[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"glymphatic-system\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:glymphatic-system":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,75,103],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100637607","sleep-and-performance-100637607",false,"NCT07608614","Sleep and Performance","Augmented Neurophysiology of Sleep and Performance Readiness","MTEC Phase 2","Inclusion Criteria:\n\n1. Physically and psychologically healthy\n2. Good habitual sleep between 6 and 10 hours in duration, as assessed by questionnaire and pre-study week sleep\u002Fwake diary\n3. Regular bedtimes, habitually getting up between 05:00 and 09:00, as assessed by questionnaire and pre-study week sleep\u002Fwake diary\n\nExclusion Criteria:\n\n* Subjects who have any type of non-MRI compatible bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps, etc.), because such devices may be displaced or malfunction.\n* Subjects who have any type of ferromagnetic bioimplant that could potentially be displaced.\n* Subjects who have cerebral aneurysm\n* Subjects who may have shrapnel imbedded in their bodies (such as from war wounds), metal workers and machinists (potential for metallic fragments in or near the eyes).\n* Minors (younger than 18 years)\n* Pregnant women ( Participants of childbearing potential will receive a urine pregnancy test. If the test is positive, the participant will be excluded)\n* Breastfeeding\n* Subjects who cannot adhere to the experimental protocols for any reason, or have an inability to communicate with the researcher.\n* no clinical disorders and\u002For illnesses, no psychiatric illnesses), as assessed by history and questionnaires\n* no alcohol during study and no normal excessive alcohol consumption assessed by questionnaire\n* No history of drug or alcohol abuse in the past year and no history of methamphetamine abuse, as assessed by questionnaires.\n* Not a dependent smoker or vaper, and not morning dependent on tobacco, nicotine, or cannabis, as assessed by questionnaire.\n* No history of moderate to severe brain injury, as assessed by questionnaire\n* No anti-psychotic medication for ADHD\u002FADD, as assessed by questionnaire\n* No previous adverse reaction to sleep deprivation, as assessed by questionnaire\n* Not vision-impaired unless corrected back to normal.\n* Not hearing impaired unless corrected to normal, as assessed by questionnaire\n* Not pregnant, as assessed by history and questionnaire\n* No sleep or circadian disorder, as assessed by questionnaires\n* No use of melatonin within 1 week of study enrollment\n* No travel across more than one time zone within one month of entering the study and no crossing times zones during study participation, as assessed by questionnaire.\n* No shift work within three months of entering the study and no shift work during duration study participation, as assessed by questionnaire.\n* epilepsy",true,"ALL","18 Years","30 Years",{"count":22,"type":23},16,"ESTIMATED","INTERVENTIONAL",[26],"NA","This research is being done to apply new, contrast-free MRI (Magnetic Resonance Imaging) methods to understand the brain's waste clearance system (the \"glymphatic\" system) in younger adults. The Investigators hope the study will show how the different brain regions are involved in maintaining memories and how poor sleep affects these regions and our ability to remember. The Investigators will test whether the Wireless Interface Sensor Pod (WISP) improves brain function after poor sleep. The WISP is a headband that combines tracking brain waves and transcranial electrical stimulation (TES) to monitor and improve slow wave sleep and glymphatic clearance.\n\nIParticipants will be asked to:\n\n* Complete 4 in-person study visits (1 per week) over 4 weeks at the Diagnostic Imaging Sciences Center (DISC), located at the University of Washington Medical Center at Montlake, Seattle. Each visit will last 2 hours and includes a 1 hour MRI and 1 hour of cognitive testing.\n* Complete a daily journal about sleep, daily habits, etc.\n* The night before each of the four study visits, participants will sleep while wearing the WISP headband.\n\n  * For two of these nights, participants will sleep only 3 hours prior to normal time of awakening. The WISP will deliver a small electrical current for one night and not for the other night, but participants will not know which.\n  * For the other two nights, participants will follow a normal sleep schedule. The WISP will deliver a small electrical current for one night and not for the other night, but participants will not know which.",[29,30],"Sleep","Glymphatic System",[32,33,34],"sleep","glymphatic system","cognitive function","RECRUITING","2026-05-19",{"date":38,"type":39},"2026-05-27","ACTUAL",{"date":41,"type":39},"2025-10-01",{"date":43,"type":23},"2027-06",{"name":45,"class":46},"University of Washington","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100638745","light-therapy-to-improve-sleep-in-tbi-sleep-active-biomarkers-and-glymphatic-function-100638745","NCT07601841","Light Therapy to Improve Sleep in TBI: Sleep-active Biomarkers and Glymphatic Function","Light Therapy to Improve Sleep in Veterans With TBI: Sleep-active Biomarkers and Glymphatic Function","GLIMPSE-LION","All subjects must:\n\n1. Male and female; any race; 18-89 years of age.\n2. Be English speaking.\\*\n3. Be accessible via phone.\n4. Be non-decisionally impaired. Determined by assessing the subject's ability to verbalize their understanding of the protocol back to us during the informed consent process.\n5. Not have a history of macular degeneration.\n6. Not have a history of bipolar disorder.\n7. Not be currently using a lightbox or a negative ion generator.\n8. Not be a shift worker.\n9. Have a documented history of TBI via the Head Trauma Events Characteristics (HTEC) or OHIO conducted in accordance with VA\u002FDoD Clinical Practice Guidelines.88\n10. Present with self-reported sleep-wake disturbances.\n11. Remain clinically stable for current pharmacologic treatment related to depression\u002Fanxiety, sleep, and pain.\n12. MRI specific compatibility requirements:\n\n    * No pacemaker, wires, defribrillator or implanted heart valves\n    * No history of head surgery requiring aneurysm clips\n    * No history of other orthopedic or general surgery requiring the implantation of ferrous pins, joints, electric devices\u002Fpumps, or other foreign metal objects\n    * History of eye exposure to metal (unprotected welding\u002Fmetalworking\u002Fshrapnel) is allowable provided the participant screens negative for metal in the eyes on an orbital x-ray or is able to provide clinical documentation of having screened negative.\n    * No history of non-removable hearing aids, middle\u002Finner ear prosthesis, or dentures\n    * No history of claustrophobia; if unsure participant will be pre-screened in our mock scanner\n    * Not currently pregnant, breastfeeding, or have an implanted IUD. Participants who are unsure of their pregnancy status will be administered an hCG urine pregnancy test the day of their scan.\n    * Able to lay flat on their back comfortably without a thick pillow for an extended period of time.\n    * Shoulder width does not exceed width for safety fitting in the MRI bore.\n\n      * This study is limited to English-speaking participants because all assessments, interventions, and consent materials are currently validated and approved only in English. Expanding to other languages would require translation and psychometric validation, which are beyond the scope and budget of this study. This limitation is acknowledged and will be addressed in future research as resources permit. Finally, the study team is only fluent in English, making it infeasible to accurately consent or interact with non-English speakers without interpreting services which again is outside of the scope of this projects budget and timeline. Proceeding without formal translation services would risk miscommunication in informed consent, data collection, or participant support and thus protects participants informed consent and participant understanding.","89 Years",{"count":58,"type":23},300,[26],"This is a clinical trial designed to examine how improved sleep through morning bright light therapy is improving downstream key physiologic processes related to brain health, i.e., mitochondrial function, systemic inflammation, and glymphatic function. All proposed methodology is already approved in other IRB applications.",[29,62,30,63,64,65],"Phototherapy","Mitochondrial Dynamics","Brain Injuries, Traumatic","Inflammation","2026-05-18",{"date":68,"type":39},"2026-05-22",{"date":70,"type":39},"2025-12-12",{"date":72,"type":23},"2030-09-30",{"name":74,"class":46},"Oregon Health and Science University",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":47},"100589106","advanced-neuroimaging-in-idiopathic-intracranial-hypertension-100589106","NCT06950099","Advanced Neuroimaging in Idiopathic Intracranial Hypertension","Pathophysiological Evaluation of Idiopathic Intracranial Hypertension Using Glymphatic and Connectomic Imaging","IIH","Inclusion Criteria:\n\n• Refractory IIH patients who require and plan to have a venous sinus stenting\n\nExclusion Criteria:\n\n* History of head trauma and shunting or leak repair\n* Major concurrent, active non-cephalic pain syndrome\n* Contradictions for MRIs","55 Years",{"count":85,"type":23},30,"OBSERVATIONAL","Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure leading to symptoms like papilledema, headache, and cognitive dysfunction. While the etiology is complex, abnormal cerebrospinal fluid dynamics due to venous outflow restriction from transverse sinus stenosis (TSS) is common. TSS may disrupt the glymphatic system, a brain-wide network facilitating cerebrospinal fluid and interstitial fluid exchange, by impairing CSF absorption, altering perivascular space dynamics, and disrupting pressure gradients crucial for waste clearance. Venous sinus stenting (VSS) can improve symptoms in many patients by alleviating venous congestion, but its effects on glymphatic function are unclear. This prospective study aims to evaluate novel quantitative brain imaging metrics as surrogate markers to better understand IIH pathophysiology before and after VSS in patients with refractory IIH and TSS. The investigators will use advanced MRI techniques, including MR elastography (MRE) to assess brain stiffness, diffusion tensor imaging (DTI) to evaluate water diffusion, arterial spin labeling (ASL) imaging to measure blood-brain barrier (BBB) permeability, and functional MRI to analyze pain networks. The investigators hypothesize that 1) these noninvasive imaging metrics will correlate with the degree of venous congestion and changes after venous sinus stenting (VSS) and 2) the imaging findings will correlate with clinical treatment outcomes. By correlating imaging markers with venous pressures and symptom changes, the investigators aim to gain insights into IIH mechanisms, expand diagnostic tools, and potentially guide clinical decision-making and treatment response monitoring. The overarching goal is to better understand IIH's underlying pathophysiology, which could lead to improved diagnostic criteria, more targeted treatments, and better prediction of treatment outcomes for patients with this challenging condition.",[89,30],"Idiopathic Intracranial Hypertension (IIH)",[91,92,93,81],"idiopathic intracranial hypertension","MRI","diffusion tensor imaging","2025-04-29",{"date":96,"type":39},"2025-05-02",{"date":98,"type":39},"2025-03-03",{"date":100,"type":23},"2025-12-31",{"name":102,"class":46},"Thomas Jefferson University",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":18,"minAge":20,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":112,"conditions":113,"keywords":4,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":4},"100582043","research-on-the-brain-glymphatic-system-of-parkinsons-disease-patients-based-on-dti-technology-100582043","NCT06858176","Research on the Brain Glymphatic System of Parkinson's Disease Patients Based on DTI Technology","Inclusion Criteria:(1) All the selected candidates were diagnosed in accordance with the \"Diagnostic Criteria for Parkinson's Disease in China\" (2016 edition) formulated by the International Society of Parkinson's Disease and Movement Disorders and the Parkinson's Disease and Movement Disorders Group and Special Committee of China; (2) Able to cooperate with and tolerate cranial magnetic resonance examination; (3) All are effective against dopamine drugs.\n\n\\- Exclusion Criteria:(1) secondary parkinsonism (such as after encephalitis, long-term use of neuroleptics such as phenothiazines and butyryls and other drugs such as reserpine, history of toxic exposure, history of vascular diseases such as cerebral infarction or hemorrhage in the basal ganglia, history of traumatic brain injury, abnormal thyroid function, etc.); (2) Parkinson's superposition syndrome (such as progressive supranuclear palsy, olivine pontine cerebellar atrophy, corticobasal ganglia degeneration, Lewy body dementia, Shv. Dräger syndrome, etc.); (3) hereditary degenerative parkinsonism; (4) Patients with diabetes mellitus and end-stage renal disease; (5) Those with contraindications to magnetic resonance examination.\n\n\\-","82 Years",{"count":111,"type":23},150,"Synopsis：The brain glymphatic system is a newly discovered anatomical system for removing waste products and maintaining homeostasis in the brain, and its damage is closely related to a variety of neurological diseases. The diffusion tensor image-analysis along the perivascular space (DTI-ALPS) technique has the advantage of being non-invasive and has been shown to be useful for assessing brain glymphatic system function. The purpose of this study is to use DTI-ALPS technology to evaluate the functional changes of the brain glymphatic system in patients with primary Parkinson's disease at different stages of the disease .\n\nImpact:DTI-ALPS technology is a potential imaging indicator for early diagnosis and monitoring of Parkinson's disease progression, and has definite value for clinical application.\n\nPurpose :the functional changes of brain glymphatic system in patients with Parkinson's disease at different stages of the disease will be investigated based on DTI-ALPS technology Methods:The clinical data of 100 patients with primary Parkinson's disease will be admitted to the First People's Hospital of Yunnan Province from March 2025 to April 2026 wil be prospectively collected, and they will be divided into two groups: 50 patients with early Parkinson's disease and 50 patients with late Parkinson's disease according to the Hoehn-Yahr Scale , and 50 healthy volunteers (HC) matched with them will be collected. All subjects will be scanned with a 3.0 T MRI system（MAGNETOM Prisma,Siemens Healthcare,Erlangen,Germany）.The scanning sequences included conventional MRI noncontrast and DTI sequences, which acquired images of b=0 s\u002Fmm² and b=1000 s\u002Fmm²4. FSL and ITK-SANP software will be used to delineate circular ROIs with voxel diameters of 5 mm in the projection fiber and contact fiber regions at the bilateral ventricular body level of the anisotropy score map, and the diffusivity of each fiber on the x, y, and z axes will be measured, and the DTI-ALPS index value will be calculated, and the one-way ANOVA wii be performed by IBM SPSS statistic 25.0 software, and the differences in the mean ALPS values of the left brain, right brain, and both sides of the subjects in the three groups will be compared. The correlation between the index and clinical data such as age, course of disease, Mini-Mental State Examination Score (MMSE), Montreal Cognitive Assessment Scale, Quality of Life Questionnaire for Patients with Parkinson's Disease (PDQ-39), Parkinson's Disease Non-motor Symptom Evaluation Scale (NMSS), Hamilton Depression Rating Scale score(HAMD), and Unified Parkinson's Rating Scale score (URPDS)will be analyzed.",[30,114,115],"Parkinson's Disease (PD)","DTI","NOT_YET_RECRUITING","2025-02-27",{"date":119,"type":39},"2025-03-05",{"date":121,"type":23},"2025-03",{"date":123,"type":23},"2026-04",{"name":125,"class":46},"The First People's Hospital of Yunnan"]