[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"head-injury-trauma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:head-injury-trauma":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,71,110],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100619030","treatment-and-outcome-of-patients-with-mild-head-injury-100619030",false,"NCT07339319","Treatment and Outcome of Patients With Mild Head Injury","Treatment and Outcome of Patients With Mild Head Injury: a Retrospective Multicentre Study in Emilia Romagna","BTER23","Inclusion Criteria:\n\n* patients aged 18 years or older capable of self-determination\n* patients assessed in the emergency department with a final diagnosis of isolated head trauma, subsequently discharged home or transferred to the OBI, Emergency Medicine and\u002For possibly admitted to other wards, who have undergone at least one brain CT scan during their diagnostic-therapeutic pathway\n* GCS 13-15\n* presentation \\\u003C24 hours after trauma\n\nExclusion Criteria:\n\n* patients aged \\\u003C 18 years\n* patients with multiple fractures outside the cranium\n* patients with head trauma who have not undergone a brain CT scan\n* GCS \\\u003C13","ALL","18 Years",{"count":20,"type":21},4500,"ESTIMATED","OBSERVATIONAL","The study aims to assess the incidence of complications, such as intracranial haemorrhages and neurological deficits, in patients with head trauma treated in the emergency departments of the Emilia-Romagna Region and to compare the prognostic accuracy of the Canadian CT Head Rule and NEXUS Head CT Instrument in predicting post-traumatic complications. This is a retrospective multicentre cohort study that includes patients aged 18 years or older with isolated head trauma who underwent brain CT within 24 hours of the trauma. The data, sourced from hospital databases, will include medical history, prognostic scores, instrumental examinations, pharmacotherapy and adverse events. The primary objective is to determine the incidence of complications in patients who require surgery or who die, while the secondary objectives aim to compare the prognostic effectiveness of the two instruments in predicting complications. In addition, the study will examine the management strategies adopted and seek to identify any predictors of complications not included in current prognostic models. The results will contribute to improving the management of head trauma in emergency departments and optimising the use of available prognostic tools.",[25],"Head Injury Trauma",[27,28,29],"isolated head injury","First Aid","brain CT scan","RECRUITING","2026-01-15",{"date":33,"type":34},"2026-01-16","ACTUAL",{"date":36,"type":34},"2024-02-01",{"date":38,"type":21},"2026-12-31",{"name":40,"class":41},"Azienda USL Reggio Emilia - IRCCS","OTHER_GOV",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":70},"100338520","platelet-inhibitor-treated-patients-with-head-injury-trauma-meeting-nice-criteria--is-the-ct-scan-mandatory--100338520","NCT03687528","Platelet Inhibitor Treated Patients With Head Injury Trauma Meeting NICE Criteria : is the CT-scan Mandatory ?","Platelet Inhibitor Treated Patients With Head Injury Trauma Without Any Clinical Symptoms of Cerebral Haemorrhage (NICE Criteria) : is the CT-scan Mandatory ?","TCAP","Inclusion Criteria:\n\n* At least 18 years old\n* Patient with a head injury trauma, described by the patient or seen at the clinical exam\n* Glasgow score between 13 and 15 at the clinical exam\n* Current treatment with antiplatelet inhibitors\n* Informed non opposition form signed\n\nExclusion Criteria :\n\n* Absence of CT-scanner\n* Patients with double anti-platelet aggregation\n* Patients on anticoagulants",{"count":51,"type":21},3200,"At the emergencies rooms, patients with head trauma meeting one of the NICE criteria, which include antiplatelet inhibitors treatment, are considered as patients with a risk of cerebral haemorrage and are taken systematically for a CT-scanner.\n\nHowever, there are more and more antiplatelet inhibitor's patient with minor head injury traumas seen at the emergencies room and the efficiency of this NICE criteria is controversial on litterature.\n\nThis study aims to determine that the absence of no other NICE criteria than antiplatelet inhibitors is a sufficient condition to eliminate a cerebral haemorrhage for patients with head injury traumas, and conversely, that antiplatelet inhibitors treatment would not be by itself an indication for a CT-scanner.",[25,54],"Emergencies",[56,57,58,59],"emergencies","platelet inhibitors","minor head injury trauma","CT-scan","2025-12-31",{"date":62,"type":34},"2026-01-05",{"date":64,"type":34},"2020-06-15",{"date":66,"type":21},"2026-12",{"name":68,"class":69},"Rennes University Hospital","OTHER",12,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":83,"conditions":84,"keywords":94,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":109},"100544564","screening-emotions-in-adolescents-at-the-hospital-for-mtbi-100544564","NCT06370520","Screening Emotions in Adolescents at the Hospital for mTBI","Screening Emotions in Adolescents Receiving Care at the Hospital for mTBI (SEARCH-mTBI)","SEARCH-mTBI","Inclusion Criteria:\n\nChildren 11 to less than 18 years old who meet the Centers for Disease Control and Prevention (CDC) definition of mTBI\\*. In brief, this is defined as a Glasgow Coma Scale (GCS) score of 13 to 15 with:\n\n\\- Head injury (e.g., direct blow or sudden deceleration\u002Facceleration) plus any neurological sign and\u002For symptom such as headache, nausea, history of loss of consciousness, confusion, dizziness, amnesia (not limited to these symptoms\u002Fsigns)\n\nAND\u002FOR\n\n\\- Traumatic intracranial abnormalities on CT or MRI (such as intracranial hemorrhage, skull fracture, or diffuse axonal injury)\n\n\\*mTBI is defined as an acute brain injury resulting in neurological symptoms such as confusion or disorientation, headache, nausea, loss of consciousness, amnesia, seizure, focal signs or symptoms, and\u002For have traumatic intracranial abnormalities on CT or MRI imaging. mTBI patients have GCS scores of 13 to 15. Per CDC precedent, we will use the term mTBI which encompasses other commonly used terms such as \"concussion\" or \"minor head injury\". This will include patients who may have neuroimaging findings of traumatic abnormalities (e.g., intracranial hemorrhage, diffuse axonal injury, skull fractures) which are risk factors for mental health problems; however, neuroimaging is not required for enrollment into the study.\n\nExclusion Criteria:\n\n* Presentation to the ED \\>72 hours post-injury\n* TBI requiring emergent neurosurgical intervention at the time of enrollment\n* Other injuries requiring emergent surgery at the time of enrollment\n* Parent or child unable to accurately complete the study questionnaires due to preexisting functional limitations (e.g., severe developmental delay)\n* Previous known enrollment into the study\n* Patient or parent does not speak English or Spanish","11 Years","17 Years",{"count":82,"type":21},2592,"The goal of this observational study is to develop and validate a clinical tool to predict which adolescents aged 11 to less than 18 years of age with mild traumatic brain injury (mTBI) are at an increased risk for developing significant new or worsening mental health conditions.\n\nThe main aims the study wish to answer are:\n\n* Does the adolescent have new or worsening depression or anxiety defined as a change from their previous medical history using self-reported questionnaires at either one or three months post-injury?\n* Does the adolescent have unmet mental health care needs, defined as not receiving any mental or behavior health care in patients with new or worsening anxiety or depression as defined by the self reported questionnaires?\n\nParticipants will be enrolled after being diagnosed in the emergency department (ED) with an mTBI. During the ED visit, the child's parent\u002Fcaregiver and the adolescent will complete several questionnaires related to mental health which include tools to measure anxiety and depression. Participants will be asked to complete these questionnaires again at 1 month and 3 months post enrollment.",[85,86,87,88,25,89,90,91,92,93],"Brain Injury Traumatic Mild","Brain Injuries","Brain Injuries, Acute","Head Injury With Intracranial Hemorrhage","Brain Injury Traumatic Focal With Loss of Consciousness","Skull Fractures","Diffuse Axonal Injury","Intracranial Hemorrhages","Head Injury",[95,96,97,86,98,99],"Child","Concussion","Wounds and Injuries","Head Injuries Trauma","Loss of Consciousness","2025-09-22",{"date":102,"type":34},"2025-09-26",{"date":104,"type":34},"2024-05-22",{"date":106,"type":21},"2028-12",{"name":108,"class":69},"University of California, Davis",6,{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":117,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":121,"phases":122,"briefSummary":124,"conditions":125,"keywords":126,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":140},"100581509","osteopathic-manipulative-treatment-rct-and-computational-modeling-for-head-injuries-in-mixed-martial-artists-100581509","NCT06851234","Osteopathic Manipulative Treatment RCT and Computational Modeling for Head Injuries in Mixed Martial Artists","Fluid Dynamics of Concussion in Mixed Martial Arts in a Pilot Randomized Controlled Trial of Osteopathic Manipulative Medicine","Inclusion Criteria:\n\n* Part 1-head injury dynamics:\n\n  1. individuals participating in MMA fights or sparring matches,\n  2. 18 to 50 years of age,\n  3. able to complete online cognitive neuropsychology tests.\n\n     Part-2-Intervention:\n\n  \u003C!-- -->\n\n  1. having a witnessed closed head injury during a fight\n\n     Exclusion Criteria:\n* Part 1-head injury dynamics:\n\n  1. having a current or previous spinal cord injury,\n  2. head injury within past six months,\n  3. being unable to complete the assessment,\n  4. been diagnosed with underlying neurodegenerative condition,\n  5. pre-existing hypopituitary function,\n  6. Pregnancy.\n\nPart-2-Intervention:\n\n1. has absolute contraindications to OMM (e.g. skull fracture, cervical spine fracture, signs of intracranial bleeding or increased intracranial pressure, cervical dissection, space occupying lesion in the cranium, or stroke),\n2. suffered a witnessed loss of consciousness (LOC) for greater than 2 minutes, seizures, intractable vomiting or paralysis at the time of the head injury, Participants won't be referred to their private doctors for additional pituitary hormone testing unless there are clinical signs. The optional referral for growth hormone and other pituitary testing by glucagon stimulation Test at Quest labs will be contraindicated if there is risk of and\u002For a history of (1) cardiovascular (heart) disease, (2) disease of the blood vessel in your brain, or (3) seizures.",true,"50 Years",{"count":120,"type":21},100,"INTERVENTIONAL",[123],"NA","The purpose is to test how osteopathic medicine (OMM) improves recovery after a hit to the head during Mixed Martials Arts (MMA). The small changes in the bone, joints, and fluids during head injuries may lead to traumatic brain injury (TBI). The OMM is adjusting the body with the doctors' hands. The goal is to restore alignment and release tension. The head is treated with the doctors' hands placed gently on the head or face. It was previously found to improve symptoms and recovery of memory after head injuries in college athletes. There haven't been clinical trials of this procedure in MMA fighters. Yet, they often get injuries to the part of the brain that releases hormones. Referrals for tests for the hormones are available. Individuals who participate in MMA fighting or sparring matches may join this study. Those who don't get hit in the head or a concussion will contribute to our understanding the osteopathic structural physical exam and fluid dynamics of the head in relation to brain function tests. Those who get hit in the head may be put in the treatment procedure or sham-placebo group. Participants will not be told which group they are in. We anticipate that 100 individuals of any gender will enroll in this study at NYIT Academic Health Care Center (AHCC). To be in this study, the participant must:\n\nPart 1 - Before the fight:\n\n1. Plan to participate in an MMA fight or sparring match,\n2. 18 to 50 years of age,\n3. Be able to do online cognitive neuropsychology tests for memory, reaction time, and symptoms.\n\nPart-2-After the fight:\n\n(1) Have been hit in the head, or had a head injury, during a fight\n\nThe participant cannot be in this study if they have:\n\nPart 1- Before the fight:\n\n1. a current or previous spinal cord injury,\n2. a traumatic brain injury within the past six months,\n3. inability to tolerate the sports physical,\n4. a diagnosis of brain degeneration,\n5. low hormones levels from the brain,\n6. Pregnancy Participants won't get referred for hormone testing if they don't have any clinical signs of this injury. They also won't get referred for it if they've had heart disease, disease of the blood vessels in their brain, or seizures.\n\nParticipants cannot be in Part-2-After the fight if they:\n\n1. cannot tolerate OMM (For example, you have a skull fracture, cervical spine fracture, bleeding or increased pressure in the head, tearing of tissues in the neck, space-occupying lesion, or stroke).\n2. were knocked out for more than 2 minutes, had seizures, persistent vomiting, or paralysis when your head was hit.\n\nParticipation involves 2 or 4 visits, which will take place over one week.\n\n* The first visit takes 30 mins. in-person and 70 mins. of online testing from home.\n* The second visit takes 30-60 mins. in-person and 70 mins. of online testing from home.\n* The third \\& fourth visits will each be 30 mins. in-person and 70 mins. online testing from home.\n\nIf participants agree to be in this study, they will be asked to do the following:\n\nVisit #1: Before the Fight\n\n* Get screened and review the consent form\n* Take the neuropsychology tests (ImPACT and Inquisit Web) online from home\n* Get a non-invasive sports physical exam of head, neck, back, arms, and legs.\n* Urine sample for the hormone from the brain called oxytocin (optional)\n* Have blood sugar checked by a lancet after pricking the finger (optional) Fight video: The study-doctors will record the participants' fights to make a computational model of the head.\n\nVisit 2: After the Fight\n\n* Get a sports physical of head, neck, back, arms, and legs.\n* IF the participant was hit in the head, the study-doctors or participants private doctor will examine them.\n* Take the ImPACT and Inquisit Web tests online from home\n* If the participant had an injury to their brain, they may get the OMM procedure or sham placebo-control (non-therapeutic light touch).\n* Urine sample for the hormone from the brain called oxytocin (optional)\n* Have your blood sugar checked by a lancet after pricking your finger (optional)\n* Referral to your doctor to test the levels of other brain hormone (optional)\n\nVisit 3 \\& 4:\n\n* Sports physical of head, neck, back, arms, and legs\n* Take the ImPACT and Inquisit Web tests online from home\n* If you had an injury to your brain, you may get the OMM procedure or sham placebo-control (nontherapeutic light touch). You will not be told which one you are getting.\n* Urine sample for oxytocin (optional)\n* Have blood sugar checked by a lancet after pricking your finger (optional)\n* Referral to test the levels of other brain hormone (optional) Any significant new findings that develop during research that may relate to the participants health or willingness to continue will be provided to them by phone call. The results will help us understand head injuries, how well OMM works to treat them, and may improve future care for fighters.",[25],[127,128,129,130],"osteopathic manipulative treatment","concussion","mixed martial arts","head injury","2025-02-26",{"date":133,"type":34},"2025-02-28",{"date":135,"type":34},"2024-11-01",{"date":137,"type":21},"2026-12-01",{"name":139,"class":69},"New York Institute of Technology",1]