[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"guillain-barre-syndrome-gbs\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:guillain-barre-syndrome-gbs":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100426171","firm-observational-clinical-unicenter-study-on-guillain-barr-syndrome-100426171",false,"NCT04829526","Firm Observational Clinical Unicenter Study on Guillain Barré Syndrome","Firm Observational Clinical Unicenter Study on Guillain Barré Syndrome (FOCUS on GBS)","FOCUS on GBS","Inclusion Criteria:\n\n* suspected diagnosis of GBS, who have been treated at the University Hospital of Basel from 01.01.2005-28.02.2021\n\nExclusion Criteria:\n\n* Patients with documented refusal of the general consent.","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","The aim of this retrospective observational single-center cohort study is to gain a deeper understanding regarding the frequency, the clinical and electrophysiologic characteristics (e.g., the diagnostic work up), complications, treatment regimes, and their associations with specific courses of disease and outcomes in adult patients with the suspected or proven diagnosis of GBS.",[25],"Guillain-Barre Syndrome (GBS)","RECRUITING","2026-06-15",{"date":29,"type":30},"2026-06-17","ACTUAL",{"date":32,"type":30},"2021-03-01",{"date":34,"type":21},"2026-07",{"name":36,"class":37},"University Hospital, Basel, Switzerland","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":4},"100584163","phase-2-efgartigimod-for-the-treatment-of-guillain-barr-syndrome-100584163","NCT06885762","Efgartigimod for the Treatment of Guillain-Barré Syndrome","Safety and Efficacy of Efgartigimod in Guillain-Barré Syndrome","Inclusion Criteria:\n\n1. Aged 18 years or older;\n2. Meet the diagnostic criteria as specified in the \\*European Guidelines for the Diagnosis and Treatment of Guillain-Barré Syndrome 2023 Edition\\*;\n3. Onset of GBS symptoms within 2 weeks prior to enrollment;\n4. GBS-DS score of 3-5;\n5. Written informed consent obtained.\n\nExclusion Criteria:\n\n1. Patients with GBS symptoms for more than 2 weeks;\n2. Known hypersensitivity of the study subject to any component of the investigational drug or any other anti-neonatal Fc receptor (FcRn) agent;\n3. Any uncontrolled active infection or severe infection within 8 weeks prior to screening;\n4. Patients with other autoimmune diseases, such as Sjögren's syndrome, systemic lupus erythematosus, neuromyelitis optica, myasthenia gravis, multiple sclerosis, etc., requiring treatment with immunosuppressive agents;\n5. Vaccination within 4 weeks prior to screening or planned vaccination during the study period;\n6. Pregnant or breastfeeding, or planning to become pregnant during the study period, or women of childbearing potential not using effective contraception;\n7. Currently participating in another clinical trial of similar investigational agents (FcRn antagonists);\n8. Use of the investigational drug within 3 months prior to screening or within five half-lives of the drug (whichever is longer);\n9. Patients with a history of malignancy, including malignant thymoma, myeloproliferative or lymphoproliferative disorders, unless considered cured by adequate treatment and without evidence of recurrence for ≥3 years prior to screening. Patients with completely resected non-melanoma skin cancer (e.g., basal cell carcinoma or squamous cell carcinoma) or carcinoma in situ of the cervix are eligible at any time;\n10. Patients with clinical evidence of other significant severe diseases or who have recently undergone major surgery, which may confound study results or place the patient at undue risk. Patients with severe renal\u002Fhepatic impairment may be included.",{"count":47,"type":21},20,"INTERVENTIONAL",[50,51],"PHASE2","PHASE3","The goal of this clinical trial is to evaluating the efficacy and safety of efgartigimod in the treatment of Guillain-Barré Syndrome and exploring the immunological mechanisms of efgartigimod therapy in Guillain-Barré Syndrome. The main questions it aims to answer are:\n\nWill efgartigimod improve the symptoms of participants? What medical problems do participants have when using efgartigimod?\n\nParticipants will:\n\nOn day 1 and day 5 of the treatment period, drug A was administered intravenously.\n\nKeep a diary of their symptoms",[25],"NOT_YET_RECRUITING","2025-03-13",{"date":57,"type":30},"2025-03-20",{"date":59,"type":21},"2025-04-13",{"date":61,"type":21},"2026-12-31",{"name":63,"class":37},"Zhongming Qiu"]