[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"head-trauma-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:head-trauma-injury":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100642854","phase-4-intravenous-metoclopramide-versus-intravenous-acetaminophen-for-acute-concussion-treatment-100642854",false,"NCT07634393","Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment","A Randomized Study of Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment","IMPACT","Inclusion Criteria:\n\n* Adults presenting to one of the study emergency departments (EDs)\n* Acute minor traumatic brain injury\u002Fconcussion as defined by the Zurich Consensus Statement, including symptoms in somatic, cognitive, emotional, behavioral, physical, cognitive impairment, or sleep domains\n* ED visit occurring within 7 days of the head injury\n* Overall pain intensity greater than \\>=6 on a 0-10 scale\n* Rivermead Post-Concussion Questionnaire (RPQ) score of at least 10\n* Reported post-concussion symptoms were not present prior to the injury\n* Treating attending physician plans to administer a parenteral medication\n\nExclusion Criteria:\n\n* Already treated with an anti-dopaminergic medication for post-concussion symptoms\n* Contraindications to study medications, including:\n* Pheochromocytoma\n* Seizure disorder\n* Parkinson's disease\n* Use of monoamine oxidase (MAO) inhibitors\n* Use of anti-rejection transplant medications\n* Pregnant patients will not be excluded because both acetaminophen and metoclopramide are commonly used during pregnancy.","ALL","18 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The IMPACT study is a randomized, double-blind clinical trial evaluating two commonly used intravenous medications - metoclopramide and acetaminophen - for treating acute post-concussion symptoms in emergency department patients after mild head injury. The study aims to determine which treatment more effectively improves symptoms such as headache, dizziness, nausea, concentration difficulties, and emotional changes within the first week after injury.\n\nParticipants will be enrolled across two Montefiore emergency departments and followed using a validated post-concussion symptom questionnaire. Findings from this study may help improve evidence-based treatment strategies for patients experiencing concussion-related symptoms after head trauma.",[27,28],"Concussion Post Syndrome","Head Trauma Injury",[30,31,32,33],"Concussion","Head Trauma","Acetaminophen","Metoclopramide","NOT_YET_RECRUITING","2026-06-06",{"date":37,"type":38},"2026-06-10","ACTUAL",{"date":40,"type":21},"2026-08-01",{"date":42,"type":21},"2028-08-04",{"name":44,"class":45},"Montefiore Medical Center","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":46},"100586833","interest-of-a-musical-intervention-on-stress-induced-during-botulinum-toxin-injections-in-spasticity-musibot-100586833","NCT06920524","Interest of a Musical Intervention on Stress Induced During Botulinum Toxin Injections in Spasticity (MUSIBOT)","Interest of a Musical Intervention on Stress Induced During Botulinum Toxin Injections in Spasticity","MUSIBOT","Inclusion Criteria:\n\n* Adult patients, male or female, suffering from spasticity of neurological origin (multiple sclerosis, stroke, head trauma, etc.) and eligible for botulinum toxin injection treatments.\n* Patients with known pain and\u002For anxiety\n* Able to give informed consent to participate in research\n* Enrolled in a French Social Security system\n\nExclusion Criteria:\n\n* Contraindication to musical intervention (severe hearing impairment, unstabilized psychotic disorders, history of auditory trauma)\n* Major cognitive impairment\n* Any medical condition deemed by the investigator to be incompatible with the research.\n* Indication for MEOPA sedation during botulinum toxin injection sessions\n* Medication or medical conditions likely to interfere with heart rate variability during the study: beta-blockers, anti-arrhythmics, anxiolytics, benzodiazepines, anti-hypertensives and calcium antagonists.\n* Pregnant or breast-feeding women\n* Refusal to participate",{"count":56,"type":21},80,[58],"NA","Botulinum toxin (BT) injections are a painful treatment frequently used to treat spasticity following central neurological damage (stroke, multiple sclerosis, spinal cord injury, head trauma). Tolerance of injections varies from patient to patient. For most patients, the pain experienced during the injection is a major source of stress.\n\nNumerous clinical trials have demonstrated the role of music therapy in pain management. Music therapy uses a \"U\" shaped technique, allowing the patient to relax in different phases. This system has demonstrated beneficial effects on pain and anxiety in various fields, such as chronic and acute pain, Alzheimer's disease, fibromyalgia and neurological pain. Given the painful nature of spasticity and anxiety treatment, we aim to use a musical intervention to help patients cope better with injections.\n\nThe primary objective of the study is to investigate the effect of exposure to a musical intervention session during botulinum toxin injections, on injection-induced stress (heart rate variability).\n\nSecondary objectives:\n\nTo study the effect of exposure to a musical intervention session during botulinum toxin injections, during the visit to injections #1, in terms of:\n\n* Injection-induced stress for HRV parameters other than LF\u002FHF\n* Injection-induced pain\n* Injection anxiety\n* Patient satisfaction\n* Effect of musical intervention on the medical procedure performed (botulinum toxin injections) expressed by the doctor at the end of the session.\n\nTo study the effect of exposure to a musical intervention session, during injections visit n°2, in order to evaluate the effect of repeated exposure to a musical intervention session, in terms of :\n\n* Injection-induced stress for HRV parameters other than LF\u002FHF\n* Injection-induced pain\n* Injection anxiety\n* Patient satisfaction\n* Effect of musical intervention on the medical procedure performed (botulinum toxin injections) expressed by the physician at the end of the session.\n\nThe hypothesis of this research is that a responsive musical intervention can, in adults, reduce the stress induced by botulinum toxin injections.\n\nPatients will be selected from the cohort of patients regularly treated for botulinum toxin injections in the Physical and Rehabilitation Medicine (PRM) department at Clermont-Ferrand University Hospital. Botulinum toxin injections will take place in the PRM department. Each patient will participate in the study for a maximum of 4 months.\n\nThis study will be carried out in patients receiving regular botulinum toxin injections to treat spasticity. The first injection will be given with (IM-IM) or without musical intervention (CT-IM), depending on the randomization group, followed by the next injection with musical intervention. Patients will be able to choose the style of music (Jazz, Classical, Electronic, R\\&B, Ambient, Rock, etc.) that appeals to them in order to benefit from a minimum 20-minute session of musical intervention (duration varying according to the number of injections to be performed).",[61,62,63,28],"Stroke","Multiple Sclerosis","Spinal Cord Injury",[65,66,67,68],"Musical intervention","Pain Management","stress","Botulinum toxin","RECRUITING","2025-05-22",{"date":72,"type":38},"2025-05-23",{"date":74,"type":38},"2025-04-25",{"date":76,"type":21},"2027-10-30",{"name":78,"class":45},"University Hospital, Clermont-Ferrand",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":4},"100571932","assessment-of-intracranial-pressure-using-optic-nerve-sheath-diameter-in-head-trauma-in-assiut-university-100571932","NCT06726681","Assessment of Intracranial Pressure Using Optic Nerve Sheath Diameter in Head Trauma in Assiut University","Assessment of Intracranial Pressure Using Optic Nerve Sheath Diameter in Head Trauma in Assiut University Emergency Department","Inclusion Criteria:\n\n* Patients aged from \\> 18 years old. Both male and female patients. GCS\\\u003C15 post injury or pt sent to CT scan by neurosurgery for Intracranial injury's Patients with no past or current neurological or neuro-ophthalmological diseases and normal neurological exams .\n\nExclusion Criteria:\n\n* Pregnant women. Patients with severe orbital trauma. penetrating eye injury, or other ocular pathologies such as glaucoma, optic neuritis, central retinal vein\u002Fartery occlusion, retrobulbar hematoma or orbital cellulitis.\n\nPatient with preexisting neurological diseases. Blind patients. Patients with cardiac arrest . Patients who refused participation in the study.","80 Years",{"count":88,"type":21},143,"OBSERVATIONAL","Clinical performance of optic nerve sheath diameter measurement using ultrasound in comparison of CT brain to measure the intra cranial pressure in head trauma",[28],[93],"optic nerve sheath diameter","2024-12-06",{"date":96,"type":38},"2024-12-10",{"date":98,"type":21},"2025-04",{"date":100,"type":21},"2026-09",{"name":102,"class":45},"Assiut University"]