[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"guided-bone-regeneration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:guided-bone-regeneration":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,42,74,110,135,166,190,212,233,255],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100592936","the-effect-of-ipd-on-lateral-bone-augmentation-100592936",false,"NCT06999915","The Effect of IPD on Lateral Bone Augmentation","Influence of Individual Phenotypical Dimension (IPD) on Hard Tissue Stability Following Lateral Bone Augmentation: a Two-centre Clinical Study","Inclusion Criteria:\n\n* Adult (\\>18 years old) patients\n* Good medical and psychological health\n* Engaged patients presenting with a Full Mouth Plaque Score (FMPS) of ≤ 20% within the 6 weeks prior to enrolment\n* Need of a tooth\u002Fteeth replacement in the incisor, canine or premolar maxillary region that could be provided with an implant-supported fixed prosthesis\n* A relatively symmetrical maxillary arch\n* A nearly intact contra-lateral alveolar ridge\n* At least one neighbouring natural tooth present with healthy periodontal conditions\n* After implant placement, presence of a buccal bone dehiscence\u002F fenestration or buccal bone plate thickness of ≤ 1.5 mm requiring GBR (Monje et al., 2022; Jensen et al.,2023, Group 1 ITI Consensus Report).\n* At least 4 weeks of post-extraction socket healing and no ridge preservation prior to implant placement.\n* No acute infection at the site; adequate availability of bone apical and palatal to obtain implant primary stability\n* A functional occlusion with a minimum of 4 occlusal units (i.e., pairs of occluding posterior teeth)\n* Willingness to read and sign a copy of the Informed Consent Form (ICF) after reading the Patient Information Sheet (PIS), and after the nature of the study has been fully explained and potential questions fully answered.\n\nExclusion Criteria:\n\n* Any known systemic disease severely affecting bone metabolism (e.g., Cushing's syndrome, Crohn's disease, rheumatoid arthritis, osteoporosis or diabetes type I and uncontrolled diabetes type II).\n* Self-reported HIV or other severe immunosuppression.\n* Self-reported alcoholism or chronic drug abuse.\n* Heavy smokers ( \\> 10 cigarettes\u002Fday)\n* Patients reporting use of vape\u002Fe-cigarettes\n* Self-reported pregnancy or lactation\n* Chronic treatment (i.e., 2 weeks or more) with any medication known to affect oral status or bone metabolism (e.g., bisphosphonates, hormone replacement therapy, immunosuppressants) within 1 month before baseline visit.\n* Chronic treatment with anticoagulants (including Aspirin), corticosteroids, immunosuppressants or other medications that may influence blood coagulation\u002Fcount.\n* Untreated caries lesions in neighbouring teeth and untreated\u002Funcontrolled periodontal disease; If patients require periodontal treatment (non-surgical and\u002For surgical), this will be arranged outside the study protocol and completed prior to enrolment;\n* Physical handicaps that would interfere with the ability to perform adequate oral hygiene in the area of implant placement.\n* Patients requiring maxillary sinus lift surgery before implant placement or presenting bone dimensions (at any time point of the study) that do not allow implant placement or there is no clinical indication to perform study procedures (i.e. bone augmentation, implant placement).\n* Patients not willing to receive animal-derived biomaterials for GBR.\n* Patients suffering from a known psychological disorder or with limited mental capacity or language skills such that study information could not be understood, informed consent could not be obtained, or simple instructions could not be followed.\n* Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or may interfere with the interpretation of trial results and, in the judgement of the investigator, would make the subject inappropriate for entry into this trial.","ALL","18 Years",{"count":19,"type":20},28,"ESTIMATED","INTERVENTIONAL",[23],"NA","Guided Bone Regeneration (GBR) is a widely used technique during dental implant surgery to help rebuild bone around the implant and improve its long-term appearance and stability. This study investigates whether the amount of bone that regrows depends on a person's original bone shape, known as the Individual Phenotypical Dimension (IPD). The aim is to compare the bone stability and overall results between two approaches: adding bone only up to the original bone line (IPD) or adding bone beyond it (over-contour augmentation). Over the course of a year, the study will assess not only bone and soft tissue healing, but also gum blood flow, implant success, and patient satisfaction.\n\nThere will be two treatment groups in this study - one group will receive bone grafting just up to their natural bone shape, while the other group will receive a slightly larger graft that extends about 3 mm beyond it. Throughout the study CBCT scans will be taken to assess bone changes around the implant area in order to measure how the bone shape and thickness change over time after surgery.",[26,27,28],"Guided Bone Regeneration","Bone Resorption","Diagnostic Imaging","NOT_YET_RECRUITING","2026-05-06",{"date":32,"type":33},"2026-05-07","ACTUAL",{"date":35,"type":20},"2026-06",{"date":37,"type":20},"2029-06",{"name":39,"class":40},"Queen Mary University of London","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":41},"100621195","assessment-of-guided-bone-regeneration-using-xenograft-mixed-with-allogenic-bone-graft-versus-xenograft-mixed-with-autogenous-graft-for-augmentation-of-maxillary-alveolar-ridges-100621195","NCT07367464","Assessment Of Guided Bone Regeneration Using Xenograft Mixed With Allogenic Bone Graft Versus Xenograft Mixed With Autogenous Graft For Augmentation Of Maxillary Alveolar Ridges","Radiographic And Histomorphometric Assessment Of Guided Bone Regeneration Using Xenograft Mixed With Allogenic Bone Graft Versus Xenograft Mixed With Autogenous Bone Graft For Augmentation Of Deficient Maxillary Alveolar Ridges A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age: 20-50 years.\n* Totally or partially edentulous maxillary ridges.\n* Patients with insufficient bone for an implant placement.\n* Residual alveolar width ranging from 2 to 4 mm.\n* Minimum of 10 mm vertical dimension to nasal floor or sinus floor.\n* Patients with healthy systemic condition (Medically free).\n* Adequate inter-arch space for placement of the implant prosthetic part.\n\nExclusion Criteria:\n\n* Pathological lesions in the defect site.\n* Systemic diseases that would interfere with bone metabolism. Uncontrolled diabetic patients.\n* Ongoing treatment or a history of recent chemotherapy or radiotherapy.\n* Patient with medical condition that contraindicates surgical procedures.\n* Patients on medication that may interfere with healing (Corticosteroids, Bisphosphonate, Chemo\u002Fradio therapy).\n* Patients with vertical bone deficiency.\n* Patients with habits that may jeopardize the implant longevity and affect the results of the study such as alcoholism or para-functional habits.",true,"20 Years","50 Years",{"count":53,"type":20},32,[23],"This study aims to evaluate the effect of Allogenic bone graft mixed with Xenograft in ratio 1:1, on the radiographic and histomorphometric assessment versus Autologous bone graft mixed with Xenograft in ratio 1:1 in maxillary deficient ridges، In guided bone regeneration of deficient edentulous maxillary ridges, will the application of Xenograft mixed with Allograft (1:1) be as effective as Xenograft mixed with Autogenous graft (1:1) in terms of dimensional ridge changes and Quality of newly formed bone?\n\nEvaluation of the patient's general condition of the oral cavity, to make sure it complies with the criteria required to be enrolled in the study in terms of oral hygiene and pathological conditions.\n\nA full thickness flap will be elevated with two releasing incisions, decortication of the buccal aspect of the ridge, placing of grafting material which will be covered by collagen pericardium membranes, tacks placement at the labial side to fix the membrane in place, horizontal mattress sutures as well as single interrupted and continuous with resorbable sutures for closure.\n\nIntervention group: will be filled with mixture of Xenogenic graft and the Allogenic bone graft chips.\n\nControl group: will be filled with mixture of Xenogenic graft and Autogenous bone particulate harvested either the ramus.\n\nFor both groups, All the subjects will be taking CBCT at pre surgical and 6 months post surgical. outcomes : Bucco-Palatal horizontal bone gain, Alveolar ridge height, Percentage of new vital bone formation and Percentage of residual bone graft 6 months post-surgical.",[26],[26,58,59,60,61,62,63],"DFDBA","Autogenous Bone Graft","Xenograft","Xenograft Mixed With Autogenous Bone Graft","Xenograft Mixed With Allogenic Bone Graft","Deficient Maxillary Alveolar Ridges","RECRUITING","2026-04-09",{"date":67,"type":33},"2026-04-14",{"date":69,"type":33},"2024-06-01",{"date":71,"type":20},"2026-06-01",{"name":73,"class":40},"Cairo University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":83,"conditions":84,"keywords":92,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":41},"100633411","digital-planning-and-clinical-assessment-of-the-treated-atrophic-posterior-maxilla-with-a-sinus-lift-procedure-a-cross-sectional-study-100633411","NCT07526337","Digital Planning and Clinical Assessment of the Treated Atrophic Posterior Maxilla With a Sinus Lift Procedure: a Cross-sectional Study.","Inclusion Criteria:\n\n* \\- Patient aged more than 18 years.\n* Partially edentulous patients having an implant rehabilitation treated with a sinus lift procedure in the atrophic posterior maxilla.\n* Patient with no systemic disease that contraindicate the surgical procedure as uncontrolled diabetes mellitus, bleeding disorders, recent myocardial infarction, head and neck radiation, and mental disorders.\n\nExclusion Criteria:\n\n* \\- Fully Edentulous patients.\n* Patients presenting sinus pathologies (sinusitis, thickening of the membrane).\n* Patient smoking more than 20 cigarettes.\n* Patient taking systemic drugs that could affect bone healing as immune suppressive drugs and bisphosphonates.\n* Patient with systemic disease that contraindicate the surgical procedure as uncontrolled diabetes mellitus, bleeding disorders, recent myocardial infarction, head and neck radiation, and mental disorders.",{"count":81,"type":20},100,"OBSERVATIONAL","Maxillary posterior area is the most challenging site for dental implant placement. Indeed, complex remodeling processes, resulting in changes of the maxillary sinus and shape of the alveolar ridge will cause difficulties in rehabilitating the posterior maxillae sites. Various techniques have been proposed in order to achieve the necessary bone volume for the placement of long term successful implants. However, unbalanced crown to implant ratio remains a risk factor after successful dental implants installation following sinus graft. No study on humans assessed the effect of apical positioning of the implants in posterior grafted sites (sinus graft or sinus graft + vertical GBR) on the following clinical parameters: The peri-implant bone remodeling (vertical bone loss (mm) and probing depth (mm) around the implants, crown bulkiness, emergence profile and crown height, and Patients satisfaction, food impaction (PROM)).\n\nThis study will elucidate these points and based on the parameter's results, suggest a treatment based classification facilitating the treatment decision-making of the clinicians in case of an atrophic posterior maxilla; aiming to ensure a long-term successful supra-implant rehabilitation which will maintain its bio-mechanically and biological success.",[85,86,87,88,89,26,90,91],"Alveolar Bone Atrophy","Alveolar Bone Grafting","Peri-Implant Health","Sinus Floor Augmentation","Vertical Ridge Deficiency","Digital Guided Bone Regeneration","Prosthetic Complication",[93,94,95,96,97,98,99,100],"alveolar bone atrophy","digital planning","guided bone regeneration","maxillary sinus","peri-implant disease","peri-implantits","sinus floor augmentation","vertical ridge deficiency","2026-04-06",{"date":103,"type":33},"2026-04-13",{"date":105,"type":33},"2025-01-01",{"date":107,"type":20},"2026-05-30",{"name":109,"class":40},"Saint-Joseph University",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":21,"phases":121,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":41},"100628238","artificial-intelligence-guided-versus-manual-cbct-planning-for-immediate-implant-placement-100628238","NCT07459036","Artificial Intelligence-Guided Versus Manual CBCT Planning for Immediate Implant Placement","Artificial Intelligence-Guided Versus Manual CBCT Planning for Immediate Implant Placement in Molar Extraction Sites: A Randomized Controlled Trial","AI","Inclusion Criteria:\n\n* Adults≥18 years are able to provide informed consent. Indicated for the extraction of a molar tooth (maxillary or mandibular) with planned implant-supported rehabilitation.\n* Candidate for immediate implant placement attempt based on preoperative clinical evaluation and CBCT availability.\n* Preoperative CBCT will be acquired using the study imaging protocol within a defined window (e.g., ≤4 weeks before surgery).\n* Adequate oral hygiene and periodontal condition compatible with implant surgery (e.g., treated\u002Fstable periodontal status per clinician judgement).\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding (due to imaging\u002Fsurgical considerations).\n* Uncontrolled systemic disease or medical contraindication to oral surgery\u002Fimplant placement (e.g., uncontrolled diabetes, immunosuppression as judged by clinician).\n* History of head and neck radiotherapy in the implant region. Use of medications associated with compromised bone healing where immediate implant placement is not advised (e.g., high-dose antiresorptives\u002FIV bisphosphonates; you can specify per your clinic policy).\n* Acute uncontrolled infection at the site requiring staged management (e.g., spreading cellulitis\u002Fabscess) or other condition precluding immediate placement per surgeon judgement.\n* Need for simultaneous major augmentation that precludes immediate implant placement (e.g., extensive ridge reconstruction planned at the same surgery rather than socket-level grafting).\n* Inadequate CBCT quality for segmentation\u002Fmeasurement (motion artifacts, incomplete field of view, or metal artifact obscuring the septum).","99 Years",{"count":120,"type":20},80,[23],"This study evaluates whether artificial intelligence (AI)-based analysis of cone-beam computed tomography (CBCT) scans can support clinical decision-making for immediate dental implant placement in molar extraction sites.\n\nWhen a molar tooth is removed, placing a dental implant immediately may reduce treatment time and preserve surrounding bone. However, immediate implant placement is not always possible and depends on the anatomy of the extraction socket, particularly the interradicular septum (the bone between the roots). CBCT imaging is routinely used to assess this anatomy before surgery. Traditionally, radiologists manually evaluate these scans. Recently, AI-based tools have been developed to automatically analyze CBCT images.\n\nIn this randomized controlled trial, patients requiring molar extraction and potential immediate implant placement will be assigned to one of two planning approaches: AI-guided CBCT assessment or conventional manual CBCT assessment. The operating surgeon will use the assigned planning report to guide treatment decisions.\n\nThe primary outcome of the study is the feasibility of immediate implant placement, defined as successful implant placement with achievement of primary stability during surgery. Secondary outcomes include surgical time, need for changes to the treatment plan, and implant stability measurements.\n\nThe goal of this study is to determine whether AI-assisted CBCT analysis performs similarly to, or improves upon, conventional manual radiologic assessment in supporting safe and effective immediate implant placement.",[124,125,26],"Dental Implant","Immediate Implant","2026-03-06",{"date":128,"type":33},"2026-03-09",{"date":130,"type":20},"2026-03-03",{"date":132,"type":20},"2026-05-02",{"name":134,"class":40},"Shalash Dental education",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":21,"phases":145,"briefSummary":146,"conditions":147,"keywords":149,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":41},"100612508","guided-bone-regeneration-in-lower-posterior-edentulous-arch-using-resorbable-or-non-resorbable-membrane-100612508","NCT07254494","Guided Bone Regeneration in Lower Posterior Edentulous Arch Using Resorbable or Non Resorbable Membrane.","Comparative Evaluation of Resorbable (Pericardium) Versus Non Resorbable (Polytetrafluoroethylene) Membrane for Horizontal Bone Augmentation of Posterior Atrophic Mandible","Inclusion Criteria:\n\n* Mandibular posterior atrophic alveolar ridge Required horizontal bone augmentation procedures prior to implant placement.\n* Alveolar bone height suitable for implant placement.\n* Free of any local or systemic condition that may contraindicate ridge expansion procedure\n* The capacity to understand and accept the conditions of the study.\n* Continuing participation over at least 1 year of follow-up.\n\nExclusion Criteria:\n\n* Heavy smokers (i.e., 2 or more packs of cigarettes per day);\n* Insufficient oral hygiene\n* Acute local or systemic infection\n* Patients with any systemic disease that may affect bone healing;\n* Pregnancy or the possibility of becoming pregnant during the study; and\n* Addiction to drugs or alcohol","80 Years",{"count":144,"type":20},30,[23],"the purpose of this study is to compare the efficiency of non-resorbable membrane versus resorbable membrane in guided bone regeneration in atrophic posterior mandible.",[148,26],"Horizontal Alveolar Bone Defect",[150,151,95,152,153,154,155,156],"atrophic","horizontal bone loss","pericardium membrane","PTFE membrane","resorbable membrane","non resorbable membrane","GBR","2025-11-25",{"date":159,"type":33},"2025-11-28",{"date":161,"type":20},"2026-05",{"date":163,"type":20},"2026-12",{"name":165,"class":40},"Beirut Arab University",{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":21,"phases":176,"briefSummary":177,"conditions":178,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":41},"100593046","alveolar-ridge-preservation-versus-spontaneous-healing-100593046","NCT07001345","Alveolar Ridge Preservation Versus Spontaneous Healing","Alveolar Ridge Preservation (ARP) Versus Spontaneous Healing in Large Buccal Bone Defects After Tooth Extraction in the Posterior Mandible","ARP versus SH","Inclusion Criteria:\n\n* A minimum age of 18 years old\n* In need for extraction of a single (pre)molar in the mandible that needs to be replaced by an implant\n* At least one adjacent tooth\n* A buccal bone defect after extraction of 50% or more\n\nExclusion Criteria:\n\n* Active periodontal disease\n* Uncontrolled diabetes mellitus\n* History of or current chemotherapy or radiation in the head and neck area\n* History of or current use of medication related to osteonecrosis of the jaw\n* Heavy and moderate smokers (\\>5 cigarettes a day)\n* Unable to maintain basic oral health (physical and\u002For mental)\n* Pregnancy (in case of pregnancy, the treatment is postponed until after the delivery)",{"count":175,"type":20},66,[23],"Rationale: To determine the effect of alveolar ridge preservation (ARP) versus spontaneous healing (SH) in large buccal bone defects in the posterior mandible.\n\nObjective: To evaluate whether ARP using a xenograft (XG) (Cerabone plus) or an allograft (AG) (Maxgraft granules) covered by a membrane (Jason membrane) reduces the need for additional bone augmentation either prior to or during implant placement in the posterior mandible compared to spontaneous healing Study design: Prospective randomized clinical study with 10-year follow-up.\n\nStudy population:\n\nInclusion criteria: patients are 18 years or older and in need for extraction of a (pre)molar in the posterior mandible with at least one adjacent tooth and a buccal bone defect of \\>50%.\n\nExclusion criteria: the presence of active periodontal disease, uncontrolled diabetes mellitus, a history of or current use of chemotherapy or radiation in the head and neck area, history of or current use of medication related to osteonecrosis of the jaw, smoking (\\> 5 cigarettes a day, disability (physical and\u002For mental), making the patient unable to maintain basic oral health or follow the study protocol, pregnancy (in case of pregnancy, the treatment is postponed until after the delivery).\n\nIntervention (if applicable): Atraumatic extraction of a (pre)molar in the posterior mandible will be performed. Patients will then be included based on the dimensions of the buccal bone defect (buccal bone defect of \\>50%). 66 patients will be randomly divided in either the XG group, the AG group or the SH group (control). In the ARP groups (XG and AG), following tooth extraction, ARP will be performed using either a XG (Cerabone plus) or an AG (Maxgraft granules), both covered by a membrane (Jason membrane). In the control group, the alveolus will be left for spontaneous healing, following tooth extraction. After 4-6 months, a cone bean computed tomography (CBCT) scan will be performed to determine the possibility of implant placement with or without additional augmentation. Implant placement will be performed in all groups with or without guided bone regeneration (GBR).\n\nMain study parameters\u002Fendpoints: Frequency of additional augmentation at implant placement.",[179,180,26],"Dental Implants, Single-tooth","Alveolar Ridge Preservation","2025-05-23",{"date":183,"type":33},"2025-06-03",{"date":185,"type":20},"2025-06-01",{"date":187,"type":20},"2035-06-01",{"name":189,"class":40},"Erasmus Medical Center",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":197,"enrollmentInfo":198,"targetDuration":4,"studyType":21,"phases":200,"briefSummary":201,"conditions":202,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":41},"100569284","efficacy-and-safety-of-additive-manufacturing-personalized-titanium-mesh-in-guided-bone-regeneration-100569284","NCT06692244","Efficacy and Safety of Additive Manufacturing Personalized Titanium Mesh in Guided Bone Regeneration","Efficacy and Safety of Additive Manufacturing Personalized Titanium Mesh in Guided Bone Regeneration: a Randomized, Single-blind, Positive-controlled Prospective Study","Inclusion Criteria:\n\n1. Patients missing single or multiple teeth with moderate to severe bone defects in the edentulous area requiring complex guided bone regeneration. （Moderate bone defects: bone loss with residual alveolar ridge width between 1 mm and 3 mm; severe bone defects: bone loss with residual alveolar ridge width ≤ 1 mm.）\n2. The edge of the edentulous area within 1 mm is alveolar bone, with no adjacent tooth roots or nerve canals, ensuring complete retention of the personalized titanium mesh edge. The apical edge of the edentulous area within 2 mm is alveolar bone, with no nerve canals, ensuring that retention screws for the personalized titanium mesh can be designed in this area.\n3. The patient and\u002For his\u002Fher guardian agrees to participate in this trial and signs the informed consent form.\n\nExclusion Criteria:\n\n1. Patients with edentulism.\n2. Patients with mild bone defects (residual alveolar ridge width greater than 3 mm).\n3. Presence of acute or chronic infection in the surgical area.\n4. Presence of acute or chronic infection in the teeth adjacent to the edentulous area.\n5. Participation in similar trials or other interventional clinical trials within 30 days prior to signing the informed consent form.\n6. History of metal allergies, severe allergy history, or severe immune deficiency.\n7. Uncontrolled metabolic diseases, such as Type 1 diabetes or Type 2 diabetes (HbA1c ≥ 7% or fasting blood glucose ≥ 7 mmol\u002FL despite medication control), severe liver or kidney dysfunction (ALT, AST \\> 2 times the upper limit of normal, serum creatinine above the upper limit of normal).\n8. Long-term use of steroid medications.\n9. History of drug abuse or alcoholism.\n10. Pregnant or breastfeeding women.\n11. Poor compliance.\n12. Other conditions deemed unsuitable for participation by the investigator.","60 Years",{"count":199,"type":20},142,[23],"This goal of this single-blind, simple randomized, positive-controlled prospective study is to evaluate the effects of additive-manufactured personalized titanium mesh and traditional titanium mesh in guided bone regeneration for large alveolar bone defects. The study will assess the short-term and long-term efficacy, safety, and incidence of complications of the additive-manufactured personalized titanium mesh, along with an analysis of risk factors. Participants will be followed up for two years after surgery with free-of-charge clinical and radiographic examinations.",[85,26],"2025-03-10",{"date":205,"type":33},"2025-03-11",{"date":207,"type":33},"2024-11-30",{"date":209,"type":20},"2028-12",{"name":211,"class":40},"Hospital of Stomatology, Sun Yat-Sen University",{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":216,"acronym":4,"eligibilityCriteria":217,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":218,"targetDuration":4,"studyType":21,"phases":219,"briefSummary":220,"conditions":221,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":41},"100569522","submerged-vs-non-submerged-guided-bone-regeneration-simultaneous-to-implant-placement-100569522","NCT06695338","Submerged Vs Non-Submerged Guided Bone Regeneration Simultaneous to Implant Placement.","Inclusion Criteria:\n\n* • Men and women over 18 years old.\n\n  * Patients requiring single-unit implant restoration in any tooth site of the maxilla and mandible in between teeth.\n  * Anticipation of a peri-implant buccal osseous dehiscence by means of a CT imaging (cone-beam computed tomography, CBCT) with a maximum vertical dimension height (VDH) of 50%.\n  * Presence of adjacent teeth.\n  * Presence of antagonist teeth.\n  * Minimum primary stability of 25Ncm.\n  * Non-smokers or light smokers (\\\u003C 10 cigarettes per day).\n  * Absence of systemic diseases that could influence the outcome of the therapy (i.e., uncontrolled diabetes mellitus, osteoporosis, biphosphonate medication).\n  * Tooth extraction performed at least 4 months before implant placement.\n  * Good level of oral hygiene (Plaque Index \\\u003C 25%) (Löe, 1967)\n  * Written informed consent signed.\n  * Keratinized mucosa of at least 2mm on the buccal and lingual of the implant.\n\nExclusion Criteria:\n\n* Implant surgery requiring sinus lift procedure.\n\n  * Previous bone augmentation at the implant site.\n  * Active periodontal disease.\n  * Acute infection at the rehabilitation site.\n  * Long-term non-steroidal anti-inflammatory drug therapy (3 months).\n  * Lactating females or currently pregnancy.\n  * Severe cognitive or psychiatric disorders.\n  * Unwillingness to return for follow-up examination.",{"count":53,"type":20},[23],"Dental implants are worldwide recognized one of the best manners to replace lost or hopeless prognosis teeth. There are different variables that creates proper conditions for long-term prognosis of implant treatments.\n\nImplant position and surrounding bone around them, have been described in scientific literature to be key factors in the longevity of those treatments.\n\nIt has to be defined the \\"critical bone thickness\\" around implants. It basically means that implants has to be completely surrounded by bone, that will serve as protection. If the implants are not surrounded by bone, procedures as guided bone regeneration may be performed.\n\nThose procedures can be executed before or simultaneously during the implant placement. In the standard procedure, the simultaneous guided bone regeneration during implant placement requires to leave the implant and the regeneration healing below the gingiva, needing a second surgery for accesing to those implants.\n\nIn this randomized controlled trial the hypothesis is to discover if not submerging this regenerations may show the same results than submerged ones.\n\nFor that, the objective is to study the different variables around these regeneration to evaluate the performance of non-submerged protocol.",[26,124,222,223],"Submerged Regeneration","Bone Atrophy","2024-11-16",{"date":226,"type":33},"2024-11-19",{"date":228,"type":20},"2024-12-15",{"date":230,"type":20},"2026-06-06",{"name":232,"class":40},"Universitat Internacional de Catalunya",{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":240,"targetDuration":4,"studyType":21,"phases":242,"briefSummary":243,"conditions":244,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":4},"100559909","res-safe-resorption-safety-and-efficacy-of-absorbable-collagen-membrane-100559909","NCT06570265","RES-SAFE (Resorption, Safety, and Efficacy of Absorbable Collagen Membrane)","Evaluation of Resorption, Safety, and Efficacy of Absorbable Collagen Membrane in Preventing Significant Bone Loss Following GBR (Guided Bone Regeneration) Procedure.","Inclusion Criteria (among others):\n\n* Patients over 18 years old (both sex) with full legal capacity who understand the treatment and sign the informed consent and who are medically healthy, except treated condition.\n\nExclusion Criteria (among others):\n\n* Patients with dental diseases or conditions (except treated condition);\n* Patients with unsatisfactory oral hygiene;\n* Patients with alcohol, substance abuse, smoking habits, known allergy to collagen;\n* Patients with severe or chronic diseases or with systemic inflammation and all patients classified as unhealthy;\n* Pregnant or breast feeding women.",{"count":241,"type":20},50,[23],"The clinical study aims to assess the long-term safety and efficacy of the interventional medical device. The clinical study will enrol up to 50 patients aged 18 years and older, who meet specific inclusion and exclusion criteria designed to ensure patient safety and reliable data collection.",[26],"2024-08-21",{"date":247,"type":33},"2024-08-26",{"date":249,"type":20},"2024-12-16",{"date":251,"type":20},"2026-06-30",{"name":253,"class":254},"Hyundai Bioland Co., Ltd.","INDUSTRY",{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":4,"eligibilityCriteria":261,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":262,"targetDuration":4,"studyType":21,"phases":264,"briefSummary":265,"conditions":266,"keywords":267,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":269,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":41},"100538113","rct-gbr-one-stages-comparing-a-oss-and-autogenous-bone-versus-a-oss-and-lcr-a-100538113","NCT06286605","RCT GBR One Stages Comparing A-Oss and Autogenous Bone Versus A-Oss and LCR-A","Horizontal Ridge Augmentation Using One-stage Guided Bone Regeneration (GBR) for Bone Defect Class IV of Cawed and Howell With Collagene Membrane (OssMem) and a Mix of Bovine Bone Substitute (A-Oss) and Autogenous Bone Versus A-Oss and LCR-A, a Synthetic Bone : a Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients that required an implant supported restoration and staged horizontal guided bone regeneration (defect of class IV according to Cawed and Howell) in both mandible or maxilla.\n* Patents able to understand and sign an informed consent.\n* Patients were to be 18 years or older with a residual horizontal ridge thickness of 4 mm or less (Cawood-Howell Class III- IV) in the intended implant site.\n* Smokers will be categorized into: 1) non smokers; 2) moderate smokers (smoking up to 10 cigarettes\u002Fday); 3) heavy smokers (smoking more than 11 cigarettes\u002Fday). Only categories 1 and 2 will be included.\n\nExclusion Criteria:\n\n* General contraindications to implant surgery.\n* Patients irradiated in the head and neck area.\n* Immunosuppressed or immunocompromised patients.\n* Patients treated or under treatment with intravenous amino-bisphosphonates.\n* Patients with untreated periodontitis.\n* Patients with poor oral hygiene and motivation.\n* Uncontrolled diabetes.\n* Pregnancy or nursing.\n* Substance abuser.\n* Heavy smokers (smoking more than 11 cigarettes\u002Fday).\n* Psychiatric problems or unrealistic expectations.\n* Lack of opposite occluding dentition in the area intended for implant placement.\n* Immediate implants (extractive sites will have to be healed from 6-8 weeks).\n* Patients participating in other studies, if the present protocol cannot be properly adhered to.\n* Patients referred only for implant placement and cannot be followed ant the treating centre.\n* Patients unable to be followed for 5 years",{"count":263,"type":20},42,[23],"The aim of this randomized controlled trial is to evaluate the tridimensional bone stability after horizontal one-stage GBR using collagene membrane (OssMem) with a mix of Bovine Bone Substitute (A-Oss) and autogenous bone (test group) versus A-Oss and LCR-A, a synthetic bone (control group).",[26,124],[124,156],"2024-02-21",{"date":270,"type":33},"2024-02-29",{"date":272,"type":20},"2024-03-01",{"date":274,"type":20},"2028-12-30",{"name":276,"class":40},"Università degli Studi di Sassari"]