[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hamstring-muscles\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hamstring-muscles":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100641550","optimizing-hamstring-activation-through-emg-feedback-and-the-hamshell-device-100641550",false,"NCT07660926","Optimizing Hamstring Activation Through EMG-Feedback and the Hamshell Device","EMG-BF","Inclusion Criteria:\n\n* Age between 18 and 40 years\n* Recreationally active, defined as engaging in at least 150 minutes per week of moderate-intensity physical activity\n\nExclusion Criteria:\n\n* Current or recent (≤6 months) musculoskeletal injury of the lower extremities\n* Inability to follow study procedures or instructions",true,"ALL","18 Years","40 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","In this study, we investigate whether training of the posterior thigh muscles with visual feedback on muscle activity is more effective than the same training without feedback. To this end, healthy, physically active adults complete a training programme on a training device twice a week for five weeks. Muscle strength, muscle activity, and flexibility are measured before and after the training. Participants are randomly assigned to one of two groups: one group trains with feedback on muscle activity, the other without. Participation involves minimal risks, similar to those of a typical strength training session (e.g. muscle soreness). The aim of the study is to improve training methods for the prevention of muscle injuries.",[28,29],"Hamstring Muscles","Hamstring Muscle Strength",[31,32,33,34],"Hamstring","Training","Biofeedback","EMG","RECRUITING","2026-06-16",{"date":38,"type":39},"2026-06-22","ACTUAL",{"date":41,"type":39},"2026-06-09",{"date":43,"type":22},"2027-07-31",{"name":45,"class":46},"Praxisklinik Rennbahn AG","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":47},"100596114","outcomes-and-complication-rates-of-anterior-cruciate-ligament-reconstruction-using-the-over-the-top-technique-combined-with-lateral-extra-articular-tenodesis-in-patients-over-50-years-old-compared-with-a-control-group-of-patients-under-30-100596114","NCT07041242","Outcomes and Complication Rates of Anterior Cruciate Ligament Reconstruction Using the \"Over-the-top\" Technique Combined With Lateral Extra-articular Tenodesis in Patients Over 50 Years Old, Compared With a Control Group of Patients Under 30","ACL_50_YO","Inclusion Criteria:\n\n* Patients operated on between 2007 and 2023 who were over 50 years old at the time of surgery (study group) and patients under 30 years old at the time of surgery (control group).\n* Patients who underwent ACL reconstruction using the gracilis and semitendinosus tendons with the over-the-top + LET technique.\n* Patients of both male and female sex.\n* Patients who have provided consent to participate in the study.\n\nExclusion Criteria:\n\n* Previous surgery on the same limb (meniscectomy, prior ACL reconstruction, surgically treated fractures, osteotomies, meniscal transplants).\n* Concomitant surgery on the same limb (osteotomies, meniscal transplants).\n* Surgical technique different from the over-the-top with LET using autologous gracilis and semitendinosus tendons.\n* Other concomitant ligament injuries requiring surgical treatment.\n* Patients younger than 18 years at the time of surgery (minors) or patients aged between 30 and 50 years at the time of surgery.\n* Patients who have not provided informed consent.\n* Patients with a follow-up period shorter than 2 years.",{"count":56,"type":22},164,"OBSERVATIONAL","The anterior cruciate ligament (ACL) is one of the main stabilizers of the knee, and its injury is among the most common soft tissue injuries of the knee. Surgical reconstruction of the ACL can be performed using various techniques and different types of tissue grafts, including both autografts and allografts.\n\nAlthough ACL reconstruction is a widely performed surgical procedure in young and physically active individuals-typically patients under 30 years of age-to promote return to sports and prevent early onset of osteoarthritic degeneration, the surgical approach has historically been less common in patients over the age of 50. This is largely due to the lower functional demands typically observed in older patients.\n\nHowever, with increasing life expectancy and a corresponding rise in functional demands among older individuals, the surgical approach to ACL reconstruction has been progressively reconsidered in the over-50 population. Several recent studies have aimed to evaluate the outcomes of ACL reconstruction in older adults, showing promising results in terms of both recurrence rates and complication rates.\n\nAt the II Clinic of the Rizzoli Orthopaedic Institute, under the direction of Professor Zaffagnini, the preferred technique for ACL reconstruction is the \"single-bundle over-the-top technique using gracilis and semitendinosus tendons, combined with a lateral extra-articular tenodesis (LET).\" LET is an additional surgical step performed alongside ACL reconstruction, which has shown excellent results, especially in young patients at high risk of reinjury. Specifically, clinical data have shown that adding LET to ACL reconstruction can reduce the failure rate by approximately 30%, significantly improve knee stability, and enable a faster return to sports-all without increasing the rate of complications compared to the standard isolated ACL reconstruction technique.\n\nGiven these encouraging results in terms of safety and reduced failure rates, the combined ACL + LET procedure has historically been used at the Rizzoli Orthopaedic Institute for all patients, including those over 50 years of age.\n\nThe consistent use of this technique allows for the creation of a homogeneous patient cohort, all treated with the same surgical approach. This also enables the formation of two comparable patient groups-one over 50 and one under 30-both treated with the same technique, allowing for a meaningful comparison of primary and secondary endpoints.\n\nWhile several studies have aimed to compare ACL reconstruction outcomes in older populations with those in younger cohorts, to date, there are no studies in the literature that specifically assess the outcomes and complication rates of ACL reconstruction using the over-the-top technique combined with LET in patients over 50, and compare them with those of younger patients undergoing the same surgical procedure.\n\nGiven the growing demand for ACL reconstruction in older patients, we believe it is important to evaluate outcomes in patients over 50 and compare them with a younger cohort, to determine whether the over-the-top + LET technique may be a valid therapeutic option not only for young patients but also for older adults.\n\nOf particular interest is the assessment of the reduced risk of failure and complication rate of the ACL + LET technique performed in over-50 patients, to determine whether the excellent clinical outcomes observed in younger individuals are also confirmed in an older population.",[60,61,28],"ACL","LET","2025-07-14",{"date":64,"type":39},"2025-07-17",{"date":66,"type":39},"2025-07-13",{"date":68,"type":22},"2027-06",{"name":70,"class":46},"Stefano Zaffagnini",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":77,"targetDuration":4,"studyType":23,"phases":79,"briefSummary":80,"conditions":81,"keywords":86,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":47},"100596413","thermal-therapies-in-the-treatment-of-muscle-injuries-100596413","NCT07045129","Thermal Therapies in the Treatment of Muscle Injuries","Inclusion Criteria:\n\n* Participant reported a sudden event\n* Acute onset pain located on the posterior thigh\n* Clinical diagnosis of an acute muscle injury defined as:\n\nLocalized pain during palpation of the area, Increasing pain during isometric contraction, Localized pain during specific tests.\n\n* MRI confirmed acute muscle lesion grade 1 - 2 - 3 (Pollock et al., 2014) of hamstring muscles\n* Available for physiotherapy treatment 4-5 days a week\n* MRI of the injury performed in Aspetar within 7 days from the injury\n* Available for follow-up\n* Compliant with heat or cold-water immersion\n\nExclusion Criteria:\n\n* Chronic condition, diabetes, or immune compromised state\n* Neurological, cardiovascular, pulmonary, or muscular pathology\n* Pacemaker wearer\n* Metallic prosthesis\n* Skin infection\n* Under medication: anti-inflammatory treatment, pain killer drugs, fluoroquinolone antibiotics\n* Contraindication to MRI\n* Previous verified or suspected lower limb muscle injury for the same leg and the same muscle within the last 6 months\n* Chronic lower limb muscle problems on the same muscle\n* Grade 0 and 4 muscle injury determined by MRI (Pollock et al., 2014)\n* Do not have an intention to return to full sport activity\n* Do not want to receive one of the therapies \u002F Noncompliance with heat or cold therapies\n* Contraindication to heat\n* Do not want to comply with follow-up\n* Pregnancy",{"count":78,"type":22},135,[25],"Muscle strain injuries represent one of the most prevalent injuries in athletes. Despite this high injury prevalence, there is no evidence to support some of the currently used therapeutic strategies. Amongst them, thermal therapies and especially cryotherapy modalities (Ice, Cold water immersion, perfused garments) have been extensively used on soft tissue injuries to reduce pain perception and decrease inflammation. However, recent findings in humans and in animals have reported conflictual results on the effects of cold on muscle regeneration. On the other hand, recent studies in humans suggest that passive heat exposure can impact positively muscle protein synthesis, mitochondrial content and muscle torque in injured, immobilized and healthy participants. Furthermore, preliminary results from our group have shown a faster removal of muscle damages from the muscle and suggest a better muscle regeneration after a localized heat exposure. As such, our preliminary results confirmed that local heating may represent a promising tool to accelerate muscle regeneration. This randomized controlled trial will investigate the therapeutic effect of two thermal interventions (Hot or cold-water immersion) in the management of acute lower limbs muscle injuries. 135 patients will be distributed in a counterbalanced way into 3 groups: Hot, Cold and Control. All the groups will receive the same physiotherapy treatment. The thermal intervention will consist in 10 sessions of either, 60-minute hot water bath (42°C) for the hot group or, 15-minute Cold water bath (12°C) for the cold group realized after the 10 first physiotherapy session. All thermal interventions will be performed after the testing and physiotherapy treatment.",[82,83,28,84,85],"Hamstring Injuries","Hamstring Muscle Repair","Hamstring Rupture","Muscle Tear",[87,88,89,90,91,92,93,94,95,96,97,98,99,100,101],"muscle injury","muscle injuries","hamstring","muscle repair","regeneration","muscle recovery","thermal therapy","CWI","HWI","cold water immersion","hot water immersion","cryotherapy","heat therapy","HD EMG","muscle tear","NOT_YET_RECRUITING","2025-06-22",{"date":105,"type":39},"2025-07-01",{"date":107,"type":22},"2025-09",{"date":109,"type":22},"2028-09",{"name":111,"class":46},"Aspetar"]