[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hbv-related-acute-on-chronic-liver-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hbv-related-acute-on-chronic-liver-failure":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":5},"100614127","analysis-of-methylomic-features-and-prognostic-risk-prediction-in-patients-with-hepatitis-b-related-acute-on-chronic-liver-failure-100614127",false,"NCT07275554","Analysis of Methylomic Features and Prognostic Risk Prediction in Patients With Hepatitis B-related Acute-on-chronic Liver Failure","Inclusion Criteria:\n\n* Chronic hepatitis B was persistent hepatitis B surface antigen (HBsAg) seropositivity for more than six months.\n\nHepatitis B-related liver cirrhosis was diagnosed based on histological examination, typical features on ultrasound or radiological imaging, endoscopic findings of portal hypertension, and clinical history.\n\nHepatitis B-related acute-on-chronic liver failure meets the diagnostic criteria of the 2018 Asia-Pacific guidelines for the diagnosis and treatment of liver failure.Laboratory tests:Jaundice: Serum total bilirubin ≥ 85 µmol\u002FL and coagulopathy \\[International Normalized Ratio (INR) ≥ 1.5 or Prothrombin Activity (PTA) \\\u003C 40%\\].\n\nExclusion Criteria:\n\n* co-infection with other hepatitis viruses; history of hepatocellular carcinoma or other malignancies; concomitant autoimmune liver disease; or insufficient clinical data.","ALL","18 Years",{"count":18,"type":19},100,"ESTIMATED","OBSERVATIONAL","This study aims to investigate the methylomic features of patients with hepatitis B-related acute-on-chronic liver failure and establish and validate a prognostic risk prediction classification model. The findings are of significant importance for guiding clinical practice and improving patient prognosis. Additionally, a methylomics-based classifier model for liver failure will be developed for disease prognosis analysis and clinical assessment, with the potential to enhance the diagnostic efficiency of liver failure.",[23,24,25],"HBV Related Acute-on-chronic Liver Failure","HBV-related Liver Cirrhosis","HBV (Hepatitis B Virus)","RECRUITING","2025-11-27",{"date":29,"type":30},"2025-12-10","ACTUAL",{"date":32,"type":30},"2024-12-31",{"date":34,"type":19},"2026-12-31",{"name":36,"class":37},"Qilu Hospital of Shandong University","OTHER"]