[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hallucinations-verbal-auditory\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hallucinations-verbal-auditory":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100517146","virtual-reality-therapy-for-voice-hearing-vr-voices-a-randomized-controlled-trial-100517146",false,"NCT06013748","Virtual Reality Therapy for Voice Hearing (VR-VOICES): a Randomized Controlled Trial","VR-VOICES","Inclusion Criteria:\n\n* Having a DSM-5 diagnosis of a psychiatric disorder\n* Distressing AVH for minimally 3 months.\n* Age 16 years or older\n\nExclusion Criteria:\n\n* Insufficient command of the Dutch language\n* Unable to provide informed consent\n* Primary diagnosis of a substance use disorder, or organic brain disease (such as dementia)\n* A degree of substance abuse that hinders treatment adherence\n* Auditory verbal hallucinations in a language not spoken by therapists\n* Patients cannot receive CBT specifically focused at gaining empowerment over voices during the study period or 6 months prior to enrolment.","ALL","16 Years",{"count":19,"type":20},112,"ESTIMATED","INTERVENTIONAL",[23],"NA","Rationale: Auditory verbal hallucinations (AVH) - hearing voices that others cannot hear - are common in mental illnesses. For many people AVH are distressing, disabling and persistent, despite medication. Current psychological interventions show low to medium effects. Preliminary studies suggest that an innovative empowering psychological therapy using computer simulations representing the AVH (avatars) can be effective for reducing AVH distress and frequency. Virtual reality (VR) has the potential to improve this treatment. Therefore, we developed a novel VR treatment for this problem. In this study, the effect of this treatment will be investigated.\n\nObjective: To test the effect of a novel VR treatment for AVH (VR-VOICES) on distress and frequency of AVH in patients with a psychiatric disorder. Furthermore, to investigate the effect of VR-VOICES on clinical symptoms, quality of life, and healthcare costs of the treatment.",[26],"Hallucinations, Verbal Auditory",[28,29,30,31],"Virtual reality","Auditory hallucination","Voice-hearing","Psychological intervention","RECRUITING","2025-09-03",{"date":35,"type":36},"2025-09-10","ACTUAL",{"date":38,"type":36},"2022-10-31",{"date":40,"type":20},"2026-02-01",{"name":42,"class":43},"University Medical Center Groningen","OTHER",3,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100562146","evaluation-of-the-efficacy-of-transcranial-magnetic-stimulation-on-resistant-auditory-hallucinations-in-schizophrenia-100562146","NCT06599372","Evaluation of the Efficacy of Transcranial Magnetic Stimulation on Resistant Auditory Hallucinations in Schizophrenia","Treatment of Resistant Auditory Hallucinations in Schizophrenia by Repetitive Transcranial Magnetic Stimulation. Naturalistic Study","HRRENAT","Inclusion Criteria:\n\n* Patient over 18 years of age\n* Patient diagnosed with schizophrenia according to DSM-V criteria (Diagnostic and Statistical Manual of Mental Disorder V5, 2013)\n* Presence of auditory hallucinations: Resistant auditory hallucinations: resistance to treatment with 2 different well-conducted antipsychotics.\n* Patient agreeing to participate in the study and having signed an informed consent\n* Patient with French language skills\n* Affiliation to a social security system\n* Women of childbearing age must be on contraception and have a negative pregnancy test (βHCG)\n\nExclusion Criteria:\n\n* Have a contraindication to MST: intracranial foreign body, unstabilized epilepsy, cochlear implant\n* Presence of an unstabilized medical condition\n* Pregnant woman (Women of childbearing age without effective contraception)\n* Current or less than one month old engagement in another research protocol\n* A person who is subject to a safeguard of justice measure\n* An adult under curatorship\n* Minor patients with mental health problems\n* Pregnant or breastfeeding women\n* A person in a social fragility (Persons deprived of liberty by a judicial or administrative decision, hospitalized persons)\n* Persons incapable or unable to give consent","18 Years",{"count":55,"type":20},30,[23],"This open naturalistic study aims to evaluate the efficacy of rTMS in routine practice on auditory resistant hallucinations (AHR) of patients with schizophrenia. To this end, two stimulation methods will be offered to patients: the rTMS stimulation method and the cTBS stimulation method.We principally use the AHRS scale to evaluate the effectiveness of rTMS on RAH in patients with schizophrenia. Our main hypothesis is that rTMS used under naturalistic conditions, in addition to antipsychotics, would allow a relative improvement of resistant auditory hallucinations assessed by the AHRS scale between baseline and end of treatment in patients with schizophrenia.",[59,60,26],"Schizophrenia","Transcranial Magnetic Stimulation",[62,63,64,65,66,67,68,69,70],"hallucinations","resistant auditory hallucinations","schizophrenia","TMS","Transcranial magnetic stimulation","TBS","Theta burst stimulation","a improvement","real-life conditions","2024-09-12",{"date":73,"type":36},"2024-09-19",{"date":75,"type":36},"2022-07-11",{"date":77,"type":20},"2027-11",{"name":79,"class":43},"Dominique JANUEL",1]