[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gonarthrosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gonarthrosis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,48,82,108,140,171,203,235,263,286,307],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100643903","phase-2-functional-brain-mri-to-understand-pain-phenotypes-in-knee-osteoarthritis-100643903",false,"NCT07668674","Functional Brain MRI to Understand Pain Phenotypes in Knee Osteoarthritis","Functional Brain MRI to Understand Pain Phenotypes in Knee Osteoarthritis: a Multicenter Comparative Pilot Study","INDIGO","Inclusion Criteria:\n\n* Women aged 40 or older (only women will be included to ensure consistency in the analyses, given the higher prevalence of osteoarthritis in women and the influence of sex\u002Fgender on the experience of pain)\n* Diagnosis of femorotibial osteoarthritis of the knee according to the 1986 American College of Rheumatology criteria\n* Presence of knee pain with an intensity of ≥ 4\u002F10 on a numerical rating scale (NRS)\n* Chronic knee pain, i.e., lasting at least 6 months with at least 15 days of pain in the past 30 days\n* Completion of the PainDETECT questionnaire, which will allow the patient to be assigned to one of two groups prior to the enrollment visit (those with nociceptive pain \\[score ≤ 12\\] and those with neuropathic pain \\[score \\> 13\\])\n* Patients have read and understood the information letter\n* Patients have signed the informed consent form\n* Patients are enrolled in a social security program\n\nExclusion Criteria:\n\n* Other joint diseases affecting the knees (gout, chondrocalcinosis, rheumatoid arthritis, spondyloarthritis, psoriatic arthritis)\n* Conditions that, in the investigator's opinion, interfere with the assessment of osteoarthritic pain, such as conditions causing neuropathic pain in the lower extremities (e.g., peripheral neuropathy, chronic radiculopathy) or fibromyalgia\n* Kellgren-Lawrence radiographic stage IV in one or both knees\n* Patients with one or more knee prostheses\n* Claustrophobia making MRI impossible\n* Contraindication to MRI\n* Pregnant or breastfeeding women\n* Patients under guardianship, conservatorship, deprived of liberty, or under judicial protection\n* Patients who have participated in an interventional clinical trial within the last 6 months that could impact the primary endpoint","FEMALE","40 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","Some people with knee osteoarthritis (gonarthrosis) experience pain differently. In some, the pain is described as \"nociceptive\" (directly related to the joint), while in others it has \"neuropathic\" characteristics (related to nerve function).\n\nThe goal of this multicenter, cross-sectional and comparative study is to compare resting brain activity in a brain region called the anterior insula among female patients with painful knee osteoarthritis who experience nociceptive pain compared to those with neuropathic pain.\n\nResearchers will compare brain activity at rest between these two types of pain in women over 40 with painful knee osteoarthritis. A better understanding could help improve pain management in the future.\n\nParticipants will be asked to :\n\n* complete questionnaires during the inclusion visit and on the day of the scan,\n* undergo a clinical examination and a blood test at the inclusion visit,\n* undergo a functional MRI (fMRI), an imaging test that allows observation of brain activity at rest.\n\nPaticipants in the study does not involve any additional treatment. the fMRI scan is non-invasive and does not require any injections.",[27,28],"Gonarthrosis","Neuropathic Pain, Nociceptive Pain",[27,30,31,32,33,34,15],"Neuropathic pain","Nociceptive Pain","Functional MRI","Anterior insula","Brain activity in the anterior insula at rest","NOT_YET_RECRUITING","2026-06-23",{"date":38,"type":39},"2026-06-25","ACTUAL",{"date":41,"type":21},"2026-07",{"date":43,"type":21},"2028-08",{"name":45,"class":46},"University Hospital, Clermont-Ferrand","OTHER",3,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100634015","prospective-cohort-study-evaluating-a-thermal-spa-programme-in-symptomatic-knee-osteoarthritis-100634015","NCT07534189","Prospective Cohort Study Evaluating a Thermal Spa Programme in Symptomatic Knee Osteoarthritis","Prospective Cohort Study Evaluating a Thermal Spa Programme for the Management of Symptomatic Knee Osteoarthritis","THERMOG","Inclusion Criteria:\n\n* Adults aged 50 years or older\n* Diagnosis of knee osteoarthritis affecting at least one knee, with radiographic Kellgren-Lawrence grade ≥ 2 confirmed by an X-ray performed within the past 3 years\n* Average knee pain intensity \\> 30 mm on a 100-mm Visual Analog Scale (VAS) during the month prior to inclusion\n* Participants scheduled to undergo a 3-week thermal spa treatment at the Balaruc-les-Bains thermal center\n\nExclusion Criteria:\n\n* Use of systemic or injectable corticosteroids within 1 month prior to inclusion\n* Intra-articular injection of hyaluronic acid or platelet-rich plasma (PRP) within the 3 months prior to inclusion\n* Active inflammatory joint disease (e.g., rheumatoid arthritis, spondyloarthritis, or crystal-induced arthropathies)\n* Current major depressive episode or psychotic disorders\n* Thermal spa treatment within the previous 6 months\n* Inability to read or write\n* Inability to complete follow-up for the entire study period (e.g., planned relocation, travel, professional commitments, or residence located more than 100 km from the study site)\n* Lack of informed consent\n* Pregnant or breastfeeding women\n* Individuals under legal protection (guardianship or curatorship)\n* Not affiliated with a national health insurance system\n* Individuals under judicial protection (safeguard of justice)\n* Participation in another clinical study with an ongoing exclusion period","ALL","50 Years",{"count":59,"type":21},300,[61],"NA","Knee osteoarthritis is a common cause of pain, functional limitation, and reduced quality of life in older adults. Thermal spa treatment is widely used as a non-pharmacological intervention for the management of osteoarthritis symptoms, but its effects on joint movement and motor control remain insufficiently characterized using objective biomechanical measures. This study evaluates the effects of a 3-week thermal spa treatment on knee joint movement in patients with knee osteoarthritis. Knee movement fluidity and gait parameters will be analyzed during standardized tasks using wearable inertial sensors (Xsens). Secondary outcomes include changes in pain, physical function, physical activity, quality of life, and blood transcriptomic profiles. Assessments will be performed at baseline, after treatment, and at 3- and 12-month follow-up visits. In addition, blood samples will be collected before and after the intervention to explore transcriptomic changes associated with the treatment.\n\nThis project proposes a combination of innovative kinematic and biological biomarkers with the aim of objectively describing the benefits of spa therapy for people with knee osteoarthritis.",[27],[65,66,67,68,69,70,71],"Knee osteoarthritis","Spa Therapy","Gait analysis","Inertial sensors","Kinematics","Mobility","Transcriptomics","2026-06-11",{"date":74,"type":39},"2026-06-15",{"date":76,"type":21},"2026-07-01",{"date":78,"type":21},"2029-07-01",{"name":80,"class":46},"University Hospital, Montpellier",1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":56,"minAge":90,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":93,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":107},"100586807","infiltration-or-nerve-blocks-in-addition-to-adductor-canal-block-100586807","NCT06920186","Infiltration or Nerve Blocks in Addition to Adductor Canal Block","Comparison of the Benefit of Peripheral Nerve Quadri-block Versus Adductor Canal Block + Surgical Infiltration in Total Knee Arthroplasty","INCA","Inclusion Criteria:\n\n* Adult male or female\n* Patient with signed consent to participate in the study,\n* Patient with uni or bilateral primary gonarthrosis\n* Indication for total knee arthroplasty.\n\nExclusion Criteria:\n\n* History of knee fracture, arthroplasty or osteotomy\n* Known or unknown contraindication to ALR or locoregional anesthesia products\n* Neurological disease, stroke sequelae\n* Mental deficiency or any other reason that may hinder understanding or strict application of the protocol\n* Patient not affiliated to the French social security system\n* Patient under court protection, guardianship or curatorship\n* Pregnant or potentially pregnant women (women of childbearing age without effective contraception)\n* Patient already included in another therapeutic study protocol","18 Years",{"count":92,"type":21},100,[61],"The aim of this study is to evaluate the analgesic efficacy of this quadruple sensory block compared with the currently recommended procedure (adductor canal block + infiltration).",[27,96],"Total Knee Arthroplasty","RECRUITING","2026-06-03",{"date":100,"type":39},"2026-06-05",{"date":102,"type":39},"2026-05-04",{"date":104,"type":21},"2027-06",{"name":106,"class":46},"GCS Ramsay Santé pour l'Enseignement et la Recherche",2,{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":56,"minAge":90,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":81},"100476677","the-impact-of-single-shot-adductor-canal-block-versus-continuous-femoral-nerve-block-on-rehabilitation-after-total-knee-replacement-100476677","NCT05487053","The Impact of Single-shot Adductor Canal Block Versus Continuous Femoral Nerve Block on Rehabilitation After Total Knee Replacement","The Impact of Single-shot Adductor Canal Block Versus Continuous Femoral Nerve Block on Rehabilitation After Total Knee Replacement (AdORe - ACB)","Inclusion Criteria:\n\n* Age ≥ 18\n* Planned primary total knee replacement\n* Planned neuraxial anesthesia\n* Written informed consent\n\nExclusion Criteria:\n\n* Urgent surgery\n* Planned revision total knee replacement\n* Known allergic reaction to anesthetics\n* Confirmed localized infection at the puncture sites\n* Confirmed localized tumor at the puncture sites\n* Peripheral neuropathy of the lower extremities\n* Parkinson's disease\n* Previously enrolled in this trial",{"count":116,"type":21},220,[61],"Total knee replacement (TKR) is considered the most effective and safe method of radical treatment of late stages of knee osteoarthritis. A well-known problem of TKR is a severe postoperative pain syndrome, which is observed in more than 50% of patients.\n\nFemoral nerve block (FNB) is the \"gold standard\" for continuous postoperative analgesia after total knee replacement, as it is effective in reducing the frequency of use of opioid analgetics and reduce the duration of hospitalization. At the same time, the negative effect of this method is the motor blockade of the quadriceps femoris muscle which leads to functional impairment and is associated with an increased risk of falling.\n\nAdductor canal block (ACB) provides adequate analgesia comparable to femoral nerve block. Moreover, ACB doesn't affect the motor function of the quadriceps femoris muscle.\n\nThe possibility of enhanced recovery after total knee replacement is the reason to compare single-shot adductor canal block and continuous femoral nerve block.",[120,27],"Osteo Arthritis Knee",[120,27,122,123,124,125,126,127,128,129],"Regional anesthesia","Analgesia","Postoperative analgesia","Total knee replacement","Continuous femoral nerve block","Femoral nerve block","Continuous adductor canal block","Adductor canal block","2026-04-10",{"date":132,"type":39},"2026-04-15",{"date":134,"type":39},"2024-02-03",{"date":136,"type":21},"2028-07-01",{"name":138,"class":139},"Negovsky Reanimatology Research Institute","OTHER_GOV",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":22,"phases":150,"briefSummary":151,"conditions":152,"keywords":155,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":81},"100619016","the-effects-of-intra-articular-and-peri-articular-platelet-rich-plasma-prp-injections-n-chronic-knee-osteoarthritis-100619016","NCT07339137","The Effects of Intra-articular and Peri-articular Platelet-rich Plasma (PRP) Injections ın Chronic Knee Osteoarthritis","The Effects of Platelet-rich Plasma (PRP) Injections Administered Into Intra-articular and Periarticular Regions Under Ultrasound Guidance in Chronic Knee Osteoarthritis on Pain, Function, Activities of Daily Living, Medial Collateral Ligament (MCL) and Distal Femoral Cartilage Thickness","Inclusion Criteria\n\n* Age between 40 and 65 years.\n* Patients with significant medial knee pain who have not responded to conservative treatment for at least 3 months.\n* Patients diagnosed with knee osteoarthritis according to the American College of Rheumatology (ACR) criteria and with Kellgren-Lawrence grade 2 or 3 radiographic osteoarthritis.\n* Intact cognitive function.\n* Willingness to participate in the study and provide signed informed consent.\n* Visual Analog Scale (VAS) score of 4 or higher.\n\nExclusion Criteria\n\n* History of previous knee trauma or surgery.\n* Physical therapy, intra-articular steroid, or hyaluronic acid injections in the knee within the last 3 months.\n* Active oncological diseases.\n* Local infection, sepsis, wounds, or scars in the injection area.\n* Systemic infections, hepatitis, or immunosuppression.\n* Bleeding diathesis or irregular International Normalized Ratio (INR) due to oral warfarin use.\n* Inflammatory arthropathies.\n* Uncontrolled hypertension, uncontrolled diabetes mellitus, decompensated heart failure, coronary artery disease, or asthma.\n* Suspected or confirmed pregnancy.\n* Use of corticosteroids or opioids.\n* Anemia.\n* Body mass index (BMI) greater than 35.\n* Allergy to citrate.\n* Use of nonsteroidal anti-inflammatory drugs (NSAIDs) within the last week that may affect platelet function analyzer-100 (PFA-100) activity.\n* Physical examination findings suggestive of patellar retinaculum, meniscus, or cruciate ligament injury.\n* General health impairment or lack of cooperation.\n* Refusal to participate in the study.","65 Years",{"count":149,"type":21},42,[61],"The primary objective of this study is to evaluate and compare the effectiveness of ultrasound-guided combined intra-articular and peri-articular platelet-rich plasma (PRP) injections with intra-articular PRP injections alone in patients with chronic knee osteoarthritis (OA). The study specifically examines the effects of these treatment approaches on pain, physical function, activities of daily living, and structural parameters, including medial collateral ligament (MCL) thickness and distal femoral cartilage thickness.\n\nOsteoarthritis is a degenerative joint disease characterized by progressive cartilage erosion, osteophyte formation, and subchondral sclerosis, leading to pain, stiffness, and functional disability. It is the most common form of arthritis and a leading cause of disability worldwide, affecting approximately 300 million individuals. Although the knee is the most frequently involved joint, OA is now recognized as a whole-joint disease, involving not only cartilage degeneration but also pathological changes in subchondral bone, synovium, and surrounding extra-articular structures.\n\nPlatelet-rich plasma is an autologous concentration of platelets suspended in a small volume of plasma and contains a variety of bioactive growth factors, such as transforming growth factor-beta (TGF-β), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF). These factors play a crucial role in promoting cell proliferation, angiogenesis, and tissue repair. In knee OA, PRP has been shown to reduce matrix metalloproteinase (MMP) activity, particularly MMP-13, enhance endogenous hyaluronic acid production, and support chondrogenesis. Although intra-articular PRP injections are widely accepted as a safe and effective treatment and have demonstrated superiority over placebo and hyaluronic acid in long-term follow-up studies, most existing research has focused exclusively on intra-articular applications.\n\nKnee OA is a multifactorial condition frequently associated with extra-articular pathologies, including ligament laxity, peri-articular edema, and soft tissue inflammation. Limiting treatment to the intra-articular space alone may therefore overlook these important contributors to pain and functional impairment. Emerging evidence suggests that a combined treatment approach targeting both intra-articular and peri-articular structures may provide superior outcomes in terms of pain reduction and functional improvement.\n\nThis prospective randomized controlled trial will include 42 patients aged 40-65 years with chronic knee OA classified as Kellgren-Lawrence grade 2 or 3. Participants will be randomly assigned to one of three groups: a control group receiving conservative treatment only (exercise therapy and lifestyle modifications), a group receiving conservative treatment plus ultrasound-guided intra-articular PRP injections, and a third group receiving conservative treatment plus combined ultrasound-guided intra-articular and peri-articular PRP injections targeting the MCL and pes anserinus regions.\n\nClinical outcomes will be assessed using validated instruments, including the Visual Analog Scale (VAS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Short Form-36 (SF-36) Quality of Life Scale. In addition, ultrasonographic measurements of MCL thickness and distal femoral cartilage thickness will be performed to evaluate structural changes. By investigating the additional value of peri-articular PRP injections, this study aims to contribute to the development of more comprehensive and effective injection protocols for the management of chronic knee osteoarthritis.",[153,154,27],"Platelet Rich Plasma Injection","Ultrasonography",[156,157,158,159,160,161],"knee osteoarthritis","periarticular","PRP","USG","Femoral Cartilage","Medial Collateral Ligament","2026-01-13",{"date":164,"type":39},"2026-01-15",{"date":166,"type":39},"2025-08-01",{"date":168,"type":21},"2026-04-30",{"name":170,"class":46},"Ankara City Hospital Bilkent",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":56,"minAge":179,"maxAge":4,"enrollmentInfo":180,"targetDuration":4,"studyType":22,"phases":182,"briefSummary":183,"conditions":184,"keywords":188,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":201,"locationsCount":81},"100608222","bimodal-vs-unimodal-high-intensity-pulsed-electromagnetic-field-therapy-in-older-adults-with-knee-osteoarthritis-100608222","NCT07198750","\"Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis\"","Effect of High-Intensity Pulsed Electromagnetic Field Therapy as a Bimodal Intervention for Analgesia and Strengthening in Older Adults With Knee Osteoarthritis: A Randomized Double-Blind Controlled Clinical Trial","HIPEMF-OAK","Inclusion Criteria:\n\n* Age ≥ 60\n* Clinical and radiological diagnosis of knee OA grade I-IV\n* Pain ≥ 3 on Numeric Analog Scale for \\>6 months\n* Can walk (with\u002Fwithout aid)\n* Cognitive ability to follow instructions\n* Signed informed consent\n* Availability for 9 treatment sessions and home exercise Exclusion Criteria\n* Prior total knee arthroplasty (unilateral or bilateral)\n* Neurological disorders affecting motor function or cognition (e.g., Parkinson's disease, stroke, moderate to severe dementia)\n* Active inflammatory rheumatic diseases (e.g., rheumatoid arthritis, lupus)\n* Presence of pacemakers, implantable defibrillators, or metallic implants near the treatment area\n* Current use of other physical therapy modalities for pain (e.g., electrotherapy, ultrasound, TENS) outside the study protocol\n* Participation in another clinical trial within the past 3 months\n* Current use of NSAIDs or systemic\u002Flocal corticosteroids (including intra-articular injections)\n* Open wounds or active infections at the treatment site\n* Decompensated cardiac conditions or medical contraindication to exercise\n* Vestibular disorders that affect balance and interfere with functional assessments\n* Uncorrected visual impairment interfering with gait or balance (visual acuity worse than 20\u002F60 in the better eye, assessed by Snellen chart)\n\nWithdrawal Criteria:\n\n* Participants who complete fewer than 7 out of the 9 planned intervention sessions (i.e., less than 80% adherence)\n* Occurrence of serious adverse events related to the intervention that contraindicate continuation\n* Repeated non-compliance with the home exercise program, documented in at least two consecutive weekly follow-up reports\n* Voluntary withdrawal of consent at any time during the study","60 Years",{"count":181,"type":21},64,[61],"This randomized, double-blind clinical trial aims to evaluate the effect of high-intensity pulsed electromagnetic field therapy (HI-PEMF) applied either exclusively on the knee joint or bimodally on the knee and quadriceps, in older adults with knee osteoarthritis. Both groups will also receive a structured home-based exercise program. The primary outcome is pain reduction, and secondary outcomes include functional performance.",[185,186,187,27],"Knee Osteoarthritis","Osteoarthritis","Osteo Arthritis of the Knee",[189,190,191,185,27,192,193,194],"High-Intensity Pulsed Electromagnetic Fields","HI-PEMF","Super Inductive System","Geriatric Rehabilitation","Chronic Pain","Functional Mobility","2025-09-22",{"date":197,"type":39},"2025-09-30",{"date":199,"type":39},"2025-09-15",{"date":132,"type":21},{"name":202,"class":46},"Hospital Civil de Guadalajara",{"id":204,"slug":205,"hasResults":11,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":4,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":56,"minAge":210,"maxAge":211,"enrollmentInfo":212,"targetDuration":4,"studyType":22,"phases":214,"briefSummary":215,"conditions":216,"keywords":217,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":81},"100586406","efficacy-of-ultrasound-guided-genicular-nerve-radiofrequency-ablation-therapy-100586406","NCT06914960","Efficacy of Ultrasound-Guided Genicular Nerve Radiofrequency Ablation Therapy","Ultrasound-Guided Genicular Nerve Radiofrequency Ablation Therapy: Effectiveness of 5 Nerve Protocols Versus 3 Nerve and 2 Nerve Protocols - A Prospective Randomized Controlled Study","Inclusion Criteria:\n\n* Age between 30-75\n* Chronic knee pain that lasts at least 6 months\n* Radiographic confirmation of osteoarthritis: Presence of Grade 3 or 4 radiographic changes characterized by significant narrowing in the medial space of the tibiofemoral joint according to the Kellgren-Lawrence classification system\n* Knee pain \\>40 mm when performing one of the two movements that cause the most severe pain (sitting to standing or going up and down stairs) according to 100 mm VAS\n\n  * 50% reduction in VAS with diagnostic genicular nerve block\n\nExclusion Criteria:\n\n* Presence of systemic inflammatory disease such as rheumatoid arthritis\n* Previous RFA treatment to the knee or hyaluronic acid or steroid injection to the knee within the last 3 months\n* History of previous knee surgery\n* Clinically significant structural abnormalities other than osteoarthritis that may lead to chronic knee pain\n* Having undergone physical therapy to the knee in the last 6 months or a history of knee trauma\n* Application of other pain treatments\n* Body-Mass İndex \\\u003C18 and \\>40 kg\u002Fm2\n* Pregnancy\n* Presence of uncontrolled serious illness (cancer, diabetes, etc.), infection, psychiatric disorder, coagulation disorder","30 Years","75 Years",{"count":213,"type":21},66,[61],"The main symptom of knee osteoarthritis, which occurs after damage to the joint cartilage with age, is pain, but this symptom often becomes chronic. Current conservative treatments have moderate effects on chronic knee pain and their use is limited due to the risk of side effects. In addition to pain, patients also experience other symptoms.\n\nAs a result of the osteoarthritis process, prorioception in the knee is impaired with a decrease in mechanoreceptors, resulting in loss of balance and an increase in the risk of falling.",[27],[218,219,220,221,222,223,224,225],"gonarthrosis","genicular nerve","radiofrequency","ablation","proprioception","balance","risk of falling","chronic pain","2025-04-06",{"date":228,"type":39},"2025-04-09",{"date":230,"type":21},"2025-04-15",{"date":232,"type":21},"2026-12-31",{"name":234,"class":139},"Bengu Turemenogullari",{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":56,"minAge":90,"maxAge":242,"enrollmentInfo":243,"targetDuration":4,"studyType":22,"phases":245,"briefSummary":246,"conditions":247,"keywords":250,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":81},"100568051","comparison-of-pivotal-medial-polyethylene-versus-ultra-congruent-in-total-knee-arthroplasty-100568051","NCT06676189","Comparison of Pivotal Medial Polyethylene Versus Ultra-congruent in Total Knee Arthroplasty","MEPCAT","Inclusion criteria :\n\n* Subjects 18 to 90 years of age, eligible for a primary total knee replacement for gonarthrosis\n* Competent subjects able to give informed consent to participate in the research\n* Affiliation to the social security system\n\nExclusion criteria :\n\n* Infection history of the knee to be replaced\n* Deformity greater than 15 degrees\n* Any surgical and\u002For anesthetic contraindication, or any condition deemed by the investigator to be incompatible with the research.\n* Any contraindication mentioned in the instructions for use of the medical device\n* Pregnant or breastfeeding women\n* Recent infection history of the surgical site\n* Adults who are subject to a legal protection measure or who are unable to express their constent (Article L1121-8 of the French Public Health Code) and subjects under judicial protection (article L. 1122-2 FPHC)\n* Subjects who refuse to participate","90 Years",{"count":244,"type":21},90,[61],"The aim of this study is to compare the forgotten joint score for the medial pivot polyethylene and ultra-congruent polyethylene which are used in total prosthetic replacement of the knee",[248,249,27],"Total Knee Replacement","Primary Knee Replacement",[251,252,253,254],"prospective","randomized study","parallel groups","forgotten joint score","2025-01-16",{"date":257,"type":39},"2025-01-17",{"date":259,"type":39},"2024-06-04",{"date":261,"type":21},"2027-03",{"name":45,"class":46},{"id":264,"slug":265,"hasResults":11,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":11,"sex":56,"minAge":90,"maxAge":4,"enrollmentInfo":270,"targetDuration":4,"studyType":22,"phases":272,"briefSummary":273,"conditions":274,"keywords":275,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":4},"100552942","efficacy-ultrasound-guided-genicular-nerve-radiofrequency-treatment-100552942","NCT06479642","Efficacy Ultrasound-guided Genicular Nerve Radiofrequency Treatment","Ultrasound-guided Genicular Nerve Radiofrequency Treatment:Eficacy of 4-nerve Protocol Versus 3-nerve Protocol","Inclusion Criteria:\n\n1. Being a male\u002Ffemale \\>18\n2. K-L stage 3-4 gonarthrosis patients with anterior knee pain and positive patellofemoral pain tests after physical examination and imaging evaluation\n3. Those whose symptoms persist for \\>3 months\n4. Participating in the study voluntarily\n\nExclusion Criteria:\n\n1. Pregnancy\n2. History of previous knee surgery\n3. Having received physical therapy in the knee area in the last 3 months\n4. Having previously undergone RF treatment or having had any therapeutic injection such as steroids or hyaluronic acid within 3 months.\n5. Those with pain referred to the waist or hip\n6. Patients with neuropathic pain\n7. History of tumor, infectious, psychiatric disease, bleeding diathesis\n8. Having a history of knee trauma in the last 6 months\n9. Those with systemic diseases such as hepatitis and coagulopathy\n10. Patients with BMI \\>40\n11. Leg length difference",{"count":271,"type":21},72,[61],"Radiofrequency (RF) application is a treatment method that temporarily blocks pain transmission in the nerve where the application is made, through the heat emitted by radio waves. Genicular nerve ablation with RF has recently become a promising treatment option for the treatment of chronic knee pain. These methods are based on the principle that interfering with the sensory nerve fibers of a painful structure can relieve pain and restore function. Their targets are sensory nerves located on the periosteum before entering the knee joint capsule. The knee joint is innervated by a complex nerve network called genicular nerves, which are articular branches of many nerves such as the femoral, tibial, peroneal, saphenous and obturator nerves. Some of the genicular nerves can be easily localized. The intermedius genicular nerve carries the sensation of subpatellar pain. The intermedius genicular nerve is located under the vastus intermedius muscle, anterior to the distal femoral shaft, just above the bony cortex. Targeting sensory nerves in addition to standard procedures and improving target identification using ultrasound guidance may increase treatment success. The aim of this study is to investigate the effect of ultrasound-guided genicular nerve radiofrequency therapy on pain and knee function by targeting only the traditional 3 genicular nerves and the intermedius genicular nerve in addition to the traditional genicular nerves in advanced gonarthrosis patients with prominent anterior knee pain.",[27],[218,276,220],"anterior knee pain","2024-08-01",{"date":279,"type":39},"2024-08-02",{"date":281,"type":21},"2024-09-01",{"date":283,"type":21},"2025-09-01",{"name":285,"class":139},"Yunus Burak Bayır",{"id":287,"slug":288,"hasResults":11,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":11,"sex":56,"minAge":90,"maxAge":4,"enrollmentInfo":294,"targetDuration":4,"studyType":296,"phases":4,"briefSummary":297,"conditions":298,"keywords":4,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":81},"100397889","assessment-of-patient-satisfaction-after-arthroplasty-a-comparative-study-by-implant-type-100397889","NCT04460989","Assessment of Patient Satisfaction After Arthroplasty: A Comparative Study by Implant Type","Evaluation of the Impact of Customization of Total Knee Prostheses on Patient Satisfaction and Functional Outcome of Arthroplasty.","ESPACE","Inclusion Criteria:\n\n* Adult man or woman who has signed consent to participate in the study\n* Patient with uni- or bilateral primary gonarthrosis\n* For which an indication for total knee arthroplasty has been established\n\nExclusion Criteria:\n\n* History of knee arthroplasty or osteotomy\n* History of knee fracture\n* Inflammatory rheumatic disease or any other progressive concomitant disease that may affect the patient's functional prognosis.\n* Joint or extra-articular deformities of the lower limb of traumatic origin\n* Neurological diseases, stroke sequelae\n* Mental disability or any other reason that may hinder the understanding or strict application of the protocol\n* Patient not affiliated to the French social security scheme\n* Patient under legal protection, guardianship or trusteeship\n* Patient already included in another therapeutic study protocol or having participated in another trial within the previous three months\n* Arthroplasty actually performed\n* Absence of per operative complications in bone (femoral or tibial bone), ligament (rupture or disinsertion of the patellar or quadricipital tendon) or nerve (lesion of the external popliteal sciatica).",{"count":295,"type":21},480,"OBSERVATIONAL","The main objective of this study is to evaluate the benefit of personalized prostheses compared to conventional prostheses on patient satisfaction 24 months after total knee arthroplasty.",[27],"2024-06-28",{"date":301,"type":39},"2024-07-01",{"date":303,"type":39},"2021-10-27",{"date":305,"type":21},"2025-10-31",{"name":106,"class":46},{"id":308,"slug":309,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":4,"eligibilityCriteria":313,"healthyVolunteers":11,"sex":56,"minAge":90,"maxAge":4,"enrollmentInfo":314,"targetDuration":4,"studyType":22,"phases":316,"briefSummary":317,"conditions":318,"keywords":319,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":81},"100457233","total-knee-arthroplasty-and-augmented-reality-based-navigation-system-100457233","NCT05233930","Total Knee Arthroplasty and Augmented Reality-based Navigation System","Does an Augmented Reality-based Navigation System in Total Knee Arthroplasty Allow a Better Alignment of the Lower Limb and Does it Improve Functional Results ? An Equivalence, Monocentric, Prospective and Randomized Study","Inclusion Criteria:\n\n1. Gonarthrosis on a varum knee requiring a Total Knee Replacement\n2. Female or male, 18 years of age or older\n3. Affiliation to a social security scheme\n4. Patient has been informed of the study and has signed an informed consent form\n\nExclusion Criteria:\n\n1. Osteonecrosis,\n2. Post traumatic osteoarthritis with femoral or tibial callus,\n3. History of tibial or femoral osteotomy,\n4. Valgum knee,\n5. Isolated patellofemoral osteoarthritis,\n6. Significant hip dysplasia or other excessive pelvic deformity,\n7. Patient already equipped with medical devices that may conflict with the instrumentation required for augmented reality navigation,\n8. Pregnant or breastfeeding women,\n9. Patients under legal protection.",{"count":315,"type":21},88,[61],"The purpose of Total Knee Replacement (TKR) is to remove worn cartilage surfaces and replace them with artificial parts of the same shape. TKR can be used in cases of osteoarthritis, inflammatory rheumatism, bone necrosis of the knee or following malformative or traumatic sequelae.\n\nImplant alignment is paramount in TKR and the last years have seen a proliferation of alignment techniques following the introduction of computer and robotic-assisted surgery. Among Computer-assisted surgery, the augmented reality-based navigation system can be an option to improve accuracy in orthopaedic surgery.\n\nThe hypothesis of this study is: the use of augmented reality-based navigation system allows a prosthesis alignment and positioning that is at least as good as with the traditional mechanically aligned technique, and therefore improves knee functional results. This study also aims at assessing the cost-effectiveness of this new technology.",[27],[320],"TKR: total knee replacement","2024-06-17",{"date":323,"type":39},"2024-06-18",{"date":325,"type":21},"2024-09",{"date":327,"type":21},"2025-10",{"name":329,"class":46},"Elsan"]