[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"graft-patency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:graft-patency":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100639181","study-of-feasibility-for-surgical-patients-undergoing-heart-surgery-with-the-mammary-arteries-reviewing-infection-occlusion-rates-and-pain-assessments-100639181",false,"NCT07599553","Study of Feasibility for Surgical Patients Undergoing Heart Surgery With the Mammary Arteries: Reviewing Infection, Occlusion Rates and Pain Assessments.","Pilot Study for COMFORT Trial Comparative Outcomes of Mammary Artery Harvesting: Infection, Occlusion Rates and Thoracic Pain Assessment","COMFORT pilot","Inclusion Criteria:\n\n* Age 18 years or older\n* Undergoing isolated CABG surgery with median sternotomy and a planned LIMA-LAD graft.\n* Provision of written informed consent.\n\nExclusion Criteria:\n\n* Non-sternotomy surgical approach (e.g., minimally invasive, thoracotomy)\n* Emergency surgery (defined as surgery required within 24 hours or presentation\n* History of prior ternotomy\n* Currently receiving systemic antibiotics or with an active bacterial infection at the time of surgery\n* History of chronic sternal pain prior to the index surgery.\n* Known left subclavian artery stenosis (\\>50%)\n* Previous radiation therapy to the chest\n* Known allergy or contraindication to iodinated contrast media that cannot be managed with premedication.\n* Estimated glomerular filtration rate (eGFR) \\\u003C30 ml\u002Fmin\u002F1.73m2 at baseline (relative contraindications to CTA contrast). The eGFR will be determined by each participating institution according to their standard practice.","ALL","18 Years",{"count":20,"type":21},35,"ESTIMATED","INTERVENTIONAL",[24],"NA","The Pilot study for the COMFORT Trial is a single centre trial to determine the feasibility of the full COMFORT Trial.\n\nThe main COMFORT Trial will be a multi-centre trial to investigate the coronary artery bypass grafting outcomes when harvesting the Left Internal Mammary Artery (LIMA) using a skeletonized approach (artery is isolated without the surrounding veins, fascia and nerves) compared to harvesting the LIMA using a non-skeletonized approach (artery is isolated with the surrounding veins, fascia and nerves). Harvesting the LIMA with the non-skeletonized approach is the standard technique. Participants will complete a Coronary Artery Tomography scan at 1 year to determine if the LIMA graft remains open. Follow up of the participants will continue until 2 years post surgery.",[27],"Graft Patency",[29,30,31,32,33,34],"bypass graft harvesting","skeletonized harvesting","non-skeletonized harvesting","CABG surgery","Left Internal Mammary Artery","LIMA","NOT_YET_RECRUITING","2026-05-14",{"date":38,"type":39},"2026-05-20","ACTUAL",{"date":41,"type":21},"2026-06",{"date":43,"type":21},"2028-06",{"name":45,"class":46},"Ottawa Heart Institute Research Corporation","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":47},"100597378","total-arterial-vs-mixed-grafting-in-left-coronary-cabg-100597378","NCT07057713","Total Arterial vs. Mixed Grafting in Left Coronary CABG","A Prospective, Randomized, Double-Blind Controlled Trial Comparing Total Arterial Grafting Versus Conventional Mixed Grafting in the Left Coronary Artery System During Coronary Artery Bypass Grafting (CABG)","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Diagnosed with multivessel coronary artery disease\n3. Indicated for elective coronary artery bypass grafting (CABG) involving ≥3 coronary vessels\n4. Right coronary artery stenosis \\>75%\n5. Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n1. Scheduled for concurrent cardiac procedures (e.g., valve surgery, congenital heart disease repair, aortic dissection surgery, atrial fibrillation ablation)\n2. Severe stenosis of left or right subclavian artery\n3. Unsuitable saphenous veins (e.g., bilateral varicosities)\n4. Unsuitable radial artery as assessed preoperatively\n5. History of intracranial hemorrhage or ischemic stroke within the past 14 days\n6. Severe hepatic or renal insufficiency\n7. Acute myocardial infarction within 72 hours prior to surgery\n8. History of prior CABG or other cardiac surgery","80 Years",{"count":57,"type":21},400,[24],"This is a prospective, randomized, double-blind controlled trial comparing the clinical efficacy of total arterial grafting (internal thoracic artery and radial artery) versus conventional mixed grafting (internal thoracic artery and great saphenous vein) in the left coronary artery system during coronary artery bypass grafting (CABG). A total of 400 patients undergoing elective CABG at the Second Hospital of Jilin University will be enrolled and randomized into two groups. The primary endpoint is graft patency at 12 months postoperatively, evaluated by coronary angiography or CT angiography. Secondary outcomes include perioperative complications, major adverse cardiovascular events (MACE), and long-term clinical prognosis. The study aims to provide evidence-based guidance on optimal graft selection in CABG.",[61,62,63,27,64],"Coronary Artery Disease","Coronary Artery Bypass Grafting","Arterial Graft","Major Adverse Cardiovascular Events","2026-04-21",{"date":67,"type":39},"2026-04-23",{"date":69,"type":21},"2026-08-01",{"date":71,"type":21},"2027-12-30",{"name":73,"class":46},"Second Hospital of Jilin University"]