[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hamstring-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hamstring-injury":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,52,81,106,131,154],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":34,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100465768","high-frequency-rf-current-effects-on-muscle-pain-and-function-100465768",false,"NCT05345015","High Frequency RF Current Effects on Muscle Pain and Function","Acute and Chronic Effects of High Frequency RF Electrical Current on Pain and Muscle Function in Individuals With Musculoskeletal Pain","Individuals with Muscle Injury\n\nInclusion Criteria:\n\n* Age over 18 years.\n* Athletes: amateur soccer players or sprinters with regular, systematic training.\n* Suspected Grade I or II hamstring strain.\n* Cessation of training due to injury.\n* No surgical intervention in the previous year (for initial assessment as potential participants).\n\nExclusion Criteria:\n\n* History of injury to the same muscle (ipsilateral side) within the last 6 months.\n* Other injury to the posterior aspect of the thigh.\n* Other injuries or chronic pain in the trunk or lower limbs.\n* Use of non-steroidal anti-inflammatory drugs (NSAIDs) in the 3 months prior to the injury.\n\nIndividuals with Acute Low Back Pain\n\nInclusion Criteria:\n\n* Age over 18 years.\n* Pain located between the lower ribs and the gluteal folds (top of the buttocks).\n* Pain occurred on fewer than half of the days over the preceding six months.\n* Pain intensity $\\\\ge$ 6\u002F10 on the Visual Analogue Scale (VAS).\n* Pain related to one or more of the following:\n\n  * Lumbar facet joints\n  * Sacroiliac joints\n  * Lumbar intervertebral discs\n  * Muscles, tendons, or ligaments of the lumbar and sacral region\n  * Other bony structures of the lumbar spine\n* Discontinuation of non-steroidal anti-inflammatory drugs (NSAIDs) or analgesics:\n\n  * 1 day prior to measurement\n  * 48 hours after measurement\n\nExclusion Criteria:\n\n* Radiographic evidence of inflammatory disease affecting the spine.\n* Spinal fracture.\n* Significant genetic structural abnormality of the spine.\n* Pregnancy.\n* Psychiatric disorders.\n* Receipt of systemic medication or treatment in the last 3 months.\n* Presence of neurological deficits (sensory, motor, or reflexes).\n* Receipt of TENS or TECAR therapy within the last year.\n\nIndividuals with Chronic Low Back Pain\n\nInclusion Criteria:\n\n* Episodes of low back pain (between the lower rib margin and the gluteal fold) for at least half of the days during the last 6 months.\n* Pain intensity $\\\\ge$ 20% on the Visual Analogue Scale (VAS).\n\nExclusion Criteria:\n\n* Spinal stenosis.\n* Radiographic evidence of inflammatory disease affecting the spine.\n* Vertebral fracture.\n* Presence of spondylolisthesis or spondylolytic lesion (spondylolysis).\n* Significant genetic structural abnormality of the spine.\n* Daily, severe low back pain.\n* Pregnancy.\n* Use of medications that might influence heart rate or blood pressure.\n* Psychiatric disorders.","ALL","18 Years","65 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to examine the acute and chronic effects of high frequency electrical current transfer (frequently called \"TECAR\") on pain and functional movement in individuals with a musculoskeletal injury or pain. The participants will be assigned into an experimental or a control group and outcome measures will be measured prior to, after, 24 and 48 hours following a single intervention session (Acute effects) as well as 3 and 6 months after the intervention (chronic effects).",[27,28,29,30,31,32,33],"Transcutaneous Electric Nerve Stimulation","Chronic Low-back Pain","Hamstring Injury","Muscle; Injury, Quadriceps (Thigh)","Physical Therapy","Calf Muscle Pulled","Acute Low Back Pain",[35,36,37,38],"Sport injuries","TECAR therapy","Low back pain","Muscle injury","RECRUITING","2026-06-23",{"date":42,"type":43},"2026-06-26","ACTUAL",{"date":45,"type":43},"2022-09-01",{"date":47,"type":21},"2029-12-31",{"name":49,"class":50},"Aristotle University Of Thessaloniki","OTHER",2,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":17,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":67,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100634770","chitosan-phonophoresis-with-recurrent-hamstring-strain-in-athletes-100634770","NCT07544004","Chitosan Phonophoresis With Recurrent Hamstring Strain in Athletes","Effectiveness of Chitosan Phonophoresis on Tissue Healing and Performance Related Outcomes in Athletes With Recurrent Hamstring Strain","Inclusion Criteria:\n\nParticipants will be included in the study if they fulfill the following criteria:\n\n1. Male recreational football players who participate in non-professional football training or matches for at least two sessions per week (each session ≥ 45 minutes) for at least the previous 12 months\n2. Aged 18-35 years\n3. Clinically diagnosed with a new episode of acute unilateral recurrent hamstring strain. Recurrent injury is defined as a new acute hamstring injury in the same limb and muscle group (biceps femoris, semitendinosus, or semimembranosus) as at least one previous hamstring strain that was professionally diagnosed, treated with rehabilitation, and after which the athlete returned to full participation. The previous injury must have occurred within the last 24 months\n4. Current injury onset within 3-10 days of enrollment.\n5. Current injury classified as Peetrons grade I or II on diagnostic musculoskeletal ultrasound performed within 7 days of enrollment by a single sonographer with at least 5 years of experience, using a 12-18 MHz linear probe in prone position (Peetrons, 2002; Heiss et al., 2025). The specific muscle involved, location within the muscle, and lesion volume (π\u002F6 × L × W × D) will be documented at baseline\n6. VISA-H score ≤ 75 at screening\n7. Body mass index between 18.5 and 30.0 kg\u002Fm².\n8. Able to walk independently without an assistive device.\n\nExclusion Criteria:\n\nParticipants will be excluded if they have any of the following:\n\n1. History of hamstring tendon avulsion (complete or partial) or surgical repair in either limb.\n2. Hamstring strain injury in the contralateral limb within the previous 12 months.\n3. Concomitant lower extremity or lumbopelvic pathology that prevents safe completion of testing at maximal effort, including but not limited to knee ligament injury, meniscal injury, hip labral pathology, sacroiliac joint dysfunction, or lumbar disc herniation with radiculopathy.\n4. Neurological disorder affecting lower extremity motor or sensory function such as peripheral neuropathy, lumbar radiculopathy, or multiple sclerosis.\n5. Known allergy or hypersensitivity to chitosan, chitin, or shellfish, identified by self-report on a standardized allergy screening questionnaire at enrollment\n6. Active skin disease, open wounds, or dermatitis over the posterior thigh of the affected limb.\n7. Corticosteroid injection to the ipsilateral hamstring within the previous 6 months\n8. Systemic conditions impairing healing such as diabetes mellitus, immunosuppressive therapy, chronic kidney disease, autoimmune connective tissue disorders, or coagulation disorders.\n9. Use of pharmacological agents or supplements with known effects on tissue healing (such as growth hormone, anabolic steroids, or collagen supplements) within the previous 3 months.",true,"MALE","35 Years",{"count":63,"type":21},80,[24],"The purpose of this randomized controlled trial is to evaluate and compare the effectiveness of adding chitosan phonophoresis as an adjunct to a rehabilitation-based exercise program compared to a rehabilitation-based exercise program with sham chitosan phonophoresis in athletes with recurrent hamstring strain injuries on the following outcomes: Hamstring-specific pain and function, Muscle strength and endurance, Lower extremity functions, Hamstring Flexibility symmetry and Hamstring injury healing score.",[29],[68,69],"Chitosan nanoparticles","Hamstring Strain","NOT_YET_RECRUITING","2026-06-12",{"date":73,"type":43},"2026-06-15",{"date":75,"type":21},"2026-07-01",{"date":77,"type":21},"2027-03",{"name":79,"class":50},"Cairo University",1,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":94,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":80},"100625356","the-effect-of-capacitive-and-resistive-electrical-transfer-therapy-on-hamstring-injuries-100625356","NCT07421570","The Effect of Capacitive and Resistive Electrical Transfer Therapy on Hamstring Injuries","The Effect of Capacitive and Resistive Electrical Transfer Therapy (CRET) on the Return to Play Time in Elite Soccer Players With Hamstring Strain Injuries","Inclusion Criteria:\n\n* History of acute onset hamstring pain.\n* Grade I or II hamstring strain injury confirmed by Magnetic Resonance Imaging (MRI) within the first 5 days following the injury.\n* No history of anterior cruciate ligament (ACL) reconstruction.\n\nExclusion Criteria:\n\n* Presence of neurological symptoms.\n* Loss of superficial sensation or skin pathologies that may prevent CRET application.\n* Refusal to sign the approval form.","40 Years",{"count":90,"type":21},22,[24],"The goal of this clinical trial is to evaluate the effects of capacitive resistive electric transference (CRET), which is frequently used in clinics and sports clubs for professional soccer players with hamstring injuries. The main questions it aims to answer are:\n\nReturn to sports time Treatments sessions number Muscle oxygen saturation\n\nThe investigators will administer the treatment to a experimental group to see if CRET therapy is effective. The investigators will also administer a standard rehabilitation program to both the control and experimental groups.\n\nParticipants will:\n\nCome for treatment and evaluations 3 times a week until participants meet the criteria for returning to sports.",[29],[95,96,97],"rehabilitation","hamstring","strain","2026-06-10",{"date":71,"type":43},{"date":101,"type":43},"2026-02-10",{"date":103,"type":21},"2026-08-20",{"name":105,"class":50},"Hacettepe University",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":113,"maxAge":88,"enrollmentInfo":114,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":80},"100630827","comparison-of-the-effects-of-selected-training-methods-and-sis-stimulation-on-balance-motor-tests-and-strength-100630827","NCT07492732","Comparison of the Effects of Selected Training Methods and SIS Stimulation on Balance, Motor Tests, and Strength","Comparison of the Effects of Selected Training Methods (Neuromuscular Training, Plyometric Training, and Nordic Hamstring Exercise) and SIS Stimulation on Balance, Motor Performance Tests, and Lower Limb Strength","Inclusion Criteria:\n\n* Healthy individuals aged 19-40,\n* Without injuries,\n* Physically active persons, athletes.\n\nExclusion Criteria:\n\n* periods of peak training load specific to the athlete's discipline,\n* evidence of overload-related pathology in the knee, hip, or lumbosacral joints,\n* the presence of any pain symptoms,\n* clinically relevant muscle fatigue or indicators of overtraining,\n* engagement in strength-based sports within several weeks preceding competition,\n* active inflammatory conditions involving osseous, articular, or ligamentous structures of the lower limbs,\n* a history of injury or surgical intervention within the 6 months prior to the study intervention.","19 Years",{"count":115,"type":21},30,"OBSERVATIONAL","The purpose of this study is to evaluate the effects of four-week training interventions-Nordic Hamstring Exercise, plyometric training, and neuromuscular training-combined with Super Inductive Stimulation (SIS) on hamstring muscle strength, balance, and motor performance.",[29],[120,121],"plyometric","neuromuscular","2026-03-19",{"date":124,"type":43},"2026-03-25",{"date":126,"type":43},"2025-03-15",{"date":128,"type":21},"2026-05-01",{"name":130,"class":50},"Gdansk University of Physical Education and Sport",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":59,"sex":16,"minAge":138,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":22,"phases":142,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":80},"100630209","myofascial-release-combined-with-fifa-11-effects-on-hamstring-flexibility-and-injury-risk-100630209","NCT07484698","Myofascial Release Combined With FIFA 11+: Effects on Hamstring Flexibility and Injury Risk","Effect of Myofascial Release Combined With the FIFA 11+ Program on Hamstring Flexibility and Injury Risk in Football Players","Inclusion Criteria:\n\n* Male football players aged 16-30 years.\n* Able to comply with a 6-week FIFA 11+ program.\n* Provide informed consent.\n\nExclusion Criteria:\n\n* Acute or chronic hamstring injury.\n* Recent major surgery of the lower limb or ongoing rehab plan.\n* Inability to safely perform exercises included in the FIFA 11+ program.\n* Non-compliance with baseline assessments or the training schedule.\n* Current musculoskeletal injuries affecting lower limb function.\n* Unable to achieve ≥65% limb symmetry index (LSI) in any hop test.\n* Undergoing physiotherapy or post-rehabilitation care.","16 Years","30 Years",{"count":141,"type":21},28,[24],"Football is a physically demanding sport that involves frequent jumping, cutting, and sudden changes in direction, making players vulnerable to various musculoskeletal injuries especially around the knee(1, 2). If not properly addressed, such mechanical demands can place excessive stress on key structures like the Hamstring, ACL and MCL, increasing the risk of injury during high-impact movement(1). Hamstring strains are one of the most common injuries among football players, with significant impact on their performance and career longevity(1). These injuries are especially prevalent due to the high-intensity nature of football, involving rapid sprinting, cutting, and changes of direction. Studies have shown that hamstring strains account for a substantial proportion of all injuries in football, ranging from 12% to 20% of total injuries in professional and amateur levels. Given the high rate of recurrence and the long recovery times associated with hamstring injuries, there has been growing interest in injury prevention programs aimed at reducing the risk of these injuries. Many of these injuries stem from deficits in dynamic balance, inadequate landing strategies, and reduced strength in the lower limbs(3). When such deficits persist, they increase biomechanical load on the knee joint, raising the likelihood of ligament injuries during explosive actions(4). By addressing these movement impairments, programs like FIFA 11+ aim to improve neuromuscular coordination and reduce injury rates among football players",[29],"2026-03-16",{"date":147,"type":43},"2026-03-20",{"date":149,"type":43},"2025-11-15",{"date":151,"type":21},"2026-07-31",{"name":153,"class":50},"Riphah International University",{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":161,"targetDuration":4,"studyType":22,"phases":163,"briefSummary":165,"conditions":166,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":80},"100556563","phase-3-hyperbaric-oxygen-therapy-in-hamstring-injury-hotham-trial-100556563","NCT06526728","Hyperbaric Oxygen Therapy in HAMstring Injury (HOTHAM) Trial","HOTHAM","Inclusion Criteria:\n\n* The participant is male or female, of any ethnic origin\n* The participant is between 18 and 65 years old\n* The participant has a clinical diagnosis of an acute hamstring injury ≤7 days old, defined as:\n\n  * Anamnestic acute injury\n  * Anamnestic pain in the posterior thigh\n  * Localized pain during palpation of hamstring muscle\n  * Localized pain during passive straight leg raise\n  * Increased pain during isometric contraction\n* The participant is able to start of HBOT treatment ≤7 days)\n\nExclusion Criteria:\n\n* The participant is not capable of doing an active exercise program.\n* The participant does not have the intention to full sporting activity or duty activities;\n* The cause of the hamstring injury is an extrinsic trauma on the posterior thigh;\n* The participant has a chronic hamstring injury \\>2 months, defined as recurrent pain or tenderness of the hamstring;\n* The current injury is a re-injury ≤2months after RTP\u002FRTD after acute ipsilateral hamstring injury;\n* Clinical suspicion of a complete proximal tendon avulsions;\n* Presence of other concurrent injuries inhibiting rehabilitation;\n* The participant is not able to give informed consent;\n* There are contra-indications for MRI: Pacemaker, pregnancy and claustrophobia\n* There are contra-indications for HBOT:\n\n  * Smoking or quit smoking \\\u003C3 months prior to injury;\n  * A previous spontaneous pneumothorax.\n  * Implantation of ICD or PM not compatible with hyperbaric pressure\n  * Current or recent (\\\u003C6 months) use of cytostatics\n  * Unable to perform a Valsalva manoeuvre to pressurize the middle ear (pre-existent ear-nose-throat complaints or a current upper airway infection).\n  * Pregnancy\n  * Claustrophobia",{"count":162,"type":21},50,[164],"PHASE3","The goal of this study is to learn if Hyperbaric Oxygen Therapy is able to accelerate and improve muscle healing following an acute hamstring injury. The main questions it aims to answer are:\n\n1. Does Hyperbaric Oxygen Therapy accelerates the time needed to return to play\u002F-duty following hamstring injury.\n2. Does Hyperbaric Oxygen Therapy decrease the amount of reinjuries within 1 year following Return to play\u002F-duty? Besides these questions this study will clinically and radiologically evaluate the healing process over time as well as the occurrence of (serious) adverse events.",[29],"2024-11-18",{"date":169,"type":43},"2024-11-20",{"date":171,"type":43},"2024-10-30",{"date":173,"type":21},"2028-03-01",{"name":175,"class":50},"JL Tol"]