[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"growth-amp-development\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:growth-amp-development":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":34,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100583027","optimizing-nutrition-and-milk-opti-num-project-100583027",false,"NCT06870981","Optimizing Nutrition and Milk (Opti-NuM) Project","Improving Growth and Neurodevelopment of Very Low Birth Weight Infants Through Precision Nutrition: The Optimizing Nutrition and Milk (Opti-NuM) Project","Opti-NuM","Inclusion Criteria:\n\n• Secondary data and biospecimens from participants of the MaxiMoM Platform RCTs\n\nExclusion Criteria:\n\n• Data and biospecimens from infants who are not enrolled in the three trials are eligible for this project.","ALL","1 Hour","21 Days",{"count":21,"type":22},1100,"ESTIMATED","OBSERVATIONAL","Early nutrition critically influences growth, neurodevelopment and morbidity among infants born of very low birth weight (VLBW), but current one-size-fits-all feeding regimes do not optimally support these vulnerable infants. There is increasing interest in \"precision nutrition\" approaches, but it is unclear which Human Milk (HM) components require personalized adjustment of doses. Previous efforts have focused on macronutrients, but HM also contains essential micronutrients as well as non-nutrient bioactive components that shape the gut microbiome. Further, it is unclear if or how parental factors (e.g. body mass index, diet) and infant factors (e.g. genetics, gut microbiota, sex, acuity) influence relationships between early nutrition and growth, neurodevelopment and morbidity. Understanding these complex relationships is paramount to developing effective personalized HM feeding strategies for VLBW infants. This is the overarching goal of the proposed Optimizing Nutrition and Milk (Opti-NuM) Project.\n\nThe Opti-NuM Project brings together two established research platforms with complementary expertise and resources: 1) the MaxiMoM Program\\* with its clinically embedded translational neonatal feeding trial network in Toronto (Dr. Deborah O'Connor, Dr. Sharon Unger) and 2) the International Milk Composition (IMiC) Consortium, a world-renowned multidisciplinary network of HM researchers and data scientists collaborating to understand how the myriad of HM components contribute \"as a whole\" to infant growth and development, using systems biology and machine learning approaches. Members of the IMiC Corsortium that will work with on this study are located at the University of Manitoba (Dr. Meghan Azad), University of California (Dr. Lars Bode) and Stanford (Dr. Nima Aghaeepour).",[26,27,28,29,30,31,32,33],"Very Low Birth Weight Baby","Early Nutrition and the Preterm Infant","Nutritional Requirements","Human Milk Fortification","Human Milk Microbiome","Human Milk Feeding","Human Milk Nutrition","Growth &Amp; Development",[35,36,37],"Very Low Birth Weight Infants","Early nutrition and the preterm infant","Human milk feeding","RECRUITING","2025-03-06",{"date":41,"type":42},"2025-03-11","ACTUAL",{"date":44,"type":42},"2010-10-01",{"date":46,"type":22},"2027-12",{"name":48,"class":49},"The Hospital for Sick Children","OTHER",6,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":17,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":64,"conditions":65,"keywords":74,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":86,"leadSponsor":88,"locationsCount":90},"100573300","oral-breath-test-to-measure-anabolic-sensitivity-to-a-protein-meal-across-the-age-and-physical-activity-spectrum-100573300","NCT06744491","Oral 'Breath Test' to Measure Anabolic Sensitivity to a Protein Meal Across the Age and Physical Activity Spectrum","Anabolic Sensitivity Across the Lifespan","NFRF","Inclusion Criteria:\n\n* Healthy will be defined as screened by the PAR-Q+ (The Physical Activity Readiness Questionnaire for everyone)\n* Chronological age for Healthy Young (age: 18-35 years) or Older (age: 60-80 years) adults\n* Chronological age between 8 to 16 years, with maturity offset \\\u003C -1 year from age of Peak Height Velocity (aPHV) for children and between -0.5 to +1.5 years from aPHV in adolescent participants\n* BMI between normal to overweight (18.5 - 29.9 kg\u002Fm2)\n\nExclusion Criteria:\n\n* Regular use of nonsteroidal anti-inflammatory dugs (with the exception of daily low-dose aspirin)\n* use of anticoagulants\n* use of a walker, cane, or assistive walking device\n* infectious or gastrointestinal disease\n* inability to comply with study protocol (e.g., unable to track diet)\n* regular tobacco use\n* self-reported illicit drug use (e.g., growth hormone, testosterone, etc.)\n* diagnosed chronic illness (e.g., type 2 diabetes, heart disease, thyroid disease)\n* pregnant\n* hormonal replacement therapy",true,"8 Years","80 Years",{"count":63,"type":22},80,"The purpose of this study is to determine how anabolic sensitivity, in response to the ingestion of a liquid protein meal, differs across the lifespan, between biological sexes, and with varying physical activity levels.",[66,67,68,69,70,71,72,73],"Inactivity, Physical","Aging","Healthy Aging","Growth & Development","Sex Differences","Anabolic Sensitivity","Protein Metabolism","Physical Activity",[75,76,77,78,79,80],"anabolic sensitivity","aging","growth and development","physical activity","skeletal muscle","stable isotopes","NOT_YET_RECRUITING","2024-12-16",{"date":84,"type":42},"2024-12-20",{"date":84,"type":22},{"date":87,"type":22},"2025-08-31",{"name":89,"class":49},"University of Toronto",1]