[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hand-injuries-and-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hand-injuries-and-disorders":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,53,78,107,151],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100643406","3d-hand-orthosis-trial-100643406",false,"NCT07633821","3D Hand Orthosis Trial","Cost-effectiveness of 3D-printed Hand Orthoses for Activities of Daily Living in Chronic Hand Conditions","Inclusion Criteria:\n\n* Diagnosed with a chronic, stable hand condition due to a neurological disorder, musculoskeletal disorder, neuromuscular disease or injury;\n* Minimum age of 18 years;\n* Indicated for a first or repeat prescription of a circular thumb, wrist or wrist-thumb orthosis for permanent use for improving ADL performance.\n\nExclusion Criteria:\n\n* Indicated for an orthosis for a non-functional hand;\n* Insufficient mastery of the Dutch language.","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"NA","In people with chronic hand conditions, hand orthoses are frequently prescribed to improve performance in activities of daily living (ADL). Conventional hand orthoses are custom-made on a plaster cast of the hand, a process that is time-consuming and labor-intensive. It has been demonstrated that the production time of manufacturing hand orthoses can be reduced by using 3-dimensional scanning and printing (i.e. 3D-printed hand orthosis), offering a promising cost-effective alternative to conventional hand orthoses. The current study builds on a previously conducted feasibility study, which demonstrated comparable effects of 3D-printed and conventional hand orthoses on ADL performance, hand function, and quality of life in people with chronic hand conditions. User satisfaction and production time favored the 3D-printed orthoses. However, to date only small and self-controlled studies have investigated the effects of 3D-printed versus conventional hand orthoses for permanent use on ADL performance and orthosis satisfaction in chronic hand conditions. Evidence from randomized controlled trials and data on the cost-effectiveness are lacking. The aims of this study are:\n\n1. To determine whether treatment with 3D-printed hand orthoses is non-inferior compared to treatment with conventional hand orthoses in terms of ADL performance, hand function, pain, quality of life and functional status in individuals with chronic hand conditions.\n2. To assess whether treatment with 3D-printed hand orthoses results in greater patient satisfaction compared to treatment with conventional hand orthoses.\n3. To assess the cost-effectiveness of treatment with 3D-printed hand orthoses compared to treatment with conventional hand orthoses.",[26,27,28,29],"Hand Injuries and Disorders","Neurological Conditions","Neuromuscular Diseases (NMD)","Musculoskeletal Conditions (e.g., Tendinitis, Capsulitis)",[31,32,33,34,35,36,37,38,39],"Orthotic Devices","Cost-Effectiveness Analysis","Hand","Printing, Three-Dimensional","Activities of Daily Living","Rehabilitation","Quality of Life","Non-Inferiority Trial","Patient Satisfaction","NOT_YET_RECRUITING","2026-06-05",{"date":43,"type":44},"2026-06-08","ACTUAL",{"date":46,"type":20},"2026-06",{"date":48,"type":20},"2030-09",{"name":50,"class":51},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":21,"phases":64,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":52},"100629456","perineural-vs-intravenous-dexamethasone-as-an-adjuvant-to-brachial-plexus-block-in-pediatric-hand-surgery-100629456","NCT07474909","Perineural vs Intravenous Dexamethasone as an Adjuvant to Brachial Plexus Block in Pediatric Hand Surgery","Comparison of Perineural Versus Intravenous Dexamethasone as an Adjuvant to Brachial Plexus Block in Pediatric Hand and Forearm Surgery: A Randomized Double-Blind Placebo-Controlled Trial With Neurological Safety Evaluation and Neurofilament Light Chain Biomarker Assessment","Inclusion Criteria:\n\n* Age 3 months to 16 years\n* Scheduled elective hand or forearm surgery under general anesthesia with a brachial plexus block\n* ASA physical status I-III\n* Planned use of ultrasound-guided regional anesthesia\n* Written informed consent from parent(s) or legal guardian and age-appropriate assent from the child\n\nExclusion Criteria:\n\n* Pre-existing neurological disease or peripheral neuropathy\n* Preoperative sensory deficit in the operative limb\n* Infection at or near the needle insertion site\n* Coagulopathy or therapeutic anticoagulation\n* Systemic infection or sepsis\n* Chronic steroid therapy within 30 days before surgery\n* Known allergy to ropivacaine or dexamethasone\n* Diabetes mellitus\n* BMI \\> 99th percentile for age and sex.\n* Pregnancy or breastfeeding\n* Participation in another interventional clinical trial within 30 days\n* Refusal of consent","3 Months","16 Years",{"count":63,"type":20},150,[23],"This clinical trial will evaluate the neurological safety and analgesic effectiveness of dexamethasone administered perineurally or intravenously as an adjuvant to brachial plexus block in children undergoing hand or forearm surgery. Dexamethasone is commonly used to prolong the duration of regional anesthesia, but there is limited evidence on long-term neurological safety, particularly in pediatric patients.\n\nAll participants will receive a single-shot brachial plexus block using ropivacaine under ultrasound guidance. Patients will be randomized into one of three treatment groups:\n\nperineural dexamethasone, intravenous dexamethasone, or placebo. The primary objective is to determine whether perineural dexamethasone causes any clinically significant nerve injury compared with intravenous administration or placebo. Neurological function will be assessed clinically and via serum neurofilament light chain (NfL) levels over a 12-month follow-up period.\n\nThis study may provide evidence regarding the long-term safety profile of perineural dexamethasone in children and help establish evidence-based dosing and administration guidelines.",[26,67],"Wrist Sprain","RECRUITING","2026-05-20",{"date":71,"type":44},"2026-05-22",{"date":73,"type":44},"2025-12-10",{"date":75,"type":20},"2027-01-31",{"name":77,"class":51},"Poznan University of Medical Sciences",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":21,"phases":88,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":52},"100636202","video-based-physiotherapy-education-and-social-participation-in-adults-with-hand-injuries-100636202","NCT07562620","Video-Based Physiotherapy Education and Social Participation in Adults With Hand Injuries","Determination of Factors Affecting Social Participation and Evaluation of the Effectiveness of Video-Based Physiotherapy Awareness Education in Adults With Hand Injuries.","Inclusion Criteria:\n\n* Adults between 18 and 65 years of age.\n* Patients requiring rehabilitation after fractures, tendon injuries, or carpal tunnel syndrome surgery in the hand region.\n* Patients who have started physical therapy sessions for the first time within the last 6 months with these diagnoses.\n* Individuals with sufficient cognitive ability to answer the questionnaires independently.\n\nExclusion Criteria:\n\n* Individuals with cognitive impairment or communication barriers (such as severe vision or hearing loss) that would prevent them from following the questionnaire and educational content.\n* Active healthcare workers.\n* Patients referred only for conservative treatment.","65 Years",{"count":87,"type":20},40,[23],"The goal of this clinical trial is to determine the factors affecting social participation in adult patients with hand injuries and to evaluate the effectiveness of a video-based physiotherapy awareness education in this population.\n\nThe main questions it aims to answer are:\n\nDoes a short, video-based physiotherapy education increase the knowledge and awareness levels of patients with hand injuries?\n\nWhat are the primary factors (body functions and activity limitations) that restrict the social participation of these patients?\n\nParticipants will:\n\nComplete baseline assessments including a sociodemographic form, the Quick-DASH questionnaire, and custom participation and awareness forms.\n\nReceive a 10-15 minute video-supported education session from physiotherapists covering home strategies, exercises, and assistive devices.\n\nComplete the knowledge and awareness test again immediately after the education session to measure acute changes.",[91,26,92],"Hand Injuries","Patient Education",[94,95,96,97,36],"Video-Based Education","Physiotherapy","Health Literacy","Social Participation","2026-05-11",{"date":100,"type":44},"2026-05-14",{"date":102,"type":44},"2026-04-30",{"date":104,"type":20},"2027-04-30",{"name":106,"class":51},"Istanbul University - Cerrahpasa",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":118,"conditions":119,"keywords":136,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":52},"100633082","early-functional-response-as-a-predictor-of-clinical-outcomes-in-hand-rehabilitation-a-prospective-feasibility-study-using-a-digital-monitoring-system-100633082","NCT07522060","Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Digital Monitoring System","Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Clinician-Developed Digital Monitoring System","HANDREHPREDICT","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Hand or upper extremity pathology requiring rehabilitation, including but not limited to: flexor or extensor tendon injuries, peripheral nerve injuries or compression syndromes (including carpal tunnel syndrome, cubital tunnel syndrome), distal radius fractures, metacarpal or phalangeal fractures, joint injuries and instabilities, arthropathy (osteoarthritis, rheumatoid arthritis), trapeziometacarpal osteoarthritis, trigger finger, Dupuytren's disease, DeQuervain tenosynovitis, lateral epicondylitis and post-surgical upper extremity conditions\n* Under clinical responsibility of the principal investigator at the Faculty of Physical Therapy and Rehabilitation, Hacettepe University\n* Expected to attend minimum 8 rehabilitation sessions\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* • Active psychiatric illness precluding participation or completion of assessment tools\n\n  * Severe cognitive impairment precluding understanding of patient-reported outcome measures\n  * Literacy difficulties preventing self-completion of questionnaires\n  * Concurrent enrollment in another interventional clinical study\n  * Refusal to provide written informed consent",{"count":116,"type":20},60,"OBSERVATIONAL","This study investigates whether early changes observed during the first weeks of hand and upper extremity rehabilitation can predict patient outcomes months later. In rehabilitation practice, clinicians make numerous decisions each session regarding exercise type, frequency, duration, and treatment approach. Most of these decisions are currently made without systematic longitudinal data. This study addresses three fundamental questions using data collected during routine clinical care: (1) Can the rate of improvement in the first weeks of treatment predict functional status months later, across both session-based and milestone-based time points? (2) Are there meaningfully different recovery profiles among hand rehabilitation patients? (3) Is there measurable variation in clinical decision-making among patients with similar profiles, and does this variation relate to outcomes? A digital patient monitoring platform developed by the principal investigator, a physiotherapist and academic researcher specializing in hand rehabilitation serves as the data collection infrastructure. The platform records standard clinical assessment measures in a structured format and has been in active clinical use at Hacettepe University prior to this study. For research purposes, the system has been expanded to include structured capture of patient-reported outcomes, patient global impression of change, treatment protocol coding, home exercise adherence, and automated calculation of early response metrics.\n\nThis is a 12-month prospective observational cohort study enrolling a minimum of 60 patients. Data are stored securely on the university's institutional network. Patients are anonymized using identification codes. The study is subject to Hacettepe University Ethics Committee approval and participant informed consent. Findings are expected to generate evidence supporting data-driven clinical decision-making in rehabilitation and to provide a feasibility foundation for a larger multi-center study.",[33,120,121,122,91,26,123,124,125,126,127,128,129,130,131,132,133,134,135],"Hand Therapy","Upper Extremity","Prediction Models","Hand Arthritis","Tendon Injuries","Wrist Fractures","Carpal Tunnel Syndrome (CTS)","Peripheral Nerve Injuries","Upper Extremity Injuries","Wrist Injuries","Finger Injuries","Trigger Finger","Trapeziometacarpal (TMC) Arthrosis","DeQuervain's Tenosynovitis","Cubital Tunnel Syndrome","Postoperative Rehabilitation",[137,138,139,140,141],"digital health monitoring","real-world evidence","clinical decision support","upper extremity rehabilitation","early response prediction","2026-04-03",{"date":144,"type":44},"2026-04-13",{"date":146,"type":20},"2026-06-15",{"date":148,"type":20},"2027-06-01",{"name":150,"class":51},"Hacettepe University",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":159,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":21,"phases":162,"briefSummary":164,"conditions":165,"keywords":171,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":52},"100397853","phase-4-the-acts-trial-n-acetylcysteine-nac-and-night-splinting-as-a-non-operative-treatment-for-carpal-tunnel-syndrome-100397853","NCT04460521","The ACTS Trial: N-acetylcysteine (NAC) and Night-splinting as a Non-operative Treatment for Carpal Tunnel Syndrome","The Use of N-acetylcysteine Supplementation in Addition to Night Splinting for Treatment of Mild to Moderate Carpal Tunnel Syndrome: A Randomized, Double-blind, Placebo-controlled Trial","ACTS","Inclusion Criteria:\n\n1. The patient has a confirmed diagnosis of mild to moderate idiopathic unilateral or bilateral CTS as determined by both clinical exam findings and electrodiagnostic nerve conduction studies (median nerve distal motor latency ≥ 4.3 milliseconds and\u002For median nerve sensory distal latency ≥ 3.5 milliseconds at the wrist) performed within the preceding year prior to enrollment\n2. Symptoms of CTS must have been present for ≥ 6 weeks\n3. The patient must be ≥ 18 years of age.\n\nExclusion Criteria:\n\n1. Any previous carpal tunnel release procedure on the ipsilateral limb\n2. Any previous corticosteroid injection in the last 6 months on the ipsilateral limb\n3. Severe CTS\u002Fsigns of median nerve denervation with axonal loss determined by constant wrist or hand pain, constant parasthesias in the median nerve distribution, or thenar muscle atrophy in the ipsilateral limb\n4. Any known or suspected allergy to NAC\n5. Any current medications which preclude use of NAC including antibiotics or nitroglycerin\n6. Breastfeeding patients or patients with nephrolithiasis\n7. Any history of proximal ipsilateral neck or proximal limb injury\n8. Secondary CTS related to pregnancy\n9. Unable for financial reasons to obtain a night splint (i.e. lack of insurance coverage or lack of financial means).",true,{"count":161,"type":20},240,[163],"PHASE4","Carpal tunnel syndrome (CTS) is the most common nerve compression syndrome worldwide, causing significant chronic pain, functional impairment, and lowered quality of life for individuals of various backgrounds. CTS is caused by chronic compression of the median nerve in the carpal tunnel of the wrist, causing numbness and pain in the palm, thumb, index, and middle fingers and eventual weakness of the hand. Many different treatments for CTS have been proposed and studied, including but not limited to non-operative treatments such as wrist splinting, steroid injections, and lifestyle modifications as well as operative treatments, such as surgical carpal tunnel release (CTR). To date, very few oral medications have been shown to be effective as conservative treatments for CTS. In this study the investigators will examine whether there is any benefit to using oral N-acetylcysteine (NAC) as an adjunctive treatment for mild to moderate CTS in addition to a standard 8-week trial of night splinting. NAC has been used in humans for various purposes, is extremely safe and has very few side effects, and has been shown to have anti-inflammation properties which may help treat CTS. The investigators will study this by performing a randomized controlled trial, comparing patients receiving oral NAC and standard night splinting to patients receiving an identical placebo and standard night splinting. Both patient groups will be assessed using a questionnaire to assess for severity of their CTS symptoms both before and after the 8-week treatment. The primary objective will be to determine whether supplementation with oral NAC in addition to night splinting has any significant impact on patient-reported symptoms and functional impairment when compared to night splinting alone. The investigators will also measure secondary outcomes including whether patients decide to have surgery for their CTS after treatment and\u002For continued use of other treatments. This study has the potential to have a significant positive impact on patients by identifying a safe, inexpensive, accessible, and well tolerated conservative treatment for mild to moderate carpal tunnel syndrome, and potentially preventing the need for additional, more invasive treatments such as surgery.",[166,26,167,168,169,170],"Carpal Tunnel Syndrome","Nerve Compression","Splints","Carpal Tunnel","Carpal Tunnel Release",[172,173,174,175,176,177,178,179,180,181],"Wrist splint","Carpal tunnel syndrome","Carpal tunnel release","Compression neuropathy","NAC","Conservative treatment","Hand surgery","Plastic surgery","N-acetylcysteine","Night splint","2024-08-21",{"date":184,"type":44},"2024-08-23",{"date":186,"type":44},"2022-04-01",{"date":188,"type":20},"2026-10-01",{"name":190,"class":51},"Emily Krauss"]