[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gum-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gum-disease":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100566526","an-evaluation-of-the-effect-of-the-erchonia-fx-405-laser-as-an-adjunctive-treatment-of-periodontitis-100566526",false,"NCT06656325","An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis","An Evaluation of the Effect of the Erchonia Corporation FX-405 Laser as an Adjunctive Treatment of Periodontitis","Inclusion Criteria:\n\n* Subject has voluntarily signed a written informed consent form.\n* Male or female 22 to 75 years of age, inclusive.\n* Subject has no evidence of Localized Aggressive Periodontitis.\n* Tooth loss due to periodontitis of ≤ 4 teeth.\n* Two or more teeth with the following characteristics: Non 3rd molar, Periodontitis: Stage III (Severity) according to the Interdental CAL (at site of greatest loss) and RBL, as classified by the American Academy of Periodontology (AAP), No evidence of caries, No abscess infection, No previous periodontal surgery within the prior 12 months\n* Subject agrees to adhere to study provided home care instructions to maintain adequate oral hygiene during the study duration.\n* Subject agrees to refrain from the use of smokeless chewing tobacco for the study duration.\n* Subject agrees to refrain from exceeding 40 milligrams per day of inhaled nicotine, encompassing cigarettes, electronic cigarettes, and cigars.\n* Subject agrees to refrain from engaging in any other treatments for his or her periodontitis that is outside the scope of this study during his or her participation in this study\n\nExclusion Criteria:\n\n* Gingival recession which may be genetic, induced secondary to orthodontic treatment, induced secondary to frenulum attachments, or present as a result of dental malocclusion.\n* History of oral cancer or HIV in the last 6 months\n* Pregnant or intending to become pregnant in the next 8 months.\n* Sensitivity to, or contraindication for, light therapy.\n* Currently enrolled in a clinical study of an investigational drug or device.","ALL","22 Years","75 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this clinical study is to determine the effectiveness of the Erchonia® FX-405 (manufactured by Erchonia Corporation (the Company) in providing a noninvasive adjunctive treatment in combination with periodontal scaling and root planing for improving the treatment of periodontal disease.",[27,28,29],"Periodontal Diseases","Periodontitis","Gum Disease","RECRUITING","2026-05-14",{"date":33,"type":34},"2026-05-18","ACTUAL",{"date":36,"type":34},"2025-01-01",{"date":38,"type":21},"2027-08-01",{"name":40,"class":41},"Erchonia Corporation","INDUSTRY",2,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":75},"100621955","cheer-oral-health-in-pregnancy-study-100621955","NCT07377344","CHEER Oral Health in Pregnancy Study","Closing Health Equity Through Empowering Oral Health for Maternal Wellness","CHEER","Inclusion Criteria:\n\n1. Pregnant individuals aged 18 years or older with indications of periodontal diseases (gingivitis or mild periodontitis, moderate to severe periodontitis)\n2. Less than 20 weeks pregnancy at time of enrollment\n3. Has dental insurance (Medi-Cal or private coverage)\n4. Willing and able to provide informed consent\n5. Planning to receive ongoing prenatal care at study-affiliated clinics\n6. Access to a mobile phone for receiving text messages\n\nExclusion Criteria:\n\n1. Presence of systemic diseases or medical conditions that require antibiotic prophylaxis for dental procedures\n2. Current immunosuppressive therapy\u002Fuse of anti-inflammatory medications\n3. Receipt of active periodontal treatment within the past 6 months\n4. Complete edentulism (no natural teeth)\n5. Unable to read and write English\n6. Less than 9th grade education\n7. Enrollment in another oral interventional study","FEMALE","18 Years",{"count":54,"type":21},160,[24],"Many pregnant people don't get the dental care they need, even though it's safe and important. The CHEER Study offers free dental check-ups, cleanings, and supplies to help participants take care of their teeth and gums during pregnancy. The purpose of this research study is to compare two types of noninvasive oral health interventions to evaluate their effectiveness. We want to learn if one method is more effective in supporting oral health and improving pregnancy outcomes. There are two aims of this study:\n\nAim 1: To evaluate whether a structured oral health intervention reduces periodontal inflammation during pregnancy and postpartum in pregnant people with indicators of periodontal disease.\n\nAim 2: To assess whether a structured oral health intervention is associated with changes in oral health behaviors or birth outcomes in pregnant people with periodontal disease.",[58,59,60,61,62,63,29],"Gingivitis","Dental Health","Pregnancy","Pregnancy Outcomes","Randomized Controlled Trial","Periodontal Disease","NOT_YET_RECRUITING","2026-04-01",{"date":67,"type":34},"2026-04-07",{"date":69,"type":21},"2026-06-01",{"date":71,"type":21},"2028-06-01",{"name":73,"class":74},"University of California, San Francisco","OTHER",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":75},"100591459","improving-oral-and-systemic-health-in-individuals-with-prediabetes-through-personalized-oral-hygiene-advice-provided-by-dentists-or-by-ai-100591459","NCT06980701","Improving Oral and Systemic Health in Individuals With Prediabetes Through Personalized Oral Hygiene Advice Provided by Dentists or by AI","Improving Oral and Systemic Health in Individuals With Prediabetes Through Personalized Oral Hygiene Advice Provided by Dentists or by Artificial Intelligence: A Randomized Clinical Trial","Inclusion Criteria:\n\n* \\- Subjects who are \\>18 years of age and able to give informed consent.\n* \\- Subjects who are mentally and cognitively healthy.\n* \\- Subjects who have at least 6 anterior maxillary or mandibular natural teeth including incisors and canine.\n* \\- Subjects who are with prediabetic state with impaired HbA1c 5.7% to 6.4%, impaired fasting plasma glucose level 5.6mmol\u002FL to 6.9 mmol\u002FL and\u002For impaired plasma glucose level after 2h OGTT 7.8 mmol\u002FL to 11.0 mmol\u002FL.\n* \\- Subjects who can speak, read, or understand Cantonese to complete the satisfaction questionnaire.\n* \\- Subjects who can practice oral hygiene procedure (regular tooth brushing and interdental cleansing\u002Fflossing\u002Fbrushing) daily on their own independently.\n\nExclusion Criteria:\n\n* \\- Subjects who have less than 6 anterior maxillary or mandibular natural teeth with or without dental prostheses in those area.\n* \\- Subjects who are with a current diagnosis or clinical history of T2DM.\n* \\- Subjects who have mental illness, or similar problems that unable to complete the satisfaction questionnaire.\n* \\- Subjects who cannot perform oral hygiene procedure (regular tooth brushing and interdental cleansing\u002Fflossing\u002Fbrushing) by any condition of oral cavity such as tumor or maxillomandibular fixation.",{"count":84,"type":21},148,[24],"Prediabetes is an intermediate stage before the development of diabetes, characterized by elevated blood glucose levels but lower than the diagnostic criteria of diabetes and is associated with multiple long-term complications. This systemic disease is mutually linked to inflammatory gum diseases through circulating inflammatory mediators. Controlling inflammatory gum diseases improves blood glucose levels and reduces long-term complications. While maintaining good oral hygiene through home care is essential for managing inflammatory gum diseases, close supervision of patients' home care is labor-intensive and expensive. Artificial Intelligence (AI) has been used to provide personalized advice on the adequacy of patients' home care (oral hygiene). The investigators hypothesize that the use of AI can improve home care, thereby enhancing both gum health and systemic health, similar to human dental professionals.",[29,88],"Prediabetes",[90,91,92,93],"gum disease","prediabetes","oral health","oral hygiene","2025-11-25",{"date":96,"type":34},"2025-12-03",{"date":98,"type":34},"2025-04-12",{"date":100,"type":21},"2026-04-18",{"name":102,"class":74},"The University of Hong Kong"]