[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hairy-cell-leukemia-hcl\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hairy-cell-leukemia-hcl":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":4,"leadSponsor":44,"locationsCount":47},"100139553","collection-of-human-samples-to-study-hairy-cell-and-other-leukemias-and-to-develop-recombinant-immunotoxins-for-cancer-treatment-100139553",false,"NCT01087333","Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment","A Study of Hairy Cell and Other Leukemias With a Focus on Recombinant Immunotoxins for Cancer Treatment","* INCLUSION CRITERIA:\n\nAll participants\n\n* 18 years of age and older\n* Desire of the individual to submit data and samples for research\n* Ability to understand and the willingness to sign a written informed consent document.\n\nIndividuals with cancer\n\n-Participants may have a diagnosis of hematologic malignancy or solid tumor. These participants would not be excluded if they were in long-term complete remission.\n\nNormal donors (Individuals without cancer)\n\n-Individuals must not have a current or prior diagnosis of a hematologic malignancy or solid tumor.\n\nEXCLUSION CRITERIA:\n\nAll participants\n\n-Known pregnancy at enrollment. NOTE: A pregnancy test will be required in individuals on study prior to any procedure done for research purposes that is greater than minimal risk.",true,"ALL","18 Years",{"count":20,"type":21},1263,"ESTIMATED","OBSERVATIONAL","Background:\n\n\\- Researchers who are studying hairy cell leukemia, and how the disease compares with other disorders, are interested in obtaining additional samples from leukemia patients and healthy volunteers. The investigators are particularly interested in samples from individuals who have diseases that can be treated with a new type of drug called immunotoxin, in which an antibody carrying a toxin binds to a cancer cell and allows the toxin to kill the cell.\n\nObjectives:\n\n\\- To collect a variety of clinical samples, including blood, urine, lymph samples, and other tissues, in order to study the samples and develop new treatments for leukemia.\n\nEligibility:\n\n\\- Individuals 18 years of age and older who have been diagnosed with leukemia or other kinds of blood and lymphatic system cancers, or who are healthy volunteers.\n\nDesign:\n\n* Individuals who have leukemia will be asked to provide blood, bone marrow, urine, and tumor tissue samples as requested by the researchers. Healthy volunteers will provide only blood and urine samples.\n* No treatment will be given as part of this protocol.",[25,26,27,28,29],"Hairy Cell Leukemia (HCL)","Chronic Lymphocytic Leukemia (CLL)","Non-Hodgkins Lymphoma (NHL)","Cutaneous T Cell Lymphoma (CTCL)","Adult T Cell Lymphoma (ATL)",[31,32,33,34,35,36],"Cytotoxicity Assay","Neutralizing Antibodies","Apheresis","Flow Cytometry","Hemolytic Uremic Syndrome (HUS)","Natural History","RECRUITING","2026-06-04",{"date":40,"type":41},"2026-06-05","ACTUAL",{"date":43,"type":41},"2010-03-02",{"name":45,"class":46},"National Cancer Institute (NCI)","NIH",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":5},"100575622","decoding-the-extracellular-vesicles-driven-communication-in-the-microenvironment-of-hairy-cell-leukemia-to-improve-patient-care-management-100575622","NCT06774677","Decoding the Extracellular Vesicles-driven Communication in the Microenvironment of Hairy Cell Leukemia to Improve Patient Care Management","Inclusion criteria for patients:\n\n* WHO2022-defined diagnosis of Hairy Cell Leukemia.\n* Age ≥18 years.\n* Signed informed consent.\n\nInclusion criteria for Healthy Donors:\n\n* Age ≥18 years.\n* Volunteers in general good health, free from any disease or serious illness.\n* Signed informed consent.\n\nExclusion criteria\n\n\\- None",{"count":55,"type":21},50,"This is a national multi-centre, experimental, cross-sectional, non-profit study.",[25],"2025-01-09",{"date":60,"type":41},"2025-01-14",{"date":62,"type":41},"2024-12-12",{"date":64,"type":21},"2026-08-30",{"name":66,"class":67},"IRCCS Azienda Ospedaliero-Universitaria di Bologna","OTHER",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":74,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":75,"conditions":76,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":47},"100574841","hairy-cell-leukemia-harnessing-the-full-power-of-extracellular-vesicles-to-improve-patient-care-management-100574841","NCT06764524","Hairy Cell Leukemia: Harnessing the Full Power of Extracellular Vesicles to Improve Patient Care Management","Inclusion criteria for patients:\n\n* WHO2022-defined diagnosis of Hairy Cell Leukemia.\n* age ≥18 years.\n* signed informed consent.\n\nInclusion criteria for Healthy Donors:\n\n* age ≥18 years.\n* Volunteers in general good health, free from any disease or serious illness.\n* Signed informed consent.\n\nExclusion criteria\n\n\\- None",{"count":55,"type":21},"Check whether patients with Hairy Cell Leukemia (HCL) of different status (at diagnosis, in complete remission \\> 2 years or relapsed requiring therapy) have a 'signature' of altered immunity based on extracellular vesicles (EV)",[25],"2025-01-02",{"date":79,"type":41},"2025-01-08",{"date":81,"type":41},"2024-12-05",{"date":83,"type":21},"2027-12-04",{"name":66,"class":67}]