[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"glucose-tolerance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:glucose-tolerance":35},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,72,103],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":44,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":71},"100629969","impact-of-training-load-on-the-gut-microbiome-and-its-relation-to-exercise-performance-muscle-phenotype-and-markers-of-overreaching-in-healthy-men-100629969",false,"NCT07481578","Impact of Training Load on the Gut miCrobiome And Its Relation to exeRcise Performance, mUscle Phenotype, and markerS of Overreaching in Healthy Men","ICARUS: Impact of Training Load on the Gut Microbiome and Its Relation to Exercise Performance, Muscle Phenotype, and Markers of Overreaching in Healthy Men: Phase A - Human Trial","ICARUS","Inclusion criteria:\n\n* Males between 18 and 45 years old.\n* Recreationally active individuals, with a weekly exercise training volume between one and six hours per week.\n* Good health status confirmed by a sport medical screening, which includes a sport medical questionnaire and resting electrocardiogram.\n* Body Mass Index (BMI) between 18.5 and 27.5 kg\u002Fm².\n* Masters the Dutch language.\n\nExclusion criteria:\n\n* Engagement in strenuous competitive sports one month prior to or during the study intervention.\n* Medication and vaccination: Pro- or antibiotic treatment during the past three months, non-steroidal anti-inflammatory drugs (NSAIDs) or cholestyramine during the past month, drugs interfering with intestinal permeability (e.g., prokinetics, laxatives, lubiprostone, loperamide, anti-spasmodics, linaclotide, proton pump inhibitors) during the past month. Vaccinations within one month prior to or during the study intervention.\n* Blood donations within three months or plasma donation within one month prior to or during the study intervention.\n* Inflammatory bowel disease (Crohn or colitis ulcerosa) or celiac disease.\n* Diagnosed irritable bowel syndrome.\n* Intake of any performance-enhancing medication or nutritional supplements known to modulate the gut microbiome in the two months prior to or during the study.\n* Substance abuse, including alcohol consumption of more than three units\u002Fday (weekly average).\n* Any injury or pathology considered a contraindication for performing physical exercise, as determined by the medical doctor overseeing the preparticipation medical screening.\n* No access to smartphone and\u002For computer with internet access.\n* No willingness to use the Polar Flow app and MijnEetmeter to collect physical activity, heart rate, sleep, and food intake data.\n* Concomitant participation in another interventional trial, without approval from the research team.\n* Any other reasons considered by the research team that the participant will not complete the study.",true,"MALE","18 Years","45 Years",{"count":22,"type":23},45,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this study is to learn how different amounts of supervised indoor cycling training change gut health (gut bacteria, the substances gut bacteria make, and the gut barrier integrity), and how these changes relate to changes in fitness, muscle health, and signs of doing too much training (a state called 'overreaching'). The study includes healthy, recreationally active men aged 18 to 45 years.\n\nThe primary questions, for which the study is powered (sufficient participants included), are:\n\n1. Does moderate load training change blood and faecal levels of butyrate (a short-chain fatty acid made by gut bacteria) after eight weeks compared with a control group?\n2. Compared to moderate load training, do higher training loads lead to different responses in blood and faecal levels of butyrate?\n\nResearchers will compare:\n\n* A control group that does not complete structured training;\n* A moderate-load training group that completes eight weeks of supervised cycling (4x\u002Fweek);\n* A high-load training group that completes four weeks of moderate-load training followed by four weeks of higher training load (twice the number of training sessions).\n\nParticipants will:\n\n* Be randomly assigned to one of the three groups;\n* Complete 8 weeks of supervised indoor cycling sessions if assigned to a training group;\n* Complete four study assessment periods (baseline, after week four, after week eight, and after a short taper (rest period);\n* Provide blood, stool, skeletal muscle, urine, saliva, and breath samples during the assessment periods;\n* Complete fitness and performance tests and questionnaires during the assessment periods.",[29,30,31,32,33,34,35,36,37,38,39,40,41,42,43],"Exercise","Overreaching","Butyrate","Gut Microbiome","Exercise Performance","Skeletal Muscle","Glucose Tolerance","Hormones","Vascular Health","Muscle Adaptation","Physical Fitness","Heart Rate Variability (HRV)","Anthropometric Measurements","Metabolic Health","Food Intake",[45,46,47,48,49,50,51,52,30,53,54,55,40,56,57,58],"Exercise training","Training load","Overload training","Fecal butyrate","Gut health","Exercise performance","Muscle phenotype","Physical fitness","Glucometabolic health","Vascular health","Muscle adaptation","Anthropometrics","Metabolic health","Food intake","RECRUITING","2026-03-16",{"date":62,"type":63},"2026-03-19","ACTUAL",{"date":65,"type":63},"2024-10-07",{"date":67,"type":23},"2027-05-31",{"name":69,"class":70},"Stefan De Smet","OTHER",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":17,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":24,"phases":83,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":71},"100578263","evaluation-of-sex-differences-in-glucose-metabolism-in-response-to-sleep-curtailment-100578263","NCT06809023","Evaluation of Sex Differences in Glucose Metabolism in Response to Sleep Curtailment","Inclusion Criteria:\n\n* Healthy adults with conventional sleep-wake timing\n* Non-smokers\n* Completion of medical, psychological, and sleep screening tests\n* Able to spend 5 consecutive days\u002Fnights in the laboratory on two separate occasions (total of 10 days\u002Fnights in the laboratory)\n* Women must have a recent history of regular menstrual cycles\n\nExclusion Criteria:\n\n* History of neurological or psychiatric disorder\n* History of sleep disorder or regular use of sleep-promoting medication\n* Current prescription, herbal, or over-the-counter medication use including hormonal birth control\n* Traveling across 2 or more time zones within past 3 months\n* Donating blood within past 8 weeks\n* Worked night or rotating shift work within past year\n* Hearing impairment, visual impairment\n* History of eye trauma or surgery\n* Drug or alcohol dependency","ALL","20 Years","40 Years",{"count":82,"type":23},32,[26],"The goal of this study is to learn whether insufficient sleep affects glucose metabolism differently in healthy men and women.",[86,87,35],"Sleep Deprivation","Sex Differences",[89,90,91,92],"glucose metabolism","sleep deprivation","sex differences","GLP-1","NOT_YET_RECRUITING","2025-12-09",{"date":96,"type":63},"2025-12-10",{"date":98,"type":23},"2026-04",{"date":100,"type":23},"2029-02",{"name":102,"class":70},"Brigham and Women's Hospital",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":17,"sex":78,"minAge":111,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":24,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":71},"100572742","the-impact-of-a-48-hour-fast-with-or-without-exercise-on-immune-cell-metabolism-and-glycemic-control-in-healthy-active-adults-100572742","NCT06737224","The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Metabolism and Glycemic Control in Healthy Active Adults","The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Function, Bioenergetics, and Glycemic Control in Healthy Active Adults: a Randomized Crossover Trial","FASTEX","Inclusion Criteria:\n\n* Aged between 19 and 35 years.\n* Physically active (engaging in ≥150 minutes of weekly moderate to vigorous physical activity).\n\nExclusion Criteria:\n\n* History of cardiometabolic diseases or inflammatory diseases (e.g., chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, cardiovascular disease).\n* Individuals currently following a ketogenic diet, low-calorie diet, periodic fasting regimen, or consuming ketogenic supplements (e.g., exogenous ketone drinks).\n* Cigarette\u002Fvaping smoking.\n* Physical limitation that will impair the ability of the participant to perform exercise.\n* Individuals having a body mass index (BMI) over 30 kg\u002Fm2.\n* Cancer diagnosis in the past 5 years.\n* Taking anti-inflammatory drugs (e.g., ibuprofen, aspirin, naproxen).\n* Being unable to read or communicate in English.","19 Years","35 Years",{"count":114,"type":23},15,[26],"Many individuals engage in fasting for its purported health benefits but the effects of fasting on immune cell and whole body metabolism are not well understood in humans. Moreover, how exercising during a prolonged fast impacts immunometabolic outcomes is unclear. This study will determine how a 2 day fast - performed with or without daily exercise - impacts immune cell bioenergetics, immune cell function, and whole-body glycemic control in healthy active individuals.",[118,119,35],"Fasting","Immune Function",[29,121,122],"Immunometabolism","Glycemic control","2025-03-04",{"date":125,"type":63},"2025-03-07",{"date":127,"type":63},"2025-01-10",{"date":129,"type":23},"2025-08-01",{"name":131,"class":70},"University of British Columbia"]