[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"glucose-intolerance-after-a-recent-history-of-gestational-diabetes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:glucose-intolerance-after-a-recent-history-of-gestational-diabetes":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100483033","phase-3-semaglutide-for-the-treatment-of-glucose-intolerance-in-women-with-prior-gestational-diabetes-100483033",false,"NCT05569772","Semaglutide for the Treatment of Glucose Intolerance in Women With Prior Gestational Diabetes","Semaglutide for the Treatment of Glucose Intolerance in Women With Prior Gestational Diabetes: a Double Blind RCT","SERENA","Inclusion Criteria:\n\n1. Voluntary written informed consent of the participant has been obtained prior to any screening procedures\n2. Women aged ≥18 years\n3. Use of highly effective methods of birth control\n4. History of GDM diagnosed according to the 2013 WHO criteria (at 24-32 weeks gestation or \\\u003C24 weeks for early GDM)\n5. Diagnosis of prediabetes between 6 weeks and 12 months postpartum according to ADA criteria (FPG 5.6-6.9 mmol\u002FL, 2-hour OGTT glucose 7.8-11.0 mmol\u002FL and\u002For HbA1c 39-46 mmol\u002Fmol \\[5.7-6.4%\\])\n\nExclusion Criteria:\n\n1. Presence of autoantibodies suggestive of type 1 diabetes, normal glucose tolerance, history of pancreatitis, previous bariatric surgery or planned surgery within two years\n2. Unable to understand and speak Dutch, French or English\n3. Female who is pregnant or intends to become pregnant within the next year\n4. Female who wants to give breastfeeding \\>22 months\n5. Use of medication with significant impact on glycaemia (such as high dose glucocorticoids or metformin)","FEMALE","18 Years",{"count":20,"type":21},252,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","Gestational diabetes (GDM) is an important contributor to the increasing prevalence of type 2 diabetes (T2DM). Women with glucose intolerance in early postpartum are a particularly high-risk group with about 50% who will develop T2DM within 5 years after the delivery. Moreover, women with a history of GDM progress more rapidly to T2DM compared to women with similarly elevated glucose levels. Early intervention after the index pregnancy is therefore crucial to prevent T2DM. With the SERENA project, the investigators aim to reduce the risk to develop T2DM with the long-acting GLP-1 agonist semaglutide in women with a recent history of GDM and glucose intolerance in early postpartum.",[27],"Glucose Intolerance After a Recent History of Gestational Diabetes",[29,30,31,32,33,34],"gestational diabetes","glucose intolerance postpartum","prevention","type 2 diabetes","GLP-1 agonist","semaglutide","RECRUITING","2026-05-28",{"date":38,"type":39},"2026-06-02","ACTUAL",{"date":41,"type":39},"2023-09-14",{"date":43,"type":21},"2029-12",{"name":45,"class":46},"Universitaire Ziekenhuizen KU Leuven","OTHER",13]