[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gynecomastia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gynecomastia":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100641621","comparison-of-endoscopic-and-open-surgery-for-gynecomastia-100641621",false,"NCT07653152","Comparison of Endoscopic and Open Surgery for Gynecomastia","Prospective Comparative Evaluation of Different Surgical Techniques in the Treatment of Gynecomastia: A Multicenter Study","Inclusion Criteria:\n\n* Male patients aged 18 to 60 years.\n* Clinically and\u002For ultrasonographically confirmed primary gynecomastia with palpable glandular tissue ≥2 cm.\n* Simon Grade II or Grade III gynecomastia.\n* Patients requesting surgical treatment because of cosmetic and\u002For psychosocial concerns.\n* Eligible for either endoscopic or conventional open nipple-areola complex-preserving mastectomy according to routine clinical practice.\n* Ability to provide written informed consent.\n* Willingness and ability to comply with the 12-month follow-up schedule.\n\nExclusion Criteria:\n\n* Secondary gynecomastia caused by endocrine disorders, medications, hypogonadism, thyroid disease, or suspected malignancy.\n* Pseudogynecomastia (lipomastia without glandular proliferation).\n* Age younger than 18 years or older than 60 years.\n* Severe uncontrolled comorbidities that may increase surgical risk.\n* Previous chest or breast surgery, chest irradiation, or significant chest trauma.\n* Active infection or coagulation disorder.\n* Immunodeficiency disorders.\n* Inability to provide informed consent.\n* Inability to complete the planned follow-up period.","MALE","18 Years","60 Years",{"count":20,"type":21},100,"ESTIMATED","12 Months","OBSERVATIONAL","The goal of this observational study is to compare the clinical outcomes, safety, and patient satisfaction of endoscopic versus conventional open surgical techniques in adult male patients undergoing surgery for gynecomastia.\n\nThe main questions it aims to answer are:\n\n* Does endoscopic gynecomastia surgery provide better aesthetic outcomes and patient satisfaction compared with conventional open surgery?\n* Does endoscopic surgery reduce postoperative complications, sensory changes of the nipple-areola complex, and visible scarring compared with conventional open surgery?\n\nResearchers will compare patients undergoing endoscopic nipple-areola complex-preserving mastectomy with patients undergoing conventional open nipple-areola complex-preserving mastectomy to evaluate differences in surgical outcomes, complications, cosmetic results, and quality of life.\n\nParticipants will:\n\n* Undergo gynecomastia surgery as part of their routine clinical care using either an endoscopic or conventional open technique.\n* Attend routine postoperative follow-up visits for up to 12 months.\n* Complete patient-reported outcome assessments, including pain and satisfaction questionnaires.\n* Undergo evaluation of scar quality, nipple-areola complex sensation, and postoperative complications during follow-up.",[26],"Gynecomastia","RECRUITING","2026-06-12",{"date":30,"type":31},"2026-06-17","ACTUAL",{"date":33,"type":31},"2026-01-08",{"date":35,"type":21},"2028-01-08",{"name":37,"class":38},"Antalya City Hospital","OTHER",2,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100620114","to-evaluate-the-effectiveness-and-safety-of-single-port-robotic-assisted-subcutaneous-gland-resection-in-males-100620114","NCT07353411","To Evaluate the Effectiveness and Safety of Single-port Robotic-assisted Subcutaneous Gland Resection in Males","A Prospective, Single-center, Single-arm Clinical Study to Evaluate the Effectiveness and Safety of Single-port Robotic-assisted Subcutaneous Gland Resection in Males","Inclusion Criteria:\n\n1. Male patients, aged 18-75 years old;\n2. Preoperative breast ultrasound indicates male breast development, and breast enlargement symptoms persist for more than 1 year;\n3. Primary male breast development that has been unresponsive to drug treatment, or those who refuse drug treatment;\n4. According to Gynecomastia's surgical indications, refer to the \"2023 Expert consensus on the clinicaldiagnosis and treatment of gynecomastia in China\" Simon grading of male breast development IIb or above;\n5. Due to social pressure or severe psychological burden caused by symptoms such as breast pain, those who have a strong desire for surgery may experience psychological burden caused by the disease and actively request surgery;\n6. Individuals without serious accompanying diseases;\n7. Suspected malignant transformation;\n8. No other serious underlying diseases in the past;\n9. The surgical procedure includes a single hole robot (intraperitoneal endoscopic single hole surgical system SP1000) for subcutaneous gland resection of the breast;\n10. Participants are able to understand the research process, voluntarily join the study, sign informed consent forms, have good compliance, and cooperate with follow-up;\n11. No swallowing difficulties; No shoulder joint movement disorders;\n12. Complete clinical data.\n\nExclusion Criteria:\n\n1. Age\\\u003C16 years old, still in puberty, or disease duration ≤ 1 year;\n2. Simple obesity, no obvious glandular tissue was found on breast ultrasound examination;\n3. Male patients with breast developmental disorders secondary to other diseases;\n4. Patients with contraindications for general anesthesia surgery such as coagulation dysfunction and severe cardiovascular disease, who cannot tolerate surgery;\n5. The clinical data is basically incomplete;\n6. Other surgical methods;\n7. Individuals with a history of breast surgery or breast tumors in the past;\n8. The serious diseases of non malignant tumors such as congenital testicular hypoplasia syndrome, cirrhosis, primary hypogonadism, and hyperthyroidism will affect the patient's compliance or put the patient in a dangerous state;\n9. Dementia, intellectual disability, or any mental illness that hinders understanding of informed consent forms;\n10. Lack of trust in surgical outcomes and weak desire for surgery.",true,"17 Years","75 Years",{"count":51,"type":21},20,"INTERVENTIONAL",[54],"NA","The new technology of robotic surgery system, as an emerging technology, has shown certain application prospects in breast surgery. However, the new technology of robotic surgery system in China in the treatment of gynecomastia is still in the exploratory stage and needs to be further improved. This prospective, single-center, single-arm clinical study was conducted to use the single-port robot and evaluate the effectiveness and safety of the subcutaneous gland resection in the treatment of gynecomastia.",[26],[58],"Single-port Robotic-assisted subcutaneous gland resection","NOT_YET_RECRUITING","2026-01-19",{"date":62,"type":31},"2026-01-20",{"date":64,"type":21},"2026-01-01",{"date":66,"type":21},"2028-11-30",{"name":68,"class":38},"The First Affiliated Hospital with Nanjing Medical University",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":76,"targetDuration":4,"studyType":52,"phases":78,"briefSummary":79,"conditions":80,"keywords":81,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":4},"100612735","modularities-of-management-of-severe-grades-of-gynecomastia-100612735","NCT07257445","Modularities of Management of Severe Grades of Gynecomastia.","Comparative Study Between Different Surgical Modalities in Management of Severe Grades of Gynecomastia.","Inclusion Criteria:\n\n1. Grade IIb, III gynecomastia according to Simon classification.\n2. Age is between 18 years and 60 years old.\n3. Stable weight in last 6 months Exclusion Criteria\n\n1- Age is below 18 years and above 60 years. 2- Grade I and IIA gynecomastia according to Simon classification. 3- Psychological problems. 4- Non compliant patient. 5- Unstable weight in last 6 months",{"count":77,"type":21},45,[54],"Gynecomastia is defined as a benign enlargement of the mammary glands, commonly diffused among men. The prevalence of gynecomastia ranges from 38 to 64 percent in the male population.\n\nGynecomastia can affect normal self-esteem and sexual identity and often patients feel ashamed of their bodies during normal social activities.\n\nThe surgical management of the high-grade gynecomastia Simon's grade III or Rohrich's grade IV has remained problematic because both liposuction and conventional subcutaneous mastectomy without skin excision have frequently resulted in significant residual skin redundancy, requiring a second operation for skin resection.\n\nTwo Classification Systems of Gynecomastia\n\nRohrich's Classification I, Minimal breast hypertrophy without ptosis; hypertrophy is either primarily glandular or fibrous II, Moderate breast hypertrophy without ptosis; hypertrophy is either primarily glandular or fibrous III, Severe breast hypertrophy with grade I ptosis glandular or fibrous IV, Severe breast hypertrophy with grade II or III ptosis glandular or fibrous Simon's Classification I, Minor breast enlargement without skin redundancy. IIa, Moderate breast enlargement without skin redundancy IIb, Moderate breast enlargement with minor skin redundancy III, Gross breast enlargement with skin redundancy that simulates a pendulous female breast Smoot stated that this approach for high-grade gynecomastia has several disadvantages. There are difficulties in obtaining precertification from third-party payers for a second operation for skin resection. In addition, the adolescent patient is often very anxious during the ensuring 1 year after the original mastectomy when skin excess is quite apparent and awaiting spontaneous shrinkage.\n\nCurrently, there are 4 main different approaches for the management of high-grade gynecomastia:\n\nFirst is simple mastectomy, which is done with free nipple graft accepting the long transverse scar and the grafted appearance of the nipple areola complex. Second is a modification of breast reduction is done with nipple transposition on a single dermal pedicle or vertical bipedicle. A visible chest scar is also present, but the blood supply of the nipple-areola complex is preserved.\n\nThird is ultrasound assisted liposuction is performed first and after several months, accept that several patients will require a second operation to excise the significant residual skin redundancy. Fourth is a single-stage procedure is done in which sub cutaneous mastectomy and circumareolar skin excision are performed. The purse string skin closure limits the scar to the circumareolar area.\n\nOpen excision techniques base their principle on a direct view and management of the gland, through several types of surgical accesses according to the surgeon's preference and entity of the defect. The main advantage of open excision is the direct control of the hemostasis and redundant skin control, with the main disadvantage of permanent scars, whose quality cannot be predicted.\n\nOnly Gusenoff et al have proposed a classification with corresponding operative treatment options, whose grades taken into account the laxity of the breast skin and the upper abdomen, the location of the inframammary fold IMF, and the lateral fat role.\n\nMinimal excess skin and fat, minimal alteration of NAC, normal IMF, No lateral skin roll: a Minimal excess skin and fat, minimal alteration of NAC, normal IMF, lateral skin roll: b NAC and IMF below, the ideal IMF, lateral chest roll, minimal upper abdominal laxity: c NAC and IMF below the ideal IMF, lateral chest roll, significant upper abdominal laxity: d",[26],[82,83],"Severe Gynecomastia","Management of gynecomastia","2025-11-20",{"date":86,"type":31},"2025-12-02",{"date":88,"type":21},"2025-12",{"date":90,"type":21},"2028-03",{"name":92,"class":38},"Assiut University"]