[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"grief\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:grief":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,46,77,98,122,149,175,192,226,254,297,322,347,378,409],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100450216","evaluation-of-grief-therapy-approaches-for-bereaved-parents-100450216",false,"NCT05142605","Evaluation of Grief Therapy Approaches for Bereaved Parents","Meaning-Centered Grief Therapy for Parents Bereaved by Cancer: A Multisite Randomized Controlled Trial","Parent Participant Inclusion Criteria:\n\n* A biological, adoptive, step-parent or legal guardian from across the United States who lost a child diagnosed with cancer as indicated by self-report\n* Age 18 or older as indicated by self-report\n* Experienced the loss of a child diagnosed with cancer at least 6 months prior to enrollment as indicated by medical record or self-report\n* Elevated prolonged grief (PG) symptoms (PG-13-R scores of 30 or above)\n* Resides in a state in which a study clinical supervisor is licensed to permit telepsychology practice or otherwise able to comply with current telehealth regulations as indicated by self-report\n* English-speaking as per the language assessment items below and willing to receive the intervention in English\n* What is the participant's preferred language?\n\n  °(Specify Lang)\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\n* How well does the participant speak English?\n\n  * Very well (PARTICIPANT IS ELIGIBLE)\n  * Well (PARTICIPANT is NOT ELIGIBLE)\n  * Not well (PARTICIPANT is NOT ELIGIBLE)\n  * Not at all (PARTICIPANT is NOT ELIGIBLE)\n* Individuals who are pregnant per self-report are eligible to participate\n\nSupport Provider Inclusion Criteria:\n\n* Must be age 18 or over as indicated by self-report\n* Has been identified by the bereaved parent participant as a support or someone important to bereaved parent\n* Resides in a state in which a study clinical supervisor is licensed to permit telepsychology practice or otherwise able to comply with current telehealth regulations as indicated by self-report\n* English-speaking as per the language assessment items below and willing to receive the intervention in English\n* What is the participant's preferred language?\n\n  °(Specify Lang)\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\n* How well does the participant speak English?\n\n  * Very well (PARTICIPANT IS ELIGIBLE)\n  * Well (PARTICIPANT is NOT ELIGIBLE)\n  * Not well (PARTICIPANT is NOT ELIGIBLE)\n  * Not at all (PARTICIPANT is NOT ELIGIBLE)\n* Individuals who are pregnant per self-report are eligible to participate.\n\nFamily Participant Inclusion Criteria:\n\n* A biological, adoptive, step-parent or legal guardian from across the United States who lost a child diagnosed with cancer as indicated by self-report\n* Age 18 or older as indicated by self-report\n* Experienced the loss of a child diagnosed with cancer at least 6 months prior to enrollment as indicated by medical record or self-report\n* Resides in a state in which a study clinical supervisor is licensed to permit telepsychology practice or otherwise able to comply with current telehealth regulations as indicated by self-report\n* English-speaking as per the language assessment items below and willing to receive the intervention in English\n* What is the participant's preferred language?\n\n  °(Specify Lang)\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\n* How well does the participant speak English?\n\n  * Very well (PARTICIPANT IS ELIGIBLE)\n  * Well (PARTICIPANT is NOT ELIGIBLE)\n  * Not well (PARTICIPANT is NOT ELIGIBLE)\n  * Not at all (PARTICIPANT is NOT ELIGIBLE)\n* Individuals who are pregnant per self-report are eligible to participate.\n\nTraining Case Inclusion Criteria:\n\n* A biological, adoptive, step-parent, or legal guardian from across the United States as indicated by self-report\n* Age 18 or older as indicated by self-report\n* Experienced the loss of a child at least 6 months prior to enrollment as indicated by medical record or self-report\n* Score of 29 or below on the PG-13-R OR lost a child to a cause other than cancer OR child's additional guardian has consented as a Parent Participant and has not provided permission to share participation status OR past participants who indicate an interest in serving as a training case and, in the judgment of the Principal Investigator, would be appropriate to enroll as a training case\n* Resides in a state in which a study clinical supervisor is licensed to permit telepsychology practice or otherwise able to comply with current telehealth regulations as indicated by self-report\n* English-speaking as per the language assessment items below and willing to receive the intervention in English\n* What is the participant's preferred language?\n\n  ° (Specify Lang)\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\n* How well does the participant speak English?\n\n  * Very well (PARTICIPANT IS ELIGIBLE)\n  * Well (PARTICIPANT is NOT ELIGIBLE)\n  * Not well (PARTICIPANT is NOT ELIGIBLE)\n  * Not at all (PARTICIPANT is NOT ELIGIBLE)\n* Individuals who are pregnant per self-report are eligible to participate.\n\nTraining Case Support Provider Inclusion Criteria:\n\n* Must be age 18 or over as indicated by self-report\n* Has been identified by the bereaved parent training case participant as a support or someone important to bereaved parent\n* Resides in a state in which a study clinical supervisor is licensed to permit telepsychology practice or otherwise able to comply with current telehealth regulations as indicated by self-report\n* English-speaking as per the language assessment items below and willing to receive the intervention in English\n* What is the participant's preferred language?\n\n  ° (Specify Lang)\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\n* How well does the participant speak English?\n\n  * Very well (PARTICIPANT IS ELIGIBLE)\n  * Well (PARTICIPANT is NOT ELIGIBLE)\n  * Not well (PARTICIPANT is NOT ELIGIBLE)\n  * Not at all (PARTICIPANT is NOT ELIGIBLE)\n* Individuals who are pregnant per self-report are eligible to participate.\n\nParent Participant Exclusion Criteria:\n\n* Significant psychiatric disturbance sufficient, in the investigator\u002Fstudy staff's judgment, to preclude completion of the assessment measures, interview or informed consent\n* Inability to access a functional device for videoconferencing and declines offer to use a study loaner device as indicated by self-report\n* Prisoners\n* Participants unable to consent\n\nSupport Provider Exclusion Criteria:\n\n* Significant psychiatric disturbance sufficient, in the investigator\u002Fstudy staff's judgment, to preclude informed consent\n* Inability to access a computer with Internet as indicated by self-report\n* Prisoners\n* Participants unable to consent\n\nFamily Participant Exclusion Criteria:\n\n* Significant psychiatric disturbance sufficient, in the investigator\u002Fstudy staff's judgment, to preclude informed consent\n* Inability to access a computer with Internet as indicated by self-report\n* Prisoners\n* Participants unable to consent\n\nTraining Case Exclusion Criteria:\n\n* Significant psychiatric disturbance sufficient, in the investigator\u002Fstudy staff's judgment, to preclude completion of the assessment measures, interview or informed consent\n* Inability to access a functional device for videoconferencing and declines offer to use a study loaner device as indicated by self-report\n* Prisoners\n* Participants unable to consent\n\nTraining Case Support Provider Exclusion Criteria\n\n* Significant psychiatric disturbance sufficient, in the investigator\u002Fstudy staff's judgment, to preclude informed consent\n* Inability to access a computer with Internet as indicated by self-report\n* Prisoners\n* Participants unable to consent","ALL","18 Years",{"count":19,"type":20},415,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to compare three types of support programs for parents who have lost a child. The study will see how these support programs affect participants' grief and depression symptoms. The three support programs are called Meaning-Centered Grief Therapy, Supportive Counseling, and Enhanced Usual Care.",[26,27,28],"Grief","Bereavement","Cancer",[30,31,32],"Parental bereavement","Parents","Elevated prolonged grief symptoms","RECRUITING","2026-06-29",{"date":36,"type":37},"2026-07-01","ACTUAL",{"date":39,"type":37},"2022-03-31",{"date":41,"type":20},"2027-05-31",{"name":43,"class":44},"University of Miami","OTHER",5,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100611363","phase-1-act-for-individuals-with-mncd-and-their-care-partners-100611363","NCT07239609","ACT for Individuals With MNCD and Their Care Partners","Acceptance and Commitment Therapy for Individuals With MNCD and Their Care Partners: An In-Person and Telehealth Individual Therapy Approach","ACT","Inclusion Criteria\n\nInclusion (person with MCI or MNCD):\n\n* 18+\n* MMSE= 21-27\n* Able to communicate in English\n\nInclusion (care partner):\n\n* 18+\n* Identifies as a care partner of a person with MNCD\n* Able to communicate in English\n* MMSE= 28-30\n* Is a family member or friend of the person with MNCD\n\nExclusion Criteria\n\nExclusion (person with MCI or MNCD):\n\n* Currently in an intervention for reducing anxiety or depression related to their dementia\n* MMSE= 28+ or less than 21\n\nExclusion (care partner):\n\n* MMSE= \\\u003C28\n* Is a formal (paid) caregiver",true,{"count":56,"type":20},100,[58],"PHASE1","This project aims to implement and evaluate a dyadic intervention (i.e., acceptance commitment therapy) for persons with AD\u002FADRD and their care partners. We hypothesize the intervention will be feasible, acceptable, and show preliminary efficacy of the dyadic interveniotns.",[61,62,26],"Depression in Adults","Anxiety Disorder Generalized",[64,65,66],"Mild Cognitive Impariment","Mild Neurocognitive Disorder","Dyadic intervention","2026-05-13",{"date":69,"type":37},"2026-05-15",{"date":71,"type":37},"2026-04-01",{"date":73,"type":20},"2027-12-31",{"name":75,"class":44},"Texas Tech University",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":92,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":76},"100492788","telehealth-to-reduce-mental-health-in-family-caregivers-100492788","NCT05696704","Telehealth to Reduce Mental Health in Family Caregivers","Utilizing Telehealth to Reduce Pre-Death Grief, Burden, and Stress in Family Caregivers","Inclusion Criteria:\n\n* Participants must be informal caregivers (e.g., spouse; child; close friend) of individuals with dementia\n* Informal caregivers can be family members or close friends\n* Adults (18 to 89 years old) who read, write, and speak in English\n* Mental Health Diagnosis (e.g., Generalized Anxiety Disorder; Major Depressive Disorder\n\nExclusion Criteria:\n\n* Formal caregivers (who are being paid to take care of the patient)\n* Any informal caregivers with cognitive impairment is identified during the assessment.","120 Years",{"count":86,"type":20},60,[23],"The overarching goal of this project is to evaluate if evidence-based interventions can reduce PDG, burden, and stress in informal caregivers of individuals with dementia when provided over telehealth.",[90,26,91],"Mental Health Issue","Burden, Caregiver",{"date":69,"type":37},{"date":94,"type":37},"2023-01-30",{"date":96,"type":20},"2028-12-31",{"name":75,"class":44},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":21,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":76},"100591528","prevention-of-psychological-health-problems-via-integrated-operational-support-100591528","NCT06981598","Prevention of Psychological Health Problems Via Integrated Operational Support","Optimizing Psychological Health and Preventing Clinical Problems: Testing the Effectiveness of an Evidence-Based Toolkit for Integrated Operational Support","IOS Toolkit","Inclusion Criteria:\n\n* Service members seeing a behavioral health (BH) technician.\n* Currently embedded BH technicians.\n\nExclusion Criteria:\n\n* Service members who are not currently seeing a BH technician.\n* BH technicians who are not embedded or have taken a clinic role.",{"count":107,"type":20},5586,[23],"Sub-clinical behavioral health services in the military are performed by BH technicians, who receive minimal training. Due to this, embedding more technicians in military units is unlikely to benefit service members. Giving technicians training in, and access to, evidence-based interventions (EBI) could make their work more effective. The proposed study is a training trial examining the efficacy of the full integrated operational support (IOS) toolkit (evidence-based interventions for behavioral health), relative to routine care using standard resources, as a prevention resource for active-duty airmen.",[111,26,112,113],"Depression, Anxiety","Leadership","Dissatisfaction","2026-05-12",{"date":69,"type":37},{"date":117,"type":37},"2025-03-10",{"date":119,"type":20},"2028-03-01",{"name":121,"class":44},"New York University",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":54,"sex":16,"minAge":130,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":21,"phases":133,"briefSummary":134,"conditions":135,"keywords":4,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":4},"100630983","a-feasibility-randomised-control-trial-to-evaluate-early-perinatal-bereavement-counselling-for-parents-who-have-experienced-a-perinatal-death-100630983","NCT07494760","A Feasibility Randomised Control Trial to Evaluate Early Perinatal Bereavement Counselling for Parents Who Have Experienced a Perinatal Death","Perinatal Loss - Early Referral for Counselling (PEARL-C): A Feasibility Randomised Controlled Trial","PEARL-C","Inclusion Criteria:\n\n* Women and partners of women who have had a late fetal loss (from 16 weeks), stillbirth or neonatal death within the maternity unit at Wythenshawe Hospital.\n* For the qualitative interviews, healthcare professionals who have been involved with referrals to the intervention and\u002For the delivery of the intervention\n\nExclusion Criteria:\n\n* Less than 16 years of age\n* Anyone who lacks the capacity to consent\n* Inability to read English (interpreters will be provided for counselling sessions and interviews if needed).","16 Years",{"count":132,"type":20},26,[23],"The goal of this feasibility randomised control trial is to determine if a trial to evaluate perinatal bereavement counselling for parents who have experienced a perinatal death is feasible. The main question it aims to answer is:\n\n• Is a trial to evaluate access to perinatal bereavement counselling feasible?\n\nResearchers will compare the intervention group (parents who have received counselling) to the control group (parents who have not received counselling) to see if there are differences in measurements of parents' grief and psychological symptoms.\n\n* Participants allocated to the intervention and control group will receive usual bereavement care from the perinatal bereavement team at the hospital\n* Parents allocated to the intervention group will receive counselling\n* Parents will complete validated psychometric questionnaires about their levels of perinatal grief, psychological distress, depression, and quality of life\n* Parents in the intervention group will be asked a series of open-ended written questions about their experience of participating in the trial\n* Healthcare professionals who have been involved with delivery of the intervention\u002Freferrals will be interviewed about their experience of the trial.",[136,137,138,26],"Stillbirth","Perinatal Death","Psychological","NOT_YET_RECRUITING","2026-03-20",{"date":142,"type":37},"2026-03-27",{"date":144,"type":20},"2026-03-01",{"date":146,"type":20},"2027-09-01",{"name":148,"class":44},"University of Manchester",{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":153,"acronym":154,"eligibilityCriteria":155,"healthyVolunteers":54,"sex":16,"minAge":156,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":21,"phases":159,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":170,"leadSponsor":172,"locationsCount":76},"100593861","walk-with-me-wwm-for-perinatal-grief-100593861","NCT07011940","Walk With Me (WWM) for Perinatal Grief","PeriGrief-II","Inclusion Criteria:\n\n* Within the first month of pregnancy or early infant loss\n* Reside in the United State\n* Speak and read either English or Spanish at a 6th grade reading level\n* 15 or older\n\nExclusion Criteria:\n\n* Not pregnant or has not experienced an early infant loss\n* Does not reside in the United State\n* Does not speak and read either English or Spanish at a 6th grade reading level\n* 14 or younger","15 Years",{"count":158,"type":20},300,[23],"The goal of this clinical trial is to learn if the Along With Me web-based intervention works to decrease posttraumatic stress symptoms and suicidal ideation among bereaved parents following pregnancy and early infant loss. It will also learn whether peer guides provide additional improvements on these outcomes.\n\nThe main questions it aims to answer are:\n\n• Do people who receive Along With Me or Along With Me plus a Peer Guide compared to services as usual have lower posttraumatic stress symptoms and suicidal ideation than those who do not receive the intervention?\n\nResearchers will compare Along With Me and Along With Me plus a Peer Guide to services as usual (referrals made in the hospital setting) to see if Along With Me works to prevent and address posttraumatic stress symptoms and suicidal ideation.\n\nParticipants will:\n\n* Receive access to a mobile app with approximately 10 therapeutic modules about how to manage grief and other symptoms.\n* Receive check-ins with a Peer Guide (in the Peer Guide condition only)",[26,162,163,164,136,165],"Post Traumatic Stress Disorder","Suicidal Ideation","Miscarriage","Infant Death","2026-03-04",{"date":168,"type":37},"2026-03-06",{"date":36,"type":20},{"date":171,"type":20},"2027-08-31",{"name":173,"class":174},"Oregon Research Behavioral Intervention Strategies, Inc.","INDUSTRY",{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":84,"enrollmentInfo":181,"targetDuration":4,"studyType":21,"phases":182,"briefSummary":183,"conditions":184,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":191,"locationsCount":76},"100464999","improving-mental-health-for-care-partners-of-persons-with-adadrd-100464999","NCT05334992","Improving Mental Health for Care Partners of Persons With AD\u002FADRD","Reducing Pre-Death Grief, Burden, and Stress in Informal Caregivers: A Group and Individual Therapy Approach",{"count":86,"type":20},[23],"The overarching goal of this project is to evaluate if evidence-based interventions can reduce PDG, burden, and stress in informal caregivers of individuals with dementia",[90,26,91],"2026-02-09",{"date":187,"type":37},"2026-02-12",{"date":189,"type":37},"2022-02-01",{"date":96,"type":20},{"name":75,"class":44},{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":198,"eligibilityCriteria":199,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":200,"targetDuration":4,"studyType":21,"phases":202,"briefSummary":203,"conditions":204,"keywords":207,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":76},"100620362","cardiovascular-effects-of-grieving-100620362","NCT07356635","Cardiovascular Effects of Grieving","Investigating Cardiovascular Reactivity and Recovery of Young Adults During Grief-Recall, With Self-Affirmation as Potential Intervention","SAGE","Inclusion Criteria:\n\n* Individuals aged 18 and older who have experienced the death of family member and\u002For friend within the last 2 to 18 months.\n* Participants must also be fluent in English as all procedures will be conducted in English.\n\nExclusion Criteria:\n\n\\- Individuals with a history of cardiovascular disease or disorders, those who report being pregnant, or are taking medication which may alter\u002Faffect cardiovascular and\u002For cognitive processes.",{"count":201,"type":20},140,[23],"Self-affirmation (SA) theory proposes that people are motivated to maintain a positive self-image of being worthy, stable, and capable. Self-affirmation (SA) manipulations have been shown to effectively increase self-worth as well as reduce cardiovascular reactivity while enhancing cardiovascular recovery in response to stress. While SA is discussed as a way to alleviate grief, its effect on cardiovascular reactivity (CVR) and recovery to grief recall has yet to be studied within laboratory settings. This study proposes an experimental design to examine how an in-lab manipulation promoting self-affirmation can improve patients' cardiovascular responses during and after a grief recall procedure. The investigators hypothesized that grief severity (a continuous variable) interacts with condition (a categorical variable with two levels, i.e., SA intervention vs. control) to predict CV reactivity and recovery as outcomes.\n\nPrimary Objective 1: To investigate effects of self-affirmation intervention on cardiovascular responses among grieving participants during and after grief recall.\n\nSecondary Objective 1: To investigate the relationship of grief severity with psychological stress.",[26,205,206],"Cardiovascular Health","Emotion",[208,209,210,211,212,213,214,215,216],"grief","cardiovascular reactivity","cardiovascular health","heart rate variability","psychophysiology","self-affirmation","value-affirmation","stress","mourning","2026-01-14",{"date":219,"type":37},"2026-01-21",{"date":221,"type":37},"2025-10-16",{"date":223,"type":20},"2027-03",{"name":225,"class":44},"University of South Florida",{"id":227,"slug":228,"hasResults":11,"nctId":229,"briefTitle":230,"officialTitle":231,"acronym":4,"eligibilityCriteria":232,"healthyVolunteers":54,"sex":233,"minAge":17,"maxAge":234,"enrollmentInfo":235,"targetDuration":4,"studyType":21,"phases":237,"briefSummary":238,"conditions":239,"keywords":241,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":76},"100618574","individualized-grief-support-with-swanson-model-100618574","NCT07333391","Individualized Grief Support With Swanson Model","Evaluation of the Effectiveness of Individualized Grief Support Based on the Swanson Caring Model in Women Experiencing Pregnancy Loss","Inclusion Criteria:\n\n* Aged 18 years and above,\n* Literate,\n* Able to understand and speak Turkish,\n* Desired and planned pregnancies\n* No diagnosed psychiatric illness,\n* No hearing or mental disabilit\n\nExclusion Criteria:\n\n* Women who experienced pregnancy loss after infertility treatment\n* Women who received psychological support during the process\n* Women who scored very high on the DAS scale\n* Women who withdrew from the study at any stage\n* Women who did not complete the data collection forms will be excluded from the study.","FEMALE","50 Years",{"count":236,"type":20},48,[23],"This study aims to examine the effects of individualized grief support for women experiencing pregnancy loss. The research, which will be conducted at Süleyman Demirel University, is a mixed-method design and includes both phenomenological qualitative analysis and randomized controlled quantitative trials. The sample will include 48 women; those with severe depression will be excluded. Quantitative data will be analyzed using SPSS, and qualitative data will be analyzed using content analysis.",[240,26],"Pregnancy Loss",[240,26,242,243,244],"İndividualized care","Swanson model","Psychosocial Support","2025-12-30",{"date":247,"type":37},"2026-01-12",{"date":249,"type":20},"2026-02-01",{"date":251,"type":20},"2026-07-30",{"name":253,"class":44},"Suleyman Demirel University",{"id":255,"slug":256,"hasResults":11,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":260,"eligibilityCriteria":261,"healthyVolunteers":11,"sex":16,"minAge":156,"maxAge":262,"enrollmentInfo":263,"targetDuration":4,"studyType":21,"phases":265,"briefSummary":266,"conditions":267,"keywords":279,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":295,"locationsCount":76},"100579744","culturally-adapted-i-cbt-for-farsidari-speaking-migrants-100579744","NCT06828276","Culturally Adapted i-CBT for Farsi\u002FDari Speaking Migrants","Culturally and Language-Adapted i-CBT for Common Mental Health Problems: A Randomized Controlled Study With Farsi\u002FDari-Speaking Migrants","i-CBT","Inclusion Criteria:\n\n* Between the ages of 15 and 29.\n* A score above the cut-off 1.75 on HSCL-25\n* Has a refugee or migrant background\n* Has a good and stable internet connection\n* Has access to a computer, tablet or smartphone\n* Is fluent in reading and writing Arabic\n* Has the ability to dedicate time to take part in the intervention for 6-10 weeks.\n\nExclusion Criteria:\n\n* Is suffering from a severe mental illness, such as psychosis or severe depression.\n* Is suffering from substance abuse\n* Is undergoing a psychological treatment\n* Has a high risk of suicide","29 Years",{"count":264,"type":20},128,[23],"The aim of this randomized controlled trial (RCT) is to investigate the effectiveness of a culturally adapted internet-based cognitive behavioral therapy (i-CBT) intervention in reducing symptoms of common mental health issues among Farsi\u002FDari-speaking youth migrants and refugees. Investigator hypothesizes that there will be a significant decrease in psychological symptoms after participants receive the intervention compared to a control group.",[268,269,26,270,271,272,273,274,275,276,277,278],"Depressive Symptoms","Anxiety Symptoms","Psychological Trauma","Insomnia","Resilience","Stress","Psychological Well Being","Marital Relationship","Wellbeing","Common Mental Health Problems","Rumination",[280,281,282,283,284,285,286,272,287],"Refugee","Cognitive behavioral therapy","Psychological problems","Persian speaking","Psychological well-being","Youth","Mental problems","Asylum seeker","2025-12-05",{"date":290,"type":37},"2025-12-12",{"date":292,"type":37},"2025-03-25",{"date":294,"type":20},"2026-12-31",{"name":296,"class":44},"Karolinska Institutet",{"id":298,"slug":299,"hasResults":11,"nctId":300,"briefTitle":301,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":303,"targetDuration":4,"studyType":21,"phases":305,"briefSummary":307,"conditions":308,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":319,"locationsCount":321},"100484398","phase-2-a-clinical-trial-of-interventions-to-support-family-surrogates-of-critically-ill-patients-100484398","NCT05587517","A Clinical Trial of Interventions to Support Family Surrogates of Critically Ill Patients","Inclusion Criteria:\n\n* Patients who, during their hospital stay, have been admitted to the ICU and are near EoL, as indicated by a modified \"surprise question\" whereby physicians are asked to identify patients whom they do not expect to survive the next 12 months.\n* Surrogate decision-makers of patients who were admitted to the ICU or step-down unit during their current admission\u002Fstay, or within 1 month of discharge from their last admission\u002Fstay.\n* Surrogate decision-makers are 18 years or older.\n* Surrogate decision-makers whom physicians or advance practice providers (i.e. physician assistants, nurse practitioners) indicate as the designated health care proxy or decision-making patient surrogates, or who are listed as such in the patient's medical charts or by self-report of the surrogate.\n* Surrogate decision-makers must speak English.\n* Surrogate decision-makers must report \"syndromal\" levels of pre-loss grief (PG-12 score ≥ 25) or peritraumatic distress (PDI ≥ 23).\n* Surrogate decision makers will need to reside in a state in which an interventionist is licensed or otherwise be able to comply with current telehealth regulations.\n* Surrogate decision-makers will need to be willing to utilize a device (computer, tablet, phone) with internet.\n* Surrogate decision-makers who are able and willing to provide an emergency contact.\n\nExclusion Criteria:\n\n* Patients and surrogate decision-makers who do not meet the eligibility criteria.\n* Surrogate decision-makers who indicate the presence of cognitive impairment based on responses to the Ultra-Brief Confusion Assessment Method and\u002For significant psychiatric or cognitive disturbance sufficient, in the investigator\u002Fstudy staff's judgment, to preclude completion of the assessment measures, interview or informed consent.\n* Surrogate-decision makers who endorse suicidal ideation in the past month based on responses to the Columbia Suicide Severity Rating Scale.\n* Surrogate-decision makers who are unable to access a functional device for videoconferencing and decline the offer to use a study loner device.",{"count":304,"type":20},172,[306],"PHASE2","Hypotheses 1a and 1b: Compared to Supportive Conversation arm, the EMPOWER intervention will significantly decrease surrogate decision makers' symptoms of grief and Post Traumatic Stress Disorder (PTSD) (primary outcomes); and H1b. experiential avoidance, depression, regrets, and increases in patients' value-concordant care (secondary outcomes) at T1-T4.\n\nHypothesis 2. Qualitative data will provide insights not captured by quantitative data.\n\nHypothesis 3. Reductions in experiential avoidance will mediate reductions in grief and Post Traumatic Stress Disorder (PTSD) symptoms, highlighting it as important to target in future implementation.",[26,309,310,311],"Trauma","Psychotherapy","Critical Care","2025-10-27",{"date":314,"type":37},"2025-10-29",{"date":316,"type":37},"2022-10-11",{"date":318,"type":20},"2027-12-11",{"name":320,"class":44},"Weill Medical College of Cornell University",3,{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":54,"sex":16,"minAge":329,"maxAge":4,"enrollmentInfo":330,"targetDuration":4,"studyType":21,"phases":332,"briefSummary":333,"conditions":334,"keywords":335,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":346},"100487268","accelerated-resolution-therapy-for-early-maladaptive-grief-100487268","NCT05624879","Accelerated Resolution Therapy for Early Maladaptive Grief","Accelerated Resolution Therapy for Early Maladaptive Grief: A Clinical Trial","Inclusion Criteria:\n\n* Primary caregiver of immediate family member who has a life expectancy of less than 12 months\n* Score of 30 or higher on the PG-12-R, indicating clinically significant pre-loss grief\n* Denial of suicidal ideation or intent, with no evidence of psychotic behavior.\n\nExclusion Criteria:\n\n* Since becoming a family caregiver (FCG), they have engaged in another trauma based psychotherapeutic regimen (EMDR, prolonged exposure therapy, trauma focused cognitive behavioral therapy) that could influence response to accelerated resolution therapy (ART).\n* Self-reported or clinically assessed major psychiatric disorder (e.g., bipolar disorder, schizophrenia).\n* Score of \\> 2 on the adapted CAGE questionnaire indicating alcohol \u002Fdrug dependence.\n* Cognitive impairment (SPMSQ \\> 4 errors).","60 Years",{"count":331,"type":20},440,[23],"The purpose study is to test the effects of accelerated resolution therapy (ART) on pre-loss grief and prolonged grief disorder among older adult family caregivers (FCGs). Additionally, to better understand predictors of response to ART, and cognitive processes that occur among grieving individuals following ART.",[26],[336],"Family Caregiver","2025-09-22",{"date":339,"type":37},"2025-09-25",{"date":341,"type":37},"2023-11-17",{"date":343,"type":20},"2028-03-14",{"name":345,"class":44},"Mayo Clinic",4,{"id":348,"slug":349,"hasResults":11,"nctId":350,"briefTitle":351,"officialTitle":352,"acronym":4,"eligibilityCriteria":353,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":354,"targetDuration":4,"studyType":21,"phases":356,"briefSummary":357,"conditions":358,"keywords":360,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":369,"lastUpdatePostDateStruct":370,"startDateStruct":372,"completionDateStruct":374,"leadSponsor":376,"locationsCount":76},"100566994","support-for-bereaved-cancer-caregivers-100566994","NCT06662409","Support for Bereaved Cancer Caregivers","Support for Bereaved Friend and Family Caregivers of Cancer Patients","Inclusion Criteria:\n\n* 18 years old or older; Able and willing to provide reflexology\n* Able to speak and understand English\n* Have access to a telephone\n* Able to hear normal conversation\n* Cognitively oriented to time, place, and person (determined via recruiter)\n\nExclusion Criteria:\n\n* Unwilling to perform return demonstration with 90% accuracy",{"count":355,"type":20},70,[23],"Friend and family caregivers of recently deceased cancer patients experience acute bereavement following the death. Post death bereavement is an intense period of mourning that includes an unfolding of the grief process and is characterized by strong emotions and demands on cognitive resources to those who have put aside their own needs to support the dying patient with cancer. This research will test the feasibility and acceptability of a nature-based healing meditation (NBHM) intervention to support cancer caregivers' during the bereavement process.",[27,28,359,26],"Caregiver",[361,362,363,208,364,365,366,367,368],"nature-based intervention","meditation","bereavement support","directed attention","quality of life","anxiety","depression","cancer caregiver","2025-09-04",{"date":371,"type":37},"2025-09-11",{"date":373,"type":37},"2025-06-01",{"date":375,"type":20},"2026-08",{"name":377,"class":44},"Michigan State University",{"id":379,"slug":380,"hasResults":11,"nctId":381,"briefTitle":382,"officialTitle":383,"acronym":4,"eligibilityCriteria":384,"healthyVolunteers":54,"sex":16,"minAge":385,"maxAge":386,"enrollmentInfo":387,"targetDuration":4,"studyType":21,"phases":389,"briefSummary":390,"conditions":391,"keywords":392,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":4},"100604559","adolescent-suicide-loss-survivors-grief-intervention-group-100604559","NCT07151092","Adolescent Suicide Loss Survivors Grief Intervention Group","Exploring Experiences of Adolescent Suicide Loss Survivors After Participating in a Grief Intervention Group","Inclusion Criteria:\n\n* \\- Adolescents aged 13-17 years.\n* Survivor of suicide loss.\n* Permission from parent or guardian.\n\nExclusion Criteria:\n\n* Adolescents who have not experienced the loss of a loved one to suicide.","13 Years","17 Years",{"count":388,"type":20},20,[23],"This study will provide evidence-based recommendations for designing interventions tailored to adolescents dealing with suicide loss. By exploring how these young people experience and make meaning of their grief, the study will contribute to the development of best practices for mental health professionals and educators working with suicide loss survivors. This study will provide evidence-based recommendations for designing interventions tailored to adolescents dealing with suicide loss. By exploring how these young people experience and make meaning of their grief, the study will contribute to the development of best practices for mental health professionals and educators working with suicide loss survivors.\n\nThis study will enhance scientific understanding by examining how adolescents experience grief after suicide loss and identifying which components of bereavement interventions are most effective for this age group. It will improve societal welfare by informing the development of targeted, evidence-based support programs that address the unique mental health needs of bereaved adolescents. Long-term, the findings may reduce the risk of complicated grief and suicidality, support emotional resilience, and guide best practices in schools, clinics, and community settings for supporting youth after traumatic loss.",[26],[393,394,27,395,396,397,398,399],"Suicide Loss","Stigmatized Grief","Traumatic grief","adolescent grief group","coping","continuing bonds","hope","2025-08-27",{"date":402,"type":37},"2025-09-03",{"date":404,"type":20},"2025-09-01",{"date":406,"type":20},"2026-03",{"name":408,"class":44},"Nova Southeastern University",{"id":410,"slug":411,"hasResults":11,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":4,"eligibilityCriteria":415,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":416,"targetDuration":4,"studyType":21,"phases":418,"briefSummary":419,"conditions":420,"keywords":424,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":346},"100581780","families-left-behind-100581780","NCT06854757","Families Left Behind","Families Left Behind: Addressing Prolonged Grief and Substance Use Disorders Among People Bereaved by Drug Overdose Deaths","Inclusion Criteria:\n\n* people who lost a loved one to an unintentional drug overdose death within the past year\n* age 18 and older\n* fluently understand English or Spanish\n* have the capacity to give consent (e.g., excluding those with severe cognitive impairment, those in active psychosis, and those with developmental disabilities).\n\nExclusion Criteria:\n\n* people who need hospitalization for psychiatric symptoms or substance use disorders. (Note, people who use drugs but who do not require hospitalization will be included.)\n* people have active suicidal ideation\n* people who lost someone to a drug overdose death more than one year ago\n* people who lost someone to a drug overdose death that was suicidal in nature or of undetermined intent",{"count":417,"type":20},340,[23],"The United States is facing unprecedented rates of drug overdose deaths, profoundly impacting millions of families who are left to navigate their grief. Those bereaved by overdose experience a unique form of grief characterized by feelings of guilt, shame, and blame, which can worsen their suffering and deter them from seeking help. Individuals coping with overdose loss often endure more severe health consequences compared to those grieving non-drug related deaths, including prolonged grief disorder, substance use disorders, PTSD, depression, and suicidal thoughts. Moreover, bereaved individuals, particularly those with a history of substance use, may engage in risky behaviors as a means of coping, further exacerbating the risk of overdose and mortality within this vulnerable population. Peer grief support interventions have emerged as a promising approach to assist those experiencing such losses. To combat these outcomes, we are collaborating with Peer Community Support Partners (PSCP) in a novel practice-research partnership to implement the RIVER peer grief support model. Though RIVER has shown success in community settings, it has yet to be rigorously evaluated. In a three-aim approach, this study aims to assess the effectiveness of the RIVER model while also enhancing and engaging grievers with support resources via medical examiner offices (MEOs), which routinely contact families during death investigations. This research represents a pivotal advancement in addressing the needs of the overlooked bereaved community, aligning with the NIH's Helping to End Addiction Long-term (HEAL) initiative to develop effective strategies against the opioid crisis. Together, community engagement and rigorous research efforts aim to enhance support for those affected by the tragedy of drug overdose.",[26,421,422,423],"Grief Disorder, Prolonged","Overdose Accidental","Substance Use Disorders",[425,208,426,427],"overdose","bereavement","prolonged grief disorder","2025-08-15",{"date":430,"type":37},"2025-08-21",{"date":432,"type":37},"2025-06-13",{"date":434,"type":20},"2030-10",{"name":436,"class":44},"RAND"]