[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"goniotomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:goniotomy":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":25,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100635298","goniotomy-in-primary-congenital-glaucoma-100635298",false,"NCT07550868","Goniotomy in Primary Congenital Glaucoma","Efficacy and Safety of Different Extents of Goniotomy in Primary Congenital Glaucoma","Inclusion Criteria:\n\n1. Diagnosis of primary congenital glaucoma (PCG).\n2. Underwent goniotomy (GT) of varying extents and grouped by surgical records (120° or 240°or 360°).\n3. Either gender; no age limit at surgery.\n4. Voluntary participation, signed informed consent, and compliance with scheduled follow-up. For legally incompetent patients, participation shall be decided by their guardians, who shall provide written informed consent and agree to follow-up.\n5. Both eyes are included if data are available for both eyes.\n\nExclusion Criteria:\n\n1. Concomitant other ocular diseases: including but not limited to diabetic retinopathy, macular degeneration, optic neuropathy, ocular trauma, strabismus, nystagmus, severe dry eye disease, blepharoptosis, or other anterior segment developmental abnormalities.\n2. The study eye treated with goniotomy (GT) has a history of prior intraocular surgery or ocular trauma.\n3. Concomitant history of severe systemic diseases: including but not limited to asthma, congenital heart disease, Kawasaki disease, nephropathy, rheumatic and immunologic disorders, digestive system diseases, and malignant neoplasms.\n4. Women who are pregnant or lactating, or those with an intended pregnancy in the near future.","ALL",{"count":18,"type":19},120,"ESTIMATED","OBSERVATIONAL","Brief Summary This is a multicenter cohort study designed to evaluate and compare the efficacy and safety of different surgical extents of goniotomy (GT) - specifically 120°, 240°, and 360° - in the treatment of Primary Congenital Glaucoma (PCG). The study incorporates both retrospective and prospective patient enrollment.\n\nPCG is a rare, severe, and blinding childhood eye disease for which surgery, particularly angle surgery, is the primary treatment. Goniotomy, a minimally invasive glaucoma surgery (MIGS), is increasingly used. However, the optimal extent of the angle incision remains uncertain, with limited and conflicting evidence comparing different ranges.\n\nThe study plans to enroll a total of 120 PCG patients, dividing them into three groups based on the surgical extent received (120°, 240°, or 360°). Patients will be recruited from participating ophthalmic centers across China. The study does not involve interventional assignment; grouping is based on the actual procedure performed as part of standard care.\n\nThe primary outcome measure is the qualified surgical success rate post-operatively, defined as intraocular pressure (IOP) ≤21 mmHg (with or without medication), without vision-threatening complications or the need for further glaucoma surgery. IOP will be measured by Goldmann or iCare tonometry. Secondary outcomes include various safety indicators such as intraoperative and postoperative complications, the number of intraocular pressure-lowering medications required, visual acuity, and the need for further surgery.\n\nThe study aims to generate comparative evidence to inform clinical decision-making, potentially contributing to optimized surgical guidelines for PCG treatment.",[23,24],"Primary Congenital Glaucoma","Goniotomy",[26,27,28],"Primary congenital glaucoma","goniotomy","Surgery extents","NOT_YET_RECRUITING","2026-04-18",{"date":32,"type":33},"2026-04-24","ACTUAL",{"date":35,"type":19},"2026-05",{"date":37,"type":19},"2029-06",{"name":39,"class":40},"Sun Yat-sen University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":41},"100553934","biometric-changes-after-intervention-of-anterior-chamber-angle--an-observational-study-100553934","NCT06492538","Biometric Changes After Intervention of Anterior Chamber Angle : an Observational Study","Inclusion Criteria:\n\n* Glaucoma patients eligible for standalone or combined angle intervention surgeries, such as LPI, LPIP, goniosynechialysis, trabeculotomy alone or combined with surgical iridectomy or phacoemulsification and intraocular lens implantation;\n* Patients capable of undergoing preoperative examinations including CASIA2-OCT (anterior segment OCT), UBM, slit-lamp gonioscopy, IOL Master (or other optical biometry);\n* Patients willing to participate in this study, signing informed consent, and agreeing to follow-up according to the study protocol.\n\nExclusion Criteria:\n\n* Patients with severe ocular conditions such as corneal infection, ulcer, trauma, ocular tumors, retinal vascular occlusion, and retinal detachment;\n* Those with various types of eye diseases that affect ocular parameter acquisition or interfere with visual field examination;\n* Long-term local or systemic use of glucocorticoids;\n* Patients with severe systemic diseases;\n* Pregnant or lactating women;\n* Unable to complete 12-month postoperative follow-up.","30 Years","85 Years",{"count":51,"type":19},300,"The drainage angle in the anterior chamber of the eye mediates the outflow of aqueous humor, and pathological changes here can lead to high intraocular pressure and glaucoma. Minimally invasive glaucoma surgery, particularly angle surgery, has advanced recently, allowing clear visualization of angle structures like the trabecular meshwork and Schlemm's canal using surgical goniolens. Techniques for angle intervention include widening the angle, reopening closed angles, and rebuilding outflow pathways using methods such as laser peripheral iridotomy, Argon laser peripheral iridoplasty, and mechanical separation of adhered tissues. Our research team plans to conduct imaging studies to track the healing of angle tissues post-surgery, aiming to support innovation and standardization of minimally invasive angle surgery.",[54,55,56,24,57],"Angle-closure Glaucoma","Minimally Invasive Glaucoma Surgery","Goniosynechialysis","Glaucoma","RECRUITING","2025-12-04",{"date":61,"type":33},"2025-12-12",{"date":63,"type":33},"2023-12-01",{"date":65,"type":19},"2025-12-30",{"name":67,"class":40},"Zhongshan Ophthalmic Center, Sun Yat-sen University",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":76,"maxAge":49,"enrollmentInfo":77,"targetDuration":4,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":41},"100531565","evaluation-of-phacogoniotomy-in-medically-controlled-poag-100531565","NCT06201455","Evaluation of Phacogoniotomy in Medically-controlled POAG","Efficacy of Phacogoniotomy in Medically-controlled Primary Open-angle Glaucoma With Cataract a Multicenter Non-inferiority Randomized Controlled Trial","ECO","Inclusion Criteria:\n\n1. 40 ≤ Age ≤ 85 years, gender unrestricted.\n2. Diagnosed with POAG.\n3. Controlled IOP under 1 to 4 topical hypotensive medications, IOP ≤ 24 mmHg\n4. Mean deviation (MD) for perimetry ≥ -16dB.\n5. Presence of clinically significant cataract and best-corrected visual acuity measured using the ETDRS chart ≤ 0.63.\n6. Voluntary participation of the patient in this study, signing an informed consent form, and agreeing to follow-up visits according to the study protocol.\n\nExclusion Criteria:\n\n1. Any history of intraocular surgery or ocular trauma.\n2. Presence of other types of glaucoma, including primary angle-closure glaucoma and various forms of secondary glaucoma (e.g. secondary angle-closure, pigmentary, steroid-induced, angle-recession, neovascular, inflammatory, and pseudoexfoliation syndrome).\n3. Presence of severe ocular diseases of various types that affect the acquisition of ocular parameters or interfere with perimetry.\n4. Axial length \\> 28 mm.\n5. Monophthalmia (best-corrected visual acuity of the non-study eye \\\u003C 0.01).\n6. Coexistence of severe systemic diseases affecting the entire body.\n7. Pregnant or lactating women.\n\n   * If both eyes of a patient meet the criteria, the eye with worse visual acuity will be selected for inclusion.","40 Years",{"count":78,"type":19},100,"INTERVENTIONAL",[81],"NA","The goal of this multicenter non-inferiority randomized controlled trial is to compare the efficacy of phacoemulsification with intraocular lens implantation (PEI) combined with goniotomy (GT) and PEI combined with medical therapy (MED) in the treatment of medically-controlled primary open-angle glaucoma (POAG) with cataract. The main questions it aims to answer are:\n\n* Whether the PEI+GT was non-inferior to PEI+MED with regard to the intraocular pressure lowering effect in medically-controlled POAG.\n* Whether the PEI+GT has value of health economics. Participants will be randomized to receive either PEI+GT or PEI+MED, and followed up with a 1-year period as a primary outcome.",[84,85,24],"Glaucoma, Open-Angle","Cataract Complicated",[84,87,24,88],"Cataract","Minimally invasive glaucoma surgery","2024-12-06",{"date":91,"type":33},"2024-12-11",{"date":93,"type":33},"2023-09-28",{"date":95,"type":19},"2029-12-31",{"name":39,"class":40}]