[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"headache-disorders-primary\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:headache-disorders-primary":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,54,110,135,163,201,231],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100627912","a-feasibility-trial-of-virtual-reality-neurofeedback-for-adolescents-with-migraine-100627912",false,"NCT07454798","A Feasibility Trial of Virtual Reality Neurofeedback for Adolescents With Migraine","Feasibility of Home-based Immersive Neurofeedback Self-regulation Training (INSeRT) for Youth With Migraine","INSeRT","Inclusion Criteria:\n\n* Age 10-16 years (inclusive)\n* Diagnosis of migraine (with or without aura, or chronic migraine) by a qualified headache specialist\n* At least 4 migraine headaches per month\n* Presence of headache-free periods between migraine episodes\n\nExclusion Criteria:\n\n* Significant physical, psychiatric, or developmental conditions that would limit ability to participate in study procedures\n* Clinically elevated Pediatric Vestibular Symptoms Questionnaire (PVSQ) score (\\>0.68) or new\u002Fworsening vestibular symptoms prior to randomization\n* Initiation of a new migraine preventive medication within 4 weeks prior to randomization\n* Current participation in behavioral treatment for migraine (e.g., cognitive behavioral therapy or biofeedback)\n* History of epilepsy or photosensitive seizures","ALL","10 Years","16 Years",{"count":21,"type":22},38,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn whether a home-based virtual reality (VR) neurofeedback program is feasible and acceptable for adolescents with migraine. The study will also explore whether the program may improve headache-related outcomes.\n\nThe main questions it aims to answer are:\n\nIs it feasible to enroll, randomize, and retain adolescents with migraine in this study?\n\nDo participants complete the VR sessions and study procedures as intended?\n\nAre there preliminary signals that the VR neurofeedback program may improve headache-related disability and symptoms?\n\nResearchers will compare Immersive Neurofeedback Self-Regulation Training (INSeRT), which uses brain activity recorded from a wearable electroencephalogram (EEG) headband to guide the VR experience, to a comparison VR program that presents immersive imagery without neurofeedback or guided relaxation training.\n\nParticipants will:\n\nComplete a 4-week baseline period that includes headache logs, questionnaires, and a laboratory EEG assessment\n\nBe randomly assigned to one of two VR programs\n\nComplete VR sessions at home three times per week for 4 weeks\n\nComplete questionnaires at the end of treatment and again approximately 3 months later\n\nRepeat the laboratory EEG assessment at the end of treatment",[28,29],"Migraine","Headache Disorders, Primary",[31,32,33,34,35,36,37,38,39,40],"Pediatric migraine","Adolescents","Neurofeedback","Virtual reality","Electroencephalogram","EEG","Cortical excitability","Self-regulation","Biofeedback","Mind-body therapy","RECRUITING","2026-06-01",{"date":44,"type":45},"2026-06-03","ACTUAL",{"date":47,"type":45},"2026-05-13",{"date":49,"type":22},"2028-05-31",{"name":51,"class":52},"Children's Mercy Hospital Kansas City","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":67,"conditions":68,"keywords":80,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":53},"100571149","aerobic-exercise-and-its-impact-on-sensory-musculoskeletal-and-psychosocial-aspects-in-migraine-100571149","NCT06716489","Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in Migraine","Influence of Aerobic Exercise on Sensory Perception, Musculoskeletal and Psychosocial Alterations in Patients With Migraine","Inclusion Criteria:\n\n* Women aged between 18 and 48 years.\n* Diagnosed with migraine by an experienced neurologist specialized in headaches, following the criteria of the International Classification of Headache Disorders (ICHD).\n* Frequency of headache between 3 and 8 days per month, to ensure adherence to the treatment.\n\nExclusion Criteria:\n\n* Presence of any other type of concurrent headache.\n* Medical conditions affecting sensitivity and autonomic modulation, such as peripheral neuropathies, autonomic disorders, severe neurological diseases, and others.\n* Conditions that prevent physical activity, such as severe musculoskeletal injuries, cardiovascular diseases, or related conditions.\n* Premature ovarian failure.\n* Regular physical exercise in the past year.\n* Body Mass Index (BMI) above 30.0.\n* Smokers or individuals using drugs that interfere with sensitivity and cardiac modulation (e.g., beta-blockers).\n* Abuse of abortive medications.","FEMALE","18 Years","48 Years",{"count":65,"type":22},100,[25],"Migraine is a neurological disorder associated with high levels of disability and changes in sensory processing, musculoskeletal function, and psychosocial factors. Aerobic exercise is a low-cost, non-pharmacological strategy that has shown potential benefits for migraine management, but its effects on sensory perception and musculoskeletal function are not yet fully understood.\n\nThis randomized controlled trial will investigate the effects of a supervised aerobic exercise program combined with pain neuroscience education compared with an active control condition in women aged 18 to 48 years diagnosed with migraine. Participants will be randomly allocated to either an intervention group, which will perform supervised aerobic exercise three times per week for 16 weeks and receive one session of pain neuroscience education, or a control group, which will receive recommendations for unsupervised physical activity at home.\n\nOutcomes related to migraine-related disability, self-reported symptoms, sensory sensitivity, and musculoskeletal function will be assessed at baseline and after the intervention period. Questionnaires will also be collected at a 6-month follow-up. The results of this study may contribute to the development of accessible and low-risk non-pharmacological treatment strategies for people with migraine.",[28,69,70,71,72,73,74,29,75,76,77,78,79],"Migraine Disease","Migraine Disorder","Migraine Disorders, Brain","Headache","Headache (Migraine)","Headache Disorders","Aerobic Exercise","Pain Management","Sensory Disorders","Psychosocial Factors","Quality of Life",[81,82,83,84,85,86,87,88,89,90,91,78,92,93,94,95,96,97,98,99,100],"migraine","aerobic exercise","sensory perception","exercise","headache","disability","musculoeskeletal alterations","quality of life","neck pain","cervical pain","Sensory Thresholds","Physical Fitness","Exercise Intervention","Central Sensitization","Physical Therapy","Migraine Management","Non-pharmacological Treatment","Clinical Trial","Headache Relief","sensitization","2026-04-27",{"date":103,"type":45},"2026-04-28",{"date":105,"type":45},"2026-03-03",{"date":107,"type":22},"2028-11-30",{"name":109,"class":52},"University of Sao Paulo",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":23,"phases":119,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":133,"locationsCount":53},"100616766","effect-of-ultrasound-guided-dry-needling-targeting-rectus-capitus-posterior-major-on-individuals-with-headaches-100616766","NCT07309874","Effect of Ultrasound-Guided Dry Needling Targeting Rectus Capitus Posterior Major on Individuals With Headaches","Inclusion Criteria:\n\n* Reports of a headache within the last 6 months (no minimum or maximum frequency or duration)\n* Current reports of headache\n* Tenderness to palpation of suboccipital muscles with Numeric Pain Rating Scale score ≥ 2\u002F10\n* No history of cervical spine surgery or neurological disorders\n\nExclusion Criteria:\n\n* History of cervical spine trauma or surgery\n* Diagnosed bleeding disorder\n* Currently using anticoagulant medications\n* Currently using anti-platelet medications\n* Diagnosed systemic joint diseases such as rheumatoid arthritis\n* Active infection\n* Diabetes\n* Cancer\n* Fibromyalgia\n* Cervical radiculopathy\n* Inability to tolerate prone positioning for the duration of the procedure.","65 Years",{"count":118,"type":22},50,[25],"Headaches such as tension-type, migraine, and cervicogenic (neck-related) headaches are among the most common and disabling conditions worldwide. and are often associated with tight or sensitive muscles at the base of the skull, which can contribute to headaches. Dry needling involves inserting a very thin, sterile needle into tight muscle areas known as trigger points to relieve pain and muscle tension. When applied to the deep neck muscles, including those beneath the skull, dry needling may reduce headache symptoms. The suboccipital region contains important structures such as the vertebral artery, greater occipital nerve, and spinal cord, which requires precise needle placement to maintain safety. Many needling techniques used in this region have not been validated for accuracy or safety in living subjects. This study will use real-time ultrasound imaging to guide dry needling of the rectus capitis posterior major muscle and directly visualize nearby structures to minimize risk.\n\nThe main goals of this research are to examine the effects of a single session of ultrasound-guided dry needling on headache symptoms and to confirm the safety, accuracy, and consistency of the proposed needling technique using ultrasound imaging.",[29,122],"Headache, Cervicogenic",[72,124,125,126],"cervical spine","suboccipital muscles","needle placement","2026-03-31",{"date":129,"type":45},"2026-04-01",{"date":131,"type":45},"2026-03-01",{"date":42,"type":22},{"name":134,"class":52},"Texas Tech University Health Sciences Center",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":17,"minAge":142,"maxAge":4,"enrollmentInfo":143,"targetDuration":145,"studyType":146,"phases":4,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":162},"100464994","china-headache-disorders-registry-100464994","NCT05334927","China HeadAche DIsorders RegiStry","CHAIRS","Inclusion Criteria:\n\n1. Age ≥ 12 years old,Any gender;\n2. The first onset age of primary headache was less than 50 years old(Age \\\u003C65 years at first diagnosis of chronic migraine);\n3. patients with primary headache (migraine, tension headache and other types of primary headache) or primary headache complicated with MOH according to ICHD-3;\n4. Sign the informed consent form.\n\nExclusion Criteria:\n\n1. According to the ICHD-3 diagnostic criteria, there are still headaches directly related to secondary factors (except drug overuse) at the time of enrollment;\n2. Those who cannot be diagnosed as primary headache or primary headache combined with medication overuse headache according to ICHD-3;\n3. According to DSM-V diagnostic criteria, patients with severe mental diseases (such as schizophrenia, mental disorders associated with mental retardation, etc.);\n4. Patients with severe organic diseases, such as malignant tumors, and the expected survival time is less than 1 year;\n5. Pregnant,planning pregnancy or Lactating women;\n6. Subjects participating in other clinical trials;\n7. Unable to cooperate to complete the follow-up due to geographical or other reasons","12 Years",{"count":144,"type":22},10000,"1 Month","OBSERVATIONAL","It is planned to include 10000 patients. In the China HeadAche DIsorders RegiStry CHAIRS）, patients aged over 12 years with primary headache and medication-overuse headache(MOH) were collected. The biomarkers, imaging features, cognition, genetic characteristics, ocial and demographic data, medical data, therapeutics used, and outcome of headache-related diseases were studied, and long-term follow-up was planned.",[29,28,149,150,151,152],"New Daily Persistent Headache","Medication Overuse Headache","Tension-Type Headache","Trigeminal Autonomic Cephalalgia","2026-01-12",{"date":155,"type":45},"2026-01-15",{"date":157,"type":45},"2022-08-29",{"date":159,"type":22},"2032-12-31",{"name":161,"class":52},"Beijing Tiantan Hospital",20,{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":116,"enrollmentInfo":170,"targetDuration":4,"studyType":23,"phases":172,"briefSummary":173,"conditions":174,"keywords":190,"overallStatus":191,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":53},"100619143","amylin-induced-migraine-attacks-without-aura-100619143","NCT07340788","Amylin-Induced Migraine Attacks Without Aura","Amylin-Induced Migraine Attacks Without Aura: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age 18 to 65 years of age upon entry into screening\n* A body weight of 50 to 100 kg\n* History of migraine without aura for ≥12 months and in accordance with ICHD-3\n* Between 1-5 monthly migraine days without aura on average across the 3 months prior to screening\n* Provision of informed consent prior to initiation of any study-specific activities\u002Fprocedures\n\nExclusion Criteria:\n\n* Any history of a primary or secondary headache disorder other than migraine without aura and infrequent episodic tension-type headache\n* Any history of moderate to severe traumatic brain injury\n* Any history of cardiovascular disease, including cerebrovascular diseases\n* Any history of pulmonary disease\n* Any other clinically significant disorders, conditions, or diseases that might impact the safety of the subject or interfere with the study's evaluation, procedures, or completion, aside from those mentioned above. This includes any relevant medical history or evidence that, in the opinion of the site investigator, might pose a risk to the subject or impact the validity of the study results\n* The subject is at risk of self-harm or harm to others as evidenced by past suicidal behavior\n* Female subjects of childbearing potential with a positive pregnancy test during any study visit\n* Cardiovascular disease of any kind, including cerebrovascular diseases\n* Hypertension (systolic blood pressure of ≥150 mmHg and\u002For diastolic blood pressure of ≥100 mmHg) prior to the start of infusion on the experimental day\n* Hypotension (systolic blood pressure of ≤90 mmHg and\u002For diastolic blood pressure of ≤50 mmHg)\n* Abnormalities on the electrocardiogram that, in the opinion of the site investigator, might pose a risk to the subject or impact the validity of the study results\n* Daily use of any medication other than contraceptives\n* Intake of any medication other than contraceptives within 48 hours of infusion start\n* Intake of caffeine, nicotine, and alcohol within 12 hours of infusion start\n* Headache of any intensity within 48 hours of infusion start\n* Migraine attack within 48 hours of infusion start\n* Aura within 48 hours of infusion start",{"count":171,"type":22},21,[25],"Pramlintide is a peptide analogue of human amylin which is a vasoactive signaling molecule involved in the pathogenesis of migraine. This study investigates whether pramlintide induces migraine attacks without aura in people with migraine without aura.",[29,74,175,176,177,178,179,180,181,72,182,183,184,185,186,187,188,189],"Brain Diseases","Nervous System Diseases","Central Nervous System Diseases","Neurologic Manifestations","Signs and Symptoms","Pathological Conditions, Signs and Symptoms","Migraine Disorders","Pain","Peptide Hormones","Hormones","Hormones, Hormone Substitutes, and Hormone Antagonists","Peptides","Amino Acids, Peptides, and Proteins","Amylin","Pramlintide",[28,72,182,188],"NOT_YET_RECRUITING","2026-01-05",{"date":194,"type":45},"2026-01-14",{"date":196,"type":22},"2026-02",{"date":198,"type":22},"2028-10-30",{"name":200,"class":52},"Danish Headache Center",{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":205,"acronym":206,"eligibilityCriteria":207,"healthyVolunteers":208,"sex":17,"minAge":209,"maxAge":210,"enrollmentInfo":211,"targetDuration":212,"studyType":146,"phases":4,"briefSummary":213,"conditions":214,"keywords":220,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":53},"100434650","china-headache-and-vertigo-registry-study-100434650","NCT04939922","China Headache and Vertigo Registry Study","CHRS","Inclusion Criteria:\n\n* Written informed consent and participant privacy information (eg, Written Authorization for Use and Release of Health and Research Study Information) obtained from the participant prior to initiation of any study-specific procedures.\n* Male or female participants ages 4 to 99 years.\n* Headache patients meeting the diagnostic criteria for ICHD-3, including primary headaches such as migraine and tension tension-type headaches, secondary headaches.\n* Patients who meet the headache diagnosis in the ICHD-3 appendix (including vestibular migraine).\n\nExclusion Criteria:\n\n* Patients who were unable to complete scales such as headache diary.\n* Patients denied or unable to be admitted for long-term follow-up.",true,"4 Years","99 Years",{"count":144,"type":22},"30 Years","In the Chinese Headache and Vertigo Registration Study, patients aged 4-99 years with headache (primary headache and secondary headache such as migraine and tension type headache), vertigo (vertigo diseases such as vestibular migraine) and chronic pain (fibromyalgia and other diseases) were collected. The biomarkers, imaging features, right-to-left shunt of the heart (lung), genetic characteristics, treatment, and outcome (in relation to other diseases) of headache-related diseases were studied, and long-term follow-up was planned.",[29,215,28,151,216,217,218,219],"Headache Disorders, Secondary","Cluster Headache","Vertigo, Constant","Vestibular Migraine","Fibromyalgia",[28,74,221,218,219],"Vertigo","2025-07-22",{"date":224,"type":45},"2025-07-25",{"date":226,"type":45},"2017-06-12",{"date":228,"type":22},"2050-12-12",{"name":230,"class":52},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":237,"eligibilityCriteria":238,"healthyVolunteers":208,"sex":17,"minAge":209,"maxAge":210,"enrollmentInfo":239,"targetDuration":241,"studyType":146,"phases":4,"briefSummary":242,"conditions":243,"keywords":244,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":53},"100471387","international-headache-registry-study-100471387","NCT05418218","International Headache Registry Study","International Headache and Vertigo Registration Study","IHRS","Inclusion Criteria:\n\nThe following are requirements for entry into the study:\n\n1. Written informed consent and participant privacy information (eg, Written Authorization for Use and Release of Health and Research Study Information) obtained from the participant prior to initiation of any study-specific procedures.\n2. Male or female participants ages 4 to 99 years, inclusive, at Visit 1.\n3. Headache patients meeting the diagnostic criteria for ICHD-3, including primary headaches such as migraine and tension tension-type headaches, secondary headaches, and patients who meet the headache diagnosis in the ICHD-3 appendix (including vestibular migraine).\n\nExclusion Criteria:\n\n1. Patients who were unable to complete scales such as headache diary.\n2. Patients denied or unable to be admitted for long-term follow-up.",{"count":240,"type":22},200000,"60 Years","In the International Headache and Vertigo Registration Study, patients aged 4-99 years with headache (primary headache and secondary headache such as migraine and tension type headache), vertigo (vertigo diseases such as vestibular migraine) and chronic pain (fibromyalgia and other diseases) were collected. The biomarkers, imaging features, right-to-left shunt of the heart (lung), genetic characteristics, treatment, and outcome (in relation to other diseases) of headache-related diseases were studied, and long-term follow-up was planned.",[29,215,28,151,221,218,219],[28,74,221,218,219],"2025-05-19",{"date":247,"type":45},"2025-05-23",{"date":249,"type":45},"2021-07-12",{"date":251,"type":22},"2082-12-31",{"name":230,"class":52}]