[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hand-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hand-injuries":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,42,75,105,136,160,186,228,249,274,295,322,348,379,406,431,453,479,499],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100644050","kinesiophobia-and-functional-outcomes-in-hand-injuries-100644050",false,"NCT07668544","Kinesiophobia and Functional Outcomes in Hand Injuries","The Effect of Kinesiophobia Level on Functional Outcomes in Surgically Performed Hand Injuries","Inclusion Criteria:\n\nAdults aged 18 years and older. Patients presenting to the emergency department with traumatic hand or forearm lacerations requiring surgical treatment.\n\nInjury involving one or more anatomical structures of the hand or forearm (skin, tendon, nerve, vessel, or combined injuries).\n\nAssessment within 1-5 days following injury. Ability to understand and complete study questionnaires and functional assessments.\n\nProvision of written informed consent. Willingness to participate in follow-up assessments at 8 and 12 weeks after injury.\n\nExclusion Criteria:\n\nAge younger than 18 years. Cognitive impairment, severe psychiatric disorder, or communication problems preventing completion of questionnaires.\n\nPrevious major injury, surgery, or permanent functional impairment of the affected upper extremity.\n\nPolytrauma or additional injuries that may substantially affect upper extremity function or rehabilitation outcomes.\n\nNeurological disorders affecting upper extremity function (e.g., stroke, peripheral neuropathy, spinal cord injury).\n\nSevere musculoskeletal disorders of the upper extremity unrelated to the index injury.\n\nInability or unwillingness to attend follow-up evaluations. Refusal to provide informed consent",true,"ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","Hand and forearm injuries are among the most common traumatic injuries and may result in substantial functional limitations, reduced work capacity, and decreased quality of life. Despite advances in surgical repair techniques, recovery outcomes vary considerably among individuals with similar injury characteristics. Psychological factors, particularly fear of movement or reinjury (kinesiophobia), may influence rehabilitation participation and functional recovery after injury.\n\nThe aim of this prospective observational study is to investigate the relationship between early kinesiophobia levels and functional outcomes in adults who undergo surgical treatment for traumatic hand or forearm lacerations. Kinesiophobia will be assessed during the acute post-injury period (within 1-5 days after injury) using the Tampa Scale of Kinesiophobia. Injury severity will be evaluated using the Modified Hand Injury Severity Classification (MHISC\u002FMEYCS).\n\nParticipants will be followed for 12 weeks after injury. Functional recovery will be assessed at the 8th week using the Buck-Gramcko Score and the Sollerman Hand Function Test, and at the 12th week using the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire and hand grip strength measurements.\n\nThe study will examine whether higher levels of early kinesiophobia are associated with greater injury severity and poorer functional recovery. Findings from this study may help identify patients at risk for delayed recovery and support the development of early rehabilitation strategies targeting psychological as well as physical aspects of hand injury recovery.",[27],"Hand Injuries",[29,30],"kinesiophobia","functionality","NOT_YET_RECRUITING","2026-06-19",{"date":34,"type":35},"2026-06-25","ACTUAL",{"date":32,"type":21},{"date":38,"type":21},"2027-03-17",{"name":40,"class":41},"Ebru Aloğlu Çiftçi","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100636501","high-energy-laser-in-the-conservative-treatment-of-rhizarthrosis-100636501","NCT07566507","High-Energy Laser in the Conservative Treatment of Rhizarthrosis","High Intensity Laser Therapy (HL) vs Exercise in Thumb Osteoarthritis","HLEX-TO","Inclusion Criteria:\n\n* arthrosis of the trapezoid-metacarpal with stage 1 or 2 of the Eaton-Littler radiographic classification and pain (recent radiograph within 6 months previously);\n* clinical picture that has been occurring for at least 6 months;\n* pain scored with VAS scale at least 4\u002F10.\n\nExclusion Criteria:\n\n* rheumatoid arthritis or outcomes of trauma in the affected area, contra-indications to treatment with laser therapy (neoplasia, pregnancy, thrombocytopenia, epilepsy, uncompensated heart disease or arrhythmia, pacemaker, local infections),\n* corticosteroid infiltration or physical therapy in the previous 4 weeks.",{"count":51,"type":21},42,[24],"Osteoarthritis (OA) is a degenerative joint disease that can affect the hands and is particularly debilitating when it involves the trapeziometacarpal joint (rhizarthrosis). It causes pain, deformity, limited movement and strength, joint instability, resulting in significant limitations in daily activities.Many conservative treatments, such as medications, therapeutic exercises, physical therapy, and orthoses, are effective for managing hand OA. For patients who do not respond to conservative treatments, surgical intervention will be necessary.",[55,27,56,57],"Thumb Osteoarthritis","Laser","Exercise",[59,60,61,62,63],"hand","rehabilitation","conservative","lasertherapy","exercise","RECRUITING","2026-05-13",{"date":67,"type":35},"2026-05-15",{"date":69,"type":35},"2025-11-01",{"date":71,"type":21},"2028-12-01",{"name":73,"class":41},"Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":74},"100636202","video-based-physiotherapy-education-and-social-participation-in-adults-with-hand-injuries-100636202","NCT07562620","Video-Based Physiotherapy Education and Social Participation in Adults With Hand Injuries","Determination of Factors Affecting Social Participation and Evaluation of the Effectiveness of Video-Based Physiotherapy Awareness Education in Adults With Hand Injuries.","Inclusion Criteria:\n\n* Adults between 18 and 65 years of age.\n* Patients requiring rehabilitation after fractures, tendon injuries, or carpal tunnel syndrome surgery in the hand region.\n* Patients who have started physical therapy sessions for the first time within the last 6 months with these diagnoses.\n* Individuals with sufficient cognitive ability to answer the questionnaires independently.\n\nExclusion Criteria:\n\n* Individuals with cognitive impairment or communication barriers (such as severe vision or hearing loss) that would prevent them from following the questionnaire and educational content.\n* Active healthcare workers.\n* Patients referred only for conservative treatment.","65 Years",{"count":84,"type":21},40,[24],"The goal of this clinical trial is to determine the factors affecting social participation in adult patients with hand injuries and to evaluate the effectiveness of a video-based physiotherapy awareness education in this population.\n\nThe main questions it aims to answer are:\n\nDoes a short, video-based physiotherapy education increase the knowledge and awareness levels of patients with hand injuries?\n\nWhat are the primary factors (body functions and activity limitations) that restrict the social participation of these patients?\n\nParticipants will:\n\nComplete baseline assessments including a sociodemographic form, the Quick-DASH questionnaire, and custom participation and awareness forms.\n\nReceive a 10-15 minute video-supported education session from physiotherapists covering home strategies, exercises, and assistive devices.\n\nComplete the knowledge and awareness test again immediately after the education session to measure acute changes.",[27,88,89],"Hand Injuries and Disorders","Patient Education",[91,92,93,94,95],"Video-Based Education","Physiotherapy","Health Literacy","Social Participation","Rehabilitation","2026-05-11",{"date":98,"type":35},"2026-05-14",{"date":100,"type":35},"2026-04-30",{"date":102,"type":21},"2027-04-30",{"name":104,"class":41},"Istanbul University - Cerrahpasa",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":74},"100167904","phase-2-human-upper-extremity-allotransplantation-100167904","NCT01459107","Human Upper Extremity Allotransplantation","Recipient Inclusion Criteria:\n\n* Recent (≥6 months) or remote (i.e., several decades) unilateral or bilateral upper limb loss (below the shoulder) desiring limb transplantation.\n* Below-shoulder amputation.\n* Functionless or minimally functional hand desiring removal of functionless \u002F minimally functional hand followed by transplantation.\n* Male or female and of any race, color or ethnicity.\n* Aged 18-69 years.\n* Completes the protocol informed consent form.\n* No co-existing medical condition which, in the opinion of the study team, could affect the immunomodulatory protocol, surgical procedure, or functional results (see Donor and Recipient Exclusion Criteria below. If the condition is amenable to treatment, the study team must agree that said condition should not significantly enhance the surgical risks of upper extremity transplantation.)\n* No co-existing psycho-social problems (i.e., alcoholism, drug abuse).\n* Negative for malignancy for past 5 years.\n* Negative for HIV at transplant.\n* Negative crossmatch with donor.\n* If female of child-bearing potential, negative serum pregnancy test.\n* If female of child-bearing potential, consent to use reliable contraception for at least one year following transplantation.\n* Consents to bone marrow infusion as part of the treatment regime.\n* USA citizen or equivalent, or foreigner with documentation of ability to pay for transplant and required follow-up care.\n* Patient agrees to comply with the protocol and states a dedication to the immunomodulatory treatment regime.\n\nDonor Inclusion Criteria:\n\nDonors will be selected by the upper extremity transplant team in conjunction with the organ procurement organization (OPO) according to the following criteria:\n\n* Brain dead meeting the criteria for Determination of Death.\n* Family consent for limb donation.\n* Stable donor (i.e., does not require excessive vasopressors to maintain blood pressure).\n* Aged 16 - 65 years.\n* Limb matched for size with recipient.\n* Same blood type as recipient.\n* Negative lymphocytotoxic crossmatch.\n* Accurately matched for gender, skin tone, and race (relative requirements depending on recipient consent).\n\nExclusion Criteria:\n\n• Positive for any of the following conditions:\n\n* Untreated sepsis.\n* HIV (active or seropositive).\n* Active tuberculosis.\n* Hepatitis B or C.\n* Viral encephalitis.\n* Toxoplasmosis.\n* Malignancy (within past 5 years).\n* Current\u002Frecent (within 3 months of donation\u002Fscreening consent) IV drug abuse.\n* Paralysis of ischemic or traumatic origin.\n* Inherited peripheral neuropathy.\n* Infectious, post infectious, or inflammatory (axonal or demyelinating) neuropathy.\n* Toxic neuropathy (i.e. heavy metal poisoning, drug toxicity, industrial agent exposure).\n* Mixed connective tissue disease.\n* Severe deforming rheumatoid or osteoarthritis in the limb.\n\nDonor Only:\n\n• Tattoos:\n\n* Non-professional tattoo within last 6 months, or\n* Personally identifiable tattoo (i.e., donor name) on potential transplant.\n\nRecipient Only:\n\n* Type I (insulin-dependent) diabetes mellitus\n* Conditions that, in the opinion of the study team, may impact the immunomodulatory protocol potentially exposing the recipient to an unacceptable risk under immunosuppressive treatment.\n* Sensitized recipients with high levels (50%) of panel-reactive human leukocyte antigen (HLA) antibodies.\n* Conditions that may impact the success of the surgical procedure or increase the risk of postoperative complications including inherited coagulopathies like Hemophilia, Von-Willebrand's disease, Protein C and S deficiency, Thrombocythemias, Thalassemias, Sickle Cell disease, etc.\n* Mixed connective tissue diseases and collagen diseases can result in poor wound healing after surgery.\n* Conditions that may impact functional outcomes including Lipopolysaccharidosis and amyloidosis (may impact nerve regeneration) or rare disorders of bone healing like osteopetrosis.\n* Patients considered unsuitable per the consulted Psychiatrists appraisal.","69 Years",{"count":113,"type":21},30,[115],"PHASE2","Background: Millions of people each year sustain injuries, have tumors surgically removed, or are born with defects that require complex reconstructive surgeries to repair. In the case of hand, forearm, or arm amputation, prostheses only provide less than optimal motor function and no sensory feedback. However, hand and arm transplantation is a means to restore the appearance, anatomy, and function of a native hand. Although over 70 hand transplants have been performed to date and good functional results have been achieved, widespread clinical use has been limited due to adverse effects of life-long and high-dose immunosuppression needed to prevent graft rejection. Risks include infection, cancer, and metabolic problems, all of which can greatly affect recipients' quality of life, make the procedure riskier, and jeopardize the potential benefits of hand transplantation.\n\nStudy Design: This non-randomized, Phase II clinical trial will document the use of a new immunomodulatory protocol (aka - Pittsburgh Protocol, Starzl Protocol) for establishing hand transplantation as a safe and effective reconstructive treatment for upper extremity amputations by minimizing maintenance immunosuppression therapy in unilateral and bilateral hand\u002Fforearm transplant patients. This protocol combines lymphocyte depletion with donor bone marrow cell infusion and has enabled graft survival using low doses of a single immunosuppressive drug followed by weaning of treatment. Initially designed for living-related solid organ donation, this regimen has been adapted for use with grafts donated by deceased donors. The investigators propose to perform 30 human hand transplants employing this novel protocol.\n\nSpecific Aims: 1) To establish hand transplantation as a safe and effective reconstructive strategy for the treatment of upper extremity amputations; 2) To reduce the risk of rejection and enable allograft survival while minimizing the requirement for long-term high dose multi-drug immunosuppression.\n\nSignificance of Research: Hand transplantation could help upper extremity amputees recover functionality, self-esteem, and the capability to reintegrate into family and social life as \"whole\" individuals. The protocol offers the potential for minimizing the morbidity of maintenance immunosuppression, thereby beneficially shifting the risk\u002Fbenefit ratio of this life-enhancing procedure and enabling widespread clinical application of hand transplantation.",[118,119,27],"Amputation, Traumatic","Wounds and Injuries",[121,122,123,124,125,126,127],"Hand Transplant","Composite Tissue Allotransplantation (CTA)","Vascularized Composite Allotransplantation (VCA)","Composite Tissue","Amputation","Upper limb","Immunosuppression",{"date":129,"type":35},"2026-05-12",{"date":131,"type":35},"2011-07-21",{"date":133,"type":21},"2036-06-30",{"name":135,"class":41},"Johns Hopkins University",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":146,"phases":4,"briefSummary":147,"conditions":148,"keywords":150,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":74},"100316497","human-upper-extremity-allotransplantation-fu-protocol-100316497","NCT03400345","Human Upper Extremity Allotransplantation: F\u002FU Protocol","Human Upper Extremity Allotransplantation: Transplanted Patient Follow-Up Protocol","Inclusion Criteria:\n\n* Males and females 5 or more years post-unilateral or bilateral upper limb transplantation.\n* Completes the protocol informed consent form.\n* Consents to sample collection and storage (biopsies).\n* USA citizen or equivalent.\n* Patient agrees to comply with the protocol and states a dedication to the immunomodulatory treatment regime.\n\nExclusion Criteria:\n\n* Candidate has not received an upper extremity allotransplant.\n* Any reason the study team thinks would cause the participant to be noncompliant or would put the patient at unacceptable risk if enrolled.","100 Years",{"count":145,"type":21},60,"OBSERVATIONAL","Upper extremity allotransplantation is a new procedure which is becoming more common in the United States. Ongoing data collection for research purposes is vital to the long-term assessment as to the safety of the procedure and accompanying immunosuppression protocol, as well as quantifying patient outcomes and changes in quality of life. For these reasons, The Johns Hopkins Hand\u002FArm Transplantation Team is interested in enrolling transplanted patients in a follow-up protocol to continue collecting informative data to further the field of vascularized composite allotransplantation.",[118,149,27],"Wounds and Injury",[121,151,123,125,152,127],"composite tissue allograft (CTA)","Upper Limb","2026-05-07",{"date":96,"type":35},{"date":156,"type":35},"2017-07-25",{"date":158,"type":21},"2036-07-30",{"name":135,"class":41},{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":4,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":167,"targetDuration":169,"studyType":146,"phases":4,"briefSummary":170,"conditions":171,"keywords":173,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":74},"100622798","perceived-ability-and-hand-function-100622798","NCT07388303","Perceived Ability and Hand Function","The Relationship Between Perceived Manual Ability and Functional Measurements in Patients With Hand-Forearm Injuries","Inclusion Criteria:\n\n* Having sustained a hand and\u002For forearm injury and\u002For having undergone surgery related to this injury.\n* Being voluntary to participate in the study.\n\nExclusion Criteria:\n\n* Patients with concomitant central nervous system involvement.\n* Patients with a history of previous injury to the same extremity.\n* Patients with rheumatological disorders.",{"count":168,"type":21},34,"12 Weeks","Patient-reported outcome measures, which are subjective by nature, need to be correlated with clinician-administered professional measurements as a further step toward expanding their clinical utility. Therefore, this study aimed to investigate the relationship between perceived manual dexterity and functional measurements in patients with hand-forearm injuries.",[27,172],"Forearm Injuries",[174,175,176],"hand forearm injuries","perceived manual ability","functional measurements","2026-04-13",{"date":179,"type":35},"2026-04-14",{"date":181,"type":35},"2025-01-06",{"date":183,"type":21},"2026-05-31",{"name":185,"class":41},"Pamukkale University",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":194,"targetDuration":4,"studyType":146,"phases":4,"briefSummary":195,"conditions":196,"keywords":214,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":74},"100633082","early-functional-response-as-a-predictor-of-clinical-outcomes-in-hand-rehabilitation-a-prospective-feasibility-study-using-a-digital-monitoring-system-100633082","NCT07522060","Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Digital Monitoring System","Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Clinician-Developed Digital Monitoring System","HANDREHPREDICT","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Hand or upper extremity pathology requiring rehabilitation, including but not limited to: flexor or extensor tendon injuries, peripheral nerve injuries or compression syndromes (including carpal tunnel syndrome, cubital tunnel syndrome), distal radius fractures, metacarpal or phalangeal fractures, joint injuries and instabilities, arthropathy (osteoarthritis, rheumatoid arthritis), trapeziometacarpal osteoarthritis, trigger finger, Dupuytren's disease, DeQuervain tenosynovitis, lateral epicondylitis and post-surgical upper extremity conditions\n* Under clinical responsibility of the principal investigator at the Faculty of Physical Therapy and Rehabilitation, Hacettepe University\n* Expected to attend minimum 8 rehabilitation sessions\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* • Active psychiatric illness precluding participation or completion of assessment tools\n\n  * Severe cognitive impairment precluding understanding of patient-reported outcome measures\n  * Literacy difficulties preventing self-completion of questionnaires\n  * Concurrent enrollment in another interventional clinical study\n  * Refusal to provide written informed consent",{"count":145,"type":21},"This study investigates whether early changes observed during the first weeks of hand and upper extremity rehabilitation can predict patient outcomes months later. In rehabilitation practice, clinicians make numerous decisions each session regarding exercise type, frequency, duration, and treatment approach. Most of these decisions are currently made without systematic longitudinal data. This study addresses three fundamental questions using data collected during routine clinical care: (1) Can the rate of improvement in the first weeks of treatment predict functional status months later, across both session-based and milestone-based time points? (2) Are there meaningfully different recovery profiles among hand rehabilitation patients? (3) Is there measurable variation in clinical decision-making among patients with similar profiles, and does this variation relate to outcomes? A digital patient monitoring platform developed by the principal investigator, a physiotherapist and academic researcher specializing in hand rehabilitation serves as the data collection infrastructure. The platform records standard clinical assessment measures in a structured format and has been in active clinical use at Hacettepe University prior to this study. For research purposes, the system has been expanded to include structured capture of patient-reported outcomes, patient global impression of change, treatment protocol coding, home exercise adherence, and automated calculation of early response metrics.\n\nThis is a 12-month prospective observational cohort study enrolling a minimum of 60 patients. Data are stored securely on the university's institutional network. Patients are anonymized using identification codes. The study is subject to Hacettepe University Ethics Committee approval and participant informed consent. Findings are expected to generate evidence supporting data-driven clinical decision-making in rehabilitation and to provide a feasibility foundation for a larger multi-center study.",[197,198,199,200,27,88,201,202,203,204,205,206,207,208,209,210,211,212,213],"Hand","Hand Therapy","Upper Extremity","Prediction Models","Hand Arthritis","Tendon Injuries","Wrist Fractures","Carpal Tunnel Syndrome (CTS)","Peripheral Nerve Injuries","Upper Extremity Injuries","Wrist Injuries","Finger Injuries","Trigger Finger","Trapeziometacarpal (TMC) Arthrosis","DeQuervain's Tenosynovitis","Cubital Tunnel Syndrome","Postoperative Rehabilitation",[215,216,217,218,219],"digital health monitoring","real-world evidence","clinical decision support","upper extremity rehabilitation","early response prediction","2026-04-03",{"date":177,"type":35},{"date":223,"type":21},"2026-06-15",{"date":225,"type":21},"2027-06-01",{"name":227,"class":41},"Hacettepe University",{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":143,"enrollmentInfo":235,"targetDuration":4,"studyType":22,"phases":237,"briefSummary":238,"conditions":239,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":246,"locationsCount":248},"100503594","conservative-treatment-of-trigger-finger-100503594","NCT05837286","Conservative Treatment of Trigger Finger","Conservative Treatment of Trigger Finger: Outcomes of a Randomized Controlled Trial","Inclusion Criteria:\n\n* Individuals 18 years old or older are included\n* Patients with trigger finger, aka stenosing flexor tenosynovitis\n* Status post receiving cortisone injection of the affected digit(s)\n\nExclusion Criteria:\n\n* Any records flagged with break the glass or research opt out\n* Patients with rheumatoid arthritis\n* Patients with a history of traumatic injury to the hand\n* Cognitive or behavioral problems which would preclude informed consent\n* Unable to speak and understand English",{"count":236,"type":21},146,[24],"This study is to analyze the effectiveness of a nighttime extension orthosis after receiving a cortisone injection for the treatment of trigger finger to improve pain and restore functional outcomes. The investigators hypothesize that the extension orthosis will improve pain and functional outcomes compared to those without a digital night extension orthosis in those with trigger finger at 12 weeks from the injection.",[27,209],"2026-03-24",{"date":242,"type":35},"2026-03-27",{"date":244,"type":35},"2023-08-01",{"date":183,"type":21},{"name":247,"class":41},"Cedars-Sinai Medical Center",2,{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":256,"targetDuration":4,"studyType":146,"phases":4,"briefSummary":257,"conditions":258,"keywords":261,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":74},"100580511","ultrasonographic-analysis-of-post-traumatic-shoulder-lesions-after-hand-trauma-100580511","NCT06838247","Ultrasonographic Analysis of Post-Traumatic Shoulder Lesions After Hand Trauma","Detection of Simultaneous Presence of Shoulder Lesions in Patients With Hand Injuries by Diagnostic Ultrasonography","Inclusion Criteria:\n\n* Having a history of hand injury and applying for hand rehabilitation after surgical and conservative treatment.\n\nExclusion Criteria:\n\n* Being under 18 and over 65 years of age\n* Patients with systemic diseases (Diabetes mellitus, Peripheral vascular diseases)\n* Any rheumatic disease involving the hand and upper extremity\n* History of neuropathy involving the hand and upper extremity\n* Those with any shoulder problems prior to the hand injury\n* Those with an open wound on the hand\n* Those who cannot cooperate\n* Other upper extremity traumatic injuries occurring during the hand injury",{"count":145,"type":21},"The purpose of the study is to reveal whether there are concurrent shoulder lesions in patients with hand injuries. Its importance is that it will shed light on whether not only the hand but also the shoulder should be included in the treatment program in hand rehabilitation.",[259,260,27],"Shoulder","Ultrasonographic",[262,259,263,264],"Hand injuries","Diagnostic","Ultrasonography","2026-03-19",{"date":267,"type":35},"2026-03-23",{"date":269,"type":35},"2024-11-11",{"date":271,"type":21},"2026-07-01",{"name":273,"class":41},"Ankara Training and Research Hospital",{"id":275,"slug":276,"hasResults":11,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":281,"targetDuration":4,"studyType":146,"phases":4,"briefSummary":283,"conditions":284,"keywords":286,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":294,"locationsCount":248},"100615352","health-literacy-level-and-functional-outcomes-in-patients-with-hand-and-forearm-injuries-100615352","NCT07291492","Health Literacy Level and Functional Outcomes in Patients With Hand and Forearm Injuries","Examining the Relationship Between Health Literacy Level and Functional Outcomes in Patients With Hand and Forearm Injuries","Inclusion Criteria:\n\n* Aged 18-65 years\n* Voluntarily agreed to participate\n* Presented with hand and\u002For forearm injuries\n\nExclusion Criteria:\n\n* Concomitant shoulder or elbow injuries\n* History of surgery due to neurological, rheumatological, or metabolic conditions affecting the entire upper extremity\n* Employment in a health-related profession",{"count":282,"type":21},117,"The aim of this study is to examine the association between health literacy, patient-reported outcome measures, and grip strength in a cohort of patients with hand injuries.",[27,285],"Forearm Fractures",[93,287],"Functional Outcomes","2026-03-09",{"date":290,"type":35},"2026-03-11",{"date":292,"type":35},"2026-01-15",{"date":267,"type":21},{"name":185,"class":41},{"id":296,"slug":297,"hasResults":11,"nctId":298,"briefTitle":299,"officialTitle":300,"acronym":4,"eligibilityCriteria":301,"healthyVolunteers":11,"sex":17,"minAge":302,"maxAge":4,"enrollmentInfo":303,"targetDuration":169,"studyType":146,"phases":4,"briefSummary":304,"conditions":305,"keywords":309,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":74},"100622100","the-cognitive-functional-relationship-in-geriatric-hand-forearm-injuries-100622100","NCT07379229","The Cognitive-Functional Relationship in Geriatric Hand-Forearm Injuries","Investigation of the Relationship Between Cognitive and Functional Status in Geriatric Patients With Hand-Forearm Injuries","Inclusion Criteria:\n\n* Being over 65 years of age\n* Having sufficient communication skills and auditory-visual abilities to complete cognitive tests\n\nExclusion Criteria:\n\n* Inability to perform functional tests due to active wounds, open fractures, or severe pain\n* Inability to administer cognitive tests due to aphasia or severe hearing or visual impairment","66 Years",{"count":168,"type":21},"Considering the complex structure of hand-forearm injuries and the long rehabilitation process, it is important to investigate factors associated with recovery in geriatric individuals. Therefore, this study aimed to examine the relationship between cognitive status and functional outcomes in geriatric individuals with hand-forearm injuries.",[306,307,308,27],"Geriatric Population","Cognitive Ability","Functional Abilities",[310,311,312,313],"geriatric population","hand Injuries","functional outcome","cognitive function","2026-01-30",{"date":316,"type":35},"2026-02-03",{"date":318,"type":21},"2026-02-23",{"date":320,"type":21},"2026-12-30",{"name":185,"class":41},{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":329,"targetDuration":4,"studyType":146,"phases":4,"briefSummary":330,"conditions":331,"keywords":334,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":340,"startDateStruct":342,"completionDateStruct":344,"leadSponsor":346,"locationsCount":74},"100618267","turkish-adaptation-and-validation-of-the-burnt-hand-outcome-tool-bhot-100618267","NCT07329400","Turkish Adaptation and Validation of the Burnt Hand Outcome Tool (BHOT)","Turkish Adaptation of the Burnt Hand Outcome Tool (BHOT): A Validity and Reliability Study in Adult Patients With Hand Burns","Inclusion Criteria:\n\n* Age 18 years or older\n* History of second-degree or higher burn injury in one or both hands\n* Ability to read and understand Turkish\n* Willingness to participate and provision of written informed consent\n\nExclusion Criteria:\n\n* History of trauma, surgery, or rheumatologic disease affecting hand function prior to the burn injury\n* Age under 18 years\n* Cognitive impairment or psychiatric disorder preventing completion of the questionnaires\n* Refusal to participate or withdrawal from the study at any time",{"count":20,"type":21},"The goal of this observational study is to evaluate the validity and reliability of the Turkish adaptation of the Burnt Hand Outcome Tool (BHOT) in adults with a history of hand burns. The participant population will include adults aged 18 years and older who have experienced unilateral or bilateral hand burns and can read and understand Turkish.The main questions this study aims to answer are:\n\nDoes the Turkish version of the BHOT demonstrate high internal consistency, test-retest reliability, and construct validity? How strongly are BHOT scores associated with objective hand function measures such as grip strength and sensory evaluation? Participants will not be assigned to comparison groups, as this is a methodological validation study.\n\nParticipants will: Complete a sociodemographic information form. Complete the Turkish version of the BHOT and the QuickDASH questionnaire. Undergo objective assessments including hand grip strength using a dynamometer and sensory evaluation using Semmes-Weinstein monofilaments. Participate in repeated assessments at baseline, 1 month, 3 months and 6 months for reliability analyses.",[332,27,333],"Hand Burn","Burn Injuries",[335,336,337,338,333],"Hand Burns","Burnt Hand Outcome Tool (BHOT)","Validation Study","Reproducibility of Results","2026-01-11",{"date":341,"type":35},"2026-01-13",{"date":343,"type":35},"2025-11-17",{"date":345,"type":21},"2026-11",{"name":347,"class":41},"Necmettin Erbakan University",{"id":349,"slug":350,"hasResults":11,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":355,"enrollmentInfo":356,"targetDuration":4,"studyType":22,"phases":358,"briefSummary":359,"conditions":360,"keywords":365,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":371,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":377,"locationsCount":74},"100366928","craniomaxillofacial-and-upper-extremity-allotransplantation-100366928","NCT04057638","Craniomaxillofacial and Upper Extremity Allotransplantation","Combined Craniomaxillofacial and Upper Extremity Allotransplantation","Inclusion Criteria:\n\n* Signed and dated all required Institutional Review Board (IRB) approved consent forms.\n* Male or female recipient between the ages of 18-64 years. Recipients do not need to be of the same sex as the donor.\n* Facial composite tissue defect requiring facial transplantation as determined by the treating Plastic and Reconstructive Surgeon. Inclusive facial functional subunit tissue loss. Including but not limited to irreparable peri-oral, peri-orbital, and peri-nasal damage.\n* Missing part of one or both hands and forearms.\n* Must be HIV negative at the time of transplant.\n* Crossmatch is negative at the time of transplant.\n* Patient has been encouraged to seek a second opinion from a Plastic Surgeon with specialized focus in facial reconstruction.\n* Patient has been encouraged to seek a second opinion from a Plastic Surgeon with specialized focus in upper extremity reconstruction.\n* Willingness to participate in ongoing psychiatric, psychological and social work evaluations prior to and post-transplant surgery.\n* The subject is able to complete pre-transplant examination and screening procedures.\n* Patient has been approved by Patient Selection Committee for placement on the recipient waiting list.\n* The subject is willing to continue immunosuppression regimen as directed by treating physician.\n* Subject is willing and able to return to follow-up visits as described in treatment plan.\n* Subjects must have autogenous tissue options available for reconstruction in event of graft failure.\n* Normal glomerular filtration rate (GFR) \\>60.\n* Negative pregnancy test within 48hrs of transplant for women of childbearing age and who agree to use a reliable form of contraception for one year following transplant.\n\nExclusion Criteria:\n\n* Uncontrolled infection or severe concomitant diseases which would exclude the recipient from transplantation\n* Serious co-morbidities\n* Positive serology for HIV; Hepatitis B Antigen\n* Active malignancy within 5 years with the exclusion of non-melanoma\n* Substance abuse disorders not currently under control (as determined by the Michigan Alcohol Screening Test - see Appendix N.1: Subjects with a score of 3 or more will be excluded)\n* Body Dysmorphic disorder (see Appendix N.2 for screening tool). Less severe psychiatric conditions are addressed on a case by case basis\n* Active Severe Psychiatric Illness\n* Cognitive limitations affecting the patient's ability to provide informed consent\n* Recent history of medical non-adherence\n* Unstable social situation as evidence by lack of stable housing and\u002For lack of a supportive significant other.\n* Recent history of medical non-adherence.\n* Lack of stable housing and\u002For supportive significant other\u002Fcaregiver throughout all phases of the study\n* Currently active smoker within 1 year\n* Subjects with any cognitive deficits related to a traumatic brain injury (TBI) and or any organic neurological disorders\n* Any other psychological status that would hinder the success or safety of the transplantation.\n* Level of amputation proximal to mid-humerus: some presence of proximal muscles is required to motor a functioning hand.\n* Congenital Abnormalities: co-existent absence\u002Fatrophy\u002Fagenesis of any tissue may affect post-transplant results\n* History of amputation of less than six months: subject must be allowed to attempt prosthetic use prior to hand transplantation. This can be waived in cases where the recipient requires amputation\u002Frevision of the transplant site at the time of transplantation. However, if at all possible, it is highly encouraged that the patient has ruled out prosthetics as an alternative to transplantation.\n* Blindness: blind amputees may be poor candidates because sensory return in the hand may not provide sufficient protective sensation\n* Pregnancy","64 Years",{"count":357,"type":21},10,[24],"The purpose of this study is to evaluate functional and aesthetic outcomes of combined facial and upper extremity composite tissue allografts on patients who have not achieved functional and aesthetic outcomes with conventional reconstructive surgical strategies and prosthetic devices.",[361,27,362,206,363,364],"Face Injuries","Craniofacial Injuries","Facial Injuries","Facial Deformity",[366,367,368,369,123],"Transplants","Transplantation","Craniomaxillofacial Transplantation","Upper Extremity Transplantation","2025-12-08",{"date":372,"type":35},"2025-12-16",{"date":374,"type":35},"2019-06-17",{"date":376,"type":21},"2026-01-01",{"name":378,"class":41},"NYU Langone Health",{"id":380,"slug":381,"hasResults":11,"nctId":382,"briefTitle":383,"officialTitle":384,"acronym":385,"eligibilityCriteria":386,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":387,"targetDuration":4,"studyType":22,"phases":389,"briefSummary":391,"conditions":392,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":74},"100504291","phase-4-cat-bite-antibiotic-prophylaxis-for-the-handforearm-catbite-100504291","NCT05846399","CAT BITE Antibiotic Prophylaxis for the Hand\u002FForearm (CATBITE)","CAT BITE Antibiotic Prophylaxis and Durations for the Hand\u002FForearm (CATBITE): A Prospective, Randomized, Placebo-controlled, Double-blinded, Clinical Trial","CATBITE","Inclusion Criteria:\n\n* Patients greater or equal to 18 years of age.\n* Bitten by a cat.\n* Location of bite is the hand and\u002For forearm (distal to elbow).\n* Presenting \\\u003C24 hours following a cat bite to the hand\u002Fforearm.\n* English speaking\n\nExclusion Criteria:\n\n* Patients who present with active local or systemic infections\n\n  1. Purulent drainage from the cat bite\n  2. Redness AND swelling at the location of the cat bite\n* Having a fever \\>100.4° F or \\>38° C)-Received antibiotics within the past 30 days\n* Received antibiotics within the past 30 days\n* Patients unwilling to take study medication\n* Patients unwilling to attend scheduled follow-up evaluations or complete study forms\n* Pregnant Women\n* Type I hypersensitivity reaction to any of the study interventions\n* Immunocompromised patients (primary and secondary immunodeficiencies) Primary\n* Autoimmune Lymphoproliferative Syndrome (ALPS)\n* Autoimmune Polyglandular Syndrome type 1 (APS-1)\n* B-cell Expansion with Nuclear factor kappa-light-chain-enhancer of activated B cells and T-cell Anergy (BENTA) Disease\n* Caspase Eight Deficiency State (CEDS)\n* Caspase Recruitment Domain Family Member 9 (CARD9) Deficiency and Other Syndromes of Susceptibility to Candidiasis\n* Cartilage-hair hypoplasia\n* Chédiak-Higashi syndrome\n* Chronic Granulomatous Disease (CGD)\n* Common Variable Immunodeficiency (CVID)\n* Complement Deficiencies\n* Congenital Neutropenia Syndromes\n* Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA4) Deficiency\n* Cyclic neutropenia\n* DiGeorge syndrome\n* Dedicator Of Cytokinesis 8 (DOCK8) Deficiency\n* GATA-binding protein 2 (GATA2) Deficiency\n* Glycosylation Disorders with Immunodeficiency\n* Hyper-Immunoglobulin E Syndromes (HIES)\n* Hyper-Immunoglobulin M Syndromes\n* Interferon Gamma, Interleukin 12 and Interleukin 23 Deficiencies\n* Leukocyte Adhesion Deficiency (LAD) Types 1 and 2\n* Lipopolysaccharide Responsive Beige-Like Anchor Protein (LRBA) Deficiency\n* Phosphatidylinositol 3-kinase (PI3-Kinase) Disease\n* Phospholipase C gamma 2 (PLCG2) associated Antibody Deficiency and Immune Dysregulation (PLAID)\n* Severe Combined Immunodeficiency (SCID)\n* Selective Immunoglobulin A (IgA) deficiency\n* Signal transducer and activator of transcription 3 (STAT3) Dominant-Negative Disease\n* STAT3 Gain-of-Function Disease\n* Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome\n* Wiskott-Aldrich Syndrome (WAS)\n* X-Linked Agammaglobulinemia (XLA)\n* X-Linked Lymphoproliferative Disease (XLP)\n* X-linked magnesium transporter 1 (MAGT1) deficiency with increased susceptibility to Epstein-Barr virus (EBV) infection and N-linked glycosylation defect (XMEN) Disease\n* Zeta-associated protein 70 (ZAP-70) deficiency\n\nSecondary\n\n* Malnutrition\n* Uncontrolled Diabetes mellitus\n* Chronic uremia\n* Genetic syndromes: trisomy 21\n* Immunomodulatory, immunosuppressive drug therapy: corticosteroids, calcineurin inhibitors, cytotoxic agents\n* Systemic lupus erythematosus\n* Malignancy\n* Active radiation therapy\n* Bone marrow ablation\n* Infectious diseases: human immunodeficiency virus (HIV) infection, Hepatitis\n\nAdditional Primary and secondary immunodeficiencies can be found at the following link.\n\nhttps:\u002F\u002Fwww.merckmanuals.com\u002Fprofessional\u002Fimmunology-allergic-disorders\u002Fimmunodeficiency-disorders\u002Foverview-of-immunodeficiency-disorders",{"count":388,"type":21},72,[390],"PHASE4","Cat bites are puncture wounds that have the potential to seed bacteria deep within the joint capsule, periosteum, and bone. The hand is the most common site of bite injuries. Pasteurella multocida is the is the most common organism isolated from the mouths of cats that can cause infections after a bite. Prophylactic antibiotics are often recommended with amoxicillin-clavulanate for 3-5 days to decrease the incidence of developing an infection. However, only one randomized controlled clinical trial consisting of 12 patients has been performed to justify this course of treatment, raising the possibility that the use of antibiotics could be reduced or even eliminated. Investigators will compare different durations of prophylactic antibiotics and a placebo control for cat bites to the hand\u002Fforearm presenting to the Emergency Department, Urgent Care, Plastic Surgery Clinic using a randomized, controlled, double-blind clinical trial. Participants presenting to the University of Missouri Hospital Emergency Department, Missouri University (MU) Healthcare Urgent Care, Plastic Surgery Clinic over the next year will be offered the chance to enroll if they meet the inclusion\u002Fexclusion criteria. For inclusion, participants will be \\>18 years of age, have cat bites to the hand or distal to elbow, and present within 24 hours of the cat bite injury. Participants must not present with active local or systemic infections, have received antibiotics within the past 30 days, or be immunocompromised (primary and secondary immunodeficiencies). Participants will be randomized to one of three treatment arms (placebo; amoxicillin-clavulanate 1 day; amoxicillin-clavulanate 5 days). Outcomes are the development of an infection at the location of the cat bite and\u002For systemic infection, adverse effects of interventions, disability assessed by Quick Disabilities of Arm, Shoulder and Hand (QuickDASH) scores, and quality of life (QOL) assessed by HAND Questionnaire (HAND-Q) scores. Infection will be assessed at day 0, day 2, day 7+\u002F-2, day 14+\u002F-2, and day 30+\u002F-2 by vital signs, laboratory values, physical examination and with an infrared and digital camera. All measures will be within the standard of care, apart from the infrared camera, QuickDASH, and HAND-Q scores. The anatomic locations of cat bites to the hand\u002Fforearm will be assessed for correlations with infections.",[393,27,394,395,396],"Cat Bite","Arm Injury","Infection, Bacterial","Anti-bacterial Agents","2025-10-13",{"date":399,"type":35},"2025-10-15",{"date":401,"type":35},"2023-09-07",{"date":403,"type":21},"2027-08-01",{"name":405,"class":41},"University of Missouri-Columbia",{"id":407,"slug":408,"hasResults":11,"nctId":409,"briefTitle":410,"officialTitle":411,"acronym":4,"eligibilityCriteria":412,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":413,"targetDuration":4,"studyType":146,"phases":4,"briefSummary":415,"conditions":416,"keywords":417,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":421,"lastUpdatePostDateStruct":422,"startDateStruct":424,"completionDateStruct":426,"leadSponsor":428,"locationsCount":430},"100546796","occupational-therapy-led-services-for-adults-presenting-acutely-with-a-hand-condition-100546796","NCT06399614","Occupational Therapy-led Services for Adults Presenting Acutely With a Hand Condition","An Evidenced Based Analytical Study of Occupational Therapy-led Services for Adults Presenting Acutely With a Hand Condition","Inclusion Criteria:\n\n* Adults aged 18 years of age and older\n* Adults presenting with an injury and\u002F or condition of their hand and\u002For forearm inhibiting function inclusive of: fractures (proximal, middle, and distal phalanx); tendon and soft tissue injury (PIPJ volar plate, central slip +\u002F- lateral band, mallet injury, trigger finger, flexor injury, extensor injury, thumb tendon and ligament injury); digital nerve injury; or carpal tunnel injury.\n\nExclusion Criteria:\n\n* Patients under 18 years of age\n* Patients presenting with complex medical issues in conjunction with a hand injury who may require an alternative pathway, for example, transfer to a different hospital, requiring prioritisation of another medical emergency\n* Other exclusions at the discretion of the service depending on team capacity and expertise",{"count":414,"type":21},150,"Traumatic hand injuries account for up to one third of acute hospital presentations. Current guidelines and standards of care recommend patients with hand trauma are seen by hand therapists, typically occupational therapists. The proposed study aims to explore the effectiveness of occupational therapy-led hand therapy services for the adult population presenting acutely to an injury unit or emergency department setting with a hand condition. The research project will consist of an analytical study, involving four different sites in Ireland to enrich findings, and to aid future service development. One site will be the comparison site, as it does not have access to occupational therapy, and will offer patients 'care as usual' upon attendance. Outcome measures will be used for all participants and will be completed at initial patient contact, at week eight and at six months. It is hoped the current proposed study will help shape future service development for those with hand injury including provision of evidence based occupational therapy assessment and intervention.",[27],[418,419,420],"Hand injury","Hand conditions","Occupational Therapy","2025-09-25",{"date":423,"type":35},"2025-10-01",{"date":425,"type":35},"2024-01-11",{"date":427,"type":21},"2025-11",{"name":429,"class":41},"University of Limerick",5,{"id":432,"slug":433,"hasResults":11,"nctId":434,"briefTitle":435,"officialTitle":436,"acronym":437,"eligibilityCriteria":438,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":439,"targetDuration":4,"studyType":22,"phases":440,"briefSummary":441,"conditions":442,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":444,"lastUpdatePostDateStruct":445,"startDateStruct":447,"completionDateStruct":449,"leadSponsor":451,"locationsCount":74},"100405613","percutaneous-pinning-vs-orthosis-and-early-mobilization-100405613","NCT04561661","Percutaneous Pinning vs Orthosis and Early Mobilization","A Randomized Comparison Between Percutaneous Pinning and Non-surgical Management of Proximal Phalangeal Fractures","POEM","Inclusion Criteria:\n\n-Fractures of the base phalanx of digit 2-5 in the hand.\n\nExclusion Criteria:\n\n* Fracture older than 2 weeks.\n* More than 25° of sagittal plane and\u002For 10° lateral angulation after reposition.\n* Intra-articular step \\>1mm.\n* Associated fractures in other bones (i e metacarpals, middle and distal phalanges) and\u002For tendon and nerve injuries in any finger.\n* Open fractures.\n* Patient age \\\u003C18 years.\n* Inability to co-operate with the follow-up protocol (i.e. language difficulties, severe psychiatric disorder, cognitive impairment, drug addiction).",{"count":145,"type":21},[24],"This study aims at investigating if splinting and early mobilization is a better method, regarding range of motion, for treating fractures of the base phalanx of the fingers compared to surgery with pinning. This will be achieved through a randomised clinical trial comparing the two methods.",[27,443],"Finger Fracture","2025-06-01",{"date":446,"type":35},"2025-06-03",{"date":448,"type":35},"2021-03-03",{"date":450,"type":21},"2026-12",{"name":452,"class":41},"Karolinska Institutet",{"id":454,"slug":455,"hasResults":11,"nctId":456,"briefTitle":457,"officialTitle":457,"acronym":458,"eligibilityCriteria":459,"healthyVolunteers":11,"sex":17,"minAge":460,"maxAge":461,"enrollmentInfo":462,"targetDuration":4,"studyType":22,"phases":463,"briefSummary":464,"conditions":465,"keywords":466,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":477,"locationsCount":4},"100593650","effect-of-instrument-assisted-soft-tissue-mobilization-on-hand-post-surgical-scars-in-primary-flexor-tendons-repair-in-zone-v-100593650","NCT07009197","Effect of Instrument Assisted Soft Tissue Mobilization on Hand Post Surgical Scars in Primary Flexor Tendons Repair in Zone v","IASTM","Inclusion Criteria:\n\n* Both sex will be included in this research\n* Hand scar in zone v\n* Age varying from 20 to 40\n* Hand scar formed post primary flexor tendons repair\n\nExclusion Criteria:\n\n* Vascular injuries requiring arterial repair\n* Soft tissue loss\n* Fractures\n* Tendon in-juries of other zones\n* Preexisting problems such as arthritis limiting joint motion\n* unhealed wounds or age of scar under 6 weeks","20 Years","40 Years",{"count":51,"type":21},[24],"this study will be conducted to investigate the effect of instrument assisted soft tissue mobilization on hand post surgical scars in primary flexor tendons repair in zone v",[27],[467,468,469],"Instrument Assisted Soft Tissue Mobilization","Primary Flexor Tendons Repair","Hand Post Surgical Scars","2025-05-29",{"date":472,"type":35},"2025-06-06",{"date":474,"type":21},"2025-06-05",{"date":476,"type":21},"2025-09-01",{"name":478,"class":41},"Cairo University",{"id":480,"slug":481,"hasResults":11,"nctId":482,"briefTitle":483,"officialTitle":483,"acronym":484,"eligibilityCriteria":485,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":486,"targetDuration":4,"studyType":22,"phases":487,"briefSummary":488,"conditions":489,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":490,"lastUpdatePostDateStruct":491,"startDateStruct":493,"completionDateStruct":495,"leadSponsor":497,"locationsCount":74},"100431269","3d-personalized-modelization-of-the-hand-using-eos-imaging-system-100431269","NCT04895891","3D Personalized Modelization of the Hand Using EOS Imaging System","M3DME","Inclusion Criteria:\n\n* Patient with hand\u002Fwrist CT required\n* Informed consent form signed",{"count":145,"type":21},[24],"This study aims to compare the quality of 3D hand modelization with EOS imaging with gold-standard computed tomography",[27],"2024-09-05",{"date":492,"type":35},"2024-09-19",{"date":494,"type":35},"2020-10-06",{"date":496,"type":21},"2025-12",{"name":498,"class":41},"Centre Hospitalier Universitaire de Besancon",{"id":500,"slug":501,"hasResults":11,"nctId":502,"briefTitle":503,"officialTitle":504,"acronym":4,"eligibilityCriteria":505,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":506,"enrollmentInfo":507,"targetDuration":4,"studyType":22,"phases":509,"briefSummary":510,"conditions":511,"keywords":514,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":520,"lastUpdatePostDateStruct":521,"startDateStruct":523,"completionDateStruct":525,"leadSponsor":526,"locationsCount":74},"100549760","clinical-utility-of-eswt-in-restoring-hand-function-of-patients-with-nerve-injury-and-hypertrophic-scars-due-to-burns-100549760","NCT06438224","Clinical Utility of ESWT in Restoring Hand Function of Patients With Nerve Injury and Hypertrophic Scars Due to Burns","Clinical Utility of Extracorporeal Shock Wave Therapy in Restoring Hand Function of Patients With Nerve Injury and Hypertrophic Scars Due to Burns","Inclusion Criteria:\n\n* ≥ 18 years old\n* had sustained a deep partial-thickness (second-degree) or a full-thickness (third-degree) burn in the right dominant hand, which had been treated with a split-thickness skin graft (STSG) after the thermal injury\n* nerve injury to the hand was confirmed by electromyography\n* \\\u003C 6 months prior to the enrollment\n\nExclusion Criteria:\n\n* musculoskeletal diseases (fracture, amputation, rheumatoid arthritis, and degenerative joint diseases) of the hands\n* acute infection\n* malignant tumors\n* coagulopathy\n* pregnancy\n* potential for additional skin damage if exposed to ESWT and conventional occupational therapy.","75 Years",{"count":508,"type":21},120,[24],"Joint contractures and nerve injuries are common after hand burns. Extracorporeal shock wave therapy (ESWT) is effective not only for the regeneration of various tissues, including scar tissues, but also for reducing pain and pruritus in patients with burns. Researchers have attempted to explore the effects of ESWT on hand dysfunction caused by nerve injury following burns. The investigators planned to evaluate the effects of ESWT (compared to sham stimulation) on hands with nerve injury and hypertrophic scars and thereby on hand function. The ESWT parameters were as follows: energy flux density, 0.05-0.30 mJ\u002Fmm2; frequency, 4 Hz; 1000 to 2000 impulses per treatment; and 12 treatments, one\u002Fweek for 12 weeks. Outcome measures were as follows: 10-point visual analog scale for pain, Jebsen-Taylor hand function test, grip strength, Purdue Pegboard test, ultrasound measurement of scar thickness, and skin characteristics before and immediately after 12 weeks of treatment.",[27,512,513],"Extracorporeal Shock Wave Therapy","Burns",[515,516,517,518,519],"Extracorporeal shock wave therapy","hypertrophic scar","burns","hand function","nerve injury","2024-08-18",{"date":522,"type":35},"2024-08-20",{"date":524,"type":35},"2023-01-01",{"date":522,"type":21},{"name":527,"class":41},"Hangang Sacred Heart Hospital"]