Seoul National University Hospital",1]