[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"granulocyte-colony-stimulating-factor-g-csf-mobilization\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:granulocyte-colony-stimulating-factor-g-csf-mobilization":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100625522","chrono-mobilize-chronotherapy-of-g-csf-for-cd34-mobilization-in-healthy-donors-100625522",false,"NCT07423728","CHRONO-MOBILIZE: Chronotherapy of G-CSF for CD34+ Mobilization in Healthy Donors","Effect of Different Administration Timing of G-CSF on Peripheral Blood CD34+ Cell Mobilization in Healthy Donors: A Prospective Multicenter Randomized Controlled Trial","CHRONO-MOBILIZ","Inclusion Criteria:\n\n1. Age 18-55 years\n2. HLA matching appropriate for intended allo-HSCT recipient and meets donor medical evaluation criteria\n3. Body weight ≥35 kg and adequate blood volume\u002FBSA for apheresis\n4. Karnofsky score ≥80\n5. Screening labs meet thresholds (Hb\u002Fplatelets\u002FANC, liver\u002Frenal\u002Fcoagulation), no splenomegaly, pregnancy test negative if applicable\n6. Written informed consent\n7. Stable circadian rhythm before mobilization (no night shift\u002Fno ≥3 time-zone travel; avoid melatonin\u002Fsedatives or other agents affecting sleep\u002Fcircadian rhythm)\n\nExclusion Criteria:\n\n1. Prior\u002Fcurrent hematologic or immune diseases (e.g., aplastic anemia, leukemia, lymphoma, autoimmune disease)\n2. Significant cardiovascular\u002Fstructural heart disease, uncontrolled hypertension, uncontrolled diabetes\n3. Neurologic\u002Fpsychiatric disorders affecting adherence\n4. Sleep\u002Fcircadian disorders; recent night shift or ≥3 time-zone travel\n5. Prohibited medications (e.g., beta-blockers, systemic steroids \\>10 mg prednisone-equivalent ≥7 days, melatonin\u002Fpsychotropics; recent G-CSF\u002FGM-CSF\u002FCXCR4 inhibitor use)\n6. Severe allergy to G-CSF or components",true,"ALL","18 Years","55 Years",{"count":22,"type":23},160,"ESTIMATED","INTERVENTIONAL",[26],"NA","Healthy donors are commonly mobilized with granulocyte colony-stimulating factor (G-CSF) to collect peripheral blood stem cells for allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the efficiency of mobilization varies among donors, and suboptimal mobilization may require additional collection procedures or rescue strategies.\n\nThis prospective, multicenter, randomized trial evaluates whether the timing of daily G-CSF administration (morning vs evening) affects the level of circulating CD34+ cells prior to apheresis in healthy donors. Participants will be randomly assigned to receive subcutaneous G-CSF 10 μg\u002Fkg once daily for 5 consecutive days either at 08:00 (±15 minutes) or at 20:00 (±15 minutes). The primary endpoint is the peripheral blood CD34+ cell count measured approximately 12 hours after the last G-CSF dose and within 60 minutes before the start of the first apheresis session. Secondary endpoints include collection efficiency and CD34+ yield metrics, the proportion of donors achieving the target CD34+ dose on the first collection day, the need for a second collection day, and donor safety outcomes.\n\nThe goal of the study is to identify a practical dosing schedule that may improve stem cell mobilization and streamline donor collection procedures.",[29],"Granulocyte Colony-Stimulating Factor (G-CSF) Mobilization",[31,32,33],"CD34","G-CSF","Allo-HSCT","RECRUITING","2026-06-25",{"date":37,"type":38},"2026-06-29","ACTUAL",{"date":40,"type":38},"2026-03-01",{"date":42,"type":23},"2027-03-30",{"name":44,"class":45},"First Affiliated Hospital of Zhejiang University","OTHER",3]