[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gummy-smile\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gummy-smile":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100633859","comparison-between-liquid-fibrin-and-soft-laser-effects-on-healing-and-relapse-after-lip-repositioning-surgery-100633859",false,"NCT07532161","Comparison Between Liquid Fibrin and Soft Laser Effects on Healing and Relapse After Lip Repositioning Surgery","Comparison Between The Effect of Liquid Platelet-Rich Fibrin and Low-Level Laser Therapy on Enhancing Healing and Reducing Relapse After Lip Repositioning Surgery","Inclusion Criteria:\n\n1. Patients of both genders.\n2. Patients presenting with a gummy smile in the maxillary anterior region (more than 3 mm) due to upper lip hypermobility.\n3. Age 18-50 years.\n4. Systemically healthy individuals, classified as ASA physical status I or II according to the American Society of Anesthesiologists (ASA) classification; that is, patients without systemic disease or with mild, well-controlled systemic conditions.\n5. Patients with good oral hygiene, defined as an O'Leary Plaque Index ≤ 40%.\n6. No previous lip repositioning surgery.\n\nExclusion Criteria:\n\n1. Pregnancy and lactation.\n2. Individuals with a previous history of receiving facial Botox or filler injections.\n3. Systemic diseases or conditions that contraindicate the use of local anesthesia.\n4. Any physical condition that impairs the ability to perform proper oral hygiene measures.\n5. Patients who are smokers or alcohol consumers.\n6. Inability or unwillingness to cooperate.\n7. In adequate width of attached gingiva.\n8. Vertical maxillary excess (moderate to severe) requiring orthognathic intervention.\n9. Short upper lip\n10. Gingival display primarily caused by altered passive eruption requiring crown lengthening.","ALL","18 Years","50 Years",{"count":20,"type":21},22,"ESTIMATED","INTERVENTIONAL",[24],"NA","A gummy smile can negatively affect a patient's self-confidence and satisfaction with their appearance, leading many individuals to seek effective esthetic solutions. The etiology of this condition varies and may include vertical maxillary excess, short upper lip, hyperactive upper lip, gingival enlargement, or altered passive eruption.\n\nLip Repositioning Surgery is one of the minimally invasive esthetic surgical procedures used to reduce the amount of gingival display during smiling. Despite its effectiveness, this surgery may be associated with challenges such as pain, swelling, delayed wound healing, and the possibility of postoperative relapse over time, which could compromise both esthetic and functional outcomes.\n\nTo overcome these challenges and enhance surgical outcomes, adjunctive techniques have been introduced to promote healing and determine whether enhancing the biological healing process can reduce the rate of relapse after LRS. Among the most prominent of these are Injectable Platelet-Rich Fibrin (i-PRF) and Low-Level Laser Therapy (LLLT).",[27],"Gummy Smile",[29,30,31,32,33,34,35,36,37,38],"Excessive gingival display","Gummy smile","Lip Repositioning Surgery","Injectable Platelet-Rich Fibrin (i-PRF)","Liquid Platelet-Rich Fibrin","Low-Level Laser Therapy (LLLT)","Wound healing","Postoperative relapse","Gingival display reduction","Esthetic dentistry","RECRUITING","2026-04-24",{"date":42,"type":43},"2026-04-29","ACTUAL",{"date":45,"type":43},"2026-04-20",{"date":47,"type":21},"2027-01-31",{"name":49,"class":50},"Damascus University","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":16,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":51},"100590282","deep-learning-for-gummy-smile-segmentation-100590282","NCT06965387","Deep Learning for Gummy Smile Segmentation","Deep Learning-Based Evaluation of Gummy Smile: Development and Validation of a Segmentation Model","Inclusion Criteria:\n\n* Individuals aged 12 years or older with no maxillary anterior (teeth #13-23) tooth loss will be included in the study.\n\nExclusion Criteria:\n\n* Patients with missing anterior maxillary teeth (teeth #13-23), significant anatomical pathologies, or smile-interfering factors (e.g., facial piercings, orthodontic appliances, facial hair) will be excluded.",true,"12 Years",{"count":62,"type":21},1740,"OBSERVATIONAL","A gummy smile (excessive visibility of the gums when smiling) is not merely an aesthetic issue but also an important parameter in terms of periodontal health. Current evaluation methods are subjective and non-standardized, leading to limitations in both clinical accuracy and patient communication. In recent years, AI-based models have begun to be effectively used in dental image analysis and diagnostic processes. This study aims to develop an AI-supported objective and reproducible analysis model capable of evaluating gummy smile from both aesthetic and periodontal perspectives using a unique dataset composed of images obtained through standard clinical protocols and labeled by the same expert.\n\nIndividuals aged 12 years or older with no maxillary anterior (teeth #13-23) tooth loss will be included in the study. Patients with missing anterior maxillary teeth (teeth #13-23), significant anatomical pathologies, or smile-interfering factors (e.g., facial piercings, orthodontic appliances, facial hair) will be excluded.\n\nStandardized frontal photographs will be taken using a single device (iPhone 15) to ensure consistency in resolution, lighting, and color balance. Images will be captured from a fixed distance of 15 cm with participants in an upright position, eyes facing forward, and heads aligned to the Frankfurt Horizontal Plane. To maintain standardization, the smartphone's grid lines will be used to align the horizontal line with the pupils and vertical lines with the nasal alae.\n\nImages of high, average, and low smile lines will be labeled by a periodontist using the web-based annotation tool MakeSense. Visible gingival areas will be annotated as polygons bounded superiorly by the lower border of the upper lip and inferiorly by the gingival margin. For participants with high smile lines, gingival display will be measured using ImageJ (National Institutes of Health, Bethesda, MD, USA), with calibration performed via a periodontal probe embedded in each photo. A pixel-to-millimeter conversion factor will be derived and applied to measurements between the upper lip and gingival margin in the anterior maxillary sextant (teeth #13-23). Distances between paired landmarks (points 7-13, 8-14, 9-15, 10-16, 11-17, 12-18) will be measured in millimeters. AI-based segmentation outputs (via MakeSense) will be statistically compared to ImageJ measurements to assess correlation.",[27],"2025-05-16",{"date":68,"type":43},"2025-05-21",{"date":70,"type":43},"2025-01-12",{"date":72,"type":21},"2025-05-20",{"name":74,"class":50},"Gazi University",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":59,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":51},"100567852","assessment-of-the-accuracy-of-complete-crown-3d-superimposition-technique-relative-to-the-gold-standard-technique-for-digital-quantification-of-volumetric-soft-tissue-changes-in-the-esthetic-zone-100567852","NCT06673576","Assessment of The Accuracy of Complete Crown 3D Superimposition Technique Relative to The Gold Standard Technique for Digital Quantification of Volumetric Soft Tissue Changes in The Esthetic Zone","Inclusion Criteria:\n\n1. Patients requiring esthetic crown lengthening.\n2. Full-mouth plaque and bleeding score not exceeding 20%.\n3. Presence of at least 2.5 mm keratinized tissue width (Pontoriero \\& Carnevale, 2001).\n4. Patients showing motivation to comply with post-operative care instructions and follow-up appointments.\n\nExclusion Criteria:\n\n* 1\\. Systemic health conditions that contraindicate or affect healing of periodontal surgery.\n\n  2\\. Patients requiring prosthetic crowns or restorations in the esthetic zone. 3. Gummy smile with normal tooth proportions. 4. Patients treated with medications known to affect the gingiva (Phenytoin, Cyclosporine and Nifedipine).\n\n  5\\. Smokers. 6. Pregnant and nursing females.",{"count":82,"type":21},12,[24],"The aim of this study is to assess the precision of the complete crown technique employed for the superimposition of 3D models, specifically in the quantitative volumetric evaluation of gingival tissues. This technique was initially introduced in an in-vitro study by Dritsas et al. (2023) as a means to achieve an accurate, reproducible, and simple method for quantification of gingival recession.\n\nThis study will involve the analysis of digital models in. ply format acquired through intraoral scanning of patients scheduled for esthetic crown lengthening, with predefined inclusion and exclusion",[86,27],"Volume Assessment","2024-11-02",{"date":89,"type":43},"2024-11-05",{"date":91,"type":43},"2024-03-15",{"date":93,"type":21},"2025-05-15",{"name":95,"class":50},"British University In Egypt"]